Patents by Inventor Josef Prassler

Josef Prassler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI EPHB4 ANTIBODIES AND ANTIBODY FRAGMENTS
    Publication number: 20090137002
    Abstract: The invention concerns antibodies and antibody fragments, specifically recognising the EphB4 receptor comprising heavy chains and light chain, comprising light and heavy CDR's, and their use as medicament for the treatment of pathological angiogenesis, in particular cancer therapy.
    Type: Application
    Filed: July 30, 2008
    Publication date: May 28, 2009
    Inventors: Heike PETRUL, Andreas Menrad, Jorg Willuda, Dieter Zopf, Jens Glienke, Josef Prassler, Andreas Popp, Stefan Steidl, Catrin Pracht
  • Compositions and methods for use for antibodies against sclerostin
    Publication number: 20090130113
    Abstract: The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat disease related to bone abnormalities such as osteoporosis. An embodiment of the invention herein provides an antibody or a functional protein comprising an antigen-binding portion of said antibody for a target in sclerostin polypeptide, characterized in that the antibody or functional protein specifically binds to sclerostin polypeptide and can increase at least one of bone formation, bone mineral density, bone mineral content, bone mass, bone quality and bone strength in a mammal.
    Type: Application
    Filed: October 10, 2008
    Publication date: May 21, 2009
    Inventors: Michaela Kneissel, Christine Halleux, Shou-Ih Hu, Beate Diefenbach-Streiber, Josef Prassler
  • High affinity human and humanized anti-alpha5beta1 integrin function blocking antibodies with reduced immunogenicity
    Publication number: 20090081207
    Abstract: The present invention relates to recombinant human or humanized polypeptides which bind to ?5?1 integrin with high affinity and blocking function. Further, diagnostic and pharmaceutic applications of the potypeptides are disclosed.
    Type: Application
    Filed: May 23, 2007
    Publication date: March 26, 2009
    Inventors: ANDREAS MENRAD, JOERG WILLUDA, KLAUS BOSSLET, DIETER ZOPF, HEIKE PETRUL, STEFAN STEIDL, JOSEF PRASSLER, CORINNE PETIT-FRERE
  • Novel tricistronic vectors and uses therefor
    Publication number: 20060121563
    Abstract: A tricistronic vector (i.e., a vector capable of expressing three exogenous genet, which are not fused together, under the control of one promoter) effectively can encode an immunoglobulin-presenting polypeptide and two immunoglobulin (Ig) polypeptides. The encoded Ig-presenting polypeptide is able to associate with at least one of the Ig polypeptides via co-expressed associating agents. A vector according to the present invention particularly is suited for phage display technology, e.g., when the Ig-presenting polypeptide is a phage coat protein and the Ig polypeptides associate to form a Fab.
    Type: Application
    Filed: July 30, 2003
    Publication date: June 8, 2006
    Applicant: Morphosys AG
    Inventors: Josef Prassler, Yvonne Stark
  • Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies
    Publication number: 20060115428
    Abstract: The invention relates to recombinant polypeptides, in particular antibodies or antibody fragments that bind Ed-B-isoforms of fibronectin and can block their function. In addition, the diagnostic and pharmaceutical application of the polypeptides according to the invention is disclosed.
    Type: Application
    Filed: October 14, 2005
    Publication date: June 1, 2006
    Inventors: Andreas Menrad, Josef Prassler, Armin Weidmann