Abstract: Anchor brackets/tethers may be used to reinforce a vehicle's resin rear door without substantially increasing the mass of the resin rear door. Such anchor brackets hold an interior trim panel(s) in place, and keep the interior trim panel(s) connected to the door structure or portion(s) thereof. The interior trim panel(s) can act as a protective interior shield that eliminates any exposure of the interior cabin/passenger compartment from any outer (and/or interior) door panel cracks/gaps that may be created during an adverse event. Moreover, conventional interior trim panels may, during a collision, break apart, the broken pieces becoming potentially dangerous projectiles. By being attached to the door structure and/or door componentry, the chance that the interior trim panel (or portions thereof) becoming a projectile is negated or at least lessened.

Abstract: An orthopaedic surgical instrument may include an elongated body with a proximal end and distal end. A clamp lever may be pivotally coupled to the proximal end of the elongated body. The clamp lever may be moveable between a locked position and an unlocked position. A biasing element may be configured to bias the clamp lever to the locked position.

Abstract: A spacer for vehicle panels can be shaped such that it absorbs a substantial portion of a first load, the first load applied in a first direction substantially perpendicular to the exterior panel; controllably deforms along a second direction when a second load is applied substantially along the second direction; wherein the second direction is other than the first direction. The spacer need not deform along the second direction when the first load is applied. The spacer can have a shaped member having a channel extending through the spacer perpendicular from the exterior panel, such that the spacer can controllably deform along a width of the channel.

Abstract: A spacer for vehicle panels can be shaped such that it absorbs a substantial portion of a first load, the first load applied in a first direction substantially perpendicular to the exterior panel; controllably deforms along a second direction when a second load is applied substantially along the second direction; wherein the second direction is other than the first direction. The spacer need not deform along the second direction when the first load is applied. The spacer can have a shaped member having a channel extending through the spacer perpendicular from the exterior panel, such that the spacer can controllably deform along a width of the channel.

Abstract: Anchor brackets/tethers may be used to reinforce a vehicle's resin rear door without substantially increasing the mass of the resin rear door. Such anchor brackets hold an interior trim panel(s) in place, and keep the interior trim panel(s) connected to the door structure or portion(s) thereof. The interior trim panel(s) can act as a protective interior shield that eliminates any exposure of the interior cabin/passenger compartment from any outer (and/or interior) door panel cracks/gaps that may be created during an adverse event. Moreover, conventional interior trim panels may, during a collision, break apart, the broken pieces becoming potentially dangerous projectiles. By being attached to the door structure and/or door componentry, the chance that the interior trim panel (or portions thereof) becoming a projectile is negated or at least lessened.

Abstract: The instant invention provides compounds of formula I which are selective JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as atopic dermatitis, arthritis, and cancer.

Abstract: The instant invention provides compounds of formula I which are selective JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as atopic dermatitis, arthritis, and cancer.

Abstract: A system for measuring performance of an enterprise architecture includes an enterprise collaborative recommender engine that provides recommendations for an account within the enterprise architecture based upon enterprise assessments; a health control process engine that triggers rebuilding of the heat map topology view that provides recommendations for updating the enterprise architecture towards increased maturity in response to recommendations from the enterprise collaborative recommender engine; and an enterprise heat map generator that presents a heat map providing maturity information of the enterprise architecture for each domain.

Abstract: A vehicle includes a rocker support that extends in a vehicle longitudinal direction. A side roof rail structure extends in a vehicle longitudinal direction along a vehicle roof assembly. A front pillar assembly is coupled to and extends upward from the rocker support to the side roof rail structure. The front pillar assembly includes a first panel that extends along a height of the front pillar assembly at a front side of the front pillar assembly. A second panel extends along the height of the front pillar assembly that is connected to the first panel at least partially defining an enclosed cavity that extends along the height of the front pillar assembly. The first panel is formed of a material having a lower minimum tensile strength than a material forming the second panel thereby forming a zone of reduced minimum tensile strength along the front side of the front pillar assembly.

Abstract: A vehicle includes a rocker support that extends in a vehicle longitudinal direction. A side roof rail structure extends in a vehicle longitudinal direction along a vehicle roof assembly. A front pillar assembly is coupled to and extends upward from the rocker support to the side roof rail structure. The front pillar assembly includes a first panel that extends along a height of the front pillar assembly at a front side of the front pillar assembly. A second panel extends along the height of the front pillar assembly that is connected to the first panel at least partially defining an enclosed cavity that extends along the height of the front pillar assembly. The first panel is formed of a material having a lower minimum tensile strength than a material forming the second panel thereby forming a zone of reduced minimum tensile strength along the front side of the front pillar assembly.

Abstract: A vehicle sliding door assembly includes a rail that extends in a vehicle longitudinal direction, a hard stop spaced apart from the rail in a vehicle vertical direction, a slide assembly including a follower member that is slidably engaged with the rail, and a closing member pivotally coupled to the follower member, where the closing member is repositionable between an open position, in which the closing member is spaced apart from the hard stop in the vehicle longitudinal direction, and a closed position, in which the closing member contacts the hard stop.

Abstract: A vehicle includes a side member that extends in a vehicle longitudinal direction. A rocker support extends in the vehicle longitudinal direction and is spaced outboard of the side member in the vehicle lateral direction. A C-pillar assembly is coupled to and extends upward from the rocker support. A floor cross member extends in a vehicle lateral direction that is connected to the side member. A pillar assembly to floor cross member reinforcement gusset links the C-pillar assembly and the floor cross member.

Abstract: A vehicle includes a side member that extends in a vehicle longitudinal direction. A rocker support extends in the vehicle longitudinal direction and is spaced outboard of the side member in the vehicle lateral direction. A C-pillar assembly is coupled to and extends upward from the rocker support. A floor cross member extends in a vehicle lateral direction that is connected to the side member. A pillar assembly to floor cross member reinforcement gusset links the C-pillar assembly and the floor cross member.

Abstract: A vehicle sliding door assembly includes a rail that extends in a vehicle longitudinal direction, a hard stop spaced apart from the rail in a vehicle vertical direction, a slide assembly including a follower member that is slidably engaged with the rail, and a closing member pivotally coupled to the follower member, where the closing member is repositionable between an open position, in which the closing member is spaced apart from the hard stop in the vehicle longitudinal direction, and a closed position, in which the closing member contacts the hard stop.

Abstract: Embodiments of a bumper assembly includes a reinforcement beam that extends in a vehicle lateral direction, the reinforcement beam including a front face that extends in the vehicle lateral direction and a rear face that is positioned rearward of and spaced apart from the front face in a vehicle longitudinal direction that is transverse to the vehicle lateral direction, and a front spacer member coupled to an outboard end of the front face of the reinforcement beam, the front spacer member including an end plate that extends between the front face and the rear face of the reinforcement beam and is positioned at least partially within the reinforcement beam.

Abstract: Vehicle structures for dissipating energy associated with a collision are described herein. In one embodiment, a vehicle includes a first side support extending in a vehicle longitudinal direction, a second side support extending in the vehicle longitudinal direction and spaced apart from the first side support in a vehicle lateral direction that is transverse to the vehicle longitudinal direction, and a cross-vehicle stabilizing structure extending between the first side support and the second side support, the cross-vehicle stabilizing structure including a first joint portion coupled to the first side support, the first joint portion including a stiffness-reducing portion positioned within a perimeter of the first joint portion, a second joint portion coupled to the second side support, and a cross-vehicle stabilizer portion coupled to the first joint portion and the second joint portion.

Abstract: Vehicles incorporating load-transferring hood hinge members are disclosed. In one embodiment, a vehicle includes an A-pillar portion, an upper side member coupled to the A-pillar portion and extending forward from the A-pillar portion in a vehicle longitudinal direction, and a dash panel coupled to the A-pillar portion and extending in a vehicle lateral direction that is transverse to the vehicle longitudinal direction. The vehicle also includes a hood hinge member that is coupled to the upper side member and positioned forward of the A-pillar portion. The hood hinge member includes an attachment portion that is coupled to the upper side member, a flange member that extends upward from the attachment portion, a hood attachment opening passing through the flange member, and a rearward-projecting protrusion having a distal surface that is positioned transverse to the flange member.

Abstract: Embodiments of a bumper assembly includes a reinforcement beam that extends in a vehicle lateral direction, the reinforcement beam including a front face that extends in the vehicle lateral direction and a rear face that is positioned rearward of and spaced apart from the front face in a vehicle longitudinal direction that is transverse to the vehicle lateral direction, and a front spacer member coupled to an outboard end of the front face of the reinforcement beam, the front spacer member including an end plate that extends between the front face and the rear face of the reinforcement beam and is positioned at least partially within the reinforcement beam.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.