Patents by Inventor Jonathan K. Stiles

Jonathan K. Stiles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-CHEMOKINE AND ASSOCIATED RECEPTORS ANTIBODIES FOR INHIBITION OF GROWTH OF NEOPLASMS
    Publication number: 20110123603
    Abstract: The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine antibodies. It is possible to identify the particular chemokines which are over-expressed in the tumor using methods of the invention and administer antibodies against that over-expressed chemokine.
    Type: Application
    Filed: January 26, 2011
    Publication date: May 26, 2011
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: James W. LILLARD, Shailesh Singh, Jonathan K. Stiles
  • COMPOSITIONS AND METHODS FOR DIAGNOSIS, PROGNOSIS AND MANAGEMENT OF MALARIA
    Publication number: 20110117107
    Abstract: Biomarkers for predicting the severity of malaria and methods for their detection are disclosed. In one aspect, the present application discloses CXCL4, CXCL10, VEGF, PGDF, IL-1Ra, IL-8, MIP-1?, sFas, Fas-L, sTNF-R2, and sTNF-R1 as biomarkers for the severity of malaria. In another aspect, the present application discloses a method for determining the severity of malaria and predicting mortality due to cerebral malaria. The method comprises the detection of the biomarkers CXCL4 and/or CXCL10 and at least one more biomarker and determining the severity of malaria and predicting mortality due to cerebral malaria based upon the ratio of expression of the biomarkers in the subject versus the expression of the biomarkers in a control.
    Type: Application
    Filed: December 2, 2010
    Publication date: May 19, 2011
    Applicant: MOREHOUSE SCHOOL OF MEDICINE
    Inventors: Jonathan K. Stiles, James W. Lillard, Henry B. Armatei Armah, Nana Otoo Wilson, Venkatachalam Udhayakumar
  • Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms
    Patent number: 7919083
    Abstract: The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine antibodies. It is possible to identify the particular chemokines which are over-expressed in the tumor using methods of the invention and administer antibodies against that over-expressed chemokine.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: April 5, 2011
    Assignee: Morehouse School of Medicine
    Inventors: James W. Lillard, Jr., Pier Nicole Hannah, Shailesh Singh, Jonathan K. Stiles
  • Trypanosome derived apoptotic factors (TAF)
    Patent number: 7901681
    Abstract: An antibody was raised against a synthetic 27 per peptide (ProEP2-1) blocked T. brucei and ProEP2-1-induced apoptosis in human brain vascular endothelial cells (HBVEC). The use of this and similar blocking antibodies have use both as diagnostic agents and in treatment to prevent damage arising from infection.
    Type: Grant
    Filed: June 18, 2004
    Date of Patent: March 8, 2011
    Assignee: Morehouse School of Medicine
    Inventors: Jonathan K. Stiles, Vincent C. Bond, Michael Powell
  • Detection of plasmodium falciparum histidine-rich protein II in saliva malaria patients
    Publication number: 20100279319
    Abstract: The detection of PfHRP II in saliva offers a practical, cost-effective alternative to PfHRP II detection in blood as a means for diagnosis of malaria. Collection of saliva is non-invasive, simple, safe, stress free, painless and can be accomplished in primitive settings. The use of Malaria Antigen ELISA kits (CELISA, Cellabs, Australia) used in accord with known procedures for testing blood samples.
    Type: Application
    Filed: April 29, 2009
    Publication date: November 4, 2010
    Inventor: Jonathan K. Stiles
  • Anti-chemokine and associated receptor antibodies and uses for inhibition of inflammation
    Publication number: 20040191255
    Abstract: It is possible to inhibit inflammatory processes by administration of antibodies to chemokines. Identification of chemokines which are over-produced makes it possible to block specific chemokine activity using antibodies to the over-expressed chemokines.
    Type: Application
    Filed: November 14, 2003
    Publication date: September 30, 2004
    Inventors: James W. Lillard, Udai P. Singh, Shailesh Singh, Jonathan K. Stiles
  • Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms
    Publication number: 20040170628
    Abstract: The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine antibodies. It is possible to identify the particular chemokines which are over-expressed in the tumor using methods of the invention and administer antibodies against that over-expressed chemokine.
    Type: Application
    Filed: November 14, 2003
    Publication date: September 2, 2004
    Inventors: James W. Lillard, Pier Nicole Hannah, Shailesh Singh, Jonathan K. Stiles