Abstract: The present invention relates to 3D cell cultures, which contains hepatic cells and are infected by a pathogen, methods for preparing such cell cultures and uses thereof.

Abstract: A hybrid panel method of (and apparatus for) manufacturing electronic devices, and electronic devices manufactured thereby. As non-limiting examples, various aspects of this disclosure provide an apparatus for manufacturing an electronic device, where the apparatus is operable to, at least, receive a panel to which a subpanel is coupled, cut around a subpanel through a layer of material, and remove such subpanel from the panel. The apparatus may also, for example, be operable to couple to an upper side of the subpanel, and remove the subpanel from the panel by, at least in part, operating to rotate the subpanel relative to the panel.

Abstract: Embodiments of the present disclosure are directed to methods, systems and devices, for precise and reduced spot-size capabilities using a laser to alter surfaces without chemical treatment, chemical waste, or chemical residues is provided for microfluidic systems (e.g., lab-on-a-disk, for example). In some embodiments, hydrophobic and super-hydrophilic areas can be created on surfaces in the same material at different areas and positions merely by using different laser settings (e.g., spot size, wavelength, spacing, and/or pulse duration). Accordingly, capillary forces that are a recurrent issue in a microfluidic devices (e.g., a centrifugal microfluidic disk) can be controlled for practical applications, including, for example when users handle the disks and insert a sample, the moment the substrate/device (e.g., disk) is placed in a system (e.g., a centrifugal system), capillary forces can take place and move the fluids, which becomes a problem for sequential bioassays taking place in substrate/device (e.

Abstract: Accordingly, in some embodiments of the disclosure, a multi-chambered assay device is provided, which is configured for arrangement on a disc, as well as configured to process an individual sample. A plurality of such assay devices can be arranged along a periphery of the disc at a distance/radius from the center, such that a plurality of individual samples can be processed, e.g., one per assay device. In addition, in an arrangement that a plurality of assay devices are used, they can be spaced apart such that they balance the disc during rotation (which can be with samples contained in one or more of the assay devices, a plurality, a majority, or all of the assay devices).

Abstract: Embodiments of the present disclosure are directed to methods, systems and devices, for precise and reduced spot-size capabilities using a laser to alter surfaces without chemical treatment, chemical waste, or chemical residues is provided for microfluidic systems (e.g., lab-on-a-disk, for example). In some embodiments, hydrophobic and super-hydrophilic areas can be created on surfaces in the same material at different areas and positions merely by using different laser settings (e.g., spot size, wavelength, spacing, and/or pulse duration). Accordingly, capillary forces that are a recurrent issue in a microfluidic devices (e.g., a centrifugal microfluidic disk) can be controlled for practical applications, including, for example when users handle the disks and insert a sample, the moment the substrate/device (e.g., disk) is placed in a system (e.g., a centrifugal system), capillary forces can take place and move the fluids, which becomes a problem for sequential bioassays taking place in substrate/device (e.

Abstract: A package that includes a substrate, an integrated device, a first encapsulation layer and a void. The substrate includes a first surface. The integrated device is coupled to the first surface of the substrate. The first encapsulation layer is located over the first surface of the substrate and the integrated device. The first encapsulation layer includes an undercut relative to a side surface of the integrated device. The void is located between the integrated device and the first surface of the substrate. The void is laterally surrounded by the undercut of the encapsulation layer.

Abstract: Accordingly, in some embodiments of the disclosure, a multi-chambered assay device is provided, which is configured for arrangement on a disc, as well as configured to process an individual sample. A plurality of such assay devices can be arranged along a periphery of the disc at a distance/radius from the center, such that a plurality of individual samples can be processed, e.g., one per assay device. In addition, in an arrangement that a plurality of assay devices are used, they can be spaced apart such that they balance the disc during rotation (which can be with samples contained in one or more of the assay devices, a plurality, a majority, or all of the assay devices).

Abstract: Disclosed are apparatuses and methods for fabricating the apparatuses. In one aspect, an apparatus includes a high-power die mounted on a backside of a package substrate. A heat transfer layer is disposed on the backside of the high-power die. A plurality of heat sink interconnects is coupled to the heat transfer layer, where each of the plurality of heat sink interconnects is directly coupled to the heat transfer layer in a vertical orientation.

Abstract: Embodiments of the present disclosure are directed to methods, systems and devices, for precise and reduced spot-size capabilities using a laser to alter surfaces without chemical treatment, chemical waste, or chemical residues is provided for microfluidic systems (e.g., lab-on-a-disk, for example). In some embodiments, hydrophobic and super-hydrophilic areas can be created on surfaces in the same material at different areas and positions merely by using different laser settings (e.g., spot size, wavelength, spacing, and/or pulse duration). Accordingly, capillary forces that are a recurrent issue in a microfluidic devices (e.g., a centrifugal microfluidic disk) can be controlled for practical applications, including, for example when users handle the disks and insert a sample, the moment the substrate/device (e.g., disk) is placed in a system (e.g., a centrifugal system), capillary forces can take place and move the fluids, which becomes a problem for sequential bioassays taking place in substrate/device (e.

Abstract: Accordingly, in some embodiments of the disclosure, a multi-chambered assay device is provided, which is configured for arrangement on a disc, as well as configured to process an individual sample. A plurality of such assay devices can be arranged along a periphery of the disc at a distance/radius from the center, such that a plurality of individual samples can be processed, e.g., one per assay device. In addition, in an arrangement that a plurality of assay devices are used, they can be spaced apart such that they balance the disc during rotation (which can be with samples contained in one or more of the assay devices, a plurality, a majority, or all of the assay devices).

Abstract: A package that includes a substrate, an integrated device, a first encapsulation layer and a void. The substrate includes a first surface. The integrated device is coupled to the first surface of the substrate. The first encapsulation layer is located over the first surface of the substrate and the integrated device. The first encapsulation layer includes an undercut relative to a side surface of the integrated device. The void is located between the integrated device and the first surface of the substrate. The void is laterally surrounded by the undercut of the encapsulation layer.

Abstract: 3D cell cultures contain hepatic cells and are infected by a pathogen. Such cell cultures are prepared by, for example, inoculating a single-cell suspension containing hepatic cells expanded in a 2D culture in an agitation-based culture system. Next, the resulting cell culture is agitated at a given agitation rate. Then, the resulting 3D cell culture containing cell aggregates is incubated with a pathogen.

Abstract: This invention relates to a bracket including a barrel with a screw-threaded recess, a disk-shaped cap and a fastener that is receivable in the recess. The fastener is configured to attached the cap to the barrel in a spaced apart arrangement, when the fastener is received in the recess. The barrel comprises a body of polymeric material, a metal bush embedded in the body and defining the screw threaded recess, and a metal sleeve that extends partially around the periphery of the body.

Abstract: This invention relates to a bracket including a barrel with a screw-threaded recess, a disk-shaped cap and a fastener that is receivable in the recess. The fastener is configured to attached the cap to the barrel in a spaced apart arrangement, when the fastener is received in the recess. The barrel comprises a body of polymeric material, a metal bush embedded in the body and defining the screw threaded recess, and a metal sleeve that extends partially around the periphery of the body.

Abstract: The present invention generally relates to methods, assays, compositions and kits related to a subpopulation of ovarian cancer stem cells which are selected or enriched by chemotherapeutic agents and inhibited by MIS (Mullerian Inhibiting Substance) and MIS mimetics. In particular, the present invention relates to a population of CD44+/CD24+/EpCam+/ECad? subpopulation of ovarian cancer stem cells. The present invention also provides methods to screen a subject with ovarian cancer to identify if they have an ovarian cancer comprising CD44+/CD24+/EpCam+/ECad? ovarian cancer stem cells, and methods to identify and enrich or isolate for such ovarian cancer cell populations.

Abstract: The invention relates to an apparatus for reflecting incident light, in particular sunlight, comprising a plurality of reflector units arranged next to one another, in particular next to one another in two directions, each reflector unit comprising at least one reflector surface (4), wherein the reflector surfaces (4) of all of the reflector units are pivotable, wherein each reflector unit (2, 3, 4, 5) comprises a rod (3) and comprises a reflector surface (4) fastened at the upper free end of the rod (3) and a lower spherical hinge (5) at the lower end of the rod (3), with which hinge the rod (3) is connected in articulated fashion to a movable coupling element (6), which is common to all of the reflector units (2, 3, 4, 5), and comprises a spherical hinge (2) in an intermediate region between the upper end and the lower end of the rod (3), said hinge connecting, in articulated fashion, the rod (3) to a stationary base element (1) which is common to all of the reflector units (2, 3, 4, 5) and bearing each ref

Abstract: Shoe having a transversal air passageway comprising a shoe sole (4) and an upper (1) and a lower (3) pliable parts for enclosing a foot of the user of the shoe, wherein the shoe further comprises a peripheral band (2) formed in the shape of a closed line and formed in a resilient material, wherein the upper and lower parts are attached by their outer edges to opposing faces of said peripheral band along its length, and wherein the lower part is attached to the shoe sole in both the front and back parts of the shoe, but not in a part between the front and back parts of the shoe, such that a transversal air passageway (5) is formed from the medial part to the lateral part of the shoe, between the front and the back parts of the shoe, and between the shoe sole and the lower part.

Abstract: A fitting (10) is formed from by clamping first and second clamp bodies (12,14) of composite plastic material together, each of the clamp bodies being covered by a pressed stainless steel shell (36,38). Each of the clamp bodies (12,14) defines a grip formation (16) that faces a recess (26), so that an edge of a glass panel can be gripped between the grip formations (16)—preferably with soft pads (18). Fasteners such as bolts pass through apertures (24,25) extend through the shells (36,38) and bodies (12,14), to hold the entire fitting (10) together and to exert a gripping force on the glass panel.

Abstract: The invention relates to an apparatus for reflecting incident light, in particular sunlight, comprising a plurality of reflector units arranged next to one another, in particular next to one another in two directions, each reflector unit comprising at least one reflector surface (4), wherein the reflector surfaces (4) of all of the reflector units are pivotable, wherein each reflector unit (2, 3, 4, 5) comprises a rod (3) and comprises a reflector surface (4) fastened at the upper free end of the rod (3) and a lower spherical hinge (5) at the lower end of the rod (3), with which hinge the rod (3) is connected in articulated fashion to a movable coupling element (6), which is common to all of the reflector units (2, 3, 4, 5), and comprises a spherical hinge (2) in an intermediate region between the upper end and the lower end of the rod (3), said hinge connecting, in articulated fashion, the rod to a stationary base element (1) which is common to all of the reflector units (2, 3, 4, 5) and bearing each reflect

Abstract: The present invention relates to pyrazoloanthrones or functional derivatives or functional analogues thereof to activate MIS receptor-mediated downstream effects in a cell. In particular, the present invention relates to method to prevent and treat cancer that expresses MIS receptor type II (MISRII) by administering to a subject at least one pyrazoloanthrone or a functional derivative or a functional analogue thereof. Another aspect of the present invention relates to methods to lower plasma androgen levels in a subject, and/or for the treatment of a subject with a disease characterized by excess androgen, whereby the subject is administered at least one pyrazoloanthrone or a functional derivative or a functional analogue thereof. Another aspect provides pharmaceutical compositions comprising at least one pyrazoloanthrone or functional a derivative or a functional analogue thereof, and optionally with one or more additional agents such as chemotherapeutic agents.