Abstract: The present invention is generally directed to various embodiments of a self-aligning insert for use with roller cone drill bits. In one illustrative embodiment, the insert comprises a generally cylindrical body, a cutting surface, a bottom surface, a tapered surface adjacent the cylindrical body, and a generally cylindrical section positioned between the bottom surface and the tapered surface. The inserts of the present invention may be installed in a roller cone of a roller cone drill bit.

Abstract: A database is disclosed for storing fast throughput experimentation information. The database is organized in a hierarchical structure such that various database objects have a parent-child relationship. The hierarchical structure facilitates control over user access to various parts of the database. A method is disclosed for automatically populating the database with sample definitions. The sample information is provided in an arbitrary electronic format, which is imported into the database. A method is also disclosed for tracking sample events. Whenever a user takes an action in the database that affects a sample, a sample event is recorded. Finally, a method for automatically importing experimental data resulting from fast throughput experimentation on samples is disclosed. The data is automatically associated with information already stored in the database, such as the test conditions that held during the experimentation and the sample recipes of the samples tested.

Abstract: A database is disclosed for storing fast throughput experimentation information. The database is organized in a hierarchical structure such that various database objects have a parent-child relationship. The hierarchical structure facilitates control over user access to various parts of the database. A method is disclosed for automatically populating the database with sample definitions. The sample information is provided in an arbitrary electronic format, which is imported into the database. A method is also disclosed for tracking sample events. Whenever a user takes an action in the database that affects a sample, a sample event is recorded. Finally, a method for automatically importing experimental data resulting from fast throughput experimentation on samples is disclosed. The data is automatically associated with information already stored in the database, such as the test conditions that held during the experimentation and the sample recipes of the samples tested.

Abstract: Compounds comprising nitric oxide derivatives of stilbenes, polyphenols and flavonoids and methods of their use are provided for treating patients suffering from any of hypercholesterolemia, vascular oxidative stress and endothelial dysfunction.

Abstract: Compounds and methods are provided for treating patients suffering from any of hypercholesterolemia, vascular oxidative stress and endothelial dysfunction.

Abstract: A combination of a cue ball and an object ball is used for aiming a cue ball to impact an object ball for motion of the object ball in a desired direction. The object ball has a series of object indicia on the outer surface that includes a center indicia and a number of auxiliary indicia on opposing sides thereof. The cue ball has a series of cue indicia on the outer surface that includes a center indicia and a number of auxiliary indicia on opposing sides thereof where the cue indicia is substantially identical to the object indicia. The object ball is aligned with its indicia parallel to a rail of the billiard table. The cue ball is aligned with its indicia parallel to the rail and facing the object indicia. An aiming line is extended through the object ball and through the object indicia to identify an object ball target indicia. Corresponding cue indicia is selected to identify a cue ball impact indicia.

Abstract: Methods for treating disease and health conditions associated with the presence of TGF-? including cancers, are provided comprising administering a therapeutically effective agent which acts as a TGF-? antagonist and cathepsin B inhibitor or lymphocytes transformed with a gene for expressing such an agent for overcoming the lymphocyte evading effect of TGF-?.

Abstract: A combination of a cue ball and an object ball is used for aiming a cue ball to impact an object ball for motion of the object ball in a desired direction. The object ball has a series of object indicia on the outer surface that includes a center indicia and a number of auxiliary indicia on opposing sides thereof. The cue ball has a series of cue indicia on the outer surface that includes a center indicia and a number of auxiliary indicia on opposing sides thereof where the cue indicia is substantially identical to the object indicia. The object ball is aligned with its indicia parallel to a rail of the billiard table. The cue ball is aligned with its indicia parallel to the rail and facing the object indicia. An aiming line is extended through the object ball and through the object indicia to identify an object ball target indicia. Corresponding cue indicia is selected to identify a cue ball impact indicia.

Abstract: A low trauma pressure-sensitive adhesive coated substrate comprising a sheet material, tape or laminate structure designed to adhere to skin or like surfaces. The pressure-sensitive adhesive layer of this adhesive coated substrate is a fibrous adhesive layer generally having a basis weight of from 5 to 200 g/m2 applied to a conformable backing or substrate. The fibrous adhesive layer has a textured outer face and persistent porosity between discrete adhesive fibers. Generally, the fibrous adhesive layer has a MVTR (measured by ASTM E 96-80 at 40° C.) of at least 1000 g/m2/day, preferably at least 6000 g/m2/day.

Abstract: A low trauma pressure-sensitive adhesive coated substrate comprising a sheet material, tape or laminate structure designed to adhere to skin or like surfaces. The pressure-sensitive adhesive layer of this adhesive coated substrate is a fibrous adhesive layer generally having a basis weight of from 5 to 200 g/m2 applied to a conformable backing or substrate. The fibrous adhesive layer has a textured outer face and persistent porosity between discrete adhesive fibers. Generally, the fibrous adhesive layer has a MVTR (measured by ASTM E 96-80 at 40° C.) of at least 1000 g/m2/day, preferably at least 6000 g/m2/day.