Patents by Inventor Joseph Sikora

Joseph Sikora has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9738378
    Abstract: A system and method for braking an aircraft. A processor unit identifies an operating condition of the aircraft. The processor unit displays available modes indications on a display device on the aircraft. The available modes indications indicate modes of operating an automatic braking system on the aircraft that are available for selection by an operator based on the operating condition of the aircraft. The processor unit receives a mode selection from an operator interface. The mode selection indicates a selected mode of operating the automatic braking system that is selected by the operator from the available modes. The processor unit displays on the display device a selected mode indication indicating the selected mode.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: August 22, 2017
    Assignee: THE BOEING COMPANY
    Inventors: Mark Ivan Nikolic, Joseph A. Sikora, William Lawrence Hunt, Jean M. Crane, Jennifer L. Gertley
  • Patent number: 8658695
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: February 25, 2014
    Assignees: Emisphere Technologies, Inc., Novartis AG
    Inventors: William Elliott Bay, Rajesh K. Agarwal, Kiran Chaudhary, Shingai Majuru, Michael M. Goldberg, JoAnne P. Corvino, Moise Azria, Joseph Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph Zielinski
  • Publication number: 20120264834
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.
    Type: Application
    Filed: May 25, 2012
    Publication date: October 18, 2012
    Applicants: NOVARTIS AG, Emisphere Technologies, Inc.
    Inventors: William E. BAY, Rajesh K. AGARWAL, Kiran CHAUDHARY, Shingai MAJURU, Michael M. GOLDBERG, JoAnne P. CORVINO, Moise AZRIA, Joseph M. AULT, Simon D. BATEMAN, Subash PATEL, Joseph SIKORA, Rebecca F. YANG, Joseph L. ZIELINSKI
  • Patent number: 8207227
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.
    Type: Grant
    Filed: March 22, 2011
    Date of Patent: June 26, 2012
    Assignees: Emisphere Technologies, Inc., Novartis AG
    Inventors: William E. Bay, Rajesh K. Agarwal, Kiran Chaudhary, Michael M. Goldberg, Joanne P. Corvino, Shingai Majuru, Moise Azria, Joseph Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph Zielinski
  • Patent number: 8061650
    Abstract: Systems and methods for operating aircraft power systems are disclosed. A power system in accordance with one embodiment of the invention includes an aircraft auxiliary power unit and a controller coupled to the aircraft auxiliary power unit, with the controller being configured to automatically stop the auxiliary power unit while the auxiliary power unit is functioning normally. The controller can also be configured to automatically start the auxiliary power unit in-flight when power supplied or expected to be supplied to a subsystem of the aircraft has a non-zero value at or below a threshold value. The controller may also be configured to start the auxiliary power unit when a load or expected load on the subsystem meets or exceeds a threshold value.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: November 22, 2011
    Assignee: The Boeing Company
    Inventors: Phuong H. Nguyen, Joseph A. Sikora, Thomas A. Campbell
  • Publication number: 20110251125
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.
    Type: Application
    Filed: March 22, 2011
    Publication date: October 13, 2011
    Applicants: Novartis AG, Emisphere Technologies, Inc.
    Inventors: William E. Bay, Rajesh K. Agarwal, Kiran Chaudhary, Shingai Majuru, Michael M. Goldberg, Joanne P. Corvino, Moise Azria, Joseph M. Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph L. Zielinski
  • Patent number: 8003697
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: August 23, 2011
    Assignees: Emisphere Technologies, Inc., Novartis AG
    Inventors: William Elliot Bay, Rajesh K. Agarwal, Kiran Chaudhary, Michael M. Goldberg, JoAnne P. Corvino, Shingai Majura, Moise Azria, Joseph Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph Zielinski
  • Publication number: 20110127372
    Abstract: Systems and methods for operating aircraft power systems are disclosed. A power system in accordance with one embodiment of the invention includes an aircraft auxiliary power unit and a controller coupled to the aircraft auxiliary power unit, with the controller being configured to automatically stop the auxiliary power unit while the auxiliary power unit is functioning normally. The controller can also be configured to automatically start the auxiliary power unit in-flight when power supplied or expected to be supplied to a subsystem of the aircraft has a non-zero value at or below a threshold value. The controller may also be configured to start the auxiliary power unit when a load or expected load on the subsystem meets or exceeds a threshold value.
    Type: Application
    Filed: February 4, 2011
    Publication date: June 2, 2011
    Applicant: The Boeing Company
    Inventors: Phuong H. Nguyen, Joseph A. Sikora, Thomas A. Campbell
  • Patent number: 7915314
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: March 29, 2011
    Assignees: Emisphere Technologies, Inc., Novartis AG
    Inventors: William Elliot Bay, Rajesh K. Agarwal, Kiran Chaudhary, Michael M. Goldberg, JoAnne P. Corvino, Shingai Majura, Moise Azria, Joseph Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph Zielinski
  • Patent number: 7891605
    Abstract: Systems and methods for operating aircraft power systems are disclosed. A power system in accordance with one embodiment of the invention includes an aircraft auxiliary power unit and a controller coupled to the aircraft auxiliary power unit, with the controller being configured to automatically stop the auxiliary power unit while the auxiliary power unit is functioning normally. The controller can also be configured to automatically start the auxiliary power unit in-flight when power supplied or expected to be supplied to a subsystem of the aircraft has a non-zero value at or below a threshold value. The controller may also be configured to start the auxiliary power unit when a load or expected load on the subsystem meets or exceeds a threshold value.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: February 22, 2011
    Assignee: The Boeing Company
    Inventors: Phuong H. Nguyen, Joseph A. Sikora, Thomas A. Campbell
  • Patent number: 7760759
    Abstract: The invention provides methods and systems for providing priority processing to critical data as the data is transmitted across a network. A plurality of Internet protocol (IP) packets, each of which contains data and priority information, are received at a first router. The data contained in the IP packets is then encapsulated into frame relay frames containing the priority information. The frame relay frames are transmitted from the first router to a frame relay network in a manner determined by the priority information included in the frame relay frames. The frame relay flames are then transmitted across a frame relay network to a second router in a manner determined by the priority information included in the frame relay frames.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: July 20, 2010
    Inventors: Hrair Aldermeshian, Arvind S Chakravarti, Richard Hellstern, Raymond L. Kimber, Ali Mohammad Kujoory, Yonatan Aharon Levy, John Babu Medamana, John Joseph Sikora
  • Publication number: 20100099621
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.
    Type: Application
    Filed: December 18, 2009
    Publication date: April 22, 2010
    Applicants: EMISPHERE TECHNOLOGIES, INC., NOVARTIS AG
    Inventors: William E. Bay, Rajesh K. Agarwal, Kiran Chaudhary, Shingai Majuru, Michael M. Goldberg, JoAnne P. Corvino, Moise Azria, Joseph M. Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph L. Zielinski
  • Patent number: 7679529
    Abstract: A method and a system for indicating a target idle running speed, a predicted core speed, a predicted time to running, current engine state or automation modes of an operating aircraft engine, and indicating that the current core speed of the aircraft engine is less than a target idle running speed or is abnormally decreasing towards a target idle running speed. The indicators may be visual or aural. The visual indicators may include graphical or numeric symbols indicating the target idle running speed, the direction of core speed change, the predicted core speed at some future time, or current engine state or automation mode.
    Type: Grant
    Filed: December 7, 2006
    Date of Patent: March 16, 2010
    Assignee: The Boeing Company
    Inventors: Samuel T. Clark, Andrew W. Houck, Joseph A. Sikora, Roglenda R. Bowe
  • Patent number: 7659311
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.
    Type: Grant
    Filed: April 29, 2008
    Date of Patent: February 9, 2010
    Assignee: Novartis AG
    Inventors: William Elliott Bay, Rajesh K. Agarwal, Kiran Chaudhary, Shingai Majuru, Michael M. Goldberg, JoAnne P. Corvino, Moise Azria, Joseph Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph L. Zielinski
  • Patent number: 7580235
    Abstract: Systems and methods for presenting information corresponding to circuit breakers and for controlling such circuit breakers are disclosed. In one embodiment, the system can include a menu-driven, pointer-accessible graphical user interface via which an operator can receive information corresponding to circuit breakers, and can automatically change the states of the circuit breakers. Menus of circuit breaker information can be organized by the state of the circuit breaker, the location of the circuit breaker, the bus to which the circuit breaker is coupled, the electrical system to which the circuit breaker belongs, and/or the system or subsystem of which the circuit breaker is a part. In further embodiments, the circuit breaker information can be organized according to custom-made arrangements.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: August 25, 2009
    Assignee: The Boeing Company
    Inventors: George H. Hamasaki, Joseph A. Sikora, Bryan P. Kesterson, Gregory P. Owens, Justin E. Hale, Norman F. Kirby, Thanh-Ha N. Herter, Michael B. McAvoy, Phuoc D. Nguyen, Robert J. Crane
  • Publication number: 20090037036
    Abstract: Systems and methods for operating aircraft power systems are disclosed. A power system in accordance with one embodiment of the invention includes an aircraft auxiliary power unit and a controller coupled to the aircraft auxiliary power unit, with the controller being configured to automatically stop the auxiliary power unit while the auxiliary power unit is functioning normally. The controller can also be configured to automatically start the auxiliary power unit in-flight when power supplied or expected to be supplied to a subsystem of the aircraft has a non-zero value at or below a threshold value. The controller may also be configured to start the auxiliary power unit when a load or expected load on the subsystem meets or exceeds a threshold value.
    Type: Application
    Filed: March 13, 2008
    Publication date: February 5, 2009
    Applicant: The Boeing Company
    Inventors: Phuong H. Nguyen, Joseph A. Sikora, Thomas A. Campbell
  • Publication number: 20080287543
    Abstract: The invention relates to a composition for the treatment of a cyclooxygenase-2-mediated disorder or condition comprising 5-methyl-2-(2?-chloro-6?-fluoroanilino)phenylacetic acid or a pharmaceutically acceptable salt, preferably the potassium salt, thereof suitable for parenteral administration, and to a method for the treatment of a cyclooxygenase-2-mediated disorder or condition in a human or animal in need of such treatment by parenteral administration of 5-methyl-2-(2?-chloro-6?-fluroanilino)phenylacetic acid or a pharmaceutically acceptable salt, preferably the potassium salt, thereof.
    Type: Application
    Filed: July 21, 2008
    Publication date: November 20, 2008
    Inventors: Rose-Marie Dannenfelser, Vivia Christine Georgousis, Maha Y. Khaled, Tarun S. Patel, Joseph Sikora, Barbara Wang
  • Publication number: 20080269134
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.
    Type: Application
    Filed: April 29, 2008
    Publication date: October 30, 2008
    Applicants: Emisphere Technologies, Inc., Novartis AG
    Inventors: William E. Bay, Rajesh K. Agarwal, Kiran Chaudhary, Shingai Majuru, Michael M. Goldberg, JoAnne P. Corvino, Moise Azria, Joseph M. Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph L. Zielinski
  • Publication number: 20080136677
    Abstract: A method and a system for indicating a target idle running speed, a predicted core speed, a predicted time to running, current engine state or automation modes of an operating aircraft engine, and indicating that the current core speed of the aircraft engine is less than a target idle running speed or is abnormally decreasing towards a target idle running speed. The indicators may be visual or aural. The visual indicators may include graphical or numeric symbols indicating the target idle running speed, the direction of core speed change, the predicted core speed at some future time, or current engine state or automation mode.
    Type: Application
    Filed: December 7, 2006
    Publication date: June 12, 2008
    Inventors: Samuel T. Clark, Andrew W. Houck, Joseph A. Sikora, Roglenda R. Bowe
  • Patent number: 7384982
    Abstract: The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are indepedently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substitued or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: June 10, 2008
    Assignees: Emisphere Technologies, Inc., Novartis AG
    Inventors: William E. Bay, Rajesh K. Agarwal, Kiran Chaudhary, Shingai Majuru, Michael M. Goldberg, JoAnne P. Russo, Mosise Azria, Joseph M. Ault, Simon D. Bateman, Subash Patel, Joseph Sikora, Rebecca F. Yang, Joseph L Zielinski