Abstract: A method for manufacturing stringers for aircraft, wherein the stringer comprises two semi-stringers, includes steps of placing tows on a flat surface for forming the semi-stringers independently or at the same time, the placement being made by partially overlapping the tows and orientating the tows on the flat surface according to boundaries of the flat surface, the tows covering the boundaries of the flat surface; and cutting the tows so that a shape of the tows corresponds to the shape of the flat surface defined by boundaries of the flat surface.

Abstract: The present invention relates to new stable modified polymer polyol dispersions. The modified polymer polyols of the present invention comprise at least one polyol and a stable dispersion of polymeric particles in the at least one polyol. There are also disclosed processes for the preparation of the herein described modified polymer polyols, and processes for preparing polyurethane materials containing them.

Abstract: A fishing rod holder with a back plate and a cover. The cover can be secured in either the open or closed position. In the closed position, the rod holder acts as a rod holder and a toolbox. In the open position, the rod holder acts as a utility table. The rod holder can be attached to a vehicle, boat, or other base using a mounting plate.

Abstract: The present application relates to antibody molecules that bind mesothelin (MSLN). The antibody molecules find application in the treatment and diagnosis of diseases and disorders, such as cancer.

Abstract: The present invention relates to the combination of ibuprofen in the form of a pharmaceutically acceptable salt, and tramadol, or a pharmaceutical acceptable salt thereof, for use in the treatment of pain in humans, wherein the dosage of ibuprofen in the combination is comprised between 350 mg and 450 mg and the dosage of tramadol is comprised between 35 mg and 40 mg, expressed as equivalent weight of tramadol hydrochloride. The combination is suitable for the treatment of moderate to severe pain, of chronic or acute origin, and is particularly effective for those patients suffering from more intense pain. It also relates to a pharmaceutical composition comprising said fixed-dose combination of ibuprofen and tramadol.

Abstract: Drug conjugates of formula [D-(X)b-(AA)w-(L)-]n-Ab wherein: D is a drug moiety having the following formula (I) or a pharmaceutically acceptable salt, ester, solvate, tautomer or stereoisomer thereof, wherein: A is selected from R1, R2 and R3 is H, ORa, OCORa, OCOORa, alkyl, alkenyl, alkynyl, etc; R3? is, CORa, COORa, CONRaRb, etc; each of R4to R10 and R12 is alkyl, alkenyl or alkynyl; R11 is H, CORa, COORa, alkyl, alkenyl or alkynyl, or R11 and R12+N+C atoms to which they are attached may form a heterocyclic group; each of R13 and R14 is H, CORa, COORa, alkyl, alkenyl or alkynyl; each Ra and Rb is H, alkyl, alkenyl, alkynyl, etc.

Abstract: The invention relates to specific binding members that bind CD137. The specific binding members comprise a CD137 antigen-binding site located in a constant domain of the specific binding member and find application in the treatment of cancer and infectious diseases, for example.

Abstract: The present application relates to antibody molecules that bind both PD-L1 and CD 137 and are able to induce agonism of CD137. The antibody molecules comprise a CDR-based binding site for PD-L1, and a CD137 antigen-binding site that is located in a constant domain of the antibody molecule. The antibody molecules of the invention find application, for example, in the treatment of diseases, such as cancer.

Abstract: Drug conjugates of formula [D-(X)b-(AA)w-(L)-]n-Ab wherein: D is a drug moiety having the following formula (I) or a pharmaceutically acceptable salt, ester, solvate, tautomer or stereoisomer thereof, wherein: A is selected from (II) and (III) R1, R2 and R3 is H, ORa, OCORa, OCO—ORa, alkyl, alkenyl, alkynyl, etc.; R3? is, CORa, COORa, CONRaRb, etc; each of R4 to R10 and R12 is alkyl, alkenyl or alkynyl; R11 is H, CORa, COORa, alkyl, alkenyl or alkynyl, or R11 and R12+N+C atoms to which they are attached may form a heterocyclic group; each of R13 and R14 is H, CORa, COORa, alkyl, alkenyl or alkynyl; each Ra and Rb is H, alkyl, alkenyl, alkynyl, etc.

Abstract: The present invention relates to antibody molecules that bind both mesothelin (MSLN) and CD137. The antibody molecules comprise a CDR-based binding site for MSLN, and a CD137 antigen-binding site located in a constant domain of the antibody molecule. The antibody molecules find application in the treatment of cancer, for example.

Abstract: The invention relates to specific binding members that bind CD137. The specific binding members comprise a CD137 antigen-binding site located in a constant domain of the specific binding member and find application in the treatment of cancer and infectious diseases, for example.

Abstract: It relates to compositions produced by microorganism cell cultures, including microorganism-free compositions as well as compositions comprising inactivated microorganisms. It also relates to methods for obtaining the compositions produced by microorganism cell cultures and to agricultural compositions comprising them. It also relates to the use of the compositions of the invention as plant growth promoting agents and to methods for promoting stimulatory activity on plants comprising administering to the plant with these compositions.

Abstract: The present invention refers to a dual camera system for automatic image recognition with a USB interface. The system includes a dual camera and a processor. The dual camera includes: a first camera with a USB interface for capturing colour images of the surroundings; a second camera with a USB interface for capturing images selected between colour and monochrome images for processing images; a microcontroller for controlling and synchronising the lighting; and a hub with a USB interface connected to the first and the second cameras. The processor with a USB connection, which is connected to the dual camera, is configured to analyse the images captured by the first and second cameras, as well as to manage the power of the first and second cameras.

Abstract: A machine for assembling boxes comprising five independent parts including two head walls, two side walls and a base with peripheral flanges that engage with grooves in a lower portion of the side walls and the head walls. Ends of the head walls have end tongues that are inserted into notches adjacent to ends of the side walls. The machine includes a central assembly station comprising a base ring inside which a stationary forming die is disposed. A base of a box to be formed is positioned on a lower face of the stationary forming die such that while the base of the box is held in position, horizontal push devices are activated which move the head walls and the side walls towards the base of the box which is locked in position against the lower face of the stationary forming die.

Abstract: The invention relates to a method for changing the development pattern, increasing the growth and starch accumulation, changing the structure of starch and increasing the resistance to water stress in plants. The method involves culturing plants in an atmosphere containing volatile elements emitted by a microorganism, without there being any physical contact between the microorganism and the plant. The method is based on the discovery that the volatile elements emitted by Gram-positive or Gram-negative bacteria, yeasts and microscopic fungi stimulate an increase in the growth of plants in general, with an increase in the height, the number of leaves and/or the number of branches of the plant, as well as an increase in the accumulated starch and structural change of this biopolymer, and modification of the development pattern, with an increase in floral buds. An increased resistance to water stress can also be observed, in addition to an increase in starch in leaves separated from whole plants.

Abstract: The invention relates to a method for changing the development pattern, increasing the growth and starch accumulation, changing the structure of starch and increasing the resistance to water stress in plants. The method involves culturing plants in an atmosphere containing volatile elements emitted by a microorganism, without there being any physical contact between the microorganism and the plant. The method is based on the discovery that the volatile elements emitted by Gram-positive or Gram-negative bacteria, yeasts and microscopic fungi stimulate an increase in the growth of plants in general, with an increase in the height, the number of leaves and/or the number of branches of the plant, as well as an increase in the accumulated starch and structural change of this biopolymer, and modification of the development pattern, with an increase in floral buds. An increased resistance to water stress can also be observed, in addition to an increase in starch in leaves separated from whole plants.

Abstract: A linear actuator comprising a motor adapted to axially rotate a rotor shaft in alternating directions, the motor having a stator positioned co-axially around the rotor shaft with the rotor shaft being co-axially coupled to a drive mechanism to convert axial rotation of the rotor shaft into reciprocal displacement of the drive mechanism, the drive mechanism having opposed ends, one end coupled to a piston arranged within a cylinder to define a pumping chamber between the piston and the cylinder, wherein alternating rotation of the rotor shaft causes reciprocal linear displacement of the piston within the pumping chamber, and the linear displacement of the drive mechanism operates a lubrication system within the linear actuator.

Abstract: A system and method for improved runnability of sheet fed and roll fed coaters comprising of a steam system and a conventional sheet fed coater. Headers of the steam system are positioned in such a way that steam from the steam system can be sprayed at the desired position over the rollers of conventional sheet fed coater. The steam system allows control of pressure, temperature, flow etc. of the steam sprayed over the rollers. The steam spray lubricates the coating roller and prevents lightweight thin substrates like paper or film etc. from sticking onto the surface of the coating roller. The present invention makes it possible to coat a lightweight thin substrate up to the edges of the substrate as clamps are not required to hold the substrate at the exit of the coater. The steam also helps to prevent drying up of coating substance over the roller surface.

Abstract: An isolated sucrose synthase peptide. Also, a method of preparing ADPglucose by incubating the isolated sucrose synthase peptide with ADP in suitable conditions and then isolating and purifying the ADPG produced. Also, an assay kit for the spectrophotometric, fluorimetric or amperometric determination of sucrose, which kit includes the isolated sucrose synthase peptide. Also, a method of producing a transgenic plant that overexpresses sucrose synthase by inserting a genetic construct containing a DNA fragment that encodes the sucrose synthase peptide into a vector and transferring to a plant genome, and a transgenic plant obtained thereby.

Abstract: A new and distinct variety of olive tree, herein referred to by its cultivar name, ‘I-20’, is provided which forms a dropping growth habit. Fruit with a low weight and obtuse shape is produced. The fruit exhibit dark violet coloration and the fruit nipple is absent or weak. The stone of the fruit of the new variety is of low weight, moderately elongated and possess a weakly rugose surface.