Abstract: The present disclosure relates generally to medical imaging, and more specifically to devices and systems for simulating a time-varying fluorescence response. An exemplary device for simulating a fluorescence response of a tissue comprises: a simulated tissue layer; one or more optical detectors to detect a fluorescence excitation light incident on the simulated tissue layer; a plurality of illumination sources underneath the simulated tissue layer; and a controller configured to control the plurality of illumination sources to emit light based on the detected fluorescence excitation light and at least one time-varying pattern.

Abstract: The present application relates to methods of preparing Compound A: or a pharmaceutically acceptable salt or solvate thereof.

Abstract: Provided herein are systems for fluorescence imaging of an object and methods of use thereof, the systems comprising: an image sensor assembly comprising at least one image sensor; and an optical assembly configured to transmit light emitted from the object to the image sensor assembly, the optical assembly comprising at least one notch filter configured to block light in a plurality of fluorescence excitation wavebands while transmitting fluorescence light that is emitted from the object, wherein the optical assembly is configured to project the emitted fluorescence light as one or more fluorescence images onto the at least one image sensor of the image sensor assembly.

Abstract: A semiconductor device includes a semiconductor body including an upper surface, input and output terminals disposed on the upper surface of the semiconductor body, first and second p-n junction devices that are monolithically integrated in the semiconductor body, and a signal line protection circuit connected between the input and output terminals and comprising a low-pass filter and a voltage clamping device, wherein each of the low-pass filter and the voltage clamping device include the first and second p-n junction devices.

Abstract: An image sensor assembly includes at least one upconverter configured to detect light in a NIR waveband that is received from an object to be imaged and generate, based on the detected light, upconverted light that is outside of the NIR waveband; and at least one image sensor configured to detect the upconverted light.

Abstract: A method for assessing fluorescence imaging agent-based visual enhancement in a color image in which a fluorescence imaging agent signal is represented by a first color, the method including: identifying at least one first region of the color image that is encompassed by a portion of anatomy or pathology of interest in which the fluorescence imaging agent is present; identifying at least one second region of the color image that is not encompassed by the anatomy or pathology of interest; and determining a measure of visual enhancement of the anatomy or pathology of interest in the color image by comparing a contribution of the first color relative to other colors in the at least one first region to a contribution of the first color relative to the other colors in the at least one second region.

Abstract: A method for selectively producing cold, warm or hot milk foam and/or milk includes providing at least one container for storing milk to be foamed, providing a fluid and a fluid line, conveying, by a pump, a predefinable amount of the milk to be foamed through a line system, which includes a milk intake line, between the at least one container and the pump, and an outlet line, between the pump and at least one outlet, potentially supplying air into the milk intake line via an air-flow regulator, which can be arranged in an air-supply line, in order to produce a milk/air mixture upstream of the pump, conveying the milk/air mixture or the milk through a heating element, producing a milk foam from the milk/air mixture by a throttle device; and dispensing the milk foam or milk at the at least one outlet. An apparatus is also provided.

Abstract: A semiconductor device includes a semiconductor body including an upper surface, input and output terminals disposed on the upper surface of the semiconductor body, first and second p-n junction devices that are monolithically integrated in the semiconductor body, and a signal line protection circuit connected between the input and output terminals and comprising a low-pass filter and a voltage clamping device, wherein each of the low-pass filter and the voltage clamping device include the first and second p-n junction devices.

Abstract: A brewing unit for an espresso and coffee machine includes a frame structure, a hand lever which is mounted on the frame structure so as to be rotatable about an axis of rotation, and a brewing piston element which is operatively connected to the hand lever by means of a lever mechanism, whereby the brewing piston element, coupled to the movement of the hand lever, is movable between a first position and at least one second position along a vertical axis. The brewing piston element includes a distributor sieve which, in the second position of the brewing piston element, and together with a filter support which can be inserted into a holding device, delimits a brewing chamber, and hot pressurized brewing water is able to be introduced into the brewing chamber through the distributor sieve; the brewing piston element also includes a piston rod to which the distributor sieve is connectible.

Abstract: An apparatus for measuring a device current of a device under test (DUT) includes a first circuit including a first terminal for coupling to a first connection terminal of the DUT. The first circuit is configured to supply a first test voltage for the first terminal and to output a first output voltage sensed at the first terminal. The apparatus further includes a second circuit having a second terminal for coupling to a second connection terminal of the DUT. The second circuit is configured to supply a second test voltage for the second terminal and to output a second output voltage sensed at the second terminal. The apparatus further includes a third circuit configured to determine the device current of the DUT based on the first output voltage, the second output voltage, the first test voltage and the second test voltage. The first circuit and the second circuit are identical.

Abstract: A device for production of milk foam with adjustable temperature includes a pump for conveying the milk from at least one container in lines to an outlet, an air supply for delivering air into the line, a continuous-flow heater and a throttle device. The continuous-flow heater can be disposed on the pressure side of the pump and the throttle device can be disposed downstream from the continuous-flow heater.

Abstract: A device for foaming liquid includes a line system and a pump, via which at least one first line of the line system is connectible to at least one storage container in which the liquid to be foamed is stored, and via a second line of the line system is connectible to at least one outlet nozzle, an air-enrichment element by means of which air can pass through the liquid, and a heating element designed as a continuous flow heater. Furthermore, the heating element is arranged in the second line of the line system of the device and is designed as a thick-film heater in which an electric heating resistor is attached to a carrier using thick-film technology, on which carrier a flow path is provided for the liquid.

Abstract: An image sensor assembly includes at least one upconverter configured to detect light in a NIR waveband that is received from an object to be imaged and generate, based on the detected light, upconverted light that is outside of the NIR waveband; and at least one image sensor configured to detect the upconverted light.

Abstract: Coffee machine (1) for preparation of a hot beverage with a heating system for dynamic thermal management, comprising a housing frame (2), in which are accommodated a water module (100) for providing brewing water, which comprises a first heating device (120), having a boiler (121) with a fresh water inlet (12) and with a first heating element (123) for providing water heated to a first temperature T1 and a brewing module (200), whereby the brewing module (200) comprises a brewing device (220) for brewing a predefined amount of coffee with brewing water and a dispensing unit (230) for dispensing brewed coffee, as well as, disposed in a brewing water feed line (260), a second heating device (250), to heat the water heated to the first temperature T1 to a second temperature T2. The coffee machine provides for the second heating device (250) accommodated in the brewing module (200) being a thick film heater (252) designed as continuous flow heater.

Abstract: An apparatus for measuring a device current of a device under test (DUT) includes a first circuit including a first terminal for coupling to a first connection terminal of the DUT. The first circuit is configured to supply a first test voltage for the first terminal and to output a first output voltage sensed at the first terminal. The apparatus further includes a second circuit having a second terminal for coupling to a second connection terminal of the DUT. The second circuit is configured to supply a second test voltage for the second terminal and to output a second output voltage sensed at the second terminal. The apparatus further includes a third circuit configured to determine the device current of the DUT based on the first output voltage, the second output voltage, the first test voltage and the second test voltage. The first circuit and the second circuit are identical.

Abstract: A fluorescence imaging system for imaging an object, the system includes a white light provider that emits white light, an excitation light provider that emits excitation light in a plurality of excitation wavebands for causing the object to emit fluorescent light, a component that directs the white light and excitation light to the object and collects reflected white light and emitted fluorescent light from the object, a filter that blocks light in the excitation wavebands and transmits at least a portion of the reflected white light and fluorescent light, and an image sensor assembly that receives the transmitted reflected white light and the fluorescent light.

Abstract: A device for preparation of a liquid such as milk with integrated rinsing system includes at least one reservoir for storing of the liquid, disposed in a cooling unit, a pump and a line system, which system includes a liquid suction line, via which the at least one reservoir is connectible to the pump, an outlet line, via which the pump is connectible to at least one outlet, and a rinsing line, via which the liquid suction line is loadable with a rinsing fluid, and an air volume controller, by which air, via an air supply line, is able to be led in a metered way to an inlet point into the liquid suction line, and a heating element designed as continuous-flow heater, which is disposed in the outlet line and is designed as thick film heater.

Abstract: A fluorescence imaging system for imaging an object, the system includes a white light provider that emits white light, an excitation light provider that emits excitation light in a plurality of excitation wavebands for causing the object to emit fluorescent light, a component that directs the white light and excitation light to the object and collects reflected white light and emitted fluorescent light from the object, a filter that blocks light in the excitation wavebands and transmits at least a portion of the reflected white light and fluorescent light, and an image sensor assembly that receives the transmitted reflected white light and the fluorescent light.

Abstract: A fluorescence imaging system for imaging an object, the system includes a white light provider that emits white light, an excitation light provider that emits excitation light in a plurality of excitation wavebands for causing the object to emit fluorescent light, a component that directs the white light and excitation light to the object and collects reflected white light and emitted fluorescent light from the object, a filter that blocks light in the excitation wavebands and transmits at least a portion of the reflected white light and fluorescent light, and an image sensor assembly that receives the transmitted reflected white light and the fluorescent light.

Abstract: Method of cleaning of a milk system with dispensing device, which system is associated with a beverage maker, including a control unit and a cleaning module.