Abstract: An on-axis aimer and distance measurement apparatus for a vision system can include a light source configured to generate a first light beam along a first axis. The first light beam can project an aimer pattern on an object and a receiver can be configured to receive reflected light from the first light beam to determine a distance between a lens of the vision system and the object. One or more parameters of vision system can be controlled based on the determined distance.

Abstract: This disclosure provides genetically engineered organisms with genetic modifications that are useful for producing desirable alkaloids. This disclosure also provides methods of making genetically engineered organisms that can produce desirable alkaloids. The organisms described herein produce alkaloids in amounts beyond that produced from comparable wild-type organisms. In certain embodiments, the genetically engineered organisms are fungi from the Basidiomycota division.

Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

Abstract: A nacelle includes in turn a nacelle frame, and a yaw bearing having likewise/in turn at least a geared ring for providing a rotatable connection between the nacelle and the tower around a yaw axis. A method includes the steps of: a) disengaging the rotatable connection between the nacelle and the tower; b) lifting the nacelle from the tower by using lifting means, allowing the rotation of the geared ring; and c) rotating the geared ring around the yaw axis until the geared ring reaches a predetermined position with respect to the component to which the geared ring is connectable, either to the nacelle or the tower.

Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.

Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

Abstract: A device and method for real-time measurement using acoustic wave sensors, without the measurement being altered by environmental conditions such as temperature, humidity, flow or pressure, and without requiring the use of external gauges. The proposed method and device improve the stability and detection limit of quartz crystal microbalance (QCM) sensors. The method and device are based on the high degree of correlation between acoustic resonators integrated into a single piezoelectric substrate. The use of a reference sample to correct the instability of the baseline is not required. The method and device are intended for the industrial sector of the production of measuring devices based on quartz crystals.

Abstract: Suitcase protector comprising a cardboard packaging, characterised by the fact that it is made from the development of a die-cut sheet of cardboard, in which a rectangular, horizontally elongated, major section is defined, which, by means of vertical folding lines, determines the two major (1-1?) and minor (2 2?) sides of a rectangular prismatic container, which by means of vertical folding lines determine the two larger (1-1?) and smaller (2 2?) sides of a rectangular prismatic container.

Abstract: Provided herein are methods for modulating the psilocybin biosynthesis pathway in fungi or other organisms. Also provided are genetically modified fungi and organisms with induced and/or increased expression of psilocybin and psilocin and psilocybin and/or psilocin compositions generated by the provided methods.

Abstract: A compact self-contained lighting system combining efficient LEDs with heat dissipating heat sinks, wherein the heat sinks are electrically connected to and provide power flow to the LEDs.

Abstract: This invention provides a system and method for detecting and acquiring one or more in-focus images of one or more barcodes within the field of view of an imaging device. A measurement process measures depth-of-field of barcode detection. A plurality of nominal coarse focus settings of a variable lens allow sampling, in steps, of a lens adjustment range corresponding to allowable distances between the one or more barcodes and the image sensor, so that a step size of the sampling is less than a fraction of the depth-of-field of barcode detection. An acquisition process acquires a nominal coarse focus image for each nominal coarse focus setting. A barcode detection process detects one or more barcode-like regions and respective likelihoods. A fine focus process fine-adjusts, for each high-likelihood barcode, the variable lens near a location of the barcode-like regions. The process acquires an image for decoding using the fine adjusted setting.

Abstract: Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence of at least 7 nucleotides that is complementary to a target region within exon 9 of a NUMB transcript. Pharmaceutical compositions comprising the antisense oligonucleotide and methods of treating a proliferative disease using the compounds or compositions of the invention are also described.

Abstract: An apparatus for controlling a depth of field for a reader in a vision system includes a dual aperture assembly having an inner region and an outer region. A first light source can be used to generate a light beam associated with the inner region and a second light source can be used to generate a light beam associated with the outer region. The depth of field of the reader can be controlled by selecting one of the first light source and second light source to illuminate an object to acquire an image of the object. The selection of the first light source or the second light source can be based on at least one parameter of the vision system.

Abstract: A process for the manufacturing of 3D reduced graphene oxide/Fe2O3 material includes the following steps: (i) putting in contact a graphene oxide (GO) water dispersion with an aqueous solution of iron(II) sulfate; (ii) hydrothermal treatment; and (iii) freezing the reaction product obtained in step (ii) at a temperature ??5° C.; and (iv) lyophilisation. A 3D reduced graphene oxide/Fe2O3 material is obtainable by the process and further relates to electrodes for CDI devices having the material. A method for removing ions from a fluid, like saline water, using the capacitive deionization device includes applying a voltage to the electrodes while supplying the fluid into the capacitive deionization device.

Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

Abstract: An elevator car (2, 2?), includes a first safety brake (8, 8?), including a first electronic safety actuator (512, 612), the first safety brake (8, 8?) positioned on a first side of the elevator car (2, 2?) at a first height (20, 20?); and a second safety brake (10, 10?), including a second electronic safety actuator (512, 612), the second safety brake (10, 10?) positioned on a second side of the elevator car (2, 2?) at a second height (22, 22?); the first height is different to the second height.

Abstract: Mandibular advancement measurement and positioning device provided with an instrument (1) with an upper slider (2) and a lower slider (3), means to measure and position the relative displacement of both sliders and two trays at one end of the instrument, one upper and one lower (11a, 11b), the trays being attached to each slider respectively, wherein the lower slider is divided into a fixed part (3a) and a pivoting part (3b) joined to the end of the fixed part (3a), being the upper and lower slider joined by means of a recess that allows a relative slide of both and wherein the pivoting part (3b) of the lower slider is provided with a vertical opening control (6). By means of the pivoting part and the opening control it is possible to measure and position the vertical opening.

Abstract: The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.

Abstract: An elevator car (2, 2?), includes a first safety brake (8, 8?), including a first electronic safety actuator (512, 612), the first safety brake (8, 8?) positioned on a first side of the elevator car (2, 2?) at a first height (20, 20?); and a second safety brake (10, 10?), including a second electronic safety actuator (512, 612), the second safety brake (10, 10?) positioned on a second side of the elevator car (2, 2?) at a second height (22, 22?); the first height is different to the second height.

Abstract: A multispectral light assembly includes a multispectral light source configured to generate a plurality of different wavelengths of light, a light pipe positioned in front of the multispectral light source and configured to provide color mixing for two or more of the plurality of different wavelengths, a diffusive surface on the light pipe exit surface, and a projection lens positioned in front of the diffusive surface. A processor device is in communication with the multispectral light assemblies to control activation of the multispectral light source. A machine vision system includes an illumination assembly with a plurality of multispectral light assemblies, an optics assembly, a sensor assembly, and a processor device in communication with the optics assembly, the sensor assembly, and the illumination assembly.