Abstract: The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.

Abstract: An electrical connector module assembly is provided and includes a first shell and a second shell configured to mate together with the first shell along an interface that extends along a portion of the shells. The first and second shells form a cavity therebetween that extends along the length of the shells. The cavity is configured to hold an electrical component therein. The module assembly also includes a plurality of shielding elements positioned along the portion of the shells. The shielding elements are configured to form a seal along the interface that shields the electrical component from electromagnetic interference.

Abstract: A connector assembly includes a cage member having a plurality of walls defining a module cavity for a pluggable module. The walls include a top wall, a bottom wall and side walls extending between the top and bottom walls. The side walls extend to a bottom edge at the bottom wall and include mounting pins extending from the bottom edge that each have a press-fit portion configured to be press fit in a plated via of a circuit board. The bottom wall has a generally planar bottom surface facing the circuit board and a generally planar top surface facing the module cavity. The bottom wall includes a locating feature extending below the bottom surface and having a datum surface configured to engage the circuit board. The datum surface is a predetermined distance from the top surface to set a position of the top surface relative to the circuit board.

Abstract: An electrical connector includes a housing stack comprising a front housing and a rear housing coupled to the front housing at a seam. The housing stack defines plural contact cavities that extend continuously through the front housing and the rear housing between mating and mounting ends. A lossy spacer is disposed at the seam between the front and rear housings. The lossy spacer has plural contact cavities aligned with corresponding contact cavities of the housing stack. Signal and ground contacts are disposed in corresponding contact cavities of the housing stack. The signal contacts extend through the lossy spacer such that the signal contacts do not directly engage the lossy spacer. The ground contacts extend through the contact cavities in the lossy spacer such that the ground contacts are coupled by the lossy spacer.

Abstract: An electrical connector includes a housing stack comprising a front housing and a rear housing coupled to the front housing at a seam. The housing stack defines plural contact cavities that extend continuously through the front housing and the rear housing between mating and mounting ends. A lossy spacer is disposed at the seam between the front and rear housings. The lossy spacer has plural contact cavities aligned with corresponding contact cavities of the housing stack. Signal and ground contacts are disposed in corresponding contact cavities of the housing stack. The signal contacts extend through the lossy spacer such that the signal contacts do not directly engage the lossy spacer. The ground contacts extend through the contact cavities in the lossy spacer such that the ground contacts are coupled by the lossy spacer.

Abstract: An electrical connector includes a housing stack having a first housing and a second housing stacked together with the first housing. The housing stack defines a mating end and a mounting end opposite the mating end. The housing stack defines signal contact cavities and ground contact cavities that extend continuously through the housings. At least one of the first housing and the second housing has pockets around the ground contact cavities with lossy spacers disposed therein each having a groove aligned with the corresponding ground contact cavity. Signal contacts are disposed in corresponding signal contact cavities. Ground contacts are disposed in corresponding ground contact cavities. The ground contacts are disposed in the grooves of the corresponding lossy spacers such that the ground contacts are coupled to the corresponding lossy spacers.

Abstract: The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.

Abstract: A leadframe for a contact module includes signal contacts arranged in pairs carrying differential signals. Each pair of signal contacts includes a first signal contact and a second signal contact. Each signal contact has a mating beam at an end thereof configured to be electrically connected to a corresponding header contact of a header assembly. Each mating beam includes a stem and a branch extending from the stem. A first paddle extends from the stem and a second paddle extends from the branch. In an initial, stamped orientation, the mating beams are stamped such that the mating beams of the first and second signal contacts within the same pair of signal contacts are angled non-parallel to one another.

Abstract: Electrical connector assembly including an electrical connector having signal contacts and ground contacts that are coupled to a connector housing and disposed along a mounting side of the connector housing. The electrical connector assembly also includes a contact organizer that is positioned along the mounting side of the connector housing. The contact organizer has signal windows and ground passages extending therethrough that are defined by respective inner surfaces of the contact organizer. The ground contacts engage the inner surfaces of the ground passages when the contact organizer is held in a pre-loaded position away from the mounting side. The contact organizer moves to a seated position against the mounting side when the electrical connector is mounted to the circuit board. Each of the signal contacts is surrounded by an air gap that exists between the signal contact and the inner surface of the corresponding signal window.

Abstract: A leadframe for a contact module includes signal contacts arranged in pairs carrying differential signals. Each pair of signal contacts includes a first signal contact and a second signal contact. Each signal contact has a mating beam at an end thereof configured to be electrically connected to a corresponding header contact of a header assembly. Each mating beam includes a stem and a branch extending from the stem. A first paddle extends from the stem and a second paddle extends from the branch. In an initial, stamped orientation, the mating beams are stamped such that the mating beams of the first and second signal contacts within the same pair of signal contacts are angled non-parallel to one another.

Abstract: The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.

Abstract: In accordance with embodiments of the present disclosure, an access controller of an information handling system may be configured to receive a management operation from a management server communicatively coupled to an out-of-band network interface of the information handling system. The access controller may further be configured to, in response to receipt of the management operation and in concert with a basic input/output system of the information handling system, cause the information handling system to enter a power state in which a computer-readable medium associated with the information handling system is powered on. The access controller may also be configured to, in concert with the basic input/output system, transfer data associated with the management operation from the management server to the computer-readable medium.

Abstract: A connection member includes a tube extending a length along a central longitudinal axis. The tube includes a central passageway that extends through the length of the tube. The tube has a non-circular cross-sectional shape along the length of the tube. The tube includes an exterior side that defines a perimeter of the non-circular cross-sectional shape of the tube. Stamped threads are formed on the exterior side of the tube along at least a portion of the length of the tube. The stamped threads are discontinuous along the perimeter of the non-circular cross-sectional shape of the tube such that the stamped threads only extend along at least one portion of the perimeter of the non-circular cross-sectional shape of the tube.

Abstract: A connection member includes a tube extending a length along a central longitudinal axis. The tube includes a central passageway that extends through the length of the tube. The tube has a non-circular cross-sectional shape along the length of the tube. The tube includes an exterior side that defines a perimeter of the non-circular cross-sectional shape of the tube. Stamped threads are formed on the exterior side of the tube along at least a portion of the length of the tube. The stamped threads are discontinuous along the perimeter of the non-circular cross-sectional shape of the tube such that the stamped threads only extend along at least one portion of the perimeter of the non-circular cross-sectional shape of the tube.

Abstract: A valve assembly for use with a catheter assembly is provided. The valve assembly includes a valve housing defining a longitudinal axis and adapted for fluid engagement with a catheter assembly. The valve housing has an internal passageway for flow of fluids relative to the catheter assembly. A valve member is at least partially disposed within the valve housing and defines a valve passage. The valve member is adapted for movement within the valve housing between an open position wherein the valve passage is in general alignment with the internal passageway of the valve housing to permit flow of fluids through the valve housing, and a closed position to substantially occlude the internal passageway of the valve housing. An actuation mechanism is selectively movable in a general longitudinal direction to cause corresponding movement of the valve member between the open position and the closed position.

Abstract: An architecture for providing high-speed access over frequency-division multiplexed (FDM) channels allows transmission of Ethernet frames and/or other data across a cable transmission network or other form of FDM transport. The architecture involves downstream and upstream FDM multiplexing techniques to allow contemporaneous, parallel communications across a plurality of frequency channels. Furthermore, the architecture allows a central concentrator to support a plurality of remote devices that each has guaranteed bandwidth through connection-oriented allocations of bi-directional data flows. The upstream and downstream bandwidth allocation can support symmetrical bandwidth as well as asymmetrical bandwidth in either direction. As a local network, the architecture supports guaranteed bandwidth for delivery of data flows to a plurality of host devices.

Abstract: A hybrid compression garment comprises a sleeve adapted for placement on a limb of a person for applying static compression to the limb. A connecting device on the sleeve enables releasable connection of the sleeve to a machine. The machine is independent of the sleeve and operable to transmit, through the connecting device, a force to the sleeve that constricts the sleeve without inflating the sleeve to apply active compression to the limb. The connecting device is adapted for connection of the sleeve to the machine such that the sleeve can be used to apply active compression to the limb and adapted for disconnection of the sleeve from the machine such that the sleeve can be used to apply static compression to the limb. A method of applying compression to a limb of a person is also disclosed.

Abstract: An architecture for providing high-speed access over frequency-division multiplexed (FDM) channels allows transmission of ethernet frames and/or other data across a cable transmission network or other form of FDM transport. The architecture involves downstream and upstream FDM multiplexing techniques to allow contemporaneous, parallel communications across a plurality of frequency channels. Furthermore, the architecture allows a central concentrator to support a plurality of remote devices that each have guaranteed bandwidth through connection-oriented allocations of bi-directional data flows. The upstream and downstream bandwidth allocation can support symmetrical bandwidth as well as asymmetrical bandwidth in either direction. The architecture generally can be used to support connection-oriented physical layer connectivity between a remote device and the central concentrator.

Abstract: Provides a non-white construction surface comprising a substrate, a first reflective coating on at least a portion of an outer surface of the substrate, the coated substrate exhibiting a minimum direct solar reflectance value of at least about 25%, and a second reflective coating on at least a portion of the first reflective coating, wherein the combination of the first reflective coating and the second reflective coating provide the substrate with a CIELAB L* lightness value of less than about 69, and at least one of (i) a reflectivity of at least about 20% at substantially all points in the wavelength range between 770 and 2500 nm; and (ii) a summed reflectance value of at least 7000 as measured in the range between 770 and 2500 nm inclusive. Also provided are various substrates having the coatings described as well as methods of providing the described construction surfaces.

Abstract: A hybrid compression garment comprises a sleeve adapted for placement on a limb of a person for applying static compression to the limb. A connecting device on the sleeve enables releasable connection of the sleeve to a machine. The machine is independent of the sleeve and operable to transmit, through the connecting device, a force to the sleeve that constricts the sleeve without inflating the sleeve to apply active compression to the limb. The connecting device is adapted for connection of the sleeve to the machine such that the sleeve can be used to apply active compression to the limb and adapted for disconnection of the sleeve from the machine such that the sleeve can be used to apply static compression to the limb. A method of applying compression to a limb of a person is also disclosed.