Abstract: A novel radio frequency sequence, suitable for performing Magnetic Resonance Imaging (MRI) of 2-dimensional (2D) slices of samples exhibiting short magnetization coherence times (i.e., hard tissues). The SS-ZTE pulse sequence contains the following steps: a) magnetizing all spins in the sample from a longitudinal direction to the transverse plane; b) exciting the 2D slice of interest, which comprises the selective locking of said 2D sample slice magnetization while spoiling the magnetization in the rest of sample volume; c) making the magnetization of the selected 2D slice impervious to reconfigurations of the magnetic field gradients from slice selection to encoding and readout; d) reading out of the free induction decay signal of the sample; e) repeating steps (a-d) with different readout directions, so as to gather a corresponding number of radial spokes of the plane defined by the 2D sample slice.

Abstract: The invention provides a method for performing magnetic resonance imaging, MRI, which exploits prior knowledge of the interactions between electromagnetic fields and spins in the sampled object. This technique is able to provide shorter acquisition times with respect to traditional (Nyquist-Shannon limited) MRI. The method is based on an encoding matrix formalism constructed from the specific knowledge of how every spin would evolve in time depending on their position for a given pulse sequence. This particular previous knowledge has not been fully exploited previously by traditional MRI techniques. Moreover, the method of the invention can be used in combination with other schemes, such as compressed sensing, parallel imaging, or deep learning, for further shortening the MRI scan time.

Abstract: A household appliance apparatus, in particular a cooktop apparatus, includes a temperature sensor unit which includes a photodiode designed to detect incident infrared radiation and to convert the incident infrared radiation into a measurement signal. The measurement signal is amplified by an amplifier of an amplifier unit. A compensation unit at least partially compensates for a temperature influence as the infrared radiation is converted into the measurement signal and/or the measurement signal is amplified.

Abstract: The present invention relates to a control method for a high-speed fluid injection system and a system configured for implementing the control method. Similarly, the invention has a monitoring system for the system configured for implementing the control method. In particular, the present invention allows automatically, precisely, and continuously controlling the amount of fluid injected or applied to a plurality of parts.

Abstract: Systems and methods for creating ophthalmic lens creation instructions are disclosed. The method includes obtaining an ophthalmic prescription and preparing lens creation instructions based on the ophthalmic prescription including determining a baseline lens design. The lens creation instructions are augmented to reduce myopia. The augmented lens creation instructions are created by determining a central region and a peripheral region in the baseline lens, computing a distortion pattern of bumps randomly located in the peripheral region of the lens such that the bumps have random sizes and random strengths, wherein the location, size and strength are created using probability distribution functions, and then computing a final back surface of the lens including incorporating the distortion pattern of bumps into the baseline lens. A lens created by this method is described herein. The method may be implemented on a computing device.

Abstract: There are provided novel topical or transdermal nano-formulations of diclofenac. The formulations are in the form of micellar solutions. The micellar solutions comprise diclofenac alkali metal salt, in a concentration of about 2% to about 5.5% (w/w), a solvent, a mixture of surfactants, and an aqueous continuous, outer phase. The micellar solution may optionally further comprise permeation enhancers. The micellar solutions can be gelled with a suitable gelling agent. The compositions disclosed are useful in the treatment of joint pain, osteoarthritis, muscle pain, back pain and/or inflammation.

Abstract: There is disclosed a nano-complex composition for topical drug delivery, comprising a diclofenac alkali metal salt, a cationic surfactant, glycol, or glycol ether or glycol ether ester, C2 to C3 alcohol, and water. The composition can further comprise hyaluronic acid. There is also provided a method of manufacture of nano-complex compositions for topical drug delivery. The compositions of the disclosure are useful in the treatment of joint pain, osteoarthritis, muscle pain, back pain and/or inflammation.

Abstract: Optimizing visual performance of a spectacle lens using metrics of visual performance includes selecting one or more metrics of visual performance for the lens. Creating functions of the metrics of visual performance, each having a function value that decreases as a values of the metrics of visual performance increase. Creating a merit function for lens optimization, the merit function having a main term that contains a weighted sum of functions that decrease as the metrics of visual performance increase, the weighted sum of functions including a set of viewing directions or a set of points with a one-to one correspondence with the set of viewing directions. Minimizing the merit function to optimize lens surfaces. Then designing an optimal lens having the optimized lens surfaces to optimize visual performance.

Abstract: Systems and methods for lens creations are disclosed. The method includes initiating light transmission from a light source through a diffuser into a container holding resin and a substrate. The light transmission is performed according to an irradiation pattern wherein each point in the resin is illuminated by at least 10% of the diffuser. This causes a lens to be formed. To achieve this illumination, at least 15% of the diffuser receives light from the light source. Further, a diameter of the diffuser is greater than or equal to a diameter of the substrate. The system performing the methods includes a polymerization apparatus and may include a resin conditioning and reservoir apparatus, a metrology unit, a resin drainage apparatus and an optional postcuring apparatus.

Abstract: The invention relates to a nutraceutical formulation of blueberry extract, fish oil (omega-3 and omega-6), recombinant human lactoferrin, vitamin A and vitamin E, for human oral consumption. The invention belongs to the field of ophthalmology and has been developed as a coadjuvant for preserving the health of the precorneal film and of the eye surface. This formulation contains an extract of natural origin (Vaccinium myrtillus L) with antioxidant and anti-inflammatory properties; it also uses eicosapentaenoic acid (EPA), omega-6, and docosahexaenoic acid (DHA), omega-3, obtained from fish oil and which, together with lactoferrin, vitamin A and vitamin E, improves tear quality, since these compounds have anti-microbial and anti-inflammatory effects. This formulation has been designed as a coadjuvant for preserving the health of the precorneal film.

Abstract: A cloud-based framework dynamically utilizes a distributed pool of accelerators to parallelize calculations of physical simulation (physics) solver code partitioned across multiple accelerators and compute nodes of one or more virtual data centers in a virtualized computing environment. Multi-level partitioning logic of the framework partitions an input data set of the physics solver code into code groups configured to run on the accelerators using a “hardware agnostic” software layer that abstracts differences in processing architectures to allow targeting of different types of accelerators. A predictive scheduler interacts with the multi-level partitioning logic to locate and predictively reserve the accelerators within the pool, dynamically access and utilize the accelerators when needed, and then promptly release them upon completion of the calculations.

Abstract: An automatic differentiation (AD) technique and implementation processes multi-physics solver code entirely on graphics processing units (GPUs) to automatically differentiate one or more outputs of the code with respect to one or more inputs. The technique provides a “factory” framework that ingests arbitrarily complex solver code to produce a version of the code that is automatically differentiated (AD code) and mapped to the GPUs. The technique provides a derivative of the solver code output with respect to the inputs that enables analysis of the output of the computed solver code with initially provided inputs coherent with sensitivity analysis of that output as the inputs are changed. The adjoint information derived from solver code execution (AD code) computed by the AD technique may also be used to estimate one or more estimates of the numerical error in a solution to the physical simulation.

Abstract: A technique manages graphics processing units (GPUs), as well as associated algorithm advancements, to improve and effectively hide computational costs of adaptive mesh refinement (AMR). A cloud-based framework dynamically utilizes a distributed pool of the GPUs to parallelize computations of physical simulation software (solver) partitioned across multiple GPUs. A highly parallelized and distributed architecture of the framework provides a hybrid approach that operates partly on GPUs, e.g., to perform the solver computations, and partly on general-purpose processing units (CPUs) to accelerate portions of AMR and mesh processing of an AMR module. In an illustrative embodiment, the technique leverages the GPUs to perform as much of the AMR module processing (e.g., algorithms that rely on fixed topology) that can be naturally and efficiently implemented on the GPUs, while maintaining those portions of processing that do not naturally map onto the GPUs (e.g., algorithms with dynamic topology changes) on CPUs.

Abstract: Configuring ophthalmic lenses that reduce oblique aberrations based on a wearer's accommodative demand values is disclosed. The accommodative demand values include A_(rel?) and A_(rel+) depend on object vergence L. The accommodative demand values are considered to and ensure no or reduced eye strain to the wearer. An improved merit function ?? is calculated based on the accommodative demand values. In the calculation, accommodative term A is a smooth and continuous function of both the object distance L and the spherical component of the power error. This ensures the accommodative demand values are well below maximum relative accommodations available to the wearer to prevent eye fatigue. The calculation may also include a smooth and continuous thresholding function ƒ that optimizes the merit function. The calculation may also include evaluation of the power error associated with various object vergencies for every direction of sight.

Abstract: Systems and methods for lens creations are disclosed. The method includes initiating light transmission from a light source through a diffuser into a container holding resin and a substrate. The light transmission is performed according to an irradiation pattern wherein each point in the resin is illuminated by at least 10% of the diffuser. This causes a lens to be formed. To achieve this illumination, at least 15% of the diffuser receives light from the light source. Further, a diameter of the diffuser is greater than or equal to a diameter of the substrate. The system performing the methods includes a polymerization apparatus and may include a resin conditioning and reservoir apparatus, a metrology unit, a resin drainage apparatus and an optional postcuring apparatus.

Abstract: Systems and methods for lens creations are disclosed. The method includes initiating light transmission from a light source through a diffuser into a container holding resin and a substrate. The light transmission is performed according to an irradiation pattern wherein each point in the resin is illuminated by at least 10% of the diffuser. This causes a lens to be formed. To achieve this illumination, at least 15% of the diffuser receives light from the light source. Further, a diameter of the diffuser is greater than or equal to a diameter of the substrate. The system performing the methods includes a polymerization apparatus and may include a resin conditioning and reservoir apparatus, a metrology unit, a resin drainage apparatus and an optional postcuring apparatus.

Abstract: Configuring ophthalmic lenses that reduce oblique aberrations based on a wearer's accommodative demand values is disclosed. The accommodative demand values include A_(rel?) and A_(rel+) depend on object vergence L. The accommodative demand values are considered to and ensure no or reduced eye strain to the wearer. An improved merit function ?? is calculated based on the accommodative demand values. In the calculation, accommodative term A is a smooth and continuous function of both the object distance L and the spherical component of the power error. This ensures the accommodative demand values are well below maximum relative accommodations available to the wearer to prevent eye fatigue. The calculation may also include a smooth and continuous thresholding function ƒ that optimizes the merit function. The calculation may also include evaluation of the power error associated with various object vergencies for every direction of sight.

Abstract: Automatic visual inspection (AVI) systems and methods are disclosed for inspecting transmissive lenses using a plurality of camera poses to provide deflectometric measurements using fringe patterns from at least two points of view. Phase and/or modulation visibility values of the deflectometric measurements are measured for two sensitivities of the patterns taken through an inspection area of the lens from the points of view. Defects are detected based on the phase and/or modulation visibility values at a defect location as compared to at the local area. A defect type is classified to be prismatic, transmissive, lenslet or cosmetic based on the phase and/or modulation visibility values. The defect is localized on the front or back surface of the lens based on the phase and modulation visibility values, and a geometry of the lens orientation. The lens can be invalidated based on defect types, numbers, relative positions and locations.

Abstract: Systems and methods for visual acuity calculation including consideration of a combination of ocular aberrations and lens aberrations are disclosed. One method includes obtaining ocular aberration data and introducing a correction in the defocus term of the ocular aberration data to account for longitudinal chromatic aberration. Lens aberration data is obtained, including performing raytracing through the ophthalmic lens of the patient. Correction to tilt and defocus terms of the lens aberration data is made to account for transverse and longitudinal chromatic aberrations. Polychromatic Point Spread Functions (PSFs) associated to the ocular aberration data and lens aberration data are used to generate retinal images. Retinal sampling is applied to the retinal images, followed by filtering and normalizing the retinal images is also performed. Finally, a maximum visual acuity value is determined. The methods are performed using one or more computing devices.

Abstract: Systems and methods for lens creations are disclosed. The method includes initiating light transmission from a light source through a diffuser into a container holding resin and a substrate. The light transmission is performed according to an irradiation pattern wherein each point in the resin is illuminated by at least 10% of the diffuser. This causes a lens to be formed. To achieve this illumination, at least 15% of the diffuser receives light from the light source. Further, a diameter of the diffuser is greater than or equal to a diameter of the substrate. The system performing the methods includes a polymerization apparatus and may include a resin conditioning and reservoir apparatus, a metrology unit, a resin drainage apparatus and an optional postcuring apparatus.