Abstract: Disclosed are compounds, compositions, and methods useful for treating neuronal and mitochondrial diseases.

Abstract: An apparatus may map one or more fields from a plurality of tables having a first table type to one or more mapped fields of a single table having a second table type and index the one or more mapped fields to correspond to a single index for the single table having the second table type. The apparatus may execute a first query using the single index corresponding to the one or more mapped fields to output a result for the first query. The apparatus may execute a second query for search activity that has occurred on the database since a last update to the single index and combine the result for the first query with the search activity that has occurred on the database since the last update to the single index to output a combined result based on the second query.

Abstract: An apparatus may map one or more fields from a plurality of tables having a first table type to one or more mapped fields of a single table having a second table type and index the one or more mapped fields to correspond to a single index for the single table having the second table type. The apparatus may execute a first query using the single index corresponding to the one or more mapped fields to output a result for the first query. The apparatus may execute a second query for search activity that has occurred on the database since a last update to the single index and combine the result for the first query with the search activity that has occurred on the database since the last update to the single index to output a combined result based on the second query.

Abstract: Provided herein are compositions, systems, and methods for causing weight loss and treating and/or preventing a disease or condition, such as obesity, diabetes, and cancer, with an agent or procedure that inhibits the TMA/FMO3/TMAO pathway in a subject.

Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.

Abstract: The present invention generally relates to golf bags having a lightweight and durable top frame assembly. The lightweight top frame assembly can have handle and leg sub-assemblies. Three-dimensional printing methods can be used to form the top frame assembly or any portion thereof. The golf bags may include a cord assembly extending across the top frame to form one or more club dividers for organizing golf clubs.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: There is disclosed system for oxygenating a patient in relation to anaesthesia using high flow gas delivery. The system has a flow source, and a controller for determining oxygenation requirements of the patient before or during anaesthesia. A method of oxygenating a patient in relation to anaesthesia using high flow gas delivery is also disclosed. The method determines oxygenation requirements of the patient before or during anaesthesia.

Abstract: The disclosure relates to methods, compositions, and kits for improving seeding efficiency of flow cells with polynucleotides, and applications thereof, including for sequencing.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, X1, X2, X3, X4, integer a and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: The present invention relates to methods of imaging template hybridisation for estimating cluster numbers prior to solid phase amplification and sequencing. More particularly, an initial round of imaging is carried out at the single molecule template hybridisation stage which allows a general estimation of cluster numbers prior to clusters being formed. Amplification of the signal allows single molecule imaging to be carried out using standard sequencing imaging apparatus.

Abstract: In an example of the method, a functionalized coating layer is applied in depressions of a patterned flow cell substrate. The depressions are separated by interstitial regions. A primer is grafted to the functionalized coating layer to form a grafted functionalized coating layer in the depressions. A hydrogel is applied on at least the grafted functionalized coating layer.

Abstract: A patient interface can have a frame supporting a sealing member. Various features of the sealing member can improve comfort and sealing performance in the context of forming seals with the nares of a user, as well as contact with other facial surfaces. The sealing member can include convex portions, concave portions and thickness variations for providing various sealing, comfort, and deformability effects.

Abstract: A voltage converter for an aircraft electrical system includes an input power line configured to receive input electrical power, an output power line configured to supply output electrical power to aircraft loads, conversion circuitry, and a controller. The conversion circuitry is configured to convert the input electrical power to supply the output electrical power based on one or more control parameters. The controller is configured to receive data relating to the aircraft loads and modify at least one control parameter based on the data.

Abstract: Systems, methods and computer-program products are provided for aiding in positioning between a surgical object and a machine vision camera in a surgical environment. The machine vision camera senses a position and orientation of a surgical object in its field of view. Controller(s) virtually define a zone within the field of view that indicates a range of acceptable positions for the surgical object relative to a position of the machine vision camera. The controller(s) obtain an acceptable orientation range for the surgical object relative to an orientation of the machine vision camera. The controller(s) execute a GUI to simultaneously present, on the display device, representations of: the field of view; the zone within the field of view; the position of the surgical object relative to the zone; and a current angle difference between the surgical object and the machine vision camera.

Abstract: Dynamically generating data tests includes: receiving test templates and metadata for a plurality of data objects and, on a trigger condition: based on at least the metadata and the test templates, determining a current set of templated data tests, wherein determining the current set of templated data tests comprises: determining at least one templated data test, from a prior set of templated data tests, to cease using; determining at least one templated data test to add to the current set of templated data tests; and determining, within the current set of templated data tests, at least one templated data tests to regenerate; generating the at least one templated data test to add to the current set of templated data tests; regenerating the least one templated data test to regenerate; and executing templated data tests, within the set of current templated data tests, on the plurality of data objects.

Abstract: Herein provided is an interface for use in transmitting data from an aircraft including a first connector configured for physically and removably coupling a communication module to a communication system which obtains the data on-board the aircraft from at least one data source within the aircraft, and a second connector for digitally coupling the communication module to a processing unit of the communication module producing at least one message for transmission based on the data, the at least one message comprising information of interest identified based on the data. The interface is configured for conducting the at least one message from the processing unit to at least one radio via the second connector.

Abstract: Generally, this disclosure enables various drivers, reversible sockets, and methods of use and manufacture thereof. For example, some of these drivers can avoid laterally rolling off an inclined surface (e.g., between about 15 degrees and about 25 degrees). For example, some of these drivers can avoid using excessive material. For example, some of these drivers can allow for stacking of drivers and thereby be efficient to package for shipping. For example, some of these sockets can provide a tactile feedback for a user to know which ends of those sockets are currently being handled.