Abstract: The present disclosure relates to systems and methods for facilitating profiling of applications. In one arrangement, the systems and methods pertain to intercepting application instructions; determining if an application instruction is a frequently used instruction according to a pre-established policy; and only if the application instruction is a frequently used instruction, instrumenting the application instruction so as to facilitate collection of information about execution of the application instruction.

Abstract: This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceuical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermedicates therefor.

Abstract: A sensor for measuring a clamp arm position in a power clamp provides a sensor wheel that may fit beneath the clamp arm. A low profile sensor body abuts an edge of the sensory wheel to detect the sensor position without undue change in the power clamp or clearance about the power clamp.

Abstract: In an automatic decision-making system, a method and a tool for the reduction of the dimension of data mining, which is automatically coupled to an empirical predictor of the system. The method includes a qualitative modeling of the interrelations between various objects whose attributes are relevant to a score made by the predictor according to which decisions are made, wherein this relevancy is determined by an input of a domain expert to the problem in hand. The model is called a Knowledge-Tree and its conclusions are represented by a graphical symbolization called the Knowledge-Tree map. Data mining, which follows the construction of the Knowledge-Tree map regards only datasets which are associated with logical and validated branches of the knowledge tree. Because the expert input which reduces the dimension of data mining was completed prior to data mining, interception by human reasoning is not needed after data mining and the decision making process can proceed automatically.

Abstract: A method to maintain isocapnia for a subject. A fresh gas is provided to the subject when the subject breathes at a rate less than or equal to the fresh gas flowing to the subject. The fresh gas flow equal to a baseline minute ventilation minus a dead space gas ventilation of the subject contains a physiological insignificant amount of CO2. An additional reserve gas is provided to the subject when the subject breathes at a rate more than the fresh gas flowing to the subject. The reserve gas has a partial pressure of carbon dioxide equal to an arterial partial pressure of carbon dioxide of the subject. A breathing circuit is applied to the method to maintain isocapnia for a subject. The breathing circuit has an exit port, a non-rebreathing valve, a source of fresh gas, a fresh gas reservoir and a reserve gas supply.

Abstract: A method to maintain isocapnia for a subject. A fresh gas is provided to the subject when the subject breathes at a rate less than or equal to the fresh gas flowing to the subject. The fresh gas flow equal to a baseline minute ventilation minus a dead space gas ventilation of the subject contains a physiological insignificant amount of CO2. An additional reserve gas is provided to the subject when the subject breathes at a rate more than the fresh gas flowing to the subject. The reserve gas has a partial pressure of carbon dioxide equal to an arterial partial pressure of carbon dioxide of the subject. A breathing circuit is applied to the method to maintain isocapnia for a subject. The breathing circuit has an exit port, a non-rebreathing valve, a source of fresh gas, a fresh gas reservoir and a reserve gas supply.

Abstract: A method of modeling a monitorable stage in a process is provided.

Abstract: The present invention provides compounds of formula (I), which are antagonists of the 5-HT6 receptor.

Abstract: A dual polarised antenna 1 has two types of antenna elements combined. Each type of antenna element is formed on a planar substrate. The substrates are furnished with inter-engaging slots to enable assembly of the elements. Signal feeds are connected to the active parts of the elements by means of connection points furnished at off axis positions. The off-axis positions for connection enable an arrangement in which the locus of the effective phase centres of the antenna element scan be co-located yielding a convenient arrangement with good performance.

Abstract: The present invention relates to melanocortin receptor agonist of the formula I useful in the treatment of obesity, diabetes, and male and/or female sexual dysfunction 1

Abstract: The present invention relates to melanocortin receptor agonists of formula (I), which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.

Abstract: A method and device for effective delivery of a gas such as oxygen for inhalation are described that sequentially dilute room air to the flow of gas during a respiratory cycle. A mask assembly is described that comprises an inspiratory and expiratory limb each containing a very low resistance one-way valve, and a sequential dilution conduit (leading from the atmosphere to the inspiratory limb) with a one-way valve that has a slightly positive cracking pressure. A sequential dilution valve may also be placed in the sequential dilution conduit.

Abstract: A method and system to enhance yield in multi-process manufacturing. The method comprising the translation of a performance parameter of a product into input variables to operate tools carrying our cooperating processes which built a structural element which determines the performance parameter, wherein the individual tools are process controlled. The method further comprising the integration of process control of individual separate processes or of stages in a process, into a combined and comprehensive (modular) process control in which the process parameters of a process are enslaved to accomplish the target output of the final process. Hence target output values of intermediate processes are dynamically reassigned during the manufacturing with respect to their initially designed values, in accordance with the output of their cooperating processes.

Abstract: A method and device for effective delivery of a gas such as oxygen for inhalation is provided by sequentially diluting room air to the flow of gas during a respiratory cycle. A mask assembly is described that comprises an inspiratory and expiratory limb each containing a very low resistance one-way valve, and a sequential dilution conduit (leading from the atmosphere to the inspiratory limb) with a one-way valve that has a slightly positive cracking pressure. A gas reservoir is also attached to the inspiratory limb. During expiration, the reservoir is filled with oxygen, for example, flowing from the oxygen source. During inspiration, oxygen from the oxygen source and the reservoir are drawn preferentially. If the oxygen flow is equal to or greater than the minute ventilation of the subject, no atmospheric air is entrained into the mask assembly and the subject gets pure oxygen. If the minute ventilation (tidal volume) exceeds the oxygen flow, the reservoir is depleted.

Abstract: The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.

Abstract: A breathing circuit system for ventilating an anaesthetized patient. The system comprises a standard primary circle anaesthetic circuit which itself comprises a one-way inspiratory limb for delivering re-breathed gas and a one-way expiratory limb for accepting expired gas. The breathing circuit system also includes a supplementary respiratory circuit which solely supplies non-rebreathed gas and comprises a source of non-rebreathed, substantially carbon dioxide-free gas, a non-rebreathed fresh gas reservoir for storing fresh gas, a source of non-rebreathed reserve gas containing carbon dioxide, and a gas delivery conduit. Disposed in communication with the inspiratory limb is a non-re-breathing valve, while disposed in communication with both the inspiratory limb and the delivery conduit is a three-way respiratory valve for selectively permitting passage of gas from the inspiratory limb or from the delivery conduit.

Abstract: A golf ball is provided that includes a molded resilient inner core made of a rubber compound and a polymeric cover surrounding the inner core. The rubber compound is a halo-butyl rubber polymer and a carbon black filler in an amount of 80% to 100% by weight of the total rubber component.

Abstract: The invention relates to novel methods of detecting alterations in cell cycle regulation in a cell or a cell population and screening for agents capable of modulating cell cycle regulation through the use of multiparameter assays and a fluorescence-activated cell sorter (FACS) machine.

Abstract: The present invention is directed to novel exocytotic polypeptides, such as Exo1 and Exo2 polypeptides and related molecules, which have an inhibitory effect on exocytosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which mediate exocytotic polypeptide bioactivity, and the use of such compositions in diagnosis and treatment of disease.

Abstract: A method of controlling PCO2 in a patient at a predetermined desired level(s) comprising a breathing circuit which is capable of organizing exhaled gas so as to be preferentially inhaled during re-breathing when necessary by providing alveolar gas for re-breathing in preference to dead space gas.