Patents by Inventor Joseph Lennox

Joseph Lennox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetra-cyclic carboline derivatives useful in the inhibition of angiogenesis
    Patent number: 8940896
    Abstract: In accordance with the present invention, tetracyclic caboline derivatives that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, these compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: January 27, 2015
    Assignee: PTC Therapeutics, Inc.
    Inventors: Young-Choon Moon, Liangxian Cao, Nadarajan Tamilarasu, Hongyan Qi, Soongyu Choi, William Joseph Lennox, Donald Thomas Corson
  • Indole derivatives and methods for antiviral treatment
    Patent number: 8735414
    Abstract: The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: May 27, 2014
    Assignee: PTC Therapeutics, Inc.
    Inventors: Malcolm MacCoss, F. George Njoroge, Amin Nomeir, Guangming Chen, Song Xiao Huang, Ramesh Kakarla, Gary Mitchell Karp, William Joseph Lennox, Chunshi Li, Ronggang Liu, Yalei Liu, Christie Morrill, Steven D. Paget, Sean W Smith, James Takasugi, Anthony A. Turpoff, Hongyu Ren, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu
  • Carboline derivatives useful in the inhibition of angiogenesis
    Patent number: 8372860
    Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: February 12, 2013
    Assignee: PTC Therapeutics, Inc.
    Inventors: Young-Choon Moon, Liangxian Cao, Nadarajan Tamilarasu, Hongyan Qi, Soongyu Choi, William Joseph Lennox, Donald Thomas Corson, Seongwoo Hwang, Thomas Davis
  • Carboline derivatives useful in the inhibition of angiogenesis
    Patent number: 8367694
    Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
    Type: Grant
    Filed: July 21, 2009
    Date of Patent: February 5, 2013
    Assignee: PTC Therapeutics, Inc.
    Inventors: Young-Choon Moon, Liangxian Cao, Nadarajan Tamilarasu, Hongyan Qi, Soongyu Choi, William Joseph Lennox, Donald Thomas Corson, Seongwoo Hwang
  • INDOLE DERIVATIVES AND METHODS FOR ANTIVIRAL TREATMENT
    Publication number: 20120184574
    Abstract: The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
    Type: Application
    Filed: April 5, 2010
    Publication date: July 19, 2012
    Applicant: PTC THERAPEUTICS, INC.
    Inventors: Malcolm Maccoss, F. George Njoroge, Amin Nomeir, Guangming Chen, Song Xiao Huang, Ramesh Kakarla, Gary Mitchell Karp, William Joseph Lennox, Chunshi Li, Ronggang Liu, Yalei Liu, Christie Morrill, Steven D. Paget, Sean W. Smith, James Takasugi, Anthony A. Turpoff, Hongyu Ren, Nanjing Zhang, Xiaoyan Zhang, Jin Zhu
  • CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS
    Publication number: 20110160190
    Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
    Type: Application
    Filed: March 4, 2011
    Publication date: June 30, 2011
    Inventors: Young-Choon MOON, Liangxian CAO, Nadarajan TAMILARASU, Hongyan QI, Soongyu CHOI, William Joseph LENNOX, Donald Thomas CORSON, Seongwoo HWANG, Thomas DAVIS
  • Carboline derivatives useful in the treatment of cancer
    Patent number: 7767689
    Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: August 3, 2010
    Assignee: PTC Therapeutics, Inc.
    Inventors: Young-Choon Moon, Liangxian Cao, Nadarajan Tamilarasu, Hongyan Qi, Soongyu Choi, William Joseph Lennox, Donald Thomas Corson, Seongwoo Hwang, Thomas Davis
  • CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS
    Publication number: 20100179132
    Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
    Type: Application
    Filed: March 2, 2010
    Publication date: July 15, 2010
    Inventors: Young-Choon Moon, Liangxian Cao, Nadarajan Tamilarasu, Hongyan Qi, Soongyu Choi, William Joseph Lennox, Donald Thomas Corson, Seongwoo Hwang, Thomas Davis
  • CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS
    Publication number: 20100125065
    Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
    Type: Application
    Filed: July 21, 2009
    Publication date: May 20, 2010
    Inventors: Young-Choon Moon, Liangxian Cao, Nadarajan Tamilarasu, Hongyan Qi, Soongyu Choi, William Joseph Lennox, Donald Thomas Corson, Seongwoo Hwang
  • Carboline derivatives useful in the inhibition of angiogenesis
    Patent number: 7601840
    Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: October 13, 2009
    Assignee: PTC Therapeutics, Inc.
    Inventors: Young-Choon Moon, Liangxian Cao, Nadarajan Tamilarasu, Hongyan Qi, Soongyu Choi, William Joseph Lennox, Donald Thomas Corson, Seongwoo Hwang
  • Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 7585876
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: September 8, 2009
    Assignee: Wyeth
    Inventors: Ronald Charles Bernotas, Derek Cecil Cole, William Joseph Lennox
  • Methods, apparatus, computer program products and computer data signals for provision of voice mailbox services
    Patent number: 7421068
    Abstract: An electronic record is stored of an agreement between first and second parties for provision of voice mailboxes. An electronic voice mailbox configuration message for configuration of a voice mailbox for a third party is then received. The voice mailbox is automatically configured responsive to the received voice mailbox configuration message based on the stored electronic record of the agreement. For example, the voice mailbox may be configured to control access to the voice mailbox by the third party and/or configure a voice mailbox feature, such as a mailbox type, a pager notification feature, an operator zero out feature, a child mailbox feature, or a line sharing feature. The voice mailbox configuration message may be a Simple Object Access Protocol (SOAP) message that is received over a data communications network.
    Type: Grant
    Filed: June 16, 2003
    Date of Patent: September 2, 2008
    Assignee: AT&T Intellectual Property I, LP
    Inventor: John Joseph Lennox
  • Tetra-Cyclic Carboline Derivatives Useful in the Inhibition of Angiogenesis
    Publication number: 20080182866
    Abstract: In accordance with the present invention, tetracyclic caboline derivatives that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, these compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.
    Type: Application
    Filed: March 15, 2005
    Publication date: July 31, 2008
    Inventors: Young-Choon Moon, Liangxian Cao, Nadarajan Tamilarasu, Hongyan Qi, Soongyu Choi, William Joseph Lennox, Donald Thomas Corson
  • AZAINDOLYLALKYLAMINE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS
    Publication number: 20080114023
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: November 16, 2007
    Publication date: May 15, 2008
    Applicant: Wyeth
    Inventors: Ronald Charles BERNOTAS, Derek Cecil Cole, William Joseph Lennox
  • 3-beta-D-Ribofuranosylthiazalo [4-5-d] pyrimidine nucleosides and uses thereof
    Publication number: 20080090844
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Application
    Filed: February 22, 2007
    Publication date: April 17, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Devron Averett, Stephen Webber, Joseph Lennox, Erik Rueden
  • Prodrugs of 5-amino-3-(3'-deoxy-b-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
    Publication number: 20080032999
    Abstract: The invention is directed to 5-amino-3-(3?-deoxy-?-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione prodrugs, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.
    Type: Application
    Filed: June 21, 2007
    Publication date: February 7, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Gregory Haley, Joseph Lennox, Alan Xiang, Stephen Webber
  • CARBONATE AND CARBAMATE PRODRUGS OF THIAZOLO[4,5-d]PYRIMIDINES
    Publication number: 20080020989
    Abstract: The invention is directed to carbonate and carbamate prodrugs of thiazolo[4,5-d]pyrimidine compounds, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.
    Type: Application
    Filed: July 17, 2007
    Publication date: January 24, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Gregory Haley, Joseph Lennox, Alan Xiang, Stephen Webber
  • Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 7297705
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: November 20, 2007
    Assignee: Wyeth
    Inventors: Ronald Charles Bernotas, Derek Cecil Cole, William Joseph Lennox
  • 3,5-Disubsitituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof
    Publication number: 20060160830
    Abstract: The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.
    Type: Application
    Filed: December 16, 2005
    Publication date: July 20, 2006
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen Webber, Gregory Haley, Joseph Lennox, Alan Xiang, Erik Rueden
  • Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 7022701
    Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: April 20, 2004
    Date of Patent: April 4, 2006
    Assignee: Wyeth
    Inventors: Derek Cecil Cole, Joseph Raymond Stock, William Joseph Lennox, Ping Zhou