Abstract: Systems and methods for creating ophthalmic lens creation instructions are disclosed. The method includes obtaining an ophthalmic prescription and preparing lens creation instructions based on the ophthalmic prescription including determining a baseline lens design. The lens creation instructions are augmented to reduce myopia. The augmented lens creation instructions are created by determining a central region and a peripheral region in the baseline lens, computing a distortion pattern of bumps randomly located in the peripheral region of the lens such that the bumps have random sizes and random strengths, wherein the location, size and strength are created using probability distribution functions, and then computing a final back surface of the lens including incorporating the distortion pattern of bumps into the baseline lens. A lens created by this method is described herein. The method may be implemented on a computing device.

Abstract: Configuring ophthalmic lenses that reduce oblique aberrations based on a wearer's accommodative demand values is disclosed. The accommodative demand values include A_(rel?) and A_(rel+) depend on object vergence L. The accommodative demand values are considered to and ensure no or reduced eye strain to the wearer. An improved merit function ?? is calculated based on the accommodative demand values. In the calculation, accommodative term A is a smooth and continuous function of both the object distance L and the spherical component of the power error. This ensures the accommodative demand values are well below maximum relative accommodations available to the wearer to prevent eye fatigue. The calculation may also include a smooth and continuous thresholding function ƒ that optimizes the merit function. The calculation may also include evaluation of the power error associated with various object vergencies for every direction of sight.

Abstract: The invention relates to logic-gate-based Type II or Type V CRISPR-Cas constructs and methods for modifying gene expression using the CRISPR-Cas constructs and CRISPR-Cas effector proteins.

Abstract: An improved method for configuring progressive ophthalmic lenses is disclosed. The method includes computing an improved merit function that modulates reduction of peripheral values of the mean sphere according to the prescription sphere. According to the method the amount of reduction of mean sphere of the lens peripheral regions is dependent on the prescription resulting from a modified merit function. As such, the reduction of peripheral mean sphere varies based on the prescription. According to the modified merit function and resulting improved merit function, the greater the hyperopia and/or presbyopia defined in a prescription, the smaller the reduction of the peripheral value of mean sphere. Accordingly, when the peripheral mean sphere reduction is relaxed, a near region is made wider.

Abstract: Provided herein is a composition, comprising: a plurality of nanoentities comprising an inner core surrounded by an outer shell, the outer shell comprising a polymer, the inner core comprising at least one hydrophobic compound, wherein the nanoentities comprise a pharmaceutical agent, wherein the pharmaceutical agent is an antibody or a fragment thereof, wherein the antibody or the fragment thereof binds to an epitope of an activated mutated KRAS protein. These anti-KRAS antibodies formulated into particular nanoentities are able to be intracellular delivered and further, are able to perform their biological activity inside the cell, thus being useful in the treatment of cancer and other disease associated with a mutation in a KRAS gene.

Abstract: Configuring ophthalmic lenses that reduce oblique aberrations based on a wearer's accommodative demand values is disclosed. The accommodative demand values include A_(rel?) and A_(rel+) depend on object vergence L. The accommodative demand values are considered to and ensure no or reduced eye strain to the wearer. An improved merit function ?? is calculated based on the accommodative demand values. In the calculation, accommodative term A is a smooth and continuous function of both the object distance L and the spherical component of the power error. This ensures the accommodative demand values are well below maximum relative accommodations available to the wearer to prevent eye fatigue. The calculation may also include a smooth and continuous thresholding function ƒ that optimizes the merit function. The calculation may also include evaluation of the power error associated with various object vergencies for every direction of sight.

Abstract: A method for monitoring the environment of a robot including at least one iteration of a detection phase including the following steps:—acquisition, at a measurement instant, of an image of the depth of the environment, referred to as a measurement image, by the at least one 3D camera,—readjustment of the reference and measurement images, and—detection of a change relating to an object in the environment of the robot by comparing the reference and measurement images. A device that implements such a method and a robot equipped with such a device is also provided.

Abstract: Systems and methods for lens creations are disclosed. The method includes initiating light transmission from a light source through a diffuser into a container holding resin and a substrate. The light transmission is performed according to an irradiation pattern wherein each point in the resin is illuminated by at least 10% of the diffuser. This causes a lens to be formed. To achieve this illumination, at least 15% of the diffuser receives light from the light source. Further, a diameter of the diffuser is greater than or equal to a diameter of the substrate. The system performing the methods includes a polymerization apparatus and may include a resin conditioning and reservoir apparatus, a metrology unit, a resin drainage apparatus and an optional postcuring apparatus.

Abstract: Automatic visual inspection (AVI) systems and methods are disclosed for inspecting transmissive lenses using a plurality of camera poses to provide deflectometric measurements using fringe patterns from at least two points of view. Phase and/or modulation visibility values of the deflectometric measurements are measured for two sensitivities of the patterns taken through an inspection area of the lens from the points of view. Defects are detected based on the phase and/or modulation visibility values at a defect location as compared to at the local area. A defect type is classified to be prismatic, transmissive, lenslet or cosmetic based on the phase and/or modulation visibility values. The defect is localized on the front or back surface of the lens based on the phase and modulation visibility values, and a geometry of the lens orientation. The lens can be invalidated based on defect types, numbers, relative positions and locations.

Abstract: The present invention generally relates to particles, including nanocapsules or other nanoentities, comprising a polymer such as polysialic acid. The particles are able to access the interior of the cells, and/or to procure the intracellular release of the associated drugs. In 5 one aspect, the present invention is directed to nanocapsules or other entities having an exterior or surface comprising a polymer such as polysialic acid. In some cases, targeting moieties such as Lyp-1 or tLyp-1 peptide are bonded to the polymer, e.g., using aminoalkyl (C1-C4) succinimide or other linkers. These may be created, for example, by reacting a carboxylate moiety on a polymer with an aminoalkyl maleimide (C1-C4) or an aminoalkyl 10 (C1-C4) methacrylamide, and reacting the resulting aminoalkyl (C1-C4) maleimide or the aminoalkyl (C1-C4) methacrylamide to a cysteine or other sulfur group.

Abstract: An improved method for configuring progressive ophthalmic lenses is disclosed. The method includes computing an improved merit function that modulates reduction of peripheral values of the mean sphere according to the prescription sphere. According to the method the amount of reduction of mean sphere of the lens peripheral regions is dependent on the prescription resulting from a modified merit function. As such, the reduction of peripheral mean sphere varies based on the prescription. According to the modified merit function and resulting improved merit function, the greater the hyperopia and/or presbyopia defined in a prescription, the smaller the reduction of the peripheral value of mean sphere. Accordingly, when the peripheral mean sphere reduction is relaxed, a near region is made wider.

Abstract: An inlet for use with a nacelle having an axis includes an outer barrel. The inlet further includes a lip skin defining a plurality of elongated exit holes including a first circumferential outer hole, a second circumferential outer hole, and a plurality of center holes located between the first circumferential outer hole and the second circumferential outer hole, the first circumferential outer hole being located at least 10 degrees of an entire circumference of the inlet away from the second circumferential outer hole.

Abstract: Methods for ophthalmic lens design incorporating a visual acuity profile are disclosed. The methods include applying rules and functions to visual acuity profile data and an ophthalmic prescription to generate ophthalmic lens parameters for a subject. The visual acuity profile data includes a maximum visual acuity for the subject. The visual acuity profile data may also include a focus tolerance or tolerable blur. Tolerable blur may be measured by an ophthalmic professional or extrapolated. The visual acuity profile data may also include eye physical data such as pupil diameter and eye size, accommodation, retinal photoreceptor cell packing information and neural processing information. The visual acuity profile data may also include personal biographic and/or medical information for the subject.

Abstract: The present invention generally relates to particles, including nanocapsules or other nanoentities, comprising a polymer such as polysialic acid. The particles are able to access the interior of the cells, and/or to procure the intracellular release of the associated drugs. In 5 one aspect, the present invention is directed to nanocapsules or other entities having an exterior or surface comprising a polymer such as polysialic acid. In some cases, targeting moieties such as Lyp-1 or tLyp-1 peptide are bonded to the polymer, e.g., using aminoalkyl (C1-C4) succinimide or other linkers. These may be created, for example, by reacting a carboxylate moiety on a polymer with an aminoalkyl maleimide (C1-C4) or an aminoalkyl 10 (C1-C4) methacrylamide, and reacting the resulting aminoalkyl (C1-C4) maleimide or the aminoalkyl (C1-C4) methacrylamide to a cysteine or other sulfur group.

Abstract: The invention relates to a nutraceutical formulation of blueberry extract, fish oil (omega-3 and omega-6), recombinant human lactoferrin, vitamin A and vitamin E, for human oral consumption. The invention belongs to the field of ophthalmology and has been developed as a coadjuvant for preserving the health of the precorneal film and of the eye surface. This formulation contains an extract of natural origin (Vaccinium myrtillus L) with antioxidant and anti-inflammatory properties; it also uses eicosapentaenoic acid (EPA), omega-6, and docosahexaenoic acid (DHA), omega-3, obtained from fish oil and which, together with lactoferrin, vitamin A and vitamin E, improves tear quality, since these compounds have anti-microbial and anti-inflammatory effects. This formulation has been designed as a coadjuvant for preserving the health of the precorneal film.

Abstract: Methods for lens configuration are disclosed. A method includes erasing a lens by heating the lens to a defined erasure temperature and writing a refractive index spatial distribution in the lens using an exposure pattern of directed ultraviolet (UV) light. The lens may be used as an ophthalmic lens or a lens used in industry. The lens comprises a rewriteable material, including, for example, liquid crystals. The lens may be erased using heat of a defined temperature. The lens may be rewritten by applying other exposure patterns to the lens using UV light.

Abstract: The present disclosure provides an apparatus i.e. shelf unit for attachment to the bed is described. The shelf is easy to install, without tools, and which will not damage the bedsides. The shelf has an upper surface to serve as a resting surface for holding items resting thereon and a lower surface called clamps which rests against the top of the bedside to support the weight of the shelf unit and the items resting thereon.

Abstract: An inlet for use with a nacelle having an axis includes an outer barrel. The inlet further includes a lip skin defining a plurality of elongated exit holes including a first circumferential outer hole, a second circumferential outer hole, and a plurality of center holes located between the first circumferential outer hole and the second circumferential outer hole, the first circumferential outer hole being located at least 10 degrees of an entire circumference of the inlet away from the second circumferential outer hole.

Abstract: Methods for lens configuration are disclosed. A method includes erasing a lens by heating the lens to a defined erasure temperature and writing a refractive index spatial distribution in the lens using an exposure pattern of directed ultraviolet (UV) light. The lens may be used as an ophthalmic lens or a lens used in industry. The lens comprises a rewriteable material, including, for example, liquid crystals. The lens may be erased using heat of a defined temperature. The lens may be rewritten by applying other exposure patterns to the lens using UV light.

Abstract: Systems and methods for additive manufacturing a homogeneous optical element are disclosed herein. A homogeneous pattern of light is shined on a polymerizable liquid to form each polymerized solid layer of the optical element.