Patents by Inventor Josef Kramer

Josef Kramer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Halogenohydroxyflavones
    Patent number: 4788215
    Abstract: Halogenohydroxyflavones ##STR1## in which R is alkyl having 1-3 C atoms,X is F, Cl, Br or I, andm, n and p are each 1, 2 or 3,and their esters with sulfuric acid and phosphoric acid, and the salts of these compounds, are suitable for the treatment of hyperthyroidism.
    Type: Grant
    Filed: September 18, 1987
    Date of Patent: November 29, 1988
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Josef Kramer, Klaus Irmscher, Helmut Prucher, Rolf-Dieter Hesch
  • Flavanone intermediates for halogenohydroxyflavones
    Patent number: 4713465
    Abstract: Halogenohydroxyflavones ##STR1## in which R is alkyl having 1-3 C atoms,X is F, Cl, Br or I, andm, n and p are each 1, 2 or 3,and their esters with sulfuric acid and phosphoric acid, and the salts of these compounds, are suitable for the treatment of hyperthyroidism.
    Type: Grant
    Filed: November 26, 1985
    Date of Patent: December 15, 1987
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Josef Kramer, Klaus Irmscher, Helmut Prucher, Rolf-Dieter Hesch
  • Thiaprostaglandins
    Patent number: 4210651
    Abstract: 13-Thiaprostanoic acid derivatives of the formula ##STR1## wherein A is --CO-- or --CHOH--, B is --CH.sub.2 --CH.sub.2 -- or --CH.dbd.CH-- R.sup.1 is H or alkyl of 1 to 4 carbon atoms, m is a whole number from 0 to 5, n is a whole number from 0 to 3 or, when B is --CH.dbd.CH--, additionally 4, 5, 6, 7, 8 or 9, R.sup.2 is alkoxy of 1 to 4 carbon atoms, phenoxy, pyridyl, thienyl, naphthyl, phenyl substituted by F, Cl, Br, OH, OCH.sub.3 or OF.sub.3 or phenoxy substituted by F, Cl, Br, OH, OCH.sub.3, CH.sub.3 or CF.sub.3 or, when B is --CH.dbd.CH--, additionally hydrogen, phenyl or tolyl, R.sup.3 is H, methyl or ethyl, possess pharmacological activity, including blood pressure lowering activity.
    Type: Grant
    Filed: January 18, 1978
    Date of Patent: July 1, 1980
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Hans-Eckart Radunz, Josef Kramer, Manfred Baumgarth, Dieter Orth
  • Thiaprostaglandins
    Patent number: 4080458
    Abstract: 13-Thiaprostanoic acid derivatives of the formula ##STR1## wherein A is --CO-- or --CHOH--, B is --CH.sub.2 --CH.sub.2 -- or --CH=CH--, R.sup.1 is H or alkyl of 1 to 4 carbon atoms, m is a whole number from 0 to 5, n is a whole number from 0 to 3 or, when B is --CH=CH--, additionally 4, 5, 6, 7, 8 or 9, R.sup.2 is alkoxy of 1 to 4 carbon atoms, phenoxy, pyridyl, thienyl, naphthyl, phenyl substituted by F, Cl, Br, OH, OCH.sub.3 or OF.sub.3 or phenoxy substituted by F, Cl, Br, OH, OCH.sub.3, CH.sub.3 or CF.sub.3 or, when B is --CH=CH--, additionally hydrogen, phenyl or tolyl, R.sup.3 is H, methyl or ethyl, possess pharmacological activity, including blood pressure lowering activity.
    Type: Grant
    Filed: May 9, 1975
    Date of Patent: March 21, 1978
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Hans-Eckart Radunz, Josef Kramer, Manfred Baumgarth, Dieter Orth
  • 13-Sulfa-prostaglandins
    Patent number: 3932487
    Abstract: Sulfides of the general formula ##SPC1##Wherein R.sub.1 is H or alkyl, R.sub.2 is =O, (H,OH), or (H,lower-acyloxy), R.sub.3 is H, OH or lower-acyloxy, R.sub.4 is alkyl or alkyl substituted by F, OH, lower-acyloxy, phenyl or p-tolyl, and A is alkylene which can be mono- or polysubstituted by F, and the physiologically acceptable salts thereof, possess, in addition to a blood-pressure-lowering activity, prostaglandin-type and antiprostaglandin-type effects.
    Type: Grant
    Filed: November 15, 1973
    Date of Patent: January 13, 1976
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Josef Kramer, Hans Radunz, Dieter Orth, Manfred Baumgarth, Jurgen Harting