Patents by Inventor Joseph M. Jacobson

Joseph M. Jacobson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170334133
    Abstract: A 3D object according to the invention comprises substrate layers infiltrated by a hardened material. The 3D object is fabricated by a method comprising the following steps: Position powder on all or part of a substrate layer. Repeat this step for the remaining substrate layers. Stack the substrate layers. Transform the powder into a substance that flows and subsequently hardens into the hardened material. The hardened material solidifies in a spatial pattern that infiltrates positive regions in the substrate layers and does not infiltrate negative regions in the substrate layers. In a preferred embodiment, the substrate is carbon fiber and excess substrate is removed by abrasion.
    Type: Application
    Filed: August 25, 2015
    Publication date: November 23, 2017
    Inventors: Robert Swartz, Buckley Crist, Eugene Gore, Joseph M. Jacobson
  • Patent number: 9776376
    Abstract: A 3D object according to the invention involves substrate layers infiltrated by a hardened material. The 3D object may be fabricated by a method comprising the following steps: Flatten a substrate layer. Position powder on all or part of a substrate layer. Repeat this step for the remaining substrate layers. Stack the substrate layers. Transform the powder into a substance that flows and subsequently hardens into the hardened material. The hardened material solidifies in a spatial pattern that infiltrates positive regions in the substrate layers and does not infiltrate negative regions in the substrate layers. In a preferred embodiment, the substrate is carbon fiber and excess substrate is removed by abrasion.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: October 3, 2017
    Assignee: Impossible Objects, LLC
    Inventors: Robert Swartz, Buckley Crist, Eugene Gore, Joseph M. Jacobson
  • Patent number: 9729182
    Abstract: A platform for context-aware experimentation includes a housing for one or more sensors for obtaining data pertaining to an on-going experiment, a communications subsystem for transmitting data obtained by the sensors, and a microcontroller for receiving data from the sensors, providing it to the communications subsystem, and possibly controlling the sensors. The housing may be a tube, which may be configured to hold a sample and may have a cap, or a waterproof package, which may have an opening to admit at least part of a sample. The platform may include a power source. The platform may include a computer processor, located outside the housing, for analyzing the data obtained by the sensors, determining the experimental context in which the sensors are operating and/or which experimental step in a protocol is being performed, and/or reminding users of required parameters for the steps in the protocol.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: August 8, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Charles Victor Fracchia, Joseph M. Jacobson
  • Publication number: 20170190802
    Abstract: Fabrication and arrangement of nanoparticles into one-dimensional linear chains is achieved by successive chemical reactions, each reaction adding one or more nanoparticles by building onto exposed, unprotected linker functionalities. Optionally, protecting groups may be used to control and organize growth. Nanoparticle spheres are functionalized in a controlled manner in order to enable covalent linkages. Functionalization of nanoparticles is accomplished by either ligand exchange or chemical modification of the terminal functional groups of the capping ligand. Nanoparticle chains are obtained by a variety of connectivity modes such as direct coupling, use of linker molecules, and use of linear polymeric templates. In particular, a versatile building block system is obtained through controlled monofunctionalization of nanoparticles.
    Type: Application
    Filed: January 19, 2017
    Publication date: July 6, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Joseph M. Jacobson, David W. Mosley, Kie-Moon Sung
  • Publication number: 20170168370
    Abstract: A dielectrophoretic display has a substrate having walls defining a cavity, the cavity having a viewing surface and a side wall inclined to the viewing surface. A fluid is contained within the cavity; and a plurality of particles are present in the fluid. There is applied to the substrate an electric field effective to cause dielectrophoretic movement of the particles so that the particles occupy only a minor proportion of the viewing surface.
    Type: Application
    Filed: February 27, 2017
    Publication date: June 15, 2017
    Inventors: Karl R. Amundson, Alexandros Cosmos Arango, Joseph M. Jacobson, Thomas H. Whitesides, Michael D. McCreary, Richard J. Paolini, JR.
  • Patent number: 9664978
    Abstract: A dielectrophoretic display comprises a substrate having walls defining at least one cavity, the cavity having a viewing surface and a side wall inclined to the viewing surface; a suspending fluid contained within the cavity; a plurality of at least one type of particle suspended within the suspending fluid; and means for applying to the fluid an electric field effective to cause dielectrophoretic movement of the particles to the side wall of the cavity.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: May 30, 2017
    Assignee: E Ink Corporation
    Inventors: Alexi C. Arango, Joseph M. Jacobson, Karl Raymond Amundson, Dirk Hertel
  • Publication number: 20170137858
    Abstract: In a method for generating an elongated nucleic acid molecule, a nucleic acid addition of a first nucleic acid molecule attached to a first 3? or 5? protecting group to a nucleic acid immobilized on a surface produces an intermediate-length immobilized nucleic acid. The first protecting group is dissociated from the first nucleic acid molecule. A second nucleic acid molecule that is attached to a second associated a 3? or 5? associated protecting group is added to the intermediate-length nucleic acid. The second associated protecting group is dissociated from the second nucleic acid molecule. A sequentially-extended elongated immobilized nucleic acid molecule having a desired sequence and length is produced by sequentially extending the intermediate-length immobilized nucleic acid by adding additional nucleic acid molecules with associated protecting groups to the intermediate-length nucleic acid and dissociating the associated protecting group after each addition.
    Type: Application
    Filed: November 22, 2016
    Publication date: May 18, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Peter A. Carr, Brian Y. Chow, Joseph M. Jacobson, David W. Mosley, Christopher Emig
  • Patent number: 9499848
    Abstract: In a method for generating a long nucleic acid molecule, nucleic acids immobilized on a surface and having overlapping complementary sequences is released into solution. The overlapping complementary sequences are hybridized to form hybridized nucleic acids, followed by extension or ligation of the hybridized nucleic acids to synthesize the long nucleic acid molecule. The nucleic acids may comprise first and second series of nucleic acids having redundant overlapping sequences, wherein nucleic acids from the first and second series are complementary to each other. The complementary nucleic acids are hybridized to form the hybridized nucleic acids. The generated long nucleic acid molecule may have a predetermined sequence element, and it may be introduced into a system wherein the predetermined sequence element is required for replication, such that replication of the synthesized long nucleic acid molecule is indicative of the presence of the predetermined sequence element in the long nucleic acid molecule.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: November 22, 2016
    Assignee: Massachusetts Institute of Technology
    Inventors: Peter A. Carr, Brian Y. Chow, Joseph M. Jacobson, David W. Mosley, Christopher Emig
  • Publication number: 20160244784
    Abstract: Population-Hastened Assembly Genetic Engineering is a method for continuous genome recoding using a mixed population of cells. Nucleic acid donors are distributed amongst a population of cells that continuously transfer nucleic acids to achieve asynchronous recoding of genetic information within a subpopulation of the cells. Recombination is achieved with biochemical systems compatible with virtually any organism. An engineered directed endonuclease comprises a nucleic acid recognition domain, a nucleic acid endonuclease domain, and a linker fusing or causing interaction between the nucleic acid recognition domain and the nucleic acid endonuclease domain. The method includes causing at least one engineered directed endonuclease to create a nick in a nucleic acid strand, the nick being offset from the recognition sequence of the nucleic acid recognition domain; causing homologous recombination of the strand with a donor nucleotide to create a modified genome; and replicating the modified genome.
    Type: Application
    Filed: February 16, 2016
    Publication date: August 25, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Joseph M. Jacobson, Noah Jakimo, Lisa Nip
  • Publication number: 20160082695
    Abstract: A 3D object according to the invention comprises substrate layers infiltrated by a hardened material. The 3D object is fabricated by a method comprising the following steps: Position powder on all or part of a substrate layer. Repeat this step for the remaining substrate layers. Stack the substrate layers. Transform the powder into a substance that flows and subsequently hardens into the hardened material. The hardened material solidifies in a spatial pattern that infiltrates positive regions in the substrate layers and does not infiltrate negative regions in the substrate layers. In a preferred embodiment, the substrate is carbon fiber and excess substrate is removed by abrasion.
    Type: Application
    Filed: August 25, 2015
    Publication date: March 24, 2016
    Applicant: IMPOSSIBLE OBJECTS LLC
    Inventors: Robert Swartz, Buckley Crist, Eugene Gore, Joseph M. Jacobson
  • Publication number: 20160082658
    Abstract: A 3D object according to the invention comprises substrate layers infiltrated by a hardened material. The 3D object is fabricated by a method comprising the following steps: Position powder on all or part of a substrate layer. Repeat this step for the remaining substrate layers. Stack the substrate layers. Transform the powder into a substance that flows and subsequently hardens into the hardened material. The hardened material solidifies in a spatial pattern that infiltrates positive regions in the substrate layers and does not infiltrate negative regions in the substrate layers. In a preferred embodiment, the substrate is carbon fiber and excess substrate is removed by abrasion.
    Type: Application
    Filed: August 25, 2015
    Publication date: March 24, 2016
    Applicant: IMPOSSIBLE OBJECTS LLC
    Inventors: Robert Swartz, Buckley Crist, Eugene Gore, Joseph M. Jacobson
  • Publication number: 20160082657
    Abstract: A 3D object according to the invention comprises substrate layers infiltrated by a hardened material. The 3D object is fabricated by a method comprising the following steps: Position powder on all or part of a substrate layer. Repeat this step for the remaining substrate layers. Stack the substrate layers. Transform the powder into a substance that flows and subsequently hardens into the hardened material. The hardened material solidifies in a spatial pattern that infiltrates positive regions in the substrate layers and does not infiltrate negative regions in the substrate layers. In a preferred embodiment, the substrate is carbon fiber and excess substrate is removed by abrasion.
    Type: Application
    Filed: August 25, 2015
    Publication date: March 24, 2016
    Applicant: IMPOSSIBLE OBJECTS LLC
    Inventors: Robert Swartz, Buckley Crist, Eugene Gore, Joseph M. Jacobson
  • Patent number: 9293511
    Abstract: A method for manufacturing a full color, reflective display includes the steps of depositing a first plurality of electrophoretic display elements in substantial registration with a first electrode and a second plurality of electrophoretic display elements in substantial registration with a second electrode. The electrophoretic display elements include a capsule containing a species of particles dispersed in a suspending fluid. The selective deposition of the display elements can be achieved by ink-jet printing methods, screen printing methods or other printing methods. In some embodiments the electrodes are printed onto the substrate before selective deposition of the display elements, while in other embodiments the substrate is provided having the electrodes already disposed on it. In still other embodiments, the sequence of printing of electrodes and electrophoretic display elements can be varied.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: March 22, 2016
    Assignee: E Ink Corporation
    Inventors: Joseph M. Jacobson, Ian D. Morrison, Russell J. Wilcox, Paul Drzaic
  • Publication number: 20160079060
    Abstract: A technique for forming nanostructures including introducing a plurality of molecular-size scale and/or nanoscale building blocks to a region near a substrate and simultaneously scanning a pattern on the substrate with an energy beam, wherein the energy beam causes a change in at least one physical property of at least a portion of the building blocks, such that a probability of the portion of the building blocks adhering to the pattern scanned by the energy beam is increased, and wherein the building blocks adhere to the pattern to form the structure. The energy beam and at least a portion of the building blocks may interact by electrostatic interaction to form the structure.
    Type: Application
    Filed: June 30, 2015
    Publication date: March 17, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Joseph M. Jacobson, David Kong, Vikas Anant, Ashley Salomon, Saul Griffith, Will DelHagen, Vikrant Agnihotri
  • Publication number: 20160017393
    Abstract: The invention provides compositions and methods for repeatable directed endonucleases (RDEs) and methods for repeatedly, and specifically cleaving DNA offset from the RDE's DNA recognition sequence on the target nucleic acid rather than within the DNA recognition sequence. Conservation of the recognition sequence of the target nucleic acid enables for re-localization of an RDE back to the DNA recognition sequence for further cleavage. The RDEs and methods of the invention are useful in applications including, but not limited to, recording data into a genome, timing the order of biochemical pathway events, efficient genome engineering and encoding lagged cellular death.
    Type: Application
    Filed: July 15, 2015
    Publication date: January 21, 2016
    Inventors: Joseph M. Jacobson, Noah Michael Jakimo
  • Publication number: 20160006813
    Abstract: A platform for context-aware experimentation includes a housing for one or more sensors for obtaining data pertaining to an on-going experiment, a communications subsystem for transmitting data obtained by the sensors, and a microcontroller for receiving data from the sensors, providing it to the communications subsystem, and possibly controlling the sensors. The housing may be a tube, which may be configured to hold a sample and may have a cap, or a waterproof package, which may have an opening to admit at least part of a sample. The platform may include a power source. The platform may include a computer processor, located outside the housing, for analyzing the data obtained by the sensors, determining the experimental context in which the sensors are operating and/or which experimental step in a protocol is being performed, and/or reminding users of required parameters for the steps in the protocol.
    Type: Application
    Filed: April 28, 2015
    Publication date: January 7, 2016
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Charles Victor Fracchia, Joseph M. Jacobson
  • Publication number: 20150346578
    Abstract: A dielectrophoretic display has a substrate having walls defining a cavity, the cavity having a viewing surface and a side wall inclined to the viewing surface. A fluid is contained within the cavity; and a plurality of particles are present in the fluid. There is applied to the substrate an electric field effective to cause dielectrophoretic movement of the particles so that the particles occupy only a minor proportion of the viewing surface.
    Type: Application
    Filed: August 7, 2015
    Publication date: December 3, 2015
    Inventors: Karl R. Amundson, Jr., Alexandros Cosmos Arango, Joseph M. Jacobson, Thomas H. Whitesides, Michael D. McCreary, Richard J. Paolini, Jr.
  • Publication number: 20150231825
    Abstract: A 3D object according to the invention involves substrate layers infiltrated by a hardened material. The 3D object may be fabricated by a method comprising the following steps: Flatten a substrate layer. Position powder on all or part of a substrate layer. Repeat this step for the remaining substrate layers. Stack the substrate layers. Transform the powder into a substance that flows and subsequently hardens into the hardened material. The hardened material solidifies in a spatial pattern that infiltrates positive regions in the substrate layers and does not infiltrate negative regions in the substrate layers. In a preferred embodiment, the substrate is carbon fiber and excess substrate is removed by abrasion.
    Type: Application
    Filed: May 4, 2015
    Publication date: August 20, 2015
    Inventors: Robert Swartz, Buckley Crist, Eugene Gore, Joseph M. Jacobson
  • Patent number: 9070556
    Abstract: A technique for forming nanostructures including introducing a plurality of molecular-size scale and/or nanoscale building blocks to a region near a substrate and simultaneously scanning a pattern on the substrate with an energy beam, wherein the energy beam causes a change in at least one physical property of at least a portion of the building blocks, such that a probability of the portion of the building blocks adhering to the pattern scanned by the energy beam is increased, and wherein the building blocks adhere to the pattern to form the structure. The energy beam and at least a portion of the building blocks may interact by electrostatic interaction to form the structure.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: June 30, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Joseph M. Jacobson, David Kong, Vikas Anant, Ashley Salomon, Saul Griffith, Will DelHagen, Vikrant Agnihotri
  • Publication number: 20150177589
    Abstract: A dielectrophoretic display comprises a substrate having walls defining at least one cavity, the cavity having a viewing surface and a side wall inclined to the viewing surface; a suspending fluid contained within the cavity; a plurality of at least one type of particle suspended within the suspending fluid; and means for applying to the fluid an electric field effective to cause dielectrophoretic movement of the particles to the side wall of the cavity.
    Type: Application
    Filed: March 4, 2015
    Publication date: June 25, 2015
    Inventors: Alexi C. Arango, Joseph M. Jacobson, Karl Raymond Amundson, Dirk Hertel