Abstract: A rewritable and freezable lens and method for manufacturing thereof are disclosed. This lens includes at least one active element that has optical properties that can be written, frozen and rewritten into new values at least twice. Rewritable and freezable lenses comprising active index polymer dispersed liquid crystal materials are disclosed. In-situ re-adaptation of spectacle and contact lenses is possible at the point of sale. In-vivo re-adaptation of intraocular lenses in the doctor's room is feasible, avoiding further surgery.

Abstract: Systems and methods for additive manufacturing a homogeneous optical element are disclosed herein. A homogeneous pattern of light is shined on a polymerizable liquid to form each polymerized solid layer of the optical element.

Abstract: The present invention relates to the design and development of nanocapsule systems for the administration of active substances, wherein the nanocapsules of the system have a mean diameter less than 1 ?m and are characterized by comprising (a) a protamine shell, (b) an oily core, and one or more surfactants characterized by having a hydrophilic-lipophilic ratio greater than 8, provided that said surfactant is not a phospholipid.

Abstract: Systems and methods for smoothing a lens are disclosed herein. A monomer used to make or augment the lens according to an additive method is deposited on the lens surface to be smoothed. A film or membrane with certain elastic properties is pressed against the layered (stepped) surface, with the monomer in between the lens and the membrane. The pressure of the membrane spreads the monomer over the surface of the lens, filling the spaces between the layered (stepped) surface and the membrane. A curing agent is applied to transition the monomer into a polymer coating matching the curve of the membrane. The membrane is removed, leaving a clean, smooth lens surface.

Abstract: A rewritable and freezable lens and method for manufacturing thereof are disclosed. This lens includes at least one active element that has optical properties that can be written, frozen and rewritten into new values at least twice. Rewritable and freezable lenses comprising active index polymer dispersed liquid crystal materials are disclosed. In-situ re-adaptation of spectacle and contact lenses is possible at the point of sale. In-vivo re-adaptation of intraocular lenses in the doctor's room is feasible, avoiding further surgery.

Abstract: The invention relates to a system for administering active ingredients, including nanocapsules comprising an oil, a cationic surfactant and a polymer selected from the group consisting of polyglutamic acid (PGA), polyglutamic-polyethyleneglycol acid (PGA-PEG), hyaluronic acid (HA) and polyasparagine (PAsn) or a combination of same and, optionally, an active ingredient, with the condition that when the polymer includes polyglutamic acid or polyglutamic-polyethyleneglycol acid (PGA-PEG) the active ingredient is not a didemnin or a tamandarin. The invention also relates to methods for obtaining said nanocapsule system, the pharmaceutical compositions thereof and the use of same in medicine.

Abstract: The present invention relates to the design and development of nanocapsule systems for the administration of active substances, wherein the nanocapsules of the system have a mean diameter less than 1 ?m and are characterized by comprising (a) a protamine shell, (b) an oily core, and one or more surfactants characterized by having a hydrophilic-lipophilic ratio greater than 8, provided that said surfactant is not a phospholipid.

Abstract: A method that adds material selectively to a lens substrate and is used to produce a customized eyewear lens with optical power that is discernibly different from the optical power of the lens substrate. The method involves obtaining the lens substrate, calculating and generating an added material design to convert the lens substrate's optical power to a desired optical power for the customized eyewear lens, contacting the lens substrate with a bulk source of flowable radiation-polymerizable material, and irradiating the material with radiation that is controlled for wavelength range, energy and spatial distribution to polymerize the radiation-polymerizable material only in a selected area according to the added material design. The method does not require the use of external shaping structures to form the customized lens on the lens substrate, and the added material is integrally bonded to the substrate.

Abstract: An additive processing method is used to produce a customized eyewear lens by selectively building layers of radiation-polymerized material onto a lens substrate that has optical power properties discernibly different from the optical properties of the customized eyewear lens. The method involves obtaining the lens substrate, calculating the modifications needed to convert the lens substrate's properties to the desired set of properties of the customized lens, generating an additive layer design to achieve the calculated modifications, and identifying at least one control point for confirmation or revision of the additive layer design. The method further involves applying liquid layers of radiation-polymerizable material to the lens substrate and irradiating the liquid layers in selected areas with controlled radiation such that the material is only polymerized and the additive layer is only formed in the select areas irradiated, according to the additive layer design.

Abstract: The invention relates to a system for administering active ingredients, including nanocapsules comprising an oil, a cationic surfactant and a polymer selected from the group consisting of polyglutamic acid (PGA), polyglutamic-polyethyleneglycol acid (PGA-PEG), hyaluronic acid (HA) and polyasparagine (PAsn) or a combination of same and, optionally, an active ingredient, with the condition that when the polymer includes polyglutamic acid or polyglutamic-polyethyleneglycol acid (PGA-PEG) the active ingredient is not a didemnin or a tamandarin. The invention also relates to methods for obtaining said nanocapsule system, the pharmaceutical compositions thereof and the use of same in medicine.

Abstract: The present invention relates to a system for administering active ingredients comprising nanocapsules with a diameter less than 1 ?m comprising a polyarginine salt, a negative phospholipid and an oil. The invention also relates to methods for obtaining said nanocapsule system, the pharmaceutical and cosmetic compositions thereof, as well as the use thereof in medicine, particularly in the preparation of a drug for treating cancer.

Abstract: The present invention is embodied in ophthalmic lenses having a first lens surface that is described by a continuous, gradual increase in optical power that proceeds without inflection points of discontinuities across substantially the entire useable optical area of this lens surface, and an opposite surface of the lens configured to cooperate with the power gradation of the first surface to provide a desired prescription, including at least one stabilized area of optical power. The power gradation of the first surface increases from one edge of the useable area to substantially the opposite edge, and may increase according to linear or non-linear relationships. In another preferred embodiment, the two lens surfaces cooperate to create two stabilized areas of optical power, for a prescription with near-viewing and distance-viewing values.

Abstract: The present invention is embodied in ophthalmic lenses having a first lens surface that is described by a continuous, gradual increase in optical power that proceeds without inflection points of discontinuities across substantially the entire useable optical area of this lens surface, and an opposite surface of the lens configured to cooperate with the power gradation of the first surface to provide a desired prescription, including at least one stabilized area of optical power. The power gradation of the first surface increases from one edge of the useable area to substantially the opposite edge, and may increase according to linear or non-linear relationships. In another preferred embodiment, the two lens surfaces cooperate to create two stabilized areas of optical power, for a prescription with near-viewing and distance-viewing values.

Abstract: The present invention relates to a nanoparticulate system useful for the delivery of pharmacologically active molecules, and especially for transfecting polynucleotides into cells. It comprises nanoparticles of chitosan of low molecular weight and hyaluronan.

Abstract: The invention is aimed at nanocapsule systems characterized in that they have high stability during long periods of time. These systems are useful for the controlled release of pharmacologically or cosmetically active ingredients of highly lipophilic nature. The system comprises nanocapsules with an average size less than 1 ?m dispersed in an aqueous medium, wherein the nanocapsules have a structure which comprises a lipophilic phase containing a phospholipid component and one or more saturated and/or unsaturated C12-C24 chain fatty acids or derivatives thereof; and a hydrophilic phase which comprises chitosan or a derivative thereof and a polyoxyalkylenated compound.

Abstract: The invention is aimed at nanoparticulate systems for the controlled release of heparin. It is specifically aimed at nanoparticulate systems comprising chitosan, heparin and optionally a polyoxyethylenated derivative, and which are ionically cross-linked, as well as being aimed at processes for obtaining them.

Abstract: This invention relates to a system comprising nanoparticles designed for the release of biologically active molecules, where the nanoparticles comprise a) at least 40% by weight of chitosan or a derivative thereof and b) less than 60% by weight of a cyclodextrin or a derivative thereof, where both components a) and b) are mixed, without any covalent bond between them. This system allows for the efficient association of biologically active molecules, as well as their subsequent release in a suitable biological environment.

Abstract: Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms for the administration of active macromolecules. The nanoparticles (having a nanometric size and a hydrophilic character), also called nanospheres or latex, are colloidal systems comprised of the combination of hydrophilic polymers and an active ingredient having a high molecular weight (active macromolecule, molecular weight higher than 1000 daltons). The hydrophilic polymers are the chitosan (an aminopolysaccharide) or its derivatives and polyoxyethylene or its derivatives. The association of the active macromolecule to said nanoparticles takes place in an aqueous phase without having to use organic solvents or auxiliary toxic substances. The active ingredient charge capacity of the nanoparticles is extremely high and additionally said charge is released in a controlled and time extended way. Additionally, said nanoparticles have a positive surface electric charge whose intensity may vary in relation to its composition.

Abstract: Stabilization of colloidal systems through the formation of lipid-polyssacharide complexes. Development of a procedure for the preparation of colloidal systems involving a combination of two ingredients: a water soluble and positively charged polyssacharide and a negatively charged phospholipid. Colloidal systems (submicron emulsions and polymeric nanoparticles and nanocapsules) are stabilized through the formation, at the interface, of an ionic complex: aminopolyssachride-phospholipid. These colloidal systems are characterized by their positive charge and their improved stability. Furthermore, they can be freeze-dried, stored in a dry state and hydrated when required. They can be interesting systems for the administration of drugs by the oral, transdermal, ocular, nasal and vaginal routes of administration. In addition, they can be of interest for cosmetic use.