Abstract: Configuring ophthalmic lenses that reduce oblique aberrations based on a wearer's accommodative demand values is disclosed. The accommodative demand values include A_(rel?) and A_(rel+) depend on object vergence L. The accommodative demand values are considered to and ensure no or reduced eye strain to the wearer. An improved merit function ?? is calculated based on the accommodative demand values. In the calculation, accommodative term A is a smooth and continuous function of both the object distance L and the spherical component of the power error. This ensures the accommodative demand values are well below maximum relative accommodations available to the wearer to prevent eye fatigue. The calculation may also include a smooth and continuous thresholding function ƒ that optimizes the merit function. The calculation may also include evaluation of the power error associated with various object vergencies for every direction of sight.

Abstract: Systems and methods for lens creations are disclosed. The method includes initiating light transmission from a light source through a diffuser into a container holding resin and a substrate. The light transmission is performed according to an irradiation pattern wherein each point in the resin is illuminated by at least 10% of the diffuser. This causes a lens to be formed. To achieve this illumination, at least 15% of the diffuser receives light from the light source. Further, a diameter of the diffuser is greater than or equal to a diameter of the substrate. The system performing the methods includes a polymerization apparatus and may include a resin conditioning and reservoir apparatus, a metrology unit, a resin drainage apparatus and an optional postcuring apparatus.

Abstract: Systems and methods for lens creations are disclosed. The method includes initiating light transmission from a light source through a diffuser into a container holding resin and a substrate. The light transmission is performed according to an irradiation pattern wherein each point in the resin is illuminated by at least 10% of the diffuser. This causes a lens to be formed. To achieve this illumination, at least 15% of the diffuser receives light from the light source. Further, a diameter of the diffuser is greater than or equal to a diameter of the substrate. The system performing the methods includes a polymerization apparatus and may include a resin conditioning and reservoir apparatus, a metrology unit, a resin drainage apparatus and an optional postcuring apparatus.

Abstract: Configuring ophthalmic lenses that reduce oblique aberrations based on a wearer's accommodative demand values is disclosed. The accommodative demand values include A_(rel?) and A_(rel+) depend on object vergence L. The accommodative demand values are considered to and ensure no or reduced eye strain to the wearer. An improved merit function ?? is calculated based on the accommodative demand values. In the calculation, accommodative term A is a smooth and continuous function of both the object distance L and the spherical component of the power error. This ensures the accommodative demand values are well below maximum relative accommodations available to the wearer to prevent eye fatigue. The calculation may also include a smooth and continuous thresholding function ƒ that optimizes the merit function. The calculation may also include evaluation of the power error associated with various object vergencies for every direction of sight.

Abstract: Automatic visual inspection (AVI) systems and methods are disclosed for inspecting transmissive lenses using a plurality of camera poses to provide deflectometric measurements using fringe patterns from at least two points of view. Phase and/or modulation visibility values of the deflectometric measurements are measured for two sensitivities of the patterns taken through an inspection area of the lens from the points of view. Defects are detected based on the phase and/or modulation visibility values at a defect location as compared to at the local area. A defect type is classified to be prismatic, transmissive, lenslet or cosmetic based on the phase and/or modulation visibility values. The defect is localized on the front or back surface of the lens based on the phase and modulation visibility values, and a geometry of the lens orientation. The lens can be invalidated based on defect types, numbers, relative positions and locations.

Abstract: Systems and methods for visual acuity calculation including consideration of a combination of ocular aberrations and lens aberrations are disclosed. One method includes obtaining ocular aberration data and introducing a correction in the defocus term of the ocular aberration data to account for longitudinal chromatic aberration. Lens aberration data is obtained, including performing raytracing through the ophthalmic lens of the patient. Correction to tilt and defocus terms of the lens aberration data is made to account for transverse and longitudinal chromatic aberrations. Polychromatic Point Spread Functions (PSFs) associated to the ocular aberration data and lens aberration data are used to generate retinal images. Retinal sampling is applied to the retinal images, followed by filtering and normalizing the retinal images is also performed. Finally, a maximum visual acuity value is determined. The methods are performed using one or more computing devices.

Abstract: Systems and methods for lens creations are disclosed. The method includes initiating light transmission from a light source through a diffuser into a container holding resin and a substrate. The light transmission is performed according to an irradiation pattern wherein each point in the resin is illuminated by at least 10% of the diffuser. This causes a lens to be formed. To achieve this illumination, at least 15% of the diffuser receives light from the light source. Further, a diameter of the diffuser is greater than or equal to a diameter of the substrate. The system performing the methods includes a polymerization apparatus and may include a resin conditioning and reservoir apparatus, a metrology unit, a resin drainage apparatus and an optional postcuring apparatus.

Abstract: Configuring ophthalmic lenses that reduce oblique aberrations based on a wearer's accommodative demand values is disclosed. The accommodative demand values include A_(rel?) and A_(rel+) depend on object vergence L. The accommodative demand values are considered to and ensure no or reduced eye strain to the wearer. An improved merit function ?? is calculated based on the accommodative demand values. In the calculation, accommodative term A is a smooth and continuous function of both the object distance L and the spherical component of the power error. This ensures the accommodative demand values are well below maximum relative accommodations available to the wearer to prevent eye fatigue. The calculation may also include a smooth and continuous thresholding function ƒ that optimizes the merit function. The calculation may also include evaluation of the power error associated with various object vergencies for every direction of sight.

Abstract: Provided herein is a composition, comprising: a plurality of nanoentities comprising an inner core surrounded by an outer shell, the outer shell comprising a polymer, the inner core comprising at least one hydrophobic compound, wherein the nanoentities comprise a pharmaceutical agent, wherein the pharmaceutical agent is an antibody or a fragment thereof, wherein the antibody or the fragment thereof binds to an epitope of an activated mutated KRAS protein. These anti-KRAS antibodies formulated into particular nanoentities are able to be intracellular delivered and further, are able to perform their biological activity inside the cell, thus being useful in the treatment of cancer and other disease associated with a mutation in a KRAS gene.

Abstract: Configuring ophthalmic lenses that reduce oblique aberrations based on a wearer's accommodative demand values is disclosed. The accommodative demand values include A_(rel?) and A_(rel+) depend on object vergence L. The accommodative demand values are considered to and ensure no or reduced eye strain to the wearer. An improved merit function ?? is calculated based on the accommodative demand values. In the calculation, accommodative term A is a smooth and continuous function of both the object distance L and the spherical component of the power error. This ensures the accommodative demand values are well below maximum relative accommodations available to the wearer to prevent eye fatigue. The calculation may also include a smooth and continuous thresholding function ƒ that optimizes the merit function. The calculation may also include evaluation of the power error associated with various object vergencies for every direction of sight.

Abstract: Systems and methods for lens creations are disclosed. The method includes initiating light transmission from a light source through a diffuser into a container holding resin and a substrate. The light transmission is performed according to an irradiation pattern wherein each point in the resin is illuminated by at least 10% of the diffuser. This causes a lens to be formed. To achieve this illumination, at least 15% of the diffuser receives light from the light source. Further, a diameter of the diffuser is greater than or equal to a diameter of the substrate. The system performing the methods includes a polymerization apparatus and may include a resin conditioning and reservoir apparatus, a metrology unit, a resin drainage apparatus and an optional postcuring apparatus.

Abstract: Automatic visual inspection (AVI) systems and methods are disclosed for inspecting transmissive lenses using a plurality of camera poses to provide deflectometric measurements using fringe patterns from at least two points of view. Phase and/or modulation visibility values of the deflectometric measurements are measured for two sensitivities of the patterns taken through an inspection area of the lens from the points of view. Defects are detected based on the phase and/or modulation visibility values at a defect location as compared to at the local area. A defect type is classified to be prismatic, transmissive, lenslet or cosmetic based on the phase and/or modulation visibility values. The defect is localized on the front or back surface of the lens based on the phase and modulation visibility values, and a geometry of the lens orientation. The lens can be invalidated based on defect types, numbers, relative positions and locations.

Abstract: The present invention generally relates to particles, including nanocapsules or other nanoentities, comprising a polymer such as polysialic acid. The particles are able to access the interior of the cells, and/or to procure the intracellular release of the associated drugs. In 5 one aspect, the present invention is directed to nanocapsules or other entities having an exterior or surface comprising a polymer such as polysialic acid. In some cases, targeting moieties such as Lyp-1 or tLyp-1 peptide are bonded to the polymer, e.g., using aminoalkyl (C1-C4) succinimide or other linkers. These may be created, for example, by reacting a carboxylate moiety on a polymer with an aminoalkyl maleimide (C1-C4) or an aminoalkyl 10 (C1-C4) methacrylamide, and reacting the resulting aminoalkyl (C1-C4) maleimide or the aminoalkyl (C1-C4) methacrylamide to a cysteine or other sulfur group.

Abstract: Methods for ophthalmic lens design incorporating a visual acuity profile are disclosed. The methods include applying rules and functions to visual acuity profile data and an ophthalmic prescription to generate ophthalmic lens parameters for a subject. The visual acuity profile data includes a maximum visual acuity for the subject. The visual acuity profile data may also include a focus tolerance or tolerable blur. Tolerable blur may be measured by an ophthalmic professional or extrapolated. The visual acuity profile data may also include eye physical data such as pupil diameter and eye size, accommodation, retinal photoreceptor cell packing information and neural processing information. The visual acuity profile data may also include personal biographic and/or medical information for the subject.

Abstract: The present invention generally relates to particles, including nanocapsules or other nanoentities, comprising a polymer such as polysialic acid. The particles are able to access the interior of the cells, and/or to procure the intracellular release of the associated drugs. In 5 one aspect, the present invention is directed to nanocapsules or other entities having an exterior or surface comprising a polymer such as polysialic acid. In some cases, targeting moieties such as Lyp-1 or tLyp-1 peptide are bonded to the polymer, e.g., using aminoalkyl (C1-C4) succinimide or other linkers. These may be created, for example, by reacting a carboxylate moiety on a polymer with an aminoalkyl maleimide (C1-C4) or an aminoalkyl 10 (C1-C4) methacrylamide, and reacting the resulting aminoalkyl (C1-C4) maleimide or the aminoalkyl (C1-C4) methacrylamide to a cysteine or other sulfur group.

Abstract: Systems and methods for additive manufacturing a homogeneous optical element are disclosed herein. A homogeneous pattern of light is shined on a polymerizable liquid to form each polymerized solid layer of the optical element.

Abstract: Methods for ophthalmic lens design incorporating a visual acuity profile are disclosed. The methods include applying rules and functions to visual acuity profile data and an ophthalmic prescription to generate ophthalmic lens parameters for a subject. The visual acuity profile data includes a maximum visual acuity for the subject. The visual acuity profile data may also include a focus tolerance or tolerable blur. Tolerable blur may be measured by an ophthalmic professional or extrapolated. The visual acuity profile data may also include eye physical data such as pupil diameter and eye size, accommodation, retinal photoreceptor cell packing information and neural processing information. The visual acuity profile data may also include personal biographic and/or medical information for the subject.

Abstract: Systems and methods for smoothing a lens are disclosed herein. A monomer used to make or augment the lens according to an additive method is deposited on the lens surface to be smoothed. A film or membrane with certain elastic properties is pressed against the layered (stepped) surface, with the monomer in between the lens and the membrane. The pressure of the membrane spreads the monomer over the surface of the lens, filling the spaces between the layered (stepped) surface and the membrane. A curing agent is applied to transition the monomer into a polymer coating matching the curve of the membrane. The membrane is removed, leaving a clean, smooth lens surface.

Abstract: A method that adds material selectively to a lens substrate and is used to produce a customized eyewear lens with optical power that is discernibly different from the optical power of the lens substrate. The method involves obtaining the lens substrate, calculating and generating an added material design to convert the lens substrate's optical power to a desired optical power for the customized eyewear lens, contacting the lens substrate with a bulk source of flowable radiation-polymerizable material, and irradiating the material with radiation that is controlled for wavelength range, energy and spatial distribution to polymerize the radiation-polymerizable material only in a selected area according to the added material design. The method does not require the use of external shaping structures to form the customized lens on the lens substrate, and the added material is integrally bonded to the substrate.

Abstract: An additive processing method is used to produce a customized eyewear lens by selectively building layers of radiation-polymerized material onto a lens substrate that has optical power properties discernibly different from the optical properties of the customized eyewear lens. The method involves obtaining the lens substrate, calculating the modifications needed to convert the lens substrate's properties to the desired set of properties of the customized lens, generating an additive layer design to achieve the calculated modifications, and identifying at least one control point for confirmation or revision of the additive layer design. The method further involves applying liquid layers of radiation-polymerizable material to the lens substrate and irradiating the liquid layers in selected areas with controlled radiation such that the material is only polymerized and the additive layer is only formed in the select areas irradiated, according to the additive layer design.