Abstract: Provided herein are pyrazoloanthrones or functional derivatives or analogs thereof to activate MIS receptor-mediated downstream effects in a cell. In particular, methods are provided to prevent and treat cancer that expresses MIS receptor type II (MISRII) by administering to a subject at least one pyrazoloanthrone or a functional derivative or analog thereof. Also provided herein are methods to lower plasma androgen levels in a subject, and/or for the treatment of a subject with a disease characterized by excess androgen, whereby the subject is administered at least one pyrazoloanthrone or a functional derivative or analog thereof. Also provided are methods to decrease the dose of a chemotherapeutic agent by administering the chemotherapeutic agent with a pyrazoloanthrone or a functional derivative or analog thereof that lowers the effective dose of the chemotherapeutic agent.

Abstract: A sensor for measuring water fraction in a fluid mixture flowing in a conductive tubing within a borehole. The sensor comprises: an active probe, a reference probe, and an electronic unit. The active probe includes a first electrode and a second electrode isolated from each other by a first insulating layer, the first and second electrodes are preferably in contact with the fluid mixture. The reference probe is formed from an internal wall of the conductive tubing contacting the fluid mixture and isolated from the reference probe by a second insulating layer. The electronic unit is coupled to the first and second electrodes, and to the reference probe, the electronic unit preferably includes a capacitance module for measuring a capacitance between the active probe and the reference probe.

Abstract: An image-processing system comprising a peripheral device 10, a web server 12 associated with the peripheral device 10 an application server 13 and a mobile phone 11. The web server 12 is configured to send a registration request to register communication parameters of the peripheral device 10 in association with a piece of identification information at the application server 13. The mobile device 11 is configured to determine the piece of identification information and to send a request to the application server 13 with the determined piece of identification information. The application server 13 is configured to associate the registered details of the peripheral device 10 with the request from the mobile device 11 thereby allowing a connection to be configured between the mobile device 11 and the peripheral device 10.

Abstract: A fitting (10) is formed from by clamping first and second clamp bodies (12,14) of composite plastic material together, each of the clamp bodies being covered by a pressed stainless steel shell (36,38). Each of the clamp bodies (12,14) defines a grip formation (16) that faces a recess (26), so that an edge of a glass panel can be gripped between the grip formations (16)—preferably with soft pads (18). Fasteners such as bolts pass through apertures (24,25) extend through the shells (36,38) and bodies (12,14), to hold the entire fitting (10) together and to exert a gripping force on the glass panel.

Abstract: An image-processing system comprising a peripheral device 10, a web server 12 associated with the peripheral device 10 an application server 13 and a mobile phone 11. The web server 12 is configured to send a registration request to register communication parameters of the peripheral device 10 in association with a piece of identification information at the application server 13. The mobile device 11 is configured to determine the piece of identification information and to send a request to the application server 13 with the determined piece of identification information. The application server 13 is configured to associate the registered details of the peripheral device 10 with the request from the mobile device 11 thereby allowing a connection to be configured between the mobile device 11 and the peripheral device 10.

Abstract: The present invention generally relates to methods, assays, compositions and kits related to a subpopulation of ovarian cancer stem cells which are selected or enriched by chemotherapeutic agents and inhibited by MIS (Mullerian Inhibiting Substance) and MIS mimetics. In particular, the present invention relates to a population of CD44+/CD24+/EpCam+/ECad? subpopulation of ovarian cancer stem cells. The present invention also provides methods to screen a subject with ovarian cancer to identify if they have an ovarian cancer comprising CD44+/CD24+/EpCam+/ECad? ovarian cancer stem cells, and methods to identify and enrich or isolate for such ovarian cancer cell populations.

Abstract: The exemplary embodiment is for an architecture integrated in a generic System on Chip (SoC) and consisting of reconfigurable coprocessors for executing nested program loops performed in a functional unit array in parallel. The data arrays are accessed from one or more system inputs and from an embedded memory array in parallel. The processed data arrays are sent back to the memory array or to system outputs and enable the acceleration of nested loops. The coprocessors are connected either synchronously or using asynchronous first in first out memories (FIFOs), forming a globally asynchronous locally synchronous system and each coprocessor can be programmed by tagging and rewriting the nested loops in the original program and produces a coprocessor configuration per each nested loop group, which is replaced in the original code with coprocessor input/output operations and control.

Abstract: Provided herein are pyrazoloanthrones or functional derivatives or analogues thereof to activate MIS receptor-mediated downstream effects in a cell. In particular, methods are provided to prevent and treat cancer that expresses MIS receptor type II (MISRII) by administering to a subject at least one pyrazoloanthrone or a functional derivative or analogue thereof. Also provided herein are methods to lower plasma androgen levels in a subject, and/or for the treatment of a subject with a disease characterized by excess androgen, whereby the subject is administered at least one pyrazoloanthrone or a functional derivative or analogue thereof. Also provided are methods to decrease the dose of a chemotherapeutic agent by administering the chemotherapeutic agent with a pyrazoloanthrone or a functional derivative or analogue thereof that lowers the effective dose of the chemotherapeutic agent.

Abstract: An image-processing system comprising a peripheral device 10, a web server 12 associated with the peripheral device 10 an application server 13 and a mobile phone 11. The web server 12 is configured to send a registration request to register communication parameters of the peripheral device 10 in association with a piece of identification information at the application server 13. The mobile device 11 is configured to determine the piece of identification information and to send a request to the application server 13 with the determined piece of identification information. The application server 13 is configured to associate the registered details of the peripheral device 10 with the request from the mobile device 11 thereby allowing a connection to be configured between the mobile device 11 and the peripheral device 10.

Abstract: A sensor for measuring water fraction in a fluid mixture flowing in a conductive tubing within a borehole. The sensor comprises: an active probe, a reference probe, and an electronic unit. The active probe includes a first electrode and a second electrode isolated from each other by a first insulating layer, the first and second electrodes are preferably in contact with the fluid mixture. The reference probe is formed from an internal wall of the conductive tubing contacting the fluid mixture and isolated from the reference probe by a second insulating layer. The electronic unit is coupled to the first and second electrodes, and to the reference probe, the electronic unit preferably includes a capacitance module for measuring a capacitance between the active probe and the reference probe.

Abstract: The proposed architecture is integrated in a generic System on Chip (SoC) and can include or consist of an expanded network interface and an infrastructure for accessing Intellectual Property (IP) cores in the system. The architecture enables the system on chip to communicate with a user workstation connected to a communication network. The invention can be used as a simplified network interface for data exchange, which does not require embedded processors and respective software. The invention can be used to temporarily replace the normal data input and output of an IP core with stimuli and responses used for a variety of purposes.

Abstract: A balustrade (10) and a method of manufacturing it are provided. The balustrade (10) has a number of upright posts (24) that are anchored in a substrate and has rails (42,44) that extend between the posts (24). The rails (42,44) are attached to the posts (24) with attachment formations (34,46), by way of a press fit, so that the balustrade (10) can be assembled without any welding on site.

Abstract: The present invention relates to pyrazoloanthrones or functional derivatives or functional analogues thereof to activate MIS receptor-mediated downstream effects in a cell. In particular, the present invention relates to method to prevent and treat cancer that expresses MIS receptor type II (MISRII) by administering to a subject at least one pyrazoloanthrone or a functional derivative or a functional analogue thereof. Another aspect of the present invention relates to methods to lower plasma androgen levels in a subject, and/or for the treatment of a subject with a disease characterized by excess androgen, whereby the subject is administered at least one pyrazoloanthrone or a functional derivative or a functional analogue thereof. Another aspect provides pharmaceutical compositions comprising at least one pyrazoloanthrone or functional a derivative or a functional analogue thereof, and optionally with one or more additional agents such as chemotherapeutic agents.

Abstract: A liner for inserting into a drain hole, comprising a resilient tubular member with a central bore; wherein the tubular member is formed from a first continuous helically wound wire provided with a passageway to allow fluid communication across the member.

Abstract: A method of making a flexible drill shaft. The method comprising: winding wire to form a helical coil spring, applying a mechanical deformation to the wire as it is being wound and using the helical coil spring to form a flexible drill shaft. The mechanical deformation applied results in the wire after being wound having a cross section such that when an axial load is applied to the drill shaft there is planar contact between adjacent coils of the spring.

Abstract: The architectures derived from the proposed template are integrated in a generic System on Chip (SoC) and consist of reconfigurable coprocessors for executing nested program loops whose bodies are expressions of operations performed in a functional unit array in parallel. The data arrays are accessed from one or more system inputs and from an embedded memory array in parallel. The processed data arrays are sent back to the memory array or to system outputs. The architectures enable the acceleration of nested loops compared to execution on a standard processor, where only one operation or datum access can be performed at a time. The invention can be used in a number of applications especially those which involve digital signal processing, such as multimedia and communications. The architectures are used preferably in conjunction with von Neumann processors which are better at implementing control flow.

Abstract: A liner for inserting into a drain hole, comprising a resilient tubular member with a central bore; wherein the tubular member is formed from a first continuous helically wound wire provided with a passageway to allow fluid communication across the member.

Abstract: The proposed architecture is integrated in a generic System on Chip (SoC) and can include or consist of an expanded network interface and an infrastructure for accessing Intellectual Property (IP) cores in the system. The architecture enables the system on chip to communicate with a user workstation connected to a communication network. The invention can be used as a simplified network interface for data exchange, which does not require embedded processors and respective software. The invention can be used to temporarily replace the normal data input and output of an IP core with stimuli and responses used for a variety of purposes.

Abstract: A flexible drill shaft for drilling lateral boreholes comprising: a helical outer wire coil spring; and at least one inner helical wire coil spring residing concentrically within the outer coil spring, with the coils of adjacent springs having an opposite pitch; wherein the wire forming each helical spring has a cross section such that when the drill shaft is in a straight alignment there is planar contact between adjacent coils of the spring.

Abstract: The invention relates to a flame-retardant methacrylic composition based on a methacrylic polymer comprising, per 100 parts of methacrylic polymer, from 15 to 25 parts, advantageously from 17 to 25 parts, preferably from 17 to 23 parts, more preferentially still from 19 to 22 parts, of at least one flame-retardant agent of formula (I) or (II): in which: R1 and R2 denote linear or branched C1-C6 alkyl groups and/or aryl groups; R3 denotes a linear or branched C1-C10 alkylene group, a C6-C10 arylene group, an alkylarylene group or an arylalkylene group; M denotes Mg, Ca, Al, Sb, Sn, Ge, Ti, Zn, Fe, Zr, Ce, Bi, Sr, Mn, Li, Na or K; m is an integer between 1 and 4; n is an integer between 1 and 4; x is an integer between 1 and 4.