Abstract: Vehicle structures for dissipating energy associated with a collision are described herein. In one embodiment, a vehicle includes a first side support extending in a vehicle longitudinal direction, a second side support extending in the vehicle longitudinal direction and spaced apart from the first side support in a vehicle lateral direction that is transverse to the vehicle longitudinal direction, and a cross-vehicle stabilizing structure extending between the first side support and the second side support, the cross-vehicle stabilizing structure including a first joint portion coupled to the first side support, the first joint portion including a stiffness-reducing portion positioned within a perimeter of the first joint portion, a second joint portion coupled to the second side support, and a cross-vehicle stabilizer portion coupled to the first joint portion and the second joint portion.

Abstract: Vehicles incorporating load-transferring hood hinge members are disclosed. In one embodiment, a vehicle includes an A-pillar portion, an upper side member coupled to the A-pillar portion and extending forward from the A-pillar portion in a vehicle longitudinal direction, and a dash panel coupled to the A-pillar portion and extending in a vehicle lateral direction that is transverse to the vehicle longitudinal direction. The vehicle also includes a hood hinge member that is coupled to the upper side member and positioned forward of the A-pillar portion. The hood hinge member includes an attachment portion that is coupled to the upper side member, a flange member that extends upward from the attachment portion, a hood attachment opening passing through the flange member, and a rearward-projecting protrusion having a distal surface that is positioned transverse to the flange member.

Abstract: Vehicle structures for dissipating energy associated with a collision are described herein. In one embodiment, a vehicle includes a first side support extending in a vehicle longitudinal direction, a second side support extending in the vehicle longitudinal direction and spaced apart from the first side support in a vehicle lateral direction that is transverse to the vehicle longitudinal direction, and a cross-vehicle stabilizing structure extending between the first side support and the second side support, the cross-vehicle stabilizing structure including a first joint portion coupled to the first side support, the first joint portion including a stiffness-reducing portion positioned within a perimeter of the first joint portion, a second joint portion coupled to the second side support, and a cross-vehicle stabilizer portion coupled to the first joint portion and the second joint portion.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: Vehicle structures for dissipating energy associated with a collision are described herein. In one embodiment, a vehicle includes a first side support extending in a vehicle longitudinal direction, a second side support extending in the vehicle longitudinal direction and spaced apart from the first side support in a vehicle lateral direction that is transverse to the vehicle longitudinal direction, and a cross-vehicle stabilizing structure extending between the first side support and the second side support, the cross-vehicle stabilizing structure including a first joint portion coupled to the first side support, the first joint portion including a stiffness-reducing portion positioned within a perimeter of the first joint portion, a second joint portion coupled to the second side support, and a cross-vehicle stabilizer portion coupled to the first joint portion and the second joint portion.

Abstract: A vehicle including a side support extending in a vehicle longitudinal direction, a cross member extending transverse to the side support, and a reinforcement gusset coupled to the side support and the cross member, where the cross member and the reinforcement gusset define an interrupted interface in which one of the cross member or the reinforcement gusset includes a recessed portion and the opposite of the cross member or the reinforcement gusset includes an extended portion, and the recessed portion and the extended portion have complementary shapes and are detached from one another.

Abstract: Vehicle structures for dissipating energy associated with a collision are disclosed herein. In one embodiment, a vehicle includes a side support that extends between a front suspension mount and a rear suspension mount of the vehicle. The side support includes a targeted energy absorption portion that defines a high-strength region of the side support. The vehicle also includes a cab mounting bracket coupled to the side support and extending outward from the side support. The cab mounting bracket includes a rearward attachment position on the side support and the rearward attachment position of the cab mounting bracket is positioned proximate to the high-strength region of the side support. The vehicle further includes a wheel assembly that is coupled to the front suspension mount and is positioned forward of the cab mounting bracket in a vehicle longitudinal direction.

Abstract: A vehicle including a side support extending in a vehicle longitudinal direction, a cross member extending transverse to the side support, and a reinforcement gusset coupled to the side support and the cross member, where the cross member and the reinforcement gusset define an interrupted interface in which one of the cross member or the reinforcement gusset includes a recessed portion and the opposite of the cross member or the reinforcement gusset includes an extended portion, and the recessed portion and the extended portion have complementary shapes and are detached from one another.

Abstract: Vehicle structures for dissipating energy associated with a collision are disclosed herein. In one embodiment, a vehicle includes a side support that extends between a front suspension mount and a rear suspension mount of the vehicle. The side support includes a targeted energy absorption portion that defines a high-strength region of the side support. The vehicle also includes a cab mounting bracket coupled to the side support and extending outward from the side support. The cab mounting bracket includes a rearward attachment position on the side support and the rearward attachment position of the cab mounting bracket is positioned proximate to the high-strength region of the side support. The vehicle further includes a wheel assembly that is coupled to the front suspension mount and is positioned forward of the cab mounting bracket in a vehicle longitudinal direction.

Abstract: Vehicle structures for dissipating energy associated with a collision are described herein. In one embodiment, a vehicle includes a side support extending in a vehicle longitudinal direction, a bumper assembly coupled to the side support and extending in a vehicle lateral direction that is transverse to the vehicle longitudinal direction, and a repositionable joint assembly extending between and pivotally coupled to the side support and the bumper assembly, the repositionable joint assembly including an outboard linking member pivotally coupled to the bumper assembly at a bumper securement location, an inboard linking member pivotally coupled to the side support at a side support securement location, and a fulcrum portion, where the outboard linking member is pivotally coupled to the inboard linking member at the fulcrum portion.

Abstract: Vehicle structures for dissipating and distributing energy associated with an impact are described herein. In one embodiment, a vehicle includes a dash panel, a wheel well portion that is positioned proximate to an outboard portion of the dash panel, and a side support coupled to the dash panel. The vehicle also includes a front suspension mount that is coupled to the side support and a rocker support positioned outboard of the side support. The vehicle further includes a wheel that is coupled to the front suspension mount and is positioned at least partially within the wheel well portion and forward of the rocker support, an A-pillar portion that is coupled to the rocker support and to the dash panel, and an inboard gusset that is coupled to the side support and the dash panel at a position proximate to the side support and is spaced apart from the A-pillar portion.

Abstract: A rear corner vehicle roof structure includes a rear structural pillar and a small cap-like reinforcement member. The rear pillar includes a vertically elongated base portion which transitions into a bifurcated upper end portion forming a longitudinally extending stub arm which is affixed to an associated side roof rail and a laterally extending stub arm which is affixed to an associated rear roof header. The reinforcement member includes a central bridge portion trifurcated to form extensions conforming to the pillar upper portion, the longitudinally extending stub arm and the laterally extending stub arm. The reinforcement member further includes peripherally flanged web segments disposed between circumferentially adjacent pairs of the pillar base portion, longitudinal and lateral stub arms. The flanged web segments are affixed to opposed continuous flange portions of the upper end portion and configured to support the central bridge portion in a spaced relation from the upper end portion.

Abstract: Vehicle structures for dissipating energy associated with a collision are described herein. In one embodiment, a vehicle includes a first side support extending in a vehicle longitudinal direction, a second side support extending in the vehicle longitudinal direction and spaced apart from the first side support in a vehicle lateral direction that is transverse to the vehicle longitudinal direction, and a cross-vehicle stabilizing structure including a cross-vehicle stabilizer portion extending between the first side support and the second side support, the cross-vehicle stabilizer portion including a first stabilizer portion coupled to the first side support at a first securement location, and a second stabilizer portion coupled to the second side support at a second securement location, where the second stabilizer portion is pivotally coupled to the first stabilizer portion.

Abstract: A vehicle includes a side member that extends in a vehicle longitudinal direction. A dash panel is coupled to the side member and extending in a vehicle lateral direction. A rocker support extends in the vehicle longitudinal direction and is spaced outboard of the side member in the vehicle lateral direction. An A-pillar is coupled to and extends upward from the rocker support. An inner front side member to rocker support reinforcement gusset includes a dash reinforcement portion that is connected to the side member and the dash panel and a floor reinforcement portion that is connected to the rocker support and the side member.

Abstract: Vehicle structures for dissipating energy associated with a collision are described herein. In one embodiment, a vehicle includes a side support extending in a vehicle longitudinal direction, a bumper assembly coupled to the side support and extending in a vehicle lateral direction that is transverse to the vehicle longitudinal direction, and a repositionable joint assembly extending between and pivotally coupled to the side support and the bumper assembly, the repositionable joint assembly including an outboard linking member pivotally coupled to the bumper assembly at a bumper securement location, an inboard linking member pivotally coupled to the side support at a side support securement location, and a fulcrum portion, where the outboard linking member is pivotally coupled to the inboard linking member at the fulcrum portion.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: A battery attachment bracket and method of assembly for protecting a battery of a motor vehicle from damage during a rear impact. The battery attachment bracket connects the battery to support structure of the motor vehicle in an area subject to deformation during a rear impact. The battery attachment bracket is formed by a body member extending from a battery-engaging surface to a vehicle-support-engaging surface. The vehicle-support-engaging surface has a bolt-receiving aperture, and a notch cut-out adjacent to the bolt-receiving aperture located in a vehicle-front direction with respect to the bolt-receiving aperture to define a narrowed portion of the battery attachment bracket. A gusset having an angled surface is located on a vehicle-front-facing surface of the battery attachment bracket. The gusset resists deformation of the battery attachment bracket and promotes separation of the battery attachment bracket from the support structure of the motor vehicle adjacent the bolt-receiving aperture.

Abstract: A battery attachment bracket and method of assembly for protecting a battery of a motor vehicle from damage during a rear impact. The bracket connects the battery to support structure of the motor vehicle in an area subject to deformation during a rear impact. The bracket is formed by a body member extending from a battery-engaging surface to a vehicle-support-engaging surface. The vehicle-support-engaging surface has a bolt-receiving aperture formed therein, and a notch cut-out adjacent to the bolt-receiving aperture located in a vehicle-front direction with respect to the bolt-receiving aperture to define a narrowed portion of the battery attachment bracket. A gusset is located on a vehicle-front-facing surface of the bracket and has an angled surface. The gusset resists deformation of the bracket and promotes separation of the bracket from the support structure of the motor vehicle adjacent the bolt-receiving aperture.