Patents by Inventor Joseph C. Walsh

Joseph C. Walsh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8691187
    Abstract: Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and ?-amyloid peptides are presented herein. The invention also relates to methods of imaging A? and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: April 8, 2014
    Assignee: Eli Lilly and Company
    Inventors: Anna Katrin Szardenings, Wei Zhang, Dhanalakshmi Kasi, Anjana Sinha, Umesh B. Gangadharmath, Joseph C. Walsh
  • Patent number: 8672822
    Abstract: A carton blank may be formed having at least one score line therein. A second layer of material may overlay at least a portion of the first layer, including the score line, thus defining an overlaid score area. The overlaid score area may include at least a portion in which the second layer is not adhered to the first layer.
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: March 18, 2014
    Assignee: Graphic Packaging International, Inc.
    Inventors: Joseph C. Walsh, Robert L. Conatser
  • Publication number: 20140034717
    Abstract: A package for holding a product. The package can comprise a carton comprising a plurality of panels at least partially enclosing an interior of the carton. A liner may optionally be at least partially positioned in the interior of the carton and can comprise an inner dispensing feature. A liner patch can overlap the inner dispensing feature and can be mounted on the liner for facilitating opening of the inner dispensing feature of the liner.
    Type: Application
    Filed: October 10, 2013
    Publication date: February 6, 2014
    Applicant: Graphic Packaging International, Inc.
    Inventors: Joseph C. Walsh, Mark Sinclair, Jeffrey T. Sloat, Norman L. Jesch
  • Publication number: 20140021204
    Abstract: A carton may include a linter. The liner may include one or more pressure control features for automatically relieving pressure from within an area enclosed by the liner. A pressure control feature may be in the form of one or more vent passageways extending through the liner.
    Type: Application
    Filed: September 24, 2013
    Publication date: January 23, 2014
    Applicant: Graphic Packaging International, Inc.
    Inventors: Mark Sinclair, Joseph C. Walsh
  • Publication number: 20130302248
    Abstract: Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formula (I) capable of binding to tau proteins and ?-amyloid peptides are presented herein. The invention also relates to methods of imaging A? and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
    Type: Application
    Filed: June 25, 2013
    Publication date: November 14, 2013
    Inventors: Umesh B. Gangadharmath, Hartmuth C. Kolb, Peter J.H. Scott, Joseph C. Walsh, Wei Zhang, Anna Katrin Szardenings, Anjana Sinha, Gang Chen, Eric Wang, Vani P. Mocharla, Chul Yu, Changhui Liu, Daniel Kurt Cashion, Dhanalakshmi Kasi
  • Publication number: 20130217887
    Abstract: Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.
    Type: Application
    Filed: March 25, 2013
    Publication date: August 22, 2013
    Inventors: Gang Chen, Umesh B. Gangadharmath, Dhanalakshmi Kasi, Harmuth C. Kolb, Changhui Liu, Anjana Sinha, Anna Katrin Szardenings, Joseph C. Walsh, Eric Wang, Chul Yu, Wei Zhang, Klaus Kopka, Guenter Haufe, Michael Schaefers, Verena Hugenberg, Stefan Wagner, Sven Hermann, Hans-Joerg Breyholz, Andreas Faust
  • Patent number: 8491869
    Abstract: Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and ?-amyloid peptides are presented herein. The invention also relates to methods of imaging A? and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: July 23, 2013
    Assignee: Eli Lilly and Company
    Inventors: Umesh B. Gangadharmath, Hartmuth C. Kolb, Peter J. H. Scott, Joseph C. Walsh, Wei Zhang, Anna Katrin Szardenings, Anjana Sinha, Gang Chen, Eric Wang, Vani P. Mocharia, Chul Yu, Changhui Liu, Daniel Kurt Cashion, Dhanalakshmi Kasi
  • Publication number: 20130183238
    Abstract: A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent.
    Type: Application
    Filed: August 15, 2011
    Publication date: July 18, 2013
    Applicant: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Vani P. Mocharla, Fanrong Mu, Umesh B. Gangadharmath
  • Patent number: 8486372
    Abstract: The present application is directed to radiolabeled cyclic polyazapeptides, pharmaceutical compositions comprising radiolabeled cyclic polyazapeptides, and methods of using the radiolabeled cyclic polyazapeptides. Such polyazapeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: July 16, 2013
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Kai Chen, Joseph C. Walsh, Dhanalakshmi Kasi, Vani P. Mocharla, Gang Chen, Qianwa Liang, Tieming Zhao
  • Patent number: 8420052
    Abstract: Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: April 16, 2013
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Wei Zhang, Umesh B. Gangadharmath, Dhanalakshmi Kasi, Kai Chen, Anjana Sinha, Eric Wang, Gang Chen, Peter J. H. Scott, Henry Clifton Padgett, Qianwa Liang, Zhiyong Gao, Tieming Zhao, Chunfang Xia, Vani P. Mocharla
  • Publication number: 20130032283
    Abstract: Portions of microwave energy interactive material may be cut and removed during intermediate steps in a lamination processes, so that remaining microwave energy interactive material in a resultant laminate is arranged in a pattern. Regarding the removal of the portions of the microwave energy interactive material, a compound laminate may be delaminated into parts, and one of the parts may be a sacrificial laminate that includes the removed portions of the microwave energy interactive material.
    Type: Application
    Filed: August 2, 2012
    Publication date: February 7, 2013
    Applicant: GRAPHIC PACKAGING INTERNATIONAL, INC.
    Inventors: Joseph C. Walsh, Mark Sinclair, Jeffrey T. Sloat
  • Patent number: 8354092
    Abstract: The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: January 15, 2013
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Dhanalakshmi Kasi, Vani P. Mocharla, Bing Wang, Umesh B. Gangadharmath, Brian A. Duclos, Kai Chen, Wei Zhang, Gang Chen, Henry Clifton Padgett, Farhad Karimi, Peter J. H. Scott, Zhiyong Gao, Qianwa Liang, Thomas Lee Collier, Tieming Zhao, Chunfang Xia
  • Publication number: 20120302755
    Abstract: Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled carbazoles and derivatives thereof and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.
    Type: Application
    Filed: May 22, 2012
    Publication date: November 29, 2012
    Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.
    Inventors: Anna Katrin Szardenings, Hartmuth C. Kolb, Joseph C. Walsh, Gang Chen, Umesh B. Gangadharmath, Dhanalakshmi Kasi, Changhui Liu, Anjana Sinha, Eric Wang, Chul Yu, Wei Zhang, Kai Chen, Vani P. Mocharla, Peter J.H. Scott
  • Patent number: 8318132
    Abstract: Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: November 27, 2012
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Wei Zhang, Peter J. H. Scott, Kai Chen, Vani P. Mocharla, Dhanalakshmi Kasi, Gang Chen, Eric Wang, Anjana Sinha
  • Publication number: 20120283490
    Abstract: A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.
    Type: Application
    Filed: April 12, 2012
    Publication date: November 8, 2012
    Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.
    Inventors: Umesh B. Gangadharmath, Joseph C. Walsh, Hartmuth C. Kolb, Ricardo Rodriguez, Arkadij M. Elizarov, Carroll Edward Ball
  • Patent number: 8293206
    Abstract: The present disclosure provides methods for treating cancer in a patient in need of such treatment, the method includes prequalifying a patient's therapeutic treatment by performing a molecular imaging procedure to the patient using a labeled biomarker specific for a cancer target at the tumor site; and administering a therapeutic effective amount of a compound comprising a targeting agent linked to a chemotherapeutic or a targeting agent linked to an antibody. Embodiments of the present invention also include compounds and compositions for using such methods.
    Type: Grant
    Filed: June 1, 2009
    Date of Patent: October 23, 2012
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Joseph C. Walsh, Kai Chen, Dhanalakshmi Kasi, Umesh B. Gangadharmath, Peter J. H. Scott, Gang Chen, Vani P. Mocharla
  • Publication number: 20120178606
    Abstract: Blanks are conveyed in series, in a machine direction. Each blank comprises an edge that extends in the machine direction during the conveying, and opposite surfaces that extend to the edge. The edges of the blanks are covered with respective elongate barrier strips, comprising serially mounting the barrier strips respectively to the blanks during the conveying.
    Type: Application
    Filed: January 5, 2012
    Publication date: July 12, 2012
    Applicant: GRAPHIC PACKAGING INTERNATIONAL, INC.
    Inventors: Joseph C. Walsh, Norman L. Jesch
  • Patent number: 8133472
    Abstract: Radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: March 13, 2012
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Kai Chen, Joseph C. Walsh, Qianwa Liang
  • Patent number: 8043601
    Abstract: The present application is directed to radiolabeled cyclic polyazapeptides, pharmaceutical compositions comprising radiolabeled cyclic polyazapeptides, and methods of using the radiolabeled cyclic polyazapeptides. Such polyazapeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: October 25, 2011
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Hartmuth C. Kolb, Kai Chen, Joseph C. Walsh, Dhanalakshmi Kasi, Vani P. Mocharla, Gang Chen, Qianwa Liang, Tieming Zhao
  • Publication number: 20110256057
    Abstract: The present application is directed to radiolabeled cyclic polyazapeptides, pharmaceutical compositions comprising radiolabeled cyclic polyazapeptides, and methods of using the radiolabeled cyclic polyazapeptides. Such polyazapeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
    Type: Application
    Filed: May 23, 2011
    Publication date: October 20, 2011
    Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.
    Inventors: Hartmuth C. Kolb, Kai Chen, Joseph C. Walsh, Dhanalakshmi Kasi, Vani P. Mocharla, Gang Chen, Qianwa Liang, Tieming Zhao