Patents by Inventor José Alonso Fernández

José Alonso Fernández has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11092823
    Abstract: Methods for ophthalmic lens design incorporating a visual acuity profile are disclosed. The methods include applying rules and functions to visual acuity profile data and an ophthalmic prescription to generate ophthalmic lens parameters for a subject. The visual acuity profile data includes a maximum visual acuity for the subject. The visual acuity profile data may also include a focus tolerance or tolerable blur. Tolerable blur may be measured by an ophthalmic professional or extrapolated. The visual acuity profile data may also include eye physical data such as pupil diameter and eye size, accommodation, retinal photoreceptor cell packing information and neural processing information. The visual acuity profile data may also include personal biographic and/or medical information for the subject.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: August 17, 2021
    Inventors: José Alonso Fernández, Eduardo Pascual, Daniel Crespo, Juan Antonio Quiroga
  • Publication number: 20210228494
    Abstract: The present invention generally relates to particles, including nanocapsules or other nanoentities, comprising a polymer such as polysialic acid. The particles are able to access the interior of the cells, and/or to procure the intracellular release of the associated drugs. In 5 one aspect, the present invention is directed to nanocapsules or other entities having an exterior or surface comprising a polymer such as polysialic acid. In some cases, targeting moieties such as Lyp-1 or tLyp-1 peptide are bonded to the polymer, e.g., using aminoalkyl (C1-C4) succinimide or other linkers. These may be created, for example, by reacting a carboxylate moiety on a polymer with an aminoalkyl maleimide (C1-C4) or an aminoalkyl 10 (C1-C4) methacrylamide, and reacting the resulting aminoalkyl (C1-C4) maleimide or the aminoalkyl (C1-C4) methacrylamide to a cysteine or other sulfur group.
    Type: Application
    Filed: November 2, 2018
    Publication date: July 29, 2021
    Applicant: Universidade de Santiago de Compostela
    Inventors: María José Alonso Fernandez, Desireé Teijeiro Osorio, Carmen María Teijeiro Valiño, Ana Cadete Pires
  • Patent number: 10363710
    Abstract: Systems and methods for additive manufacturing a homogeneous optical element are disclosed herein. A homogeneous pattern of light is shined on a polymerizable liquid to form each polymerized solid layer of the optical element.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: July 30, 2019
    Assignee: Indizen Optical Technologies of America, LLC
    Inventors: Diego Rodriguez, José Alonso Fernández, Daniel Crespo Vázquez, Juan Antonio Quiroga
  • Publication number: 20190086690
    Abstract: Methods for ophthalmic lens design incorporating a visual acuity profile are disclosed. The methods include applying rules and functions to visual acuity profile data and an ophthalmic prescription to generate ophthalmic lens parameters for a subject. The visual acuity profile data includes a maximum visual acuity for the subject. The visual acuity profile data may also include a focus tolerance or tolerable blur. Tolerable blur may be measured by an ophthalmic professional or extrapolated. The visual acuity profile data may also include eye physical data such as pupil diameter and eye size, accommodation, retinal photoreceptor cell packing information and neural processing information. The visual acuity profile data may also include personal biographic and/or medical information for the subject.
    Type: Application
    Filed: September 18, 2018
    Publication date: March 21, 2019
    Inventors: José Alonso Fernández, Eduardo Pascual, Daniel Crespo, Juan Antonio Quiroga
  • Patent number: 10086575
    Abstract: Systems and methods for smoothing a lens are disclosed herein. A monomer used to make or augment the lens according to an additive method is deposited on the lens surface to be smoothed. A film or membrane with certain elastic properties is pressed against the layered (stepped) surface, with the monomer in between the lens and the membrane. The pressure of the membrane spreads the monomer over the surface of the lens, filling the spaces between the layered (stepped) surface and the membrane. A curing agent is applied to transition the monomer into a polymer coating matching the curve of the membrane. The membrane is removed, leaving a clean, smooth lens surface.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: October 2, 2018
    Assignee: Indizen Optical Technologies of America, LLC
    Inventors: Diego Rodriguez, José Alonso Fernández, Juan Antonio Quiroga, Daniel Crespo Vázquez
  • Patent number: 9952448
    Abstract: A method that adds material selectively to a lens substrate and is used to produce a customized eyewear lens with optical power that is discernibly different from the optical power of the lens substrate. The method involves obtaining the lens substrate, calculating and generating an added material design to convert the lens substrate's optical power to a desired optical power for the customized eyewear lens, contacting the lens substrate with a bulk source of flowable radiation-polymerizable material, and irradiating the material with radiation that is controlled for wavelength range, energy and spatial distribution to polymerize the radiation-polymerizable material only in a selected area according to the added material design. The method does not require the use of external shaping structures to form the customized lens on the lens substrate, and the added material is integrally bonded to the substrate.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: April 24, 2018
    Assignee: Indizen Optical Technologies, S.L.
    Inventors: Daniel Crespo Vázquez, José Alonso Fernández, Juan Antonio Quiroga, Andrew John McKenzie, David Mark Ambler
  • Patent number: 9933632
    Abstract: An additive processing method is used to produce a customized eyewear lens by selectively building layers of radiation-polymerized material onto a lens substrate that has optical power properties discernibly different from the optical properties of the customized eyewear lens. The method involves obtaining the lens substrate, calculating the modifications needed to convert the lens substrate's properties to the desired set of properties of the customized lens, generating an additive layer design to achieve the calculated modifications, and identifying at least one control point for confirmation or revision of the additive layer design. The method further involves applying liquid layers of radiation-polymerizable material to the lens substrate and irradiating the liquid layers in selected areas with controlled radiation such that the material is only polymerized and the additive layer is only formed in the select areas irradiated, according to the additive layer design.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: April 3, 2018
    Assignee: Indizen Optical Technologies, S.L.
    Inventors: Andrew J. McKenzie, David Mark Ambler, Daniel Crespo Vázquez, Jose Alonso Fernández, Juan Antonio Quiroga
  • Patent number: 9726907
    Abstract: A rewritable and freezable lens and method for manufacturing thereof are disclosed. This lens includes at least one active element that has optical properties that can be written, frozen and rewritten into new values at least twice. Rewritable and freezable lenses comprising active index polymer dispersed liquid crystal materials are disclosed. In-situ re-adaptation of spectacle and contact lenses is possible at the point of sale. In-vivo re-adaptation of intraocular lenses in the doctor's room is feasible, avoiding further surgery.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: August 8, 2017
    Assignee: Indizen Optical Technologies, S.L.
    Inventors: Juan Antonio Quiroga, José Alonso Fernández, Daniel Crespo Vázquez
  • Publication number: 20170210072
    Abstract: Systems and methods for additive manufacturing a homogeneous optical element are disclosed herein. A homogeneous pattern of light is shined on a polymerizable liquid to form each polymerized solid layer of the optical element.
    Type: Application
    Filed: January 22, 2016
    Publication date: July 27, 2017
    Inventors: Diego Rodriguez, José Alonso Fernández, Daniel Crespo Vázquez, Juan Antonio Quiroga
  • Patent number: 9642816
    Abstract: The present invention relates to the design and development of nanocapsule systems for the administration of active substances, wherein the nanocapsules of the system have a mean diameter less than 1 ?m and are characterized by comprising (a) a protamine shell, (b) an oily core, and one or more surfactants characterized by having a hydrophilic-lipophilic ratio greater than 8, provided that said surfactant is not a phospholipid.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: May 9, 2017
    Assignee: Universidade de Santiago de Compostela
    Inventors: María José Alonso Fernández, Noemi Csaba, José Vicente González Aramundiz
  • Publication number: 20170100903
    Abstract: Systems and methods for smoothing a lens are disclosed herein. A monomer used to make or augment the lens according to an additive method is deposited on the lens surface to be smoothed. A film or membrane with certain elastic properties is pressed against the layered (stepped) surface, with the monomer in between the lens and the membrane. The pressure of the membrane spreads the monomer over the surface of the lens, filling the spaces between the layered (stepped) surface and the membrane. A curing agent is applied to transition the monomer into a polymer coating matching the curve of the membrane. The membrane is removed, leaving a clean, smooth lens surface.
    Type: Application
    Filed: October 9, 2015
    Publication date: April 13, 2017
    Inventors: Diego Rodriguez, José Alonso Fernández, Juan Antonio Quiroga, Daniel Crespo Vázquez
  • Publication number: 20160377886
    Abstract: A rewritable and freezable lens and method for manufacturing thereof are disclosed. This lens includes at least one active element that has optical properties that can be written, frozen and rewritten into new values at least twice. Rewritable and freezable lenses comprising active index polymer dispersed liquid crystal materials are disclosed. In-situ re-adaptation of spectacle and contact lenses is possible at the point of sale. In-vivo re-adaptation of intraocular lenses in the doctor's room is feasible, avoiding further surgery.
    Type: Application
    Filed: June 23, 2015
    Publication date: December 29, 2016
    Applicant: Indizen Optical Technologies, S.L.
    Inventors: Juan Antonio Quiroga, José Alonso Fernández, Daniel Crespo Vázquez
  • Patent number: 9415019
    Abstract: The invention relates to a system for administering active ingredients, including nanocapsules comprising an oil, a cationic surfactant and a polymer selected from the group consisting of polyglutamic acid (PGA), polyglutamic-polyethyleneglycol acid (PGA-PEG), hyaluronic acid (HA) and polyasparagine (PAsn) or a combination of same and, optionally, an active ingredient, with the condition that when the polymer includes polyglutamic acid or polyglutamic-polyethyleneglycol acid (PGA-PEG) the active ingredient is not a didemnin or a tamandarin. The invention also relates to methods for obtaining said nanocapsule system, the pharmaceutical compositions thereof and the use of same in medicine.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: August 16, 2016
    Assignee: Universidade de Santiago de Compostela
    Inventors: María José Alonso Fernández, Dolores Torres Lopez, Gustavo Rivera Rodriguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo, Teresa Gonzalo Lázaro, Marcos García Fuentes
  • Publication number: 20160038433
    Abstract: The present invention relates to the design and development of nanocapsule systems for the administration of active substances, wherein the nanocapsules of the system have a mean diameter less than 1 ?m and are characterized by comprising (a) a protamine shell, (b) an oily core, and one or more surfactants characterized by having a hydrophilic-lipophilic ratio greater than 8, provided that said surfactant is not a phospholipid.
    Type: Application
    Filed: December 17, 2013
    Publication date: February 11, 2016
    Inventors: María José Alonso Fernández, Noemi Csaba, José Vicente González Aramundiz
  • Publication number: 20150276987
    Abstract: An additive processing method is used to produce a customized eyewear lens by selectively building layers of radiation-polymerized material onto a lens substrate that has optical power properties discernibly different from the optical properties of the customized eyewear lens. The method involves obtaining the lens substrate, calculating the modifications needed to convert the lens substrate's properties to the desired set of properties of the customized lens, generating an additive layer design to achieve the calculated modifications, and identifying at least one control point for confirmation or revision of the additive layer design. The method further involves applying liquid layers of radiation-polymerizable material to the lens substrate and irradiating the liquid layers in selected areas with controlled radiation such that the material is only polymerized and the additive layer is only formed in the select areas irradiated, according to the additive layer design.
    Type: Application
    Filed: March 26, 2014
    Publication date: October 1, 2015
    Applicant: Indizen Optical Technologies, S.L.
    Inventors: Andrew J. McKenzie, David Mark Ambler, Daniel Crespo Vazquez, Jose Alonso Fernandez, Juan Antonio Quiroga
  • Publication number: 20150277146
    Abstract: A method that adds material selectively to a lens substrate and is used to produce a customized eyewear lens with optical power that is discernibly different from the optical power of the lens substrate. The method involves obtaining the lens substrate, calculating and generating an added material design to convert the lens substrate's optical power to a desired optical power for the customized eyewear lens, contacting the lens substrate with a bulk source of flowable radiation-polymerizable material, and irradiating the material with radiation that is controlled for wavelength range, energy and spatial distribution to polymerize the radiation-polymerizable material only in a selected area according to the added material design. The method does not require the use of external shaping structures to form the customized lens on the lens substrate, and the added material is integrally bonded to the substrate.
    Type: Application
    Filed: November 11, 2014
    Publication date: October 1, 2015
    Inventors: Daniel Crespo Vázquez, José Alonso Fernández, Juan Antonio Quiroga, Andrew John McKenzie, David Mark Ambler
  • Publication number: 20140023703
    Abstract: The invention relates to a system for administering active ingredients, including nanocapsules comprising an oil, a cationic surfactant and a polymer selected from the group consisting of polyglutamic acid (PGA), polyglutamic-polyethyleneglycol acid (PGA-PEG), hyaluronic acid (HA) and polyasparagine (PAsn) or a combination of same and, optionally, an active ingredient, with the condition that when the polymer includes polyglutamic acid or polyglutamic-polyethyleneglycol acid (PGA-PEG) the active ingredient is not a didemnin or a tamandarin. The invention also relates to methods for obtaining said nanocapsule system, the pharmaceutical compositions thereof and the use of same in medicine.
    Type: Application
    Filed: January 9, 2012
    Publication date: January 23, 2014
    Applicant: Universidade de Santiago de Compostela
    Inventors: María José Alonso Fernández, Dolores Torres Lopez, Gustavo Rivera Rodriguez, Felipe Andrés Oyarzún Ampuero, Giovanna Lollo, Teresa Gonzalo Lázaro, Marcos Garcia Fuentes
  • Publication number: 20120121670
    Abstract: The present invention relates to a system for administering active ingredients comprising nanocapsules with a diameter less than 1 ?m comprising a polyarginine salt, a negative phospholipid and an oil. The invention also relates to methods for obtaining said nanocapsule system, the pharmaceutical and cosmetic compositions thereof, as well as the use thereof in medicine, particularly in the preparation of a drug for treating cancer.
    Type: Application
    Filed: April 22, 2010
    Publication date: May 17, 2012
    Inventors: Victoria Lozano López, José Alonso Fernández, Dolores Torres López
  • Patent number: 8042941
    Abstract: The present invention is embodied in ophthalmic lenses having a first lens surface that is described by a continuous, gradual increase in optical power that proceeds without inflection points of discontinuities across substantially the entire useable optical area of this lens surface, and an opposite surface of the lens configured to cooperate with the power gradation of the first surface to provide a desired prescription, including at least one stabilized area of optical power. The power gradation of the first surface increases from one edge of the useable area to substantially the opposite edge, and may increase according to linear or non-linear relationships. In another preferred embodiment, the two lens surfaces cooperate to create two stabilized areas of optical power, for a prescription with near-viewing and distance-viewing values.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: October 25, 2011
    Assignee: Indizen Optical Technologies, S.I.
    Inventors: José Alonso Fernández, Daniel Crespo Vázquez, Thomas A. Balch, Nancy L. S. Yamasaki
  • Publication number: 20110187993
    Abstract: The present invention is embodied in ophthalmic lenses having a first lens surface that is described by a continuous, gradual increase in optical power that proceeds without inflection points of discontinuities across substantially the entire useable optical area of this lens surface, and an opposite surface of the lens configured to cooperate with the power gradation of the first surface to provide a desired prescription, including at least one stabilized area of optical power. The power gradation of the first surface increases from one edge of the useable area to substantially the opposite edge, and may increase according to linear or non-linear relationships. In another preferred embodiment, the two lens surfaces cooperate to create two stabilized areas of optical power, for a prescription with near-viewing and distance-viewing values.
    Type: Application
    Filed: January 29, 2010
    Publication date: August 4, 2011
    Inventors: José Alonso Fernández, Daniel Crespo Vázquez, Thomas A. Balch, Nancy L.S. Yamasaki