Abstract: An authentication system may receive an authentication MAC, an integrity MAC, and data transmitted from a payment application and a payment terminal. A local integrity MAC may be generated using the data as an input to a first cryptographic operation. The system may compare the local integrity MAC to the received integrity MAC to authenticate the received integrity MAC. A local authentication MAC may be generated using a second cryptographic operation and compare the local authentication MAC to the received authentication MAC. The system may authenticate the payment application in response to a successful authentication of at least one of the received authentication MAC or the received integrity MAC.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: Disclosed is a data processing system that processes data therein and a method of using the data processing system. The data processing system includes a plurality of data processing nodes that are coupled together via a data communication network arrangement. The data processing system distributes a plurality of computing tasks across plurality of data processing nodes, wherein plurality of computing tasks are distributed according to a directed acyclic graph (DAG) allocation arrangement, wherein the DAG allocation arrangement employs consensus voting arrangement employing recursive elections of nodes or users of data processing system to control operation of the DAG allocation arrangement to incentivize participation of the plurality of data processing nodes to process the plurality of computing tasks and wherein the DAG allocation arrangement is associated with a ledger arrangement operable to control or record execution of the plurality of computing tasks.

Abstract: A system and method for detecting harmful substances within a consumable sample comprising: receiving a consumable sample at a first chamber of a test container; transforming the consumable sample into a homogenized sample upon processing of the consumable sample; delivering the homogenized sample to a second chamber of the test container, wherein the second chamber is configured to receive the homogenized sample comprises an outlet port; mixing the homogenized sample with a process reagent within the second chamber, thereby producing a dispersion; transmitting a volume of the dispersion to an analysis chamber, of the test container, configured to position a detection substrate proximal the port of the second chamber and comprising a detection window that enables detection of presence of the allergen; and detecting presence of the allergen within the consumable sample by way of an optical sensor configured to detect signals indicative of the allergen through the detection window.

Abstract: Disclosed is a resource management system that maintains records relating to transactions associated with resources, wherein the system is implemented as a distributed ledger arrangement including data processing nodes that are coupled via a data communication network. The records are maintained in corresponding chains, wherein each chain includes a temporally defined sequence of verified entries and each entry defines corresponding transactions. When new entry is to be made to a given chain, information concerning the new entry is communicated to the data processing nodes for verification thereof. The system records the new entry when verified, to its corresponding given chain. The system includes a filter arrangement for limiting communication regarding the new entry to be made only to a subset of the data processing nodes of the system for verifying the new entry.

Abstract: A method for expression of transcribable unit(s) in a target cell is provided. The method comprises the steps of: a) providing a target cell expressing a site-specific recombinase, b) providing a DNA vector characterized by a 5? to 3? vector sequence orientation. The DNA vector comprises a plurality of recombination units, wherein a single recombination unit comprises at least one transcribable unit and a first type and a second type of target site that are recognizable by the site-specific recombinase. Recombination can only occur between two target sites of the same type and the first type of target site is located at the 5? start of the recombination unit and the second type of target site is located at the 3? end of the recombination unit. For all recombination units comprised within the DNA vector, the orientation of all of the first type of target sites are the same, and the orientation of all of the second type of target sites are the same.

Abstract: In a general aspect, values of input parameters for a quantum approximate optimization algorithm (QAOA) are selected by a Bayesian optimizer. The QAOA can be configured to solve a combinatorial optimization problem (COP), such as Maximum Cut. A hybrid classical-quantum computing system can be used to execute the QAOA and select the input parameters.

Abstract: A system and method for detecting harmful substances within a consumable sample comprising: receiving a consumable sample at a first chamber of a test container; transforming the consumable sample into a homogenized sample upon processing of the consumable sample; delivering the homogenized sample to a second chamber of the test container, wherein the second chamber is configured to receive the homogenized sample comprises an outlet port; mixing the homogenized sample with a process reagent within the second chamber, thereby producing a dispersion; transmitting a volume of the dispersion to an analysis chamber, of the test container, configured to position a detection substrate proximal the port of the second chamber and comprising a detection window that enables detection of presence of the allergen; and detecting presence of the allergen within the consumable sample by way of an optical sensor configured to detect signals indicative of the allergen through the detection window.

Abstract: A vessel for storing fluid, the vessel including a liner having a liner body that defines: a liner cavity; a plurality of flexible connector portions that include a corrugated length that provides for flexibility of the respective connector portions, the connector portions having a first maximum diameter; a plurality of elongated tubing portions between the respective flexible connector portions, the elongated tubing portions having a second minimum diameter that is larger than the first maximum diameter of the flexible connector portions; and a plurality of taper portions coupling adjoining flexible connector portions and tubing portions configured to provide a transition between a smaller diameter of the connector portion and a larger diameter of the tubing portion.

Abstract: A system and method includes a test container for detecting a target substance in a consumable sample, where the test container includes a test container body defining a test container top, a test container bottom opposing the test container top, a first chamber proximal the test container top, and a second chamber proximal the test container bottom, a magnetic diaphragm situated between the first chamber and the second chamber, the magnetic diaphragm obstructing flow of the consumable sample, and the magnetic diaphragm including a magnetic element embedded in the magnetic diaphragm, and a driving element geometrically complementary to the first chamber, the driving element including a consumable sample grinding feature protruding from a surface of the driving element.

Abstract: A system and method includes a test container for detecting a target substance in a consumable sample, where the test container includes a test container body defining a test container top, a test container bottom opposing the test container top, a first chamber proximal the test container top, and a second chamber proximal the test container bottom, a magnetic diaphragm situated between the first chamber and the second chamber, the magnetic diaphragm obstructing flow of the consumable sample, and the magnetic diaphragm including a magnetic element embedded in the magnetic diaphragm, and a driving element geometrically complementary to the first chamber, the driving element including a consumable sample grinding feature protruding from a surface of the driving element.

Abstract: Selective chelation of bismuth radionuclide ions from a mixture including actinium radionuclide ions involves exposing a ligand to an aqueous solution that includes bismuth radionuclide ions and actinium radionuclide ions under conditions whereby the bismuth radionuclide ions selectively chelate to the ligand for form cationic complexes of the bismuth radionuclide ions. and separating the cationic complexes of the bismuth radionuclide ions from the actinium radionuclide ions. The ligands have a structure based on a 12-membered cyclen ring and may include pendant functional groups that can be derivatized with biological targeting vectors for targeted alpha therapy.

Abstract: A system and method includes a test container for detecting a target substance in a consumable sample, where the test container includes a test container body defining a test container top, a test container bottom opposing the test container top, a first chamber proximal the test container top, and a second chamber proximal the test container bottom, a magnetic diaphragm situated between the first chamber and the second chamber, the magnetic diaphragm obstructing flow of the consumable sample, and the magnetic diaphragm including a magnetic element embedded in the magnetic diaphragm, and a driving element geometrically complementary to the first chamber, the driving element including a consumable sample grinding feature protruding from a surface of the driving element.

Abstract: An authentication system may receive an authentication MAC, an integrity MAC, and data transmitted from a payment application and a payment terminal. A local integrity MAC may be generated using the data as an input to a first cryptographic operation. The system may compare the local integrity MAC to the received integrity MAC to authenticate the received integrity MAC. A local authentication MAC may be generated using a second cryptographic operation and compare the local authentication MAC to the received authentication MAC. The system may authenticate the payment application in response to a successful authentication of at least one of the received authentication MAC or the received integrity MAC.

Abstract: A system and method includes a test container for detecting a target substance in a consumable sample, where the test container includes a test container body defining a test container top, a test container bottom opposing the test container top, a first chamber proximal the test container top, and a second chamber proximal the test container bottom, a magnetic diaphragm situated between the first chamber and the second chamber, the magnetic diaphragm obstructing flow of the consumable sample, and the magnetic diaphragm including a magnetic element embedded in the magnetic diaphragm, and a driving element geometrically complementary to the first chamber, the driving element including a consumable sample grinding feature protruding from a surface of the driving element.

Abstract: A tunable, all-optical, coupling method for a high-Q silica microsphere and an optical waveguide is disclosed. By means of a novel optical nanopositioning method, induced thermal expansion of an asymmetric microsphere stem for laser powers up to 211 mW is observed and used to fine tune the microsphere-waveguide coupling. Microcavity displacements ranging from (0.61±0.13)-(3.49±0.13) ?m and nanometer scale sensitivities varying from (2.81±0.08)-(17.08±0.76) nm/mW are obtained. Additionally, an apparent linear dependency of coupling distance on stem laser heating is achieved. Using these methods, coupling can be altered such that the differing and customizable coupling regimes can be achieved.

Abstract: A tunable, all-optical, coupling method for a high-Q silica microsphere and an optical waveguide is disclosed. By means of a novel optical nanopositioning method, induced thermal expansion of an asymmetric microsphere stem for laser powers up to 211 mW is observed and used to fine tune the microsphere-waveguide coupling. Microcavity displacements ranging from (0.61±0.13)?(3.49±0.13) ?m and nanometer scale sensitivities varying from (2.81±0.08)?(17.08±0.76) nm/mW are obtained. Additionally, an apparent linear dependency of coupling distance on stem laser heating is achieved. Using these methods, coupling can be altered such that the differing and customizable coupling regimes can be achieved.

Abstract: A method for expression of transcribable unit(s) in a target cell is provided. The method comprises the steps of: a) providing a target cell expressing a site-specific recombinase, b) providing a DNA vector characterized by a 5? to 3? vector sequence orientation. The DNA vector comprises a plurality of recombination units, wherein a single recombination unit comprises at least one transcribable unit and a first type and a second type of target site that are recognizable by the site-specific recombinase. Recombination can only occur between two target sites of the same type and the first type of target site is located at the 5? start of the recombination unit and the second type of target site is located at the 3? end of the recombination unit. For all recombination units comprised within the DNA vector, the orientation of all of the first type of target sites are the same, and the orientation of all of the second type of target sites are the same.

Abstract: A system and method for detecting harmful substances within a consumable sample comprising: receiving a consumable sample at a first chamber of a test container; transforming the consumable sample into a homogenized sample upon processing of the consumable sample; delivering the homogenized sample to a second chamber of the test container, wherein the second chamber is configured to receive the homogenized sample comprises an outlet port; mixing the homogenized sample with a process reagent within the second chamber, thereby producing a dispersion; transmitting a volume of the dispersion to an analysis chamber, of the test container, configured to position a detection substrate proximal the port of the second chamber and comprising a detection window that enables detection of presence of the allergen; and detecting presence of the allergen within the consumable sample by way of an optical sensor configured to detect signals indicative of the allergen through the detection window.

Abstract: A system and method for detecting harmful substances within a consumable sample comprising: receiving a consumable sample at a first chamber of a test container; transforming the consumable sample into a homogenized sample upon processing of the consumable sample; delivering the homogenized sample to a second chamber of the test container, wherein the second chamber is configured to receive the homogenized sample comprises an outlet port; mixing the homogenized sample with a process reagent within the second chamber, thereby producing a dispersion; transmitting a volume of the dispersion to an analysis chamber, of the test container, configured to position a detection substrate proximal the port of the second chamber and comprising a detection window that enables detection of presence of the allergen; and detecting presence of the allergen within the consumable sample by way of an optical sensor configured to detect signals indicative of the allergen through the detection window.