Abstract: A wellbore system includes an upper head and a lower head coupled to the upper head by one or more fasteners. The wellbore system also includes a seal ring positioned within a seal pocket to engage the upper head to form a first seal interface between the upper head and the seal ring. The wellbore system includes a hanger arranged within a bore. The wellbore system includes a packoff positioned between the hanger and the lower head. The wellbore system includes one or more lock screws to apply a downward force to the packoff to establish a second seal interface between the packoff and the seal ring and a third seal interface between the packoff and the hanger.

Abstract: The present invention refers to a semiautonomous apparatus (1) for preparation and distribution of edible products, such as for example beverages, that presents a subsystem of preparation of edible products based upon portions (2) of edible substances, for example capsules of roasted and ground coffee for preparing coffee of the espresso type, and comprising at least one brewing device (4), and a subsystem of propulsion and locomotion (5), and further presenting a control device (8) provided so that can control said systems and so that the operation of said brewing device (4) and of said propulsion and locomotion means (5) is mutually exclusive, so that said semiautonomous apparatus (1) does not provide edible products while being moved by respective propulsion and locomotion means (5).

Abstract: A computer-readable media, system, and method for providing role-based access management to channels within a group-based communication system. Role-based access management allows for a plurality of roles to be established and for users to be associated with these roles. Roles may be associated with sets of permissions allowing users assigned to the respective role to perform various actions within the group-based communication system. The group-based communication system may include preset, system roles with predetermined permissions and custom, user-defined roles may be created by administrators within the group-based communication system.

Abstract: Illustrative embodiments provide a method and system for communicating air traffic control information. An audio signal comprising voice activity is received. Air traffic control information in the voice activity is identified using an artificial intelligence algorithm. A text transcript of the air traffic control information is generated and displayed on a confirmation display. Voice activity in the audio signal may be detected by identifying portions of the audio signal that comprise speech based on a comparison between the power spectrum of the audio signal and the power spectrum of noise and forming speech segments comprising the portions of the audio signal that comprise speech.

Abstract: A computer-readable media, system, and method for providing role-based access management to channels within a group-based communication system. Role-based access management allows for a plurality of roles to be established and for users to be associated with these roles. Roles may be associated with sets of permissions allowing users assigned to the respective role to perform various actions within the group-based communication system. The group-based communication system may include preset, system roles with predetermined permissions and custom, user-defined roles may be created by administrators within the group-based communication system.

Abstract: The invention relates to a pharmaceutical combination and related methods for reducing tumor volume and/or increasing the survival of a cancer patient. The combination comprises an intravenous administration of a recombinant MVA encoding a tumor-associated antigen and an administration of an antibody to a cancer patient.

Abstract: The invention relates to a recombinant Modified Vaccinia Virus Ankara (MVA) encoding a spike (S) protein or a part thereof, such as a receptor-binding domain (RBD), and additional antigenic sequences derived from other proteins of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease 19 (COVID-19).

Abstract: The invention relates to a composition and related methods for reducing tumor volume and/or increasing the survival of a cancer patient. The composition comprises a recombinant MVA encoding a Tumor Associated Antigen (“TAA”) as well as 4-1BBL and/or CD40L and can be administered to a subject in any suitable manner, including by intravenous and/or intratumoral administration.

Abstract: Described herein are compounds of Formula I and pharmaceutically acceptable salt thereof, stereoisomers, tautomers as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: The invention relates to a recombinant Modified Vaccinia Virus Ankara (MVA) expressing a TAA and the costimulatory molecule 4-1BBL for use in (i) the prevention of recurrence of a solid tumor, wherein the recombinant MVA is intratumorally administered to the solid tumor, or (ii) the treatment, prevention and/or prevention of recurrence of a tumor, wherein the recombinant MVA is intratumorally administered to another solid tumor.

Abstract: A computer-readable media, system, and method for providing role-based access management to channels within a group-based communication system. Role-based access management allows for a plurality of roles to be established and for users to be associated with these roles. Roles may be associated with sets of permissions allowing users assigned to the respective role to perform various actions within the group-based communication system. The group-based communication system may include preset, system roles with predetermined permissions and custom, user-defined roles may be created by administrators within the group-based communication system.

Abstract: The invention relates to a pharmaceutical combination and related methods for reducing tumor volume and/or increasing the survival of a cancer patient. The combination comprises an intravenous administration of a recombinant MVA encoding a tumor-associated antigen and an administration of an antibody to a cancer patient.

Abstract: A computer-readable media, system, and method for providing role-based access management to channels within a group-based communication system. Role-based access management allows for a plurality of roles to be established and for users to be associated with these roles. Roles may be associated with sets of permissions allowing users assigned to the respective role to perform various actions within the group-based communication system. The group-based communication system may include preset, system roles with predetermined permissions and custom, user-defined roles may be created by administrators within the group-based communication system.

Abstract: A computer-readable media, system, and method for providing role-based access management to channels within a group-based communication system. Role-based access management allows for a plurality of roles to be established and for users to be associated with these roles. Roles may be associated with sets of permissions allowing users assigned to the respective role to perform various actions within the group-based communication system. The group-based communication system may include preset, system roles with predetermined permissions and custom, user-defined roles may be created by administrators within the group-based communication system.

Abstract: A floor includes structural floor joist that includes a flange and tabs punched out of the flange (forming holes in the flange). Flooring material of the floor that extrudes through at least one of the holes is bonded to some of the tabs and the flange of the structural floor joist, forming a bonded composite assembly of the structural floor joist and the forming material, that has a centroid that is located in or near the forming material, placing some of the forming material in compression and placing at least 90% of the structural floor joist in tension.

Abstract: The invention relates to a pharmaceutical combination and related methods for reducing tumor volume and/or increasing the survival of a cancer patient. The combination comprises an intravenous administration of a recombinant MVA encoding a tumor-associated antigen and an administration of an antibody to a cancer patient.

Abstract: The invention relates to a composition and related methods for reducing tumor volume and/or increasing the survival of a cancer patient. The composition comprises a recombinant MVA encoding a Tumor Associated Antigen (“TAA”) as well as 4-1BBL and/or CD40L and can be administered to a subject in any suitable manner, including by intravenous and/or intratumoral administration.

Abstract: Illustrative embodiments provide a method and system for communicating air traffic control information. An audio signal comprising voice activity is received. Air traffic control information in the voice activity is identified using an artificial intelligence algorithm. A text transcript of the air traffic control information is generated and displayed on a confirmation display. Voice activity in the audio signal may be detected by identifying portions of the audio signal that comprise speech based on a comparison between the power spectrum of the audio signal and the power spectrum of noise and forming speech segments comprising the portions of the audio signal that comprise speech.

Abstract: The invention relates to a pharmaceutical combination and related methods for reducing tumor volume and/or increasing the survival of a cancer patient. The combination comprises an intravenous administration of a recombinant MVA encoding a tumor-associated antigen and an administration of an antibody to a cancer patient.

Abstract: Customers shop for clothing items online for convenience and selection, to save time or because they dislike trying on such clothing items. However, such online customers often struggle to find clothing items that are right for them. How a clothing item looks, fits, and feels are all important factors when making a purchasing decision, but images of clothing items and reviews can be misleading, sizing is guesswork, reviews are hit or miss, and online customers cannot physically interact with clothing items at the online point of sale. Given this uncertainty, customers often make poor buying decisions. Returns of clothing items due to poor fit and product misunderstandings frustrate customers and cost the fashion industry billions of dollars each year. This disclosure describes an online web application, preferably used in connection with mobile devices, that aims to reduce returns and improve customer experience by combining the convenience of online shopping with information gained through physical try-ons.