Patents by Inventor Joseph H. Gorman

Joseph H. Gorman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170365057
    Abstract: A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape.
    Type: Application
    Filed: September 6, 2017
    Publication date: December 21, 2017
    Inventors: Benjamin M. Jackson, Robert C. Gorman, Joseph H. Gorman, Alison M. Pouch, Chandra M. Sehgal, Paul A. Yushkevich, Brian B. Avants, Hongzhi Wang
  • Patent number: 9779496
    Abstract: A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: October 3, 2017
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Benjamin M. Jackson, Robert C. Gorman, Joseph H. Gorman, Alison M. Pouch, Chandra M. Sehgal, Paul A. Yushkevich, Brian B. Avants, Hongzhi Wang
  • Publication number: 20170258921
    Abstract: The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.
    Type: Application
    Filed: May 22, 2017
    Publication date: September 14, 2017
    Inventors: Jason Alan Burdick, Robert C. Gorman, Joseph H. Gorman, III, Brendan Patrick Purcell
  • Patent number: 9694081
    Abstract: The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: July 4, 2017
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Jason Alan Burdick, Robert C. Gorman, Joseph H. Gorman, III, Brendan Patrick Purcell
  • Publication number: 20170143485
    Abstract: The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.
    Type: Application
    Filed: February 6, 2017
    Publication date: May 25, 2017
    Inventors: JOSEPH H. GORMAN, III, ROBERT C. GORMAN, MATTHEW J. GILLESPIE
  • Publication number: 20170065299
    Abstract: Disclosed are systems, methods, and devices for percutaneous retrieval of objects, such as endovascular devices, from an internal body space. The present inventions have vascular, non-vascular (gastrointestinal), and surgical (laproscopic) applications. The inventions include a retrieval end having one or more compressed states and an expanded state, the retrieval end adopting the expanded state when the retrieval end is deployed into a subject's internal body space, the retrieval end having a mouth through which an object can be passed into an interior space within the retrieval end when the retrieval end is in the expanded state, the mouth being adjustable between an opened state and a closed state; wherein when at least a portion of the retrieval end of the inner sheath is transitioned to a compressed state following capture of the object, the retrieval end exerts an inward force that at least partially collapses or compresses the object.
    Type: Application
    Filed: September 2, 2016
    Publication date: March 9, 2017
    Inventors: Matthew J. GILLESPIE, JOSEPH H. GORMAN, III, ROBERT C. GORMAN, MARK PIPER
  • Publication number: 20170035298
    Abstract: A retrospective reconstruction method uses cardiac self-gating for patients with severe arrhythmias. Self-gated myocardial systolic and diastolic motion is determined from low-spatial and high-temporal resolution images and then the MRI-data-set is retrospectively reconstructed to obtain high quality images. The method uses undersampled image reconstruction to obtain the low-spatial and high-temporal resolution images, including those of different beat morphologies. Processing of these images is utilized to generate a cardiac phase signal. This signal allows for arrhythmia detection and cardiac phase sorting. The cardiac phase signal allows for detection of end-systolic and diastolic events which allows for improved sampling efficiency. In the case of frequent and severe arrhythmia, the method utilizes data from the normal and interrupted beats to improve sampling and image quality.
    Type: Application
    Filed: April 24, 2015
    Publication date: February 9, 2017
    Inventors: Francisco CONTIJOCH, Walter R.T, WITSCHEY, Robert C. GORMAN, Yuchi HAN, Joseph H. GORMAN
  • Patent number: 9486404
    Abstract: Provided are methods of treating cardiac infarction by using an injectable material to influence cardiac structure and remodeling after infarction. Also provided are kits that comprise an injectable material to influence cardiac structure.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: November 8, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Jason A. Burdick, Robert C. Gorman, Joseph H. Gorman, III, Jamie L. Ifkovits
  • Publication number: 20160287632
    Abstract: Provided are methods and kits for safe and effective therapy that can be administered early after a heart attack in order to prevent progressive heart dilatation and resultant loss of function. The therapy includes the administration of particulate compositions to a region comprising an infarct or a portion thereof.
    Type: Application
    Filed: December 8, 2015
    Publication date: October 6, 2016
    Inventors: ROBERT C. GORMAN, JOSEPH H. GORMAN, III, LIAM P. RYAN
  • Patent number: 9406142
    Abstract: A fully automatic method for segmentation of the mitral leaflets in 3D transesophageal echocardiographic (3D TEE) images is provided. The method combines complementary probabilistic segmentation and geometric modeling techniques to generate 3D patient-specific reconstructions of the mitral leaflets and annulus from 3D TEE image data with no user interaction. In the model-based segmentation framework, mitral leaflet geometry is described with 3D continuous medial representation (cm-rep). To capture leaflet geometry in a target 3D TEE image, a pre-defined cm-rep template of the mitral leaflets is deformed such that the negative log of a Bayesian posterior probability is minimized. The likelihood of the objective function is given by a probabilistic segmentation of the mitral leaflets generated by multi-atlas joint label fusion, while the validity constraints and regularization terms imposed by cm-rep act as shape priors that preserve leaflet topology and constrain model fitting.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: August 2, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Joseph H. Gorman, III, Alison M. Pouch, Robert C. Gorman, Hongzhi Wang, Paul Yushkevich, Benjamin M Jackson, Brian B. Avants, Chandra M. Sehgal
  • Publication number: 20160199182
    Abstract: The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.
    Type: Application
    Filed: March 18, 2016
    Publication date: July 14, 2016
    Inventors: JOSEPH H. GORMAN, III, ROBERT C. GORMAN, MATTHEW J. GILLESPIE
  • Publication number: 20160151154
    Abstract: The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.
    Type: Application
    Filed: February 4, 2016
    Publication date: June 2, 2016
    Inventors: JOSEPH H. GORMAN, III, ROBERT C. GORMAN, MATTHEW J. GILLESPIE
  • Patent number: 9289291
    Abstract: The present disclosure relates to valve replacement devices that are foldable for catheter-based deployment to the site of implantation, as well as systems for the delivery of valve prostheses, including prostheses having the special characteristics of the disclosed valve replacement devices. The devices include highly effective adhering mechanisms for secure and enduring precision implantation. The adhering mechanisms may employ a unique sealing mechanism that includes a cuff that expands slowly whereby the device is not secured in place until the completion of the implantation procedure. The implanted device, optionally together with the cuff, prevents perivalvular leaks and incorporate an appropriate leaflet system for reliable functioning in situ.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: March 22, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Joseph H. Gorman, III, Robert C. Gorman, Matthew J. Gillespie
  • Publication number: 20160035087
    Abstract: A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape.
    Type: Application
    Filed: March 12, 2014
    Publication date: February 4, 2016
    Inventors: Benjamin M. Jackson, Robert C. Gorman, Joseph H. Gorman, Alison M. Pouch, Chandra M. Sehgal, Paul A. Yushkevich, Brian B. Avants, Hongzhi Wang
  • Patent number: 9238046
    Abstract: Provided are methods and kits for safe and effective therapy that can be administered early after a heart attack in order to prevent progressive heart dilatation and resultant loss of function. The therapy includes the administration of particulate compositions to a region comprising an infarct or a portion thereof.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: January 19, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Robert C. Gorman, Joseph H. Gorman, III, Liam P. Ryan
  • Patent number: 9129392
    Abstract: A series of rt-3DE images of the mitral valve are quantitatively analyzed so as to enable, for example, prediction of the degree of recurrent ischemic mitral regurgitation (IMR) and comprehensive assessments of leaflet tethering and “tenting” for the entire mitral valve. In accordance with the method, first, the rt-3DE images are registered with symmetric diffeomorphism to obtain information about how the mitral valve deforms over time. Second, the mitral valve is segmented with the level sets or other known segmentation method at each time point in the cardiac cycle with minimal user interaction. Third, the information about mitral valve structure is reduced into a 3D medial model, a compact representation of shape. In other words, a volumetric segmentation of the mitral valve is condensed to a form that is amenable to clinically relevant morphometry.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: September 8, 2015
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Robert C. Gorman, Alison Pouch, Joseph H. Gorman, III, Chandra Sehgal, Paul A. Yushkevich, Benjamin Jackson
  • Publication number: 20150178938
    Abstract: A fully automatic method for segmentation of the mitral leaflets in 3D transesophageal echocardiographic (3D TEE) images is provided. The method combines complementary probabilistic segmentation and geometric modeling techniques to generate 3D patient-specific reconstructions of the mitral leaflets and annulus from 3D TEE image data with no user interaction. In the model-based segmentation framework, mitral leaflet geometry is described with 3D continuous medial representation (cm-rep). To capture leaflet geometry in a target 3D TEE image, a pre-defined cm-rep template of the mitral leaflets is deformed such that the negative log of a Bayesian posterior probability is minimized. The likelihood of the objective function is given by a probabilistic segmentation of the mitral leaflets generated by multi-atlas joint label fusion, while the validity constraints and regularization terms imposed by cm-rep act as shape priors that preserve leaflet topology and constrain model fitting.
    Type: Application
    Filed: October 8, 2014
    Publication date: June 25, 2015
    Inventors: JOSEPH H. GORMAN, III, ALISON M. POUCH, ROBERT C. GORMAN, HONGZHI WANG, PAUL YUSHKEVICH, BENJAMIN M. JACKSON, BRIAN B. AVANTS, CHANDRA M. SEHGAL
  • Publication number: 20150073544
    Abstract: A stent-based vascular reducer platform adapted for percutaneous delivery to and anchoring in a pulmonary or tricuspid valve annulus and a valved-stent prosthetic device adapted to be percutaneously delivered to the pulmonary or tricuspid valve annulus for mounting in the vascular reducer platform. The vascular reducer platform includes an at least partially self-expanding stent and a cuff made of an absorbent material disposed at least partially circumferentially around the outer and inner surfaces of the stent. Upon placement at an implantation site such as the pulmonary or tricuspid valve annulus, the absorbent material expands by absorption of a fluid to substantially adhere and seal the stent at the implantation site. Preferably, the cuff expansion is delayed for a time sufficient to permit positioning of the stent at the implantation site. The stent and cuff may also be used as a space-reducer for venous insufficiency, aortic aneurysms, and hydroureter treatment.
    Type: Application
    Filed: March 5, 2013
    Publication date: March 12, 2015
    Inventors: Joseph H. Gorman, III, Robert C. Gorman, Matthew J. Gillespie
  • Publication number: 20150011821
    Abstract: A transvenously deployed myocardial restraint device provides mechanical restraint of a dilated left ventricle and improves heart function. The device includes a delivery wire with a restraining coil that is straightened for percutaneous delivery to the heart and recoiled once positioned in a pericardial space adjacent a ventricular heart wall. Alternatively, a balloon on the end of the delivery wire is delivered similarly to the coil and is then inflated in the pericardial space to restrain the dilated portion of the left ventricle. A trailing end of the coil forms a tether that is anchored to the left ventricular free wall and to the ventricular septum by an intraventricular septal anchor and connected by the tether through the ventricular septum using the same delivery system.
    Type: Application
    Filed: December 21, 2012
    Publication date: January 8, 2015
    Inventors: Robert C. Gorman, Matthew J. Gillespie, Joseph H. Gorman
  • Publication number: 20140357938
    Abstract: A method and device are provided for non-blood contact mechanically assisting an injured (e.g., infarcted) ventricle by coupling an inflatable bladder or other volume adjustable device to the injured ventricle and selectively inflating the bladder or increasing the size of the volume in systole to apply force against the injured ventricle and deflating the bladder or reducing the size of the volume in diastole to remove force against the injured ventricle. When no mechanical assistance is being provided to the injured ventricle, the inflatable bladder or volume adjustable device is preferably maintained at a predetermined pressure so as to selectively stiffen the injured tissue and alter ventricular geometry a desired amount.
    Type: Application
    Filed: November 30, 2012
    Publication date: December 4, 2014
    Inventors: James J. Pilla, Robert C. Gorman, Joseph H. Gorman