Abstract: The invention relates to an immunogenic formulation containing one or more modified recombinant strains of Bacillus Calmette-Guerin (BCG), in a concentration between 104?109 bacteria, where each BCG strain expresses at least one protein or immunogenic fragment of SARS-CoV-2, in a pharmaceutically acceptable saline buffer, where this formulation serves to prepare vaccines to prevent, treat or attenuate SARS-CoV-2 infections.

Abstract: In a first aspect this invention provides methods comprising administering an aqueous contrast agent to the vascular system of a subject, and performing a magnetic resonance scan to detect the MR signal enhancement effects of the aqueous contrast agent. In embodiments the magnetic resonance scan comprises applying at least one pulse sequence selected from a PD-weighted pulse sequence, a T1-weighted pulse sequence, a T2-weighted pulse sequence, and a D-weighted pulse sequence. In embodiments the magnetic resonance scan comprises applying a T1-weighted pulse sequence. A system for performing perfusion MRI comprising an aqueous contrast solution and an injection apparatus configured to provide a maximum injection rate of the aqueous contrast solution to a subject vascular system of at least about 5 ml/s. is also provided.

Abstract: Methods and apparatuses for detecting microRNA from a tissue sample. In particular, described herein are multiplexed methods and apparatuses for implementing them for rapid and parallel detection of a profile of different microRNAs in a patient sample using a modified loop-mediated isothermal amplification (“LAMP”) technique.

Abstract: A rubber composition and a tire using the rubber composition utilizing a functionalized silica dry precipitated silica with a specific surface area in the range of 100 to 300 m2/gm treated with a plurality of silanes coupling agents to form a wet polymer silica masterbatch, then blending the masterbatch with a latex rubber component that includes a styrene-butadiene copolymer rubber or a blend of the styrene-butadiene copolymer rubber and another conjugated diene base rubber using a plurality of coupling agents simultaneously.

Abstract: A polymer masterbatch in latex form having nanomaterials and a compatibilized silica for incorporation into natural and synthetic polymers in latex form using precipitated or fumed silica with at least two organosilicon coupling compounds attached to the silica in an aqueous suspension.

Abstract: A flame retardant brominated rubber polymeric composition, wherein the composition can include ethylene propylene ethylidene norbornene rubber polymer and from 12 weight percent to 55 weight percent of bromine covalently bonded thereto. The method can include dissolving a liquid ethylene propylene ethylidene norbornene rubber polymer in hexane with myrcene, forming the composition. The method can include dissolving ethylene propylene ethylidene norbornene rubber polymer in hexane, forming a solution, and adding bromine, or blending N-bromo-succinimide into the solution, forming a suspension. The method can include heating the suspension and stifling the suspension until all bromine in the N-bromo-succinimide has reacted with the ethylene propylene ethylidene norbornene rubber polymer, forming the composition as a solid in a liquid. The method can include removing the liquid from the solid, and flashing off the hexane from the liquid to extract the composition.

Abstract: A functionalized silica for incorporation into natural and synthetic polymers in latex form using precipitated or fumed silica with at least two organosilicon coupling compounds in an aqueous suspension to allow polyamide to load into the polymer latex or to allow polyurethane to load into the polymer latex without disturbing silica-polymer bonds. Polymer-silica reinforced masterbatches are prepared by addition of the functionalized silica slurry using the formed functionalized silica having two different silanes, one for coupling to polyamide or polyurethane and the polymer, the other for connecting directly to the polymer.

Abstract: A polymer masterbatch in latex form having nanomaterials and a compatibilized silica for incorporation into natural and synthetic polymers in latex form using precipitated or fumed silica with at least two organosilicon coupling compounds attached to the silica in an aqueous suspension.

Abstract: A user interface device for controlling an audio visual system. In one embodiment, a device for interfacing with an audio/visual system includes a sensor mat including a surface and operable to be disposed on a substantially flat floor. The sensor mat is further operable for generating electrical signals responsive to physical interactions of a user with the surface. The interface device also includes an electronic control unit including circuitry for coupling to the mat, the electronic control unit for detecting the physical interactions of the mat and the electronic control unit operable to be placed on the substantially flat floor. The interface device further includes an elongated shaft having a first end and a second end and physically coupled to the electronic control unit via the first end and extending laterally therefrom. The second end of the elongated shaft is operable to be displaced in various directions by interactions with both hands of the user.

Abstract: A method for making a high silica loaded polymeric composition by forming a pretreated silica by creating an aqueous slurry with a silica and a silane, mixing a solvent with the silane and adding the mixture to the silica, or spraying silane on the silica allowing the liquids to be absorbed into the silica. The method includes coupling the silane onto the silica, adding the pretreated silica to a carrier, forming a slurry, heating the slurry, and mixing preheated polymeric rubber latex with the heated slurry to form a latex slurry, then blending a coagulant with the latex slurry while stirring and allowing coagulation of the latex slurry to form the high silica loaded polymeric rubber composite.

Abstract: A rubber composition and a tire using the rubber composition utilizing a functionalized silica dry precipitated silica with a specific surface area in the range of 100 to 300 m2/gm treated with a plurality of silanes coupling agents to form a wet polymer silica masterbatch, then blending the masterbatch with a latex rubber component that includes a styrene-butadiene copolymer rubber or a blend of the styrene-butadiene copolymer rubber and another conjugated diene base rubber using a plurality of coupling agents simultaneously.

Abstract: A flame retardant brominated rubber polymeric composition, wherein the composition can include ethylene propylene ethylidene norbornene rubber polymer and from 12 weight percent to 55 weight percent of bromine covalently bonded thereto. The method can include dissolving a liquid ethylene propylene ethylidene norbornene rubber polymer in hexane with myrcene, forming the composition. The method can include dissolving ethylene propylene ethylidene norbornene rubber polymer in hexane, forming a solution, and adding bromine, or blending N-bromo-succinimide into the solution, forming a suspension. The method can include heating the suspension and stifling the suspension until all bromine in the N-bromo-succinimide has reacted with the ethylene propylene ethylidene norbornene rubber polymer, forming the composition as a solid in a liquid. The method can include removing the liquid from the solid, and flashing off the hexane from the liquid to extract the composition.

Abstract: A user interface device for controlling an audio visual system. In one embodiment, a device for interfacing with an audio/visual system includes a sensor mat including a surface and operable to be disposed on a substantially flat floor. The sensor mat is further operable for generating electrical signals responsive to physical interactions of a user with the surface. The interface device also includes an electronic control unit including circuitry for coupling to the mat, the electronic control unit for detecting the physical interactions of the mat and the electronic control unit operable to be placed on the substantially flat floor. The interface device further includes an elongated shaft having a first end and a second end and physically coupled to the electronic control unit via the first end and extending laterally therefrom. The second end of the elongated shaft is operable to be displaced in various directions by interactions with both hands of the user.

Abstract: An apparatus and method of interacting with a user is described. The method includes identifying a structure coupled to a base unit, wherein the structure includes a visual identifier. A sound is generated using a speaker of the base unit, wherein the sound is associated with the visual identifier of the structure.

Abstract: An interactive educational apparatus is described. The educational toy apparatus includes an indicium containing structure and a base unit capable of being vertically attached to a vertical surface such as a refrigerator door. The indicium containing structure is capable of being attached to the base unit so that the indicium containing structure and the base unit are vertically oriented.

Abstract: Metal complexes comprising a substituted inden-1-yl group or hydrogenated or partially hydrogenated derivative thereof, said group being substituted at least at the 2-position thereof with a C4-30 ligand group containing a secondary or tertiary substitution pattern at the ?-carbon thereof, polymerization catalysts; and olefin polymerization processes using the same are disclosed.

Abstract: A three-dimensional position locating system is disclosed. In one embodiment, the three-dimensional position locating system includes a housing including a substantially planar surface. The housing includes a first antenna element under the substantially planar surface. A stylus including a second antenna element is coupled to the housing. A processor is electrically coupled to the first antenna element and the second antenna element, and a three-dimensional structure overlies the first antenna element. An antenna coupling element is associated with the three-dimensional structure and an output device can be coupled to the processor.

Abstract: Game apparatuses, systems and methods are provided for interactive play by a user. In preferred embodiments, the game apparatus is comprised of a platform having a surface and a print medium having print elements corresponding to a game, wherein the print medium is capable of being received on the surface of the platform. By positioning the print medium on the platform, the game becomes interactive for the user. The platform includes an array of electrical elements under the surface which are coupled to a processor unit. The processor unit is coupled to a memory device having code which provides for the interactive gaming experience for the user.

Abstract: Low molecular weight olefin polymers are prepared by a polymerization process employing titanium complexes comprising a 3-aryl-substituted cyclopentadienyl ring or substituted derivatives thereof as polymerization catalysts.

Abstract: Metal complexes comprising a substituted inden-1-yl group or hydrogenated or partially hydrogenated derivative thereof, said group being substituted at least at the 2-position thereof with a C4-30 ligand group containing a secondary or tertiary substitution pattern at the ?-carbon thereof, polymerization catalysts; and olefin polymerization processes using the same are disclosed.