Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.

Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.

Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.

Abstract: An electronic record is stored of an agreement between first and second parties for provision of voice mailboxes. An electronic voice mailbox configuration message for configuration of a voice mailbox for a third party is then received. The voice mailbox is automatically configured responsive to the received voice mailbox configuration message based on the stored electronic record of the agreement. For example, the voice mailbox may be configured to control access to the voice mailbox by the third party and/or configure a voice mailbox feature, such as a mailbox type, a pager notification feature, an operator zero out feature, a child mailbox feature, or a line sharing feature. The voice mailbox configuration message may be a Simple Object Access Protocol (SOAP) message that is received over a data communications network.

Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.

Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.

Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.

Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.

Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.

Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.

Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.

Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.

Abstract: A medical coupling for a cannula or the like includes a female member (1) with a body providing a hub (4) defining a socket (11), a valve section (5) with a valve actuator (15) slidable on the body, and a finger gripping section, and a male member (2) including a spigot (20) for engagement in the socket (11), a cap (21) with a screw thread for engagement with a flange (9) of the hub (4), an internally splined sleeve (24) and a finger gripping section (22). When the spigot (20) is inserted into the socket (11), the cap (21) is rotated onto the flange (10) to hold them against being pulled apart, and the valve actuator is displaced to open the valve and to bring a splined collar (19) into locking engagement with the sleeve (24). A separate casing (30) is provided to form sealed housing around the coupled parts of the male and female members between their griping sections (6, 22).

Abstract: A medical coupling has male and female members (1, 2) which push fit together, and a screw cap (7) which secures the members against separation. To prevent unintentional release of the cap, locking means, such as a ratchet and pawl mechanism, are provided between the cap and female member. An outer shell (25) can enclose the cap for providing an enclosure around the fluid connection to deter bacterial contamination. Alternatively a separate capsule can enclose the coupling for this purpose. The two members and cap are connectable by holding gripping portions which are located remotely from the parts forming the fluid connection to reduce risk of contamination. A valve system is associated with the female member for closing a flexible tube connected to this member and to displace liquid to fill the space left in this member when the male member is disconnected from it.