Publication number: 20050222243
Abstract: The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent.
Type:
Application
Filed:
May 23, 2005
Publication date:
October 6, 2005
Applicant:
NitroMed, Inc.
Inventors:
Richard Earl, Maiko Ezawa, Xinqin Fang, David Garvey, Ricky Gaston, Subhash Khanapure, L. Gordon Letts, Chia-En Lin, Ramani Ranatunga, Stewart Richardson, Joseph Schroeder, Cheri Stevenson, Shiow-Jyi Wey