Abstract: The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (I), or pharmaceutically acceptable salts thereof, in which n, m, R1, R2, and R3 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms, such as PI3K?. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3K?.

Abstract: The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (I), or pharmaceutically acceptable salts or isomers thereof, in which n, m, R1, R2, R4, and R3 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms, such as PI3K?. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts or isomers thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3K?.

Abstract: The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein X, Y, Z, n, m?, A?, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.

Abstract: The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein W, B, n, m, A?, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.

Abstract: The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, or a mixture thereof, wherein n, m, q, A?, W1, W2, W3, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.

Abstract: Devices and methods for automatic sharing of digital multimedia include, in one embodiment, obtaining factor data affecting a decision on whether or not to enter a digital multimedia sharing mode for an event or meeting; entering the digital multimedia sharing mode based on identifying calendar entry data for the event or meeting stored in a calendar database that satisfies the factor data; storing digital photograph data produced by a camera module while in the sharing mode in a digital multimedia container designated to store digital multimedia for the event or meeting; obtaining participant data for the event or meeting from the calendar entry data; and automatically making the digital photograph data available to the one or more participants based on the participant data.

Abstract: The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (I), or pharmaceutically acceptable salts thereof, in which n, m, R1, R2, and R3 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms, such as PI3K?. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3K?.

Abstract: The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (I), or pharmaceutically acceptable salts or isomers thereof, in which n, m, R1, R2, R4, and R3 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms, such as PI3K?. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts or isomers thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3K?.

Abstract: An operating system of a computer provides an interface, such as an application programming interface, through which applications on that computer can store link data in a consistent format across applications and resources. Thus, when an application stores link data, it sends a command to the operating system providing the link data, invoking a command to store the link data. When an application retrieves link data, it sends a command to the operating system to retrieve link data. Thus, an application can store link data for a history of resources accessed, favorite resources accessed, and other types of resources to be accessed. As a result, the operating system provides a single mechanism for a heterogeneous set of applications and a heterogeneous set of resources to store link data in a single repository.

Abstract: A function of a device, such as volume, may be controlled using a combination of gesture recognition and an interpolation scheme. Distance between two objects such as a user's hands may be determined, at a first time point and a second time point. The difference between the distances calculated at two time points may be mapped onto a plot of determined difference versus a value of the function to set the function of a device to the mapped value.

Abstract: A medium is disclosed that incorporates instructions including: a user interface module that receives from a user a first work-targeting input, the first work associated with intellectual property; an asset identifier module that identifies automatically, based on a relation to the first work-targeting input, the first work; the user interface module receiving, as a first work-adapting input, from the user, an input for adapting, modifying or creating a derivative work from the first work; and an adaptation generator module that generates automatically a record of a grant in rights in the adaptation of the first work according to the first work-adapting input, and provides a report of the grant in the adaptation of the first work to the user.

Abstract: The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (I), or pharmaceutically acceptable salts thereof, in which n, m, R1, R2, and R3 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms, such as PI3K?. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by one or more PI3K isoforms, such as PI3K?.

Abstract: Certain implementations of the disclosed technology may include systems and methods for enhanced function access in mobile applications. According to an example implementation, a method is provided. The method includes outputting an application selection screen including one or more icons. The method includes receiving an indication of a first gesture input entered at a first location of a presence-sensitive display, the first location being associated with a first icon from the one or more icons. The method also includes outputting an indication of the one or more predefined functions of the application associated with the first icon, and responsive to a selection, executing the selected at least one of the one or more predefined functions without outputting the respective primary application user interface for the application associated with the first icon.

Abstract: An outlet cover safety device with an integrated safety device having an electrical with at least one aperture. The electrical cover mounting on an electrical outlet. The matching up with electrical gangs of the electrical outlet. The safety device having a at least one strap, with at least one prong disposed on the strap. The strap being biased to remain in an open position away from the plug accepting outlet when not in use. When wishing to engage the safety device, the strap is bent in a direction such that the prong is gets inserted into an aperture of a plug receiving outlet. The safety device may be incorporated with an outlet cover or may be a separate mechanism.

Abstract: This invention provides compounds of Formula (I), having the structure where G1, G2, G3, G4, A1, A2, Y1, Y2, L1, Z, e and f are defined herein, or a pharmaceutically acceptable salt thereof, which are useful for treating or preventing cancer.

Abstract: A form fitting closure structure and method for an internal tightening of shoe facilitated the closure system to ensure the retention of the position of the shoe wearer's foot. The system comprises (1) an outer sole which is open to allow insertion of a foot and capable of being closed over the foot by a closure system, (2) an internal sock-like tightening structure that encases the instep of the foot and is affixed to the shoe's closure system. A method of providing a better fit of the shoe around the shoe wearer's foot by ensuring the retention of the position of the foot within the shoe is also disclosed.

Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, and R8 are defined herein.

Abstract: The invention provides compounds of formula (I): wherein E, A, B?, R6, R7, R8, and R9 are defined in the specification which compounds exhibit anticancer activity and are useful for treating cancer.

Abstract: A portable digital media playback apparatus is preloaded with digital media files for preview. The files may be tagged with information to indicate the user wishes to purchase the digital media file or purchase certain digital rights associated with the digital media file. When the portable device is re-synched with a library of digital media files available for purchase, the files designated for purchase are downloaded to the portable device. In one embodiment, a user profile is created and includes a record of user events relating to the digital media files previewed, deleted or purchased. The content provider adopts a set of criteria for matches and creates a list of additional digital media files that are compatible with the user and which will be pushed down to the portable device the next time that the user synchronizes the device.

Abstract: The present invention relates to Pyrazolopyrimidine Analogs, methods of making Pyrazolopyrimidine Analogs, compositions comprising a Pyrazolopyrimidine Analog, and methods for treating mTOR-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog. The invention also relates to treating PI3K-related disorders comprising administering to a subject in need thereof an effective amount of a Pyrazolopyrimidine Analog.