Patents by Inventor Joseph Ready

Joseph Ready has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR PRESERVING DNA METHYLATION
    Publication number: 20260043067
    Abstract: The disclosure provides methods for storage solutions for preserving DNA methylation patterns over a period of time. The disclosure also provides for methods of using methylated DNA stored in such storage solutions.
    Type: Application
    Filed: August 18, 2025
    Publication date: February 12, 2026
    Applicant: Case Western Reserve University
    Inventors: Sanford D. Markowitz, Helen Moinova, Joseph Ready
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR PROMOTING NEUROGENESIS AND INHIBITING NERVE CELL DEATH
    Publication number: 20260007642
    Abstract: A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Application
    Filed: September 12, 2025
    Publication date: January 8, 2026
    Inventors: Sanford Markowitz, Joseph Ready, Andrew Pieper
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20250304597
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: October 9, 2024
    Publication date: October 2, 2025
    Inventors: Sanford Markowitz, Monika Antczak, Joseph Ready, Yongyou Zhang
  • Compositions and methods for preserving DNA methylation
    Patent number: 12404538
    Abstract: The disclosure provides methods for storage solutions for preserving DNA methylation patterns over a period of time. The disclosure also provides for methods of using methylated DNA stored in such storage solutions.
    Type: Grant
    Filed: May 26, 2021
    Date of Patent: September 2, 2025
    Assignee: Case Western Reserve University
    Inventors: Sanford D. Markowitz, Helen Moinova, Joseph Ready
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20250243217
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: October 23, 2024
    Publication date: July 31, 2025
    Inventors: Sanford Markowitz, Joseph Ready, Yongyou Zhang, Monika Antczak, James K.V. Willson, Bruce Posner, William Greenlee
  • Compositions and methods of modulating short-chain dehydrogenase activity
    Patent number: 12336982
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: June 24, 2025
    Assignees: Rodeo Therapeutics Corporation, Case Western Reserve University, Board of Regents of the University of Texas System
    Inventors: Sanford Markowitz, Joseph Ready, Stephen L. Gwaltney, II, Monika Antczak
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20250161277
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: January 17, 2025
    Publication date: May 22, 2025
    Inventors: Sanford Markowitz, Joseph Ready, Stephen L. Gwaltney, II, Monika Antczak
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR MODULATING HEMATOPOIETIC STEM CELLS AND HEMATOPOIESIS
    Publication number: 20250134868
    Abstract: A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
    Type: Application
    Filed: October 3, 2024
    Publication date: May 1, 2025
    Inventors: Sanford Markowitz, Amar Desai, Joseph Ready
  • COMPOSITIONS AND METHODS FOR PRESERVING DNA METHYLATION
    Publication number: 20240417775
    Abstract: The disclosure provides methods for storage solutions for preserving DNA methylation patterns over a period of time. The disclosure also provides for methods of using methylated DNA stored in such storage solutions.
    Type: Application
    Filed: May 26, 2021
    Publication date: December 19, 2024
    Inventors: Sanford D. Markowitz, Helen Moinova, Joseph Ready
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20240174688
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: October 5, 2023
    Publication date: May 30, 2024
    Inventors: Sanford Markowitz, Joseph Ready, Yongyou Zhang, Monika Antczak, James K.V. Willson, Bruce Posner, William Greenlee
  • NOVEL ANTIPARASITIC COMPOUNDS AND METHODS
    Publication number: 20240139190
    Abstract: Novel compounds for treating or inhibiting leishmaniasis and other parasitic protozoan diseases are disclosed herein. The compounds bind to Leishmania tubulin, induce parasite microtubule polymerization, stall Leishmania cell division, and have broad antiparasitic activity.
    Type: Application
    Filed: October 19, 2020
    Publication date: May 2, 2024
    Inventors: Dawn M. WETZEL, Imran ULLAH, Laela M. BOOSHEHRI, Joseph READY, Suraksha GAHALAWAT, Bin HU, Yesu ADDEPALLI
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR PROMOTING NEUROGENESIS AND INHIBITING NERVE CELL DEATH
    Publication number: 20240100026
    Abstract: A method of promoting neuroprotection in a subject from axonal degeneration, neuronal cell death, and/or glia cell damage after injury, augmenting neuronal signaling underlying learning and memory, stimulating neuronal regeneration after injury, and/or treating a disease, disorder, and/or condition of the nervous system in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Application
    Filed: May 11, 2023
    Publication date: March 28, 2024
    Inventors: Sanford MARKOWITZ, Joseph READY, Andrew PIEPER
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20240043440
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: November 21, 2022
    Publication date: February 8, 2024
    Inventors: Sanford Markowitz, Monika Antczak, Joseph Ready, Yongyou Zhang
  • COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
    Publication number: 20240043443
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Application
    Filed: July 31, 2023
    Publication date: February 8, 2024
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Yongyou Zhang, Hsin-Hsiung Tai, Monica Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE
    Publication number: 20230322684
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: June 9, 2023
    Publication date: October 12, 2023
    Inventors: Sanford Markowitz, Yiyuan Yuan, Yongyou Zhang, Joseph Ready, Bin Hu
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING NEURODEGENERATION
    Publication number: 20230310390
    Abstract: A method of treating neurodegeneration and/or neurodegenerative condition, disease, or disorder caused by and/or associated with elevated or aberrant 15-PGDH activity in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Application
    Filed: August 9, 2021
    Publication date: October 5, 2023
    Inventors: Sanford Markowitz, Andrew Pieper, Hongyun Li, Edwin Vazquez Rosa, Min-Kyoo Shin, Yeojung Koh, Joseph Ready
  • Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity
    Publication number: 20230285402
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: March 3, 2023
    Publication date: September 14, 2023
    Inventors: Sanford Markowitz, James K. V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • Compositions and methods of modulating short-chain dehydrogenase
    Patent number: 11718589
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: August 8, 2023
    Assignees: Case Western Reserve University, Board of Regents of the University of Texas System
    Inventors: Sanford Markowitz, Yiyuan Yuan, Yongyou Zhang, Joseph Ready, Bin Hu
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20230192717
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: May 19, 2021
    Publication date: June 22, 2023
    Inventors: Stephen L Gwaltney, Joseph Ready, Monika Antczak, Sanford Markowitz, Amar Desai, Stanton Gerson
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING CORONARY DISORDERS
    Publication number: 20230165883
    Abstract: A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.
    Type: Application
    Filed: August 23, 2022
    Publication date: June 1, 2023
    Inventors: Sanford Markowitz, Won Jin Ho, Yiyuan Yuan, Mukesh Jain, Mohamad Sabeh, Joseph Ready, Noelle Williams