Abstract: The present invention relates to arylcyclohexyl pyrazole compounds of Formula (I) methods of making them, pharmaceutical compositions containing them and their use as NRF2 regulators.

Abstract: An automatic medication injection device (20) including injecting progress indicators (82-85) visible along a periphery of the device housing (23). The injecting progress indicators include a flag element (100) which is movable as a drive mechanism (60) of the device advances a sealing plunger (58) within a container of medication (50). The injecting progress indicators are configured to indicate sequentially during a single injection as the flag element moves to cooperatively complete different injecting progress indicators at different times during the single injection, whereby injecting progress of the injection may be monitored by a user.

Abstract: A compact portable coordinate measuring machine (CMM) with a large working volume for measuring workpieces is provided. The CMM includes a vertical support, a workpiece stage and a movement configuration that provides relative motion between a measurement probe and a workpiece. The movement configuration includes a vertical translation mechanism with a vertical translation element that couples to a vertical guide and moves over a vertical translation range. The workpiece stage is located above a top end of the vertical support and at least a majority of the vertical guide and the vertical translation range is located below a top end of the workpiece stage. In various implementations, the movement configuration may also include a rotary motion configuration and a horizontal translation mechanism. A controller controls the movement configuration to provide relative motion between the measurement probe and a workpiece that is located in the working volume on the workpiece stage.

Abstract: A method for controlling mollusk populations is provided. Invasive mollusk populations may colonize lakes, rivers, streams, or other water sources such as commercial or industrial facilities. Mollusk populations may be eliminated or controlled by administering an organic acid solution to a raw water source colonized by mollusks. Organic acids such as lactic acid, citric acid, gluconic acid, or glycolic acid may be utilized. Invasive mollusks may also attach to static surfaces such as marine equipment, boat hulls, or live wells. Attached mollusk or mollusk veligers may be eliminated or controlled by spraying attachment surfaces with an organic acid solution.

Abstract: Disclosed herein are spirocyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

Abstract: Methods of preparing substituted bicyclo[0.1.1.1]pentane compounds of Formula (I) comprise reacting a compound of Formula (A) with a compound of Formula (B) in the presence of a first transition metal catalyst selected from a palladium catalyst and a nickel catalyst, where the variables R1, R2, X1 and X2 are as described herein.

Abstract: A method according to one embodiment includes combining an amorphous iron-based alloy and at least one metal selected from a group consisting of molybdenum, chromium, tungsten, boron, gadolinium, nickel phosphorous, yttrium, and alloys thereof to form a mixture, wherein the at least one metal is present in the mixture from about 5 atomic percent (at %) to about 55 at %; and ball milling the mixture at least until an amorphous alloy of the iron-based alloy and the at least one metal is formed. Several amorphous iron-based metal alloys are also presented, including corrosion-resistant amorphous iron-based metal alloys and radiation-shielding amorphous iron-based metal alloys.

Abstract: Embodiments of systems and methods to relate a human operator to a welding power source are disclosed. One embodiment is a networked system having a server computer. The server computer is configured to receive first data including at least one of an identity or a location of a welding helmet within a welding environment, and a triggering status indicating a triggering of an arc detection sensor of the welding helmet due to initiation of a welding arc. The server computer is configured to receive second data including at least one of an identity or a location of a welding power source within the welding environment, and an activation status indicating an activation of the welding power source. The server computer is configured to match the welding power source to a human operator using the welding helmet based on at least the first data and the second data.

Abstract: Various systems and methods are provided that allow a weld sequencer to use a statistical analysis of generated reports to automatically determine weld parameter limits for the welds defined by various functions in a sequence file. For example, the weld sequencer can take reports generated for a specific type of part and statistically analyze the weld data included in the reports according to a set of analysis parameters provided by a user. The weld sequencer can use the statistical analysis to identify and remove outlier data and define a set of weld parameter limits based on the remaining data. The weld parameter limits can define a low limit and/or a high limit for one or more weld parameters associated with a function. The weld sequencer can then update the sequence file to include the weld parameter limits.

Abstract: A scrubber filter assembly including: a shaft mounted in an interior passage of a housing and configured to reciprocally move within the housing; a water outlet coupling on a side of the shaft which extends through a slot in the housing wherein the outlet coupling moves reciprocally within the slot as the shaft moves reciprocally, an inlet at a distal end of the shaft and the inlet extends into a water passage within the collar, wherein the inlet includes an outer surface having a filter configured to allow water to enter the inlet and prevent debris entering the water passage; and an edge extending around the perimeter of the outer surface of the inlet, wherein the edge is fixed to the collar, and the edge is configured to scrape debris from the filter as the inlet moves reciprocally with the shaft.

Abstract: A system for localizing a swarm of robotic platforms utilizing ranging sensors. The swarm is localized by purposely leaving some of the platforms of the swarm stationary, providing localization to the moving ones. The platforms in the swarm can alternate between a stationary and moving state.

Abstract: System includes a controller configured to obtain one or more of a route parameter or a vehicle parameter from discrete examinations of one or more of a route or a vehicle system. The route parameter is indicative of a health of the route over which the vehicle system travels. The vehicle parameter is indicative of a health of the vehicle system. The discrete examinations of the one or more of the route or the vehicle system separated from each other by one or more of location or time. The controller is configured to examine the one or more of the route parameter or the vehicle parameter to determine whether the one or more of the route or the vehicle system is damaged. The system also includes examination equipment configured to continually monitor the one or more of the route or the vehicle system responsive to determining that the one or more of the route or the vehicle is damaged.

Abstract: Methods and systems for determining optimal ticket pricing using an estimated future interest in a live event. The methods and systems may include processors configured to determine relationships that are indicative of interest in a live event using one or more types of data, including live event data that indicates characteristics of individual live events, ticket data that indicates information regarding ticket sales to past live events, user data that indicates characteristics, past purchases, and/or affinities of individual users. The processors may also generate and maintain a live event interest model that is configured to use one or more determined relationships to estimate interest in an upcoming live event. The processors may use one or more types of data, the determined relationships, or the live event interest model to estimate future interest in an upcoming live event.

Abstract: A system for and method of controlling the heat input in a welding operation are provided. The system includes an arc welding power supply configured to output a welding waveform to a welding torch. The welding power supply includes a waveform generator to generate an output welding waveform. The power supply also includes a controller to optimize the output welding waveform based on a desired welding temperature. The optimization is performed by adjusting at least one of a power ratio and a duration ratio. The power ratio is a ratio of a power of a negative portion of the welding waveform to a power of a positive portion of the welding waveform, and the duration ratio is a ratio of a duration of a negative portion of the welding waveform to a duration of a positive portion of the welding waveform. The desired welding temperature is one of a temperature setpoint and a temperature range.

Abstract: The invention provides a support for use in a leisure activity or cosmetic treatment in a reclined position wherein the support comprises two sections connected by a section hinge wherein a first section comprises a leg connected by a leg hinge to the first section where the leg hinge is substantially perpendicular to the section hinge.

Abstract: Deposition of carbene monolayers that excluded starting anions, such as iodide ions, has been achieved. Anions such as iodide are a typical contaminant in carbene hydrogen carbonate salts when synthesized using the state-of-the-art method. A method is described for eliminating substantially all starting anion (e.g., iodide) contamination from the monolayer. Air stable, purified carbenes precursors were used to deposit an intact monolayer on the surface of some industrially relevant metals. The monolayer's ability to protect these metals against, for example, oxidation has been demonstrated.

Abstract: Disclosed herein are compounds of Formulae (I) and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.

Abstract: A lid system for a front load dumpster is provided. The lid system provides a container assembly, an upper frame assembly having a curved lid, and a lower frame assembly, wherein the container assembly may rotate relative to the lower frame assembly and the upper frame assembly in a forward direction and an opposing rearward direction, while the upper frame assembly may rotate relative to the lower frame assembly only in the rearward direction so that the curved lid opens during dumping when the container assembly is in an upended condition, but the upper frame assembly and its curved lid may remain locked in a closed configuration when the container assembly is in an upright condition, before and after the dumping.

Abstract: Embodiments of systems and methods for supporting weld quality across a manufacturing environment are disclosed. One embodiment includes manufacturing cells within a manufacturing environment, where each manufacturing cell includes a cell controller and welding equipment. A communication network supports data communications between a central controller and the cell controller of each of the manufacturing cells. The central controller collects actual weld parameter data from the cell controller of each manufacturing cell, via the communication network, to form aggregated weld parameter data for a same type of workpiece being welded in each of the manufacturing cells. The central controller analyzes the aggregated weld parameter data to generate updated weld settings. The updated weld settings are communicated from the central controller to the cell controller of each of the manufacturing cells via the communication network.

Abstract: Systems for producing articles from glass tube include a converter having a base with a plurality of processing stations and a turret moveable relative to the base. The turret indexes a plurality of holders for holding the glass tubes successively through the processing stations. The systems further include a gas flow system or a suction system for producing a flow of gas through the glass tube during one or more heating, forming, separating or piercing operations. The flow of gas through the glass tube produced by the gas flow system or suction system may be sufficient to evacuate or purge volatile constituents of the glass from the glass tube and/or pierce a meniscus formed on the glass tube during separation, thereby reducing the Surface Hydrolytic Response (SHR) of the interior surface of the glass tube and articles made therefrom.