Abstract: A method of treatment of rheumatoid arthritis administers an effective amount of a compound that inhibits phospho-diesterase-4.

Abstract: Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.

Abstract: Non-aqueous based fragrance compositions containing a siloxane material are disclosed. The fragrance compositions are suitable for many applications including cosmetics, laundry care and personal care items. The fragrance compositions can also be used in air fresheners, particularly those air fresheners that contain heating elements.

Abstract: Non-aqueous based fragrance compositions containing a siloxane material are disclosed. The fragrance compositions are suitable for many applications including cosmetics, laundry care and personal care items. The fragrance compositions can also be used in air fresheners, particularly those air fresheners that contain heating elements.

Abstract: The invention discloses a cDNA consisting of human cyclooxygenase-2 cDNA attached to 3′ flanking sequence of human cyclooxygenase-1 methods for increasing the expression of human cyclooxygenase-2 in transformed cells and assays for preferentially and independently measuring cyclogenase-2 in samples.

Abstract: A system and method for adjusting fuel vapor delivery from a fuel vapor recovery system in an internal combustion engine. An engine controller calculates a purge fuel fraction that is indicative of an amount of fuel vapor passing through the vapor recovery system relative to a total amount of purge flow, including air, passing through the vapor recovery system. A purge percent fuel parameter indicative of an amount of fuel vapor delivered to the engine from the fuel vapor recovery system relative to a total amount of fuel delivered to the engine is calculated based on the purge fuel fraction. Finally, the controller adjusts an amount of fuel vapor released from the vapor recovery system based on the purge percent fuel parameter.

Abstract: Non-aqueous based fragrance compositions containing a siloxane material are disclosed. The fragrance compositions are suitable for many applications including cosmetics, laundry care and personal care items. The fragrance compositions can also be used in air fresheners, particularly those air fresheners that contain heating elements.

Abstract: Non-aqueous based fragrance compositions containing a siloxane material are disclosed. The fragrance compositions are suitable for many applications including cosmetics, laundry care and personal care items. The fragrance compositions can also be used in air fresheners, particularly those air fresheners that contain heating elements.

Abstract: A system and method for adjusting fuel vapor delivery from a fuel vapor recovery system in an internal combustion engine. A requested amount of fuel vapor delivery is determined based upon a desired fuel vapor delivery amount and various system constraints, which ensure continued optimal operation of the vehicle. Purge fuel ratios are calculated by comparing desired levels to actual levels of various operating parameters. The purge fuel ratios are compared to each other to determine the minimum value from among the various purge fuel ratios, which is indicative of the most limiting system constraint. The most limiting system constraint is used to calculate an amount of fuel vapor to be delivered from the vapor recovery system.

Abstract: Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.

Abstract: The invention discloses a cDNA consisting of human cyclooxygenase-2 cDNA attached to 3′ flanking sequence of human cyclooxygenase-1 methods for increasing the expression of human cyclooxygenase-2 in transformed cells and assays for preferentially and independently measuring cyclogenase-2 in samples.

Abstract: A method for minimizing evaporative fuel emissions of a vehicle having an internal combustion engine, the engine having a combustion chamber, a corresponding fuel injector and a throttle valve assembly in cooperation with a corresponding intake manifold, the method including the step of storing fuel vapors that emanate from the engine to prevent “upstream” migration of the fuel vapors from the engine through the throttle valve assembly. The stored fuel vapors can then be released back into the engine for combustion thereby avoiding release into the atmosphere.

Abstract: A method is presented for controlling fuel tank pressure in an internal combustion engine. The engine, the fuel tank and the carbon canister are connected in a three-way connection. The engine can be selectively isolated by a purge control valve, and the fuel tank can be selectively isolated by a fuel tank control valve. The operation of both valves is coordinated by an electronic engine controller. By isolating the fuel tank during the carbon canister purge, vapor spikes into the engine are eliminated, thus preventing engine stalls. Also, canister durability is improved by continuously storing and purging vapors in opposite directions.

Abstract: A method for removing fuel vapors from an intake manifold of an internal combustion engine includes storing a vacuum in a vacuum storage device coupled to the intake manifold and applying the stored vacuum to the intake manifold to remove the vapors from the intake manifold.

Abstract: An evaporative emission control system for an internal combustion engine isolates the fuel tank from the engine during purging of a carbon canister used to store fuel vapor drawn from the fuel tank during refueling. The flow of vapor from the tank to the canister is controlled by a main vapor control valve, and the flow of vapor from the canister to the engine is controlled by a purge valve. Pressure transducers are used to independently sense vapor pressure in the tank and in the canister. An electronic controller operates the valves based in part on the pressure information generated by the pressure transducers.

Abstract: The invention discloses a cDNA consisting of human cyclooxygenase-2 cDNA attached to 3′ flanking sequence of human cyclooxygenase-1 methods for increasing the expression of human cyclooxygenase-2 in transformed cells and assays for preferentially and independently measuring cyclogenase-2 in samples.

Abstract: The present invention relates to a whole cell assay for cathepsin K. The present invention is useful for determining cathepsin K activity in a mammalian cell systems and for identifying and evaluating inhibitors of cathepsin K.

Abstract: A fuel system, a method for operating the fuel system and a method for operating an engine which is supplied by the fuel system each comprise: (1) a fuel tank; (2) a fuel vapor tank in fluid communication with the fuel tank by means of a first fuel vapor conduit; and (3) an engine in fluid communication with the fuel vapor tank by means of a second fuel vapor conduit. Within each of the fuel system and the two methods, there is captured, contained and compressed within the fuel vapor tank a fuel vapor extracted from the fuel tank when either: (1) refueling the fuel tank whether or not the engine is operating; (2) when the engine is operating whether or not refueling the fuel tank; or (2) immediately after shutting down the engine after having operated the engine. The fuel vapor within the fuel vapor tank may then be employed alone for restarting the engine, in absence of liquid fuel from the fuel tank.

Abstract: The invention discloses a cDNA consisting of human cyclooxygenase-2 cDNA attached to 3'flanking sequence of human cyclooxygenase-1 methods for increasing the expression of human cyclooxygenase-2 in transformed cell and assays for preferentially and independently measuring cyclogense-2 in samples.

Abstract: The invention discloses a human cyclooxygenase-2 cDNA, a human cyclooxygenase-2 and assays for preferentially and independently measuring cyclogenase-2 or cyclooxygenase-1 activity present in a given sample.