Abstract: Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence of at least 7 nucleotides that is complementary to a target region within exon 9 of a NUMB transcript. Pharmaceutical compositions comprising the antisense oligonucleotide and methods of treating a proliferative disease using the compounds or compositions of the invention are also described.

Abstract: The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.

Abstract: Methods of preparing a composition from chia seeds are provided. Compositions, including compositions prepared by the presently disclosed methods, and methods regarding selecting chia seeds and administering chia seed extracts are also disclosed.

Abstract: This provides an ID reader, typically configured for handheld operation, which integrates three types of illumination into a compact package that generates robust performance and resistance to harsh environmental conditions, such as dust and moisture. These illumination types include, direct (diffuse) light, low-angle light and polarized light. The ID reader includes a sealed reader module assembly having the illuminators in combination with an imager assembly (optics and image sensor) at its relative center. Additionally, also an on-axis aimer and a variable focus system with liquid lens have been integrated in this module and is placed on axis using a mirror assembly that includes a dichroic filter. As the optimal distance to read a code with low-angle light is typically shorter than the optimal distance to use the polarized illumination a variable (e.g. liquid) lens can adjust the focus of the reader to the optimal distance for the selected illumination.

Abstract: A multispectral light assembly for an illumination system includes a multispectral light source configured to generate a plurality of different wavelengths of light and a light pipe positioned in front of the multispectral light source and configured to provide color mixing for two or more of the plurality of different wavelengths. The multispectral light assembly also includes a diffusive surface on the light pipe and a projection lens positioned in front of the diffusive surface. A processor device may be in communication with the multispectral light assemblies and may be configured to control activation of the multispectral light source.

Abstract: A machine vision system can include an image sensor assembly including an image sensor, a lens assembly coupled to the image sensor assembly, an illumination assembly coupled to the lens assembly, and a removable front cover positioned in front of the illumination assembly. The illumination assembly can include a plurality of multispectral light assemblies. Each multispectral light assembly of the plurality of multispectral light assemblies can include a multispectral light source having a plurality of color LED dies configured to generate at least two different wavelengths of light, a light pipe positioned in front of the multispectral light source and having an exit surface, a diffusive surface on the exit surface of the light pipe, and a projection lens positioned in front of the diffusive surface. The machine vision system can also include an illumination sensor configured to detect light from the illumination assembly.

Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

Abstract: Provided herein are methods for modulating the psilocybin biosynthesis pathway in fungi or other organisms. Also provided are genetically modified fungi and organisms with induced and/or increased expression of psilocybin and psilocin and psilocybin and/or psilocin compositions generated by the provided methods.

Abstract: The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.

Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.

Abstract: This invention provides an illumination assembly that is typically attached to the front end of a vision system camera assembly, adapted to generate an illumination pattern onto an object, which allows the vision system process(or) to perform basic shape inspection of the object in addition to feature detection and decoding. A dome illuminator with a diffuse inner surface is provided to the camera assembly with a sufficient opening side to surround the object. The dome illuminator has two systems to create the pattern on an object, including a diffuse illuminator for specular/shiny object surfaces and a secondary, projecting illuminator for matte/diffusive object surfaces. The diffuse illuminator includes a set of light-filtering structures on its inner surface—for example concentric strips or rings that allow projection of a ringed fringe pattern on an (e.g. shiny/specular) object. The fringes can additionally be generated in a given a certain wavelength and/or visible color.

Abstract: This invention provides a system and method for detecting and acquiring one or more in-focus images of one or more barcodes within the field of view of an imaging device. A measurement process measures depth-of-field of barcode detection. A plurality of nominal coarse focus settings of a variable lens allow sampling, in steps, of a lens adjustment range corresponding to allowable distances between the one or more barcodes and the image sensor, so that a step size of the sampling is less than a fraction of the depth-of-field of barcode detection. An acquisition process acquires a nominal coarse focus image for each nominal coarse focus setting. A barcode detection process detects one or more barcode-like regions and respective likelihoods. A fine focus process fine-adjusts, for each high-likelihood barcode, the variable lens near a location of the barcode-like regions. The process acquires an image for decoding using the fine adjusted setting.

Abstract: Provided herein are methods for modulating the cannabinoid biosynthesis pathway in plants. Also provided are cannabinoid compositions comprising rare cannabinoids, new cannabinoids, and variant cannabinoids generated by the provided methods.

Abstract: Provided herein are methods for modulating the psilocybin biosynthesis pathway in fungi or other organisms. Also provided are genetically modified fungi and organisms with induced and/or increased expression of psilocybin and psilocin and psilocybin and/or psilocin compositions generated by the provided methods.

Abstract: Provided herein are compositions comprising genetically modified cells, organisms, or plants described herein or extracts and products thereof and methods for making and using the same. Also provided are therapeutics derived from genetically modified cells, organisms, or plants described herein or extracts and products thereof for use in preventing, treating, or stabilizing disease and conditions.

Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

Abstract: Embodiments disclosed herein are related to implementing a near-real-time stream processing system using the same distributed file system as a batch processing system. A data container and partition files are generated according to a partition window that specifies a time range that controls when data is to be included in the partition files. The data container is scanned to determine if the partition files are within a partition lifetime window that specifies a time range that controls how long the partition files are active for processing. For each partition file within the lifetime window, processing tasks are created based on an amount of data included in the partition files. The data in the partition files is accessed and the processing tasks are performed. Information about the partition files is recorded in a configuration data store.

Abstract: Embodiments disclosed herein are related to implementing a near-real-time stream processing system using the same distributed file system as a batch processing system. A data container and partition files are generated according to a partition window that specifies a time range that controls when data is to be included in the partition files. The data container is scanned to determine if the partition files are within a partition lifetime window that specifies a time range that controls how long the partition files are active for processing. For each partition file within the lifetime window, processing tasks are created based on an amount of data included in the partition files. The data in the partition files is accessed and the processing tasks are performed. Information about the partition files is recorded in a configuration data store.