Patents by Inventor Josef Koller

Josef Koller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190375707
    Abstract: The invention relates to a novel process for the preparation of a chiral pyrollidine-2-yl-methanol derivative or a salt thereof of the formula I wherein R1 is aryl or heteroaryl and both aryl or heteroaryl are optionally substituted by C1-4-alkyl, halo-C1-4-alkyl, C1-4-alkoxy or halogen. The chiral pyrollidine-2-yl-methanol derivatives of the formula I are versatile building blocks in the synthesis of pharmacologically active compounds, such as for the stereospecific synthesis of oligonucleotides carrying chiral phosphonate moieties (see e.g. Int. PCT Publication WO 2010/064146).
    Type: Application
    Filed: August 21, 2019
    Publication date: December 12, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Raffael Josef Koller, Christophe Pfleger
  • Patent number: 8428916
    Abstract: Systems and methods for calculating L* in the magnetosphere with essentially the same accuracy as with a physics based model at many times the speed by developing a surrogate trained to be a surrogate for the physics-based model. The trained model can then beneficially process input data falling within the training range of the surrogate model. The surrogate model can be a feedforward neural network and the physics-based model can be the TSK03 model. Operatively, the surrogate model can use parameters on which the physics-based model was based, and/or spatial data for the location where L* is to be calculated. Surrogate models should be provided for each of a plurality of pitch angles. Accordingly, a surrogate model having a closed drift shell can be used from the plurality of models.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: April 23, 2013
    Assignee: Los Alamos National Security, LLC
    Inventors: Josef Koller, Geoffrey D. Reeves, Reiner H. W. Friedel
  • Patent number: 7889462
    Abstract: At least one embodiment of the invention relates to a protective circuit for protection of an appliance, in particular of an electric motor, against thermal overloading. In at least one embodiment, the protective circuit includes a first and a second terminal for connecting a temperature detection element; a detection unit for detecting whether a resistance value of the temperature detector element which is connected between the first and the second terminals, is in a first or a second resistance range; a short-circuit detector for identifying whether there is a short circuit between the first and the second terminals; signaling outputs for emitting signal messages to an evaluation unit when the detected resistance value is in the second resistance range and/or when a short circuit has been identified by the short-circuit detector; and a third terminal, which is connected to the second terminal via a predetermined resistance.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: February 15, 2011
    Assignee: Siemens Aktiengesellschaft
    Inventors: Konrad Spindler, Josef Koller, Markus Meier, Johann Seitz, Andreas Fritsch
  • Publication number: 20100088074
    Abstract: The calculation of L* in the magnetosphere can be calculated with essentially the same accuracy as with a physics based model at many times the speed by developing a surrogate trained to be a surrogate for the physics-based model. The trained model can then beneficially process input data falling within the training range of the surrogate model. The surrogate model can be a feedforward neural network and the physics-based model can be the TSK03 model. Operatively, the surrogate model can use parameters on which the physics-based model was based, spatial data for the location where L* is to be calculated. Surrogate models should be provided for each of a plurality of pitch angles. Accordingly, a surrogate model having a closed drift shell can be used from the plurality of models.
    Type: Application
    Filed: February 23, 2009
    Publication date: April 8, 2010
    Applicant: Los Alamos National Security, LLC
    Inventors: Josef KOLLER, Geoffrey D. REEVES, Reiner H. W. FRIEDEL
  • Publication number: 20100039736
    Abstract: At least one embodiment of the invention relates to a protective circuit for protection of an appliance, in particular of an electric motor, against thermal overloading. In at least one embodiment, the protective circuit includes a first and a second terminal for connecting a temperature detection element; a detection unit for detecting whether a resistance value of the temperature detector element which is connected between the first and the second terminals, is in a first or a second resistance range; a short-circuit detector for identifying whether there is a short circuit between the first and the second terminals; signaling outputs for emitting signal messages to an evaluation unit when the detected resistance value is in the second resistance range and/or when a short circuit has been identified by the short-circuit detector; and a third terminal, which is connected to the second terminal via a predetermined resistance.
    Type: Application
    Filed: September 6, 2006
    Publication date: February 18, 2010
    Inventors: Konrad Spindler, Josef Koller, Markus Meier, Johann Seitz, Andreas Fritsch
  • Patent number: 6497815
    Abstract: A device is described for mechanically cleaning fluids, especially for [cleaning] the cooling water that enters a heat exchanger, having a pipe segment (12) as housing, a sieve element (20) that essentially covers the cross section of the pipe, and a suction device (20) on influx side (22) that is capable of moving around an axle (18), the purpose of the device being to aspirate the surface area of sieve element (16) and in this manner clean it, wherein, according to the invention, sieve element (16) forms a partially cylindrical casing having a cylindrical axle (56) perpendicular to axle (24) of pipe segment (12), wherein the open part of cylindrical casing (16) is arranged toward influx side (22) (FIGS. 1, 2).
    Type: Grant
    Filed: June 3, 2000
    Date of Patent: December 24, 2002
    Inventor: Josef Koller
  • Patent number: 5929216
    Abstract: Disclosed are dyes having the formula ##STR1## in which R.sub.1 is C.sub.1 -C.sub.4 alkoxy or chlorine,R.sub.2 is C.sub.1 -C.sub.4 alkyl,R.sub.3 is C.sub.1 -C.sub.4 alkyl,R.sub.4 is C.sub.1 -C.sub.4 alkyl,R.sub.5 is hydroxyethyl or hydroxypropyl, andAn.sup..crclbar. is an anion, in which R.sub.3 and R.sub.4 are not both ethyl at the same time, compositions containing the dyes and methods of using and preparing the dyes. The dyes are especially useful for dyeing polyacrylonitrile.
    Type: Grant
    Filed: September 10, 1997
    Date of Patent: July 27, 1999
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Wilfried Herter, Josef Koller
  • Patent number: 5728297
    Abstract: An apparatus for the mechanical cleaning of liquids, especially cooling water delivered from a heat exchanger and flowing in a pipeline (10), with a rotationally symmetrical, conical sieve (12) of substantially the size of the pipe diameter, as well as a coaxial suction device (20) which is disposed on the upstream side of the sieve, is mounted for rotation continuously or with interruptions for the duration of a cleaning interval, and during the cleaning interval sucks bit by bit the entire surface of the sieve (12) on the upstream side, the sieve (12) being divided into areas, the intake nozzle (22) of the suction device (20) can cover each area, and in each area of the actual sieve surface and of the suction device there is a cavity for the temporary accommodation of contaminants, the sieve (12) being divided on its upstream side by substantially radial barriers (36) into individual sectors forming the areas, the intake nozzle (22) of the suction device (20) has such a shape that, at the moment in which th
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: March 17, 1998
    Inventor: Josef Koller
  • Patent number: 5325992
    Abstract: A dispensing device including a container for a supply of items forming a web. The dispensing device includes a recess formed in an outer wall of the container, a braking unit overlapping the recess. The braking unit includes two lips which work together when items are dispensed and a linear slit between the two lips which enables the items to pass between the two lips, the two lips being fitted with bristles which constitute active elements of the two lips, unattached ends of the bristles of one of the lips extend into, and mesh with, an area of unattached ends of the bristles of the opposite lip. The items are camisole-shaped and sequentially joined bags having a body with a bottom part and handles at the upper part. The bottom part of the body of one of the bags is connected to the leading edge of the handles of the next bag.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: July 5, 1994
    Assignee: Folag AG Folienwerke
    Inventors: Josef Koller, Rudolf Schmid
  • Patent number: 5275728
    Abstract: The invention pertains to a device to separate solid materials from a stream of liquid, particularly from cooling water. In the case of the known devices, difficulties occur in cleaning the filter from fibrous contaminants generally or starting with a certain size. The subject device draws off fibrous as well as coarse grained contaminants equally well.A preferably funnel shaped filter 3 with a suction device 4 running at an angle to the surface line 6 of the funnel filter 3 is arranged in a pipe shaped housing. The inclination creates a force component 19 which transports the coarse grained contaminants to the tip of the filter where they are drawn off by the suction opening 8 of the suction rotor 7. The fibrous contaminants are drawn off by the suction device 4.
    Type: Grant
    Filed: February 6, 1992
    Date of Patent: January 4, 1994
    Inventor: Josef Koller
  • Patent number: 5207799
    Abstract: A process is described for fibre- and surface-level dyeing of wool and blends thereof with other fibers using a compound of formula (1) ##STR1## in which n is 0 or 1, and if n is 1, A is a radical of the formula ##STR2## and B is an alkylene or alkenylene group or a direct bond, or if n is zero, A is a compound of the formula ##STR3## Fibre- and surface-level dyeings, in particular in light to medium color shades are obtained by the dyeing process according to the invention. The dyeing aid according to this invention can be used to substitute formaldehyde containing wool dyeing aids.
    Type: Grant
    Filed: August 27, 1991
    Date of Patent: May 4, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: Gerhard Back, Klaus Hannemann, Josef Koller
  • Patent number: 5163972
    Abstract: Process to dye polyacrylonitrile in blue shades with cationic dye compounds: substituted benzothiazolium azo N-alkyl-N-hydroxyalkyl alkyl-aniline salts.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: November 17, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Wilfried Herter, Josef Koller
  • Patent number: 5112958
    Abstract: The fibre-reactive formazan dyes of the formula ##STR1## in which R is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen, cyano or nitro, X is fluorine or chlorine, Y is .beta.-chloroethyl or vinyl and n is the number 0, 1 or 2 produce dyeings which have good fastness properties on nitrogen-containing or hydroxyl-containing fibre materials.
    Type: Grant
    Filed: July 19, 1990
    Date of Patent: May 12, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Urs Lehmann, Josef Koller
  • Patent number: 5076811
    Abstract: The fibre-reactive formazan dyes of the formula ##STR1## in which R is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen, cyano or nitro, X is fluorine or chlorine, and n is the number 0, 1 or 2 produce dyeings which have good fastness properties on nitrogen-containing or hydroxyl-containing fibre materials.
    Type: Grant
    Filed: July 19, 1990
    Date of Patent: December 31, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Urs Lehmann, Josef Koller
  • Patent number: 5023274
    Abstract: The fibre-reactive formazan dyes of the formula ##STR1## where X is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen, cyano or nitro, Y is .beta.-haloethyl or vinyl, m is 1, 2 or 3, n is 3 or 4, p is 0, 1 or 2 and q is 0 or 1, produce dyeings having good fastness properties on nitrogen-containing or hydroxyl-containing fibre materials.
    Type: Grant
    Filed: April 25, 1989
    Date of Patent: June 11, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Alois Puntener, Urs Lehmann, Peter Scheibli, Josef Koller
  • Patent number: 4818246
    Abstract: For improving the light-fastness of leather dyed with anionic dyes, the leather is treated, before, during or after dyeing, with a compound of copper.
    Type: Grant
    Filed: September 17, 1987
    Date of Patent: April 4, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Alois Puntener, Gerhard Back, Josef Koller
  • Patent number: 4799933
    Abstract: A mixture comprising a yellow dye and a red dye each of formula I and a grey dye of formula II is employed in accordance with claim 1 for the trichromatic dyeing of leather.
    Type: Grant
    Filed: January 12, 1987
    Date of Patent: January 24, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Fabio Beffa, Josef Koller
  • Patent number: 4620589
    Abstract: The invention relates to a device for cleaning the pipes of heat-exchangers by means of cleaning bodies, generally sponge balls. The removal and reintroduction of the cleaning bodies occurs with the aid of a device installed in the outlet pipe, which consists of a casing (1) with one or two screens (2) arranged within it. The screens (2) end on the downstream side at a pipe (3) with an opening (4). Inside this pipe (3) there is another pipe (5) with an opening (6) which preferably rotates continuously. The cleaning bodies (9) are collected in the inner pipe (5). A pressure water pipe (7) and a cleaning body outlet pipe (8) are connected to the outer pipe (3). When the inner pipe (5) is in the appropriate position, the cleaning bodies (9) are washed out of the inner pipe (5) by pressure water and introduced into the inlet pipe of the heat-exchanger via the cleaning body outlet pipe (8). A lock (11) is built into the cleaning body return pipe in order to introduce and remove the cleaning bodies (9).
    Type: Grant
    Filed: January 29, 1985
    Date of Patent: November 4, 1986
    Inventor: Josef Koller
  • Patent number: 4507125
    Abstract: The dyes of the formula I given in claim 1 are suitable for dyeing furs and especially leather.They are preferably used in admixture with one or more suitable yellow, blue or red dyes for dyeing leather in dark shades.
    Type: Grant
    Filed: October 26, 1983
    Date of Patent: March 26, 1985
    Assignee: Ciba-Geigy Corporation
    Inventors: Alois Puntener, Josef Koller
  • Patent number: 4452602
    Abstract: A mixture of at least three selected 1:2 chromium or 1:2 cobalt complex dyes of different colors and belonging to the azo or azomethine series is used for dyeing leather and furs. The mixtures of dyes make it possible for the first time to dye leather by the trichromatic process.
    Type: Grant
    Filed: March 19, 1982
    Date of Patent: June 5, 1984
    Inventors: Alois Puntener, Josef Koller, Fabio Beffa