Patents by Inventor Jong Shin Yoo
Jong Shin Yoo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20130112864Abstract: Provided are a controller and a control method for improving signal performance of an ion cyclotron resonance mass spectrometer. The controller and control method apply electric signals for causing ions injected into an ion trap of the ion cyclotron resonance mass spectrometer to be injected to the center of the trap as close as possible to trap electrodes, and adjust biased ion motion by appropriately adjusting signals of trap electrodes for causing the injected ions to make ion motion, thereby improving the fidelity of ion signals. The control method for improving signal performance of an ion cyclotron resonance mass spectrometer includes an ion position adjustment process and an ion signal detection process.Type: ApplicationFiled: October 31, 2011Publication date: May 9, 2013Applicant: Korea Basic Science InstituteInventors: Seung Yong Kim, Hyun Sik Kim, Myoung Choul Choi, Jong Shin Yoo
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Publication number: 20120322160Abstract: A method for discovering pharmacologically active substances from natural products at high speed, including: obtaining an activity profile by testing pharmacological activity of a plurality of samples; obtaining mass profiles based on mass spectra resulting from analysis of the samples by mass spectrometry; and determining molecular weight of pharmacologically active substances by comparing and analyzing the activity profile and the mass profile. The method allows fast discovery of pharmacologically active substances by performing high resolution mass spectrometry for numerous components included in an extract sample of natural products and comparing with the activity test data. The information about the intensity of the activity of the pharmacologically active substances of the natural products allows effective utilization of the natural products.Type: ApplicationFiled: June 29, 2012Publication date: December 20, 2012Inventors: Kyu Hwan Park, Hyun Sik Kim, Kyung Hoon Kwon, Jong Shin Yoo
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Publication number: 20120282628Abstract: The present invention relates to a method for diagnosing cancer using information on aberrant glycosylation of glycoproteins, which is related with cancer progression. More particularly, the present invention relates to a peptide marker for cancer diagnosis and a method for diagnosing cancer using the peptide marker, wherein glycoproteins aberrantly glycosylated due to cancer incidence and progression is isolated using lectin; and marker peptides generated by hydrolysis of the glycoproteins isolated by the lectin is selected and quantified.Type: ApplicationFiled: May 3, 2012Publication date: November 8, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Yeoung Hee AHN, Jong Shin YOO, Park Min SHIN, Eun Sun JI
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Publication number: 20120267524Abstract: The present invention relates to an apparatus and method for controlling a pipeline-type ion cyclotron resonance mass spectrometer, in which an ion trap unit of the ion cyclotron resonance mass spectrometer is capable of using two digitizers at the same time, thus enabling a measurement process for detecting an electrical signal which indicates the mass of ions corresponding to a specific purpose, and another measurement process for detecting another electrical signal which indicates the mass of ions corresponding to another specific purpose, to be simultaneously performed. Accordingly, it is an aim of the present invention to provide an apparatus and method to for controlling a pipeline-type ion cyclotron resonance mass spectrometer, which can overcome the problems of time delay among control procedures, and can present a signal detection step wherein an excitation electrode is utilized to improve the sensitivity and speed of signal detection.Type: ApplicationFiled: November 16, 2010Publication date: October 25, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Seung Yong Kim, Hyun Sik Kim, Jong Shin Yoo
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Patent number: 8296300Abstract: The present invention relates to a method for reconstructing protein database for identifying a protein and a method for screening a protein using the same, more precisely a method for reconstructing protein database, and a method for identifying a protein using the same. The method for reconstructing protein database and the method for identifying the protein of the invention are very useful for the investigation of endogenous proteins and their functions and interactions, and are further effectively used for the development of diagnostic and therapeutic agents for various diseases.Type: GrantFiled: August 18, 2006Date of Patent: October 23, 2012Assignee: Korea Basic Science InstituteInventors: Kyung-Hoon Kwon, Jong Shin Yoo
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Publication number: 20120258484Abstract: The present invention relates to a method for diagnosing cancer using information on the aberrant glycosylation of a glycoprotein. More precisely, the present invention relates to a cancer diagnosis peptide marker, which is screened by: a step of separating, using a lectin, a glycoprotein which is aberrantly glycosylated in accordance with the occurrence of cancer; and a step of selecting a hydrolyzed peptide marker derived from the aberrantly glycosylated glycoprotein by observing the quantitative changes in the separated glycoprotein. The present invention also relates to a method for diagnosing cancer using the peptide marker as an agent.Type: ApplicationFiled: December 29, 2009Publication date: October 11, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Yeong Hee Ahn, Jong Shin Yoo
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Publication number: 20120258471Abstract: The present invention relates to a peptide marker for cancer diagnosis and a cancer diagnosis method using the same, more precisely to a peptide marker for cancer diagnosis screened by the following steps: separating and concentrating glycoproteins including a certain glycan chain related to the occurrence of cancer; hydrolyzing the glycoproteins to obtain polypeptides; and quantitatively analyzing the polypeptides to identify certain polypeptides that can track quantitative changes in glycoproteins glycosylated in a specific manner by the occurrence of cancer, and to a cancer diagnosis method using the said peptide marker.Type: ApplicationFiled: December 6, 2010Publication date: October 11, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Yeong Hee Ahn, Jong Shin Yoo
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Publication number: 20120107858Abstract: The present invention relates to a cancer diagnosis method using peptides containing information on the glycosylation of a glycoprotein involving cancer development. More particularly, the present invention relates to a cancer diagnosis method which obtains peptides from the glycoprotein involving cancer development through a hydrolysis process using an enzyme, and quantitatively detects, from among the thus-obtained peptides, glycosylation-related specific peptides which are influenced by the glycosylation of proteins and show specific quantitative changes in the hydrolysis process, to thereby select glycosylation-related specific peptides which show specific quantitative changes in accordance with cancer development. The cancer diagnosis method of the present invention uses the thus-selected glycosylation-related specific peptides as a marker.Type: ApplicationFiled: November 19, 2009Publication date: May 3, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Jong Shin Yoo, Yeong Hee Ahn, Ju Yeon Lee, Jin Young Kim
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Publication number: 20120049082Abstract: An apparatus for electrospray ionization may include: a platform including an inlet port, a first channel connected to the inlet port, a second channel connected to the first channel, and an outlet port connected to the second channel; a nebulizer provided in the first channel and configured to spray inert gas to a sample sprayed into the first channel through the inlet port; and a focusing lens provided in the second channel and configured to focus ions produced from the sprayed sample toward the outlet port.Type: ApplicationFiled: December 23, 2010Publication date: March 1, 2012Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Duk Jin Kang, Myoung Choul Choi, Jong Shin Yoo, Hyun Sik Kim
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Patent number: 8119356Abstract: The present invention relates to an analyzing method of measuring the changes of glycosylation in various glycoproteins which participate in tumorigenesis and metastasis.Type: GrantFiled: April 8, 2010Date of Patent: February 21, 2012Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Jeong-Heon Ko, Yong-Sam Kim, Hyang-Sook Yoo, Jong-Shin Yoo, Se-Jeong Oh, Cheorl-Ho Kim, Ok-Lye Son
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Patent number: 8084218Abstract: The present invention relates to a method for diagnosing cancers by measuring proteins associated with tumorigenesis and metastasis, and a diagnostic kit using the same, particularly relates to the method for diagnosing cancers by measuring the changes of glycosylation of proteins and the kit for diagnosis of cancers using the said method. The method and kit of the present invention can effectively be used for the sensitive diagnosis of cancers comprising colon cancer, stomach cancer, lung cancer and liver cancer.Type: GrantFiled: November 9, 2009Date of Patent: December 27, 2011Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Jeong Heon Ko, Soo Young Hwang, Hosung Sohn, Sejeong Oh, Jeong Hwa Lee, Sang Chul Lee, Jong-Shin Yoo, Dae-Sil Lee
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Publication number: 20110114834Abstract: A high throughput apparatus for multiple sample analysis is disclosed. The high throughput apparatus for multiple sample analysis may include: a laser light source; a lens array configured to focus laser irradiated by the laser light source into a plurality of focused laser beams; and a focusing unit disposed between the lens array and a sample, the focusing unit configured to focus ions produced from the sample by the plurality of focused laser beams into a plurality of ion beams. A high throughput method for multiple sample analysis may include: producing a plurality of focused laser beams by focusing laser; ionizing a sample by irradiating the plurality of focused laser beams to the sample; and producing a plurality of ion beams by focusing ions, wherein the ions are produced from the sample by the plurality of focused laser beams.Type: ApplicationFiled: November 17, 2010Publication date: May 19, 2011Applicant: KOREA BASIC SCIENCE INSTITUTEInventors: Myoung Choul Choi, Hyun Sik Kim, Jong Shin Yoo, Geon Hee Kim, Ki Soo Chang
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Patent number: 7939799Abstract: A tandem Fourier transform ion cyclotron resonance mass spectrometer is provided. In the mass spectrometer, the ions selected by a FT-ICR mass analyzer, which can perform an ion selection process and a mass measurement process with a time interval between the processes, are transmitted through an ion guide to a collision cell, which is located a predetermined distance from the FT-ICR mass analyzer, to split into fragment ions. The fragment ions are transmitted to the FT-ICR mass analyzer that measures the mass of the fragment ions. The fragment ions are generated in the collision cell 60 established separately from the FT-ICR mass analyzer 40 according to the mass spectrometer. Accordingly, It can solve various problems (e.g., the radius reduction of cyclotron motion of colliding ions, or the removal of periphery gas after generating the fragment ions) occurred in a tandem mass spectrometer using a conventional tandem-in-time mass analysis method.Type: GrantFiled: September 12, 2006Date of Patent: May 10, 2011Assignee: Korea Basic Science InstituteInventors: Hyun Sik Kim, Myoung Choul Choi, Jong Shin Yoo
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Patent number: 7889034Abstract: Disclosed is a method for designing a superconducting magnet for generating high magnetic fields with high uniformity for controlling a stray field to be within an allowable range and acquiring structural and magnetic stability by optimizing the arrangement of positions and shapes of coils configuring the superconducting magnet. Volumes of a main coil and a shielding coil are set to be variables, and the critical value of a wires related on the current and magnetic field, the heat transfer depth, and the quench strain are defined to be restriction conditions so that linear programming is applied to determine an initial shape of the shielding coil and division of the main coil based on the sum of total volumes, that is, an objective function. The initial shapes of the main coil and the shielding coil determined through the linear programming are revised and the shape of a shimming coil is determined by using non-linear programming based on the objective function.Type: GrantFiled: November 29, 2005Date of Patent: February 15, 2011Assignee: Korea Basic Science InstituteInventors: Byoung-Seob Lee, Dong-Lak Kim, Hyun-Sik Kim, Jong-Shin Yoo
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Publication number: 20100255500Abstract: The present invention relates to an analyzing method of measuring the changes of glycosylation in various glycoproteins which participate in tumorigenesis and metastasis.Type: ApplicationFiled: April 8, 2010Publication date: October 7, 2010Applicant: Korea Research Institute of Bioscience and BiotechnologyInventors: Jeong-Heon Ko, Yong-Sam Kim, Hyang-Sook Yoo, Jong-Shin Yoo, Se-Jeong Oh, Cheorl-Ho Kim, Ok-Lye Son
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Patent number: 7755039Abstract: A differential pumping system in which a vacuum chamber is manufactured to have a plurality of vacuum pumps and conductance limit plates between the vacuum pumps. The differential pumping system in which an ion is implanted from an ionization source, passes through the vacuum chamber and is detected by a detection unit includes a plurality of vacuum pumps in the vacuum chamber and one or more conductance limit plates between the vacuum pumps, and the conductance limit plates form an angle less than 90° with the transmission direction of the ion. According to such a constitution, higher degree of vacuum and the ion transmission efficiency are maintained without increasing the length of the vacuum chamber. Furthermore, it is possible to minimize the attenuation of an ion detection signal due to a collision with a neighboring neutral molecule, improving the sensitivity of an ion detection device.Type: GrantFiled: October 26, 2007Date of Patent: July 13, 2010Assignee: Korea Basic Science InstituteInventors: Myoung Choul Choi, Jong Shin Yoo, Hyun Sik Kim
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Publication number: 20100099121Abstract: The present invention relates to a method for diagnosing cancers by measuring proteins associated with tumorigenesis and metastasis, and a diagnostic kit using the same, particularly relates to the method for diagnosing cancers by measuring the changes of glycosylation of proteins and the kit for diagnosis of cancers using the said method. The method and kit of the present invention can effectively be used for the sensitive diagnosis of cancers comprising colon cancer, stomach cancer, lung cancer and liver cancer.Type: ApplicationFiled: November 9, 2009Publication date: April 22, 2010Inventors: Jeong Heon Ko, Soo Young Hwang, Hosung Sohn, Sejeong Oh, Jeong Hwa Lee, Sang Chul Lee, Jong-Shin Yoo, Dae-Sil Lee
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Patent number: 7696476Abstract: Disclosed is apparatus and method for improving the signal by changing the voltage applied to an analyzing trap of a high resolving power Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometer. More specifically, after the ion activation, a voltage different from that of a trap electrode is applied to an additional electrode in the center of the trap electrode, and the voltage is maintained until the end of a detection cycle. Applying the above method, the stability of the ions confined in a trap is more increased, and therefore, the detected time domain signal is being lengthened. The lengthened time domain signal results in an increase of the frequency or an improvement of the resolving power and the sensitivity of the mass-to-charge domain signal.Type: GrantFiled: May 25, 2007Date of Patent: April 13, 2010Assignee: Korea Basic Science InstituteInventors: Sung Hwan Kim, Myoung Choul Choi, Jong Shin Yoo, Hyun Sik Kim
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Publication number: 20090322457Abstract: Disclosed is a method for designing a superconducting magnet for generating high magnetic fields with high uniformity for controlling a stray field to be within an allowable range and acquiring structural and magnetic stability by optimizing the arrangement of positions and shapes of coils configuring the superconducting magnet. Volumes of a main coil and a shielding coil are set to be variables, and the critical value of a wires related on the current and magnetic field, the heat transfer depth, and the quench strain are defined to be restriction conditions so that linear programming is applied to determine an initial shape of the shielding coil and division of the main coil based on the sum of total volumes, that is, an objective function. The initial shapes of the main coil and the shielding coil determined through the linear programming are revised and the shape of a shimming coil is determined by using non-linear programming based on the objective function.Type: ApplicationFiled: November 29, 2005Publication date: December 31, 2009Inventors: Byoung-Seob Lee, Dong-Lak Kim, Hyun-Sik Kim, Jong-Shin Yoo
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Publication number: 20090319558Abstract: The present invention relates to a method for reconstructing protein database for identifying a protein and a method for screening a protein using the same, more precisely a method for reconstructing protein database comprising the steps of i) Grouping proteins having a required homology by using the clustering software from the primary database which minimizes the overlapping of proteins and then recording sequence information of each protein group on a recording system of a computer; and ii) Designating a representative protein in each protein group and then constructing the representative protein database composed of the representative proteins, followed by recording the results containing sequence information on a recording system of a computer, and a method for identifying a protein using the same; and iii) Identifying proteins from the protein sequences of the protein group which the identified representative protein belongs to.Type: ApplicationFiled: August 18, 2006Publication date: December 24, 2009Inventors: Kyung-Hoon Kwon, Jong Shin Yoo