Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: An example operation includes starting, by a vehicle, a timer when a pairing request is initiated; receiving, by the vehicle, a first response to the pairing request from a first device and a second response to the pairing request from a second device; recording the timer when each of the first response and the second response are received; determining a first connection time, from the recorded timer, for the first device, and determining a second connection time, from the recorded timer, for the second device; and connecting, by the vehicle, to a device having a fastest connection time among the first device and the second device.

Abstract: An engine system optionally including: a crankcase of an engine having a blow-by gas passing therethrough; a liquid source containing a liquid; and an oil separating apparatus in fluid communication with the blow-by gas. The oil separating apparatus having a coalescing filter to separate oil from the blow-by gas. Separate from the blow-by gas and the coalescing filter, the oil separating apparatus is in fluid communication with the liquid source to receive the liquid. The liquid is passed through the oil separating apparatus in a heat exchange relationship with the blow-by gas to maintain a desired temperature range for the blow-by gas.

Abstract: Fibrous structures that exhibit a Tensile Ratio of less than 1.75 and/or less than 1.49 as measured according to the Tensile Strength Test Method described herein and a Geometric Mean Modulus (GM Modulus) of less than 1402.4 g/cm at 15 g/cm and/or a Machine Direction Modulus (MD Modulus) of less than 1253.4 g/cm at 15 g/cm and/or a Cross Machine Direction Modulus (CD Modulus) of less than 1569.2 g/cm at 15 g/cm, are provided.

Abstract: Aspects of the present disclosure involve systems, methods, devices, and the like for obtaining real-time estimates. In one embodiment, a novel customizable, transferable system architecture is presented that enables the characterization of a task, designated for time estimate, into steps or processes. The characterization may occur using the novel architecture which introduces an estimates service module that can provide an initial timing estimate by obtaining a composite time estimate of all steps. Timing of each of the steps can be predicted using a job scheduling enterprise designed to model the job or step. In another embodiment, delays are captured by time estimate monitors which can provide the alerts and delta time differences. Such alerts and time differences can be updated and presented to the user.

Abstract: Aspects of the present disclosure involve systems, methods, devices, and the like for segmentation of the processor architecture platform. In one embodiment, a system and method are introduced which enable the use of a segmented platform in an extended network. The segmented platform is introduced for processing using standardized plugins enabling the use of processing and services available at the segmented network. In another embodiment, processing on the segmented platform can include the integration of microservices for the completion of the transaction.

Abstract: In general, the present disclosure describes inventory management systems and methods which track all inventory of items within a retail supply chain. A computerized system aggregates inventory movement events to produce a common source of truth for the location and disposition of items within a supply chain. Order events and inventory events are received from multiple data sources. Additionally, a current inventory level for each item at each location within the supply chain is provided according to the data source. The computerized system normalizes the information in the event messages before it is stored in the centralized inventory database. The inventory information in the database can be accessed by multiple consumers through an API to obtain the most up-to-date information about the disposition and location of an item.

Abstract: Three-dimensional (3D) image modeling systems and methods are described for automatically generating virtual 3D store environments. The 3D image modeling systems and methods comprise loading, from a computer memory, a product set of 3D imaging assets including product texture images and standard product model(s). A virtual 3D area is generated by a 3D engine inputting a matrix file that depicts one or more 3D products. The 3D engine positions the one or more virtual 3D products based on positioning data in the matrix file. A virtual 3D store environment is generated based on the virtual 3D area and a 3D structural model. The virtual 3D store environment is configured for rendering as a photorealistic environment in virtual 3D space.

Abstract: What is disclosed is a cellulose-based product and a method for producing the aggregate admix product that includes the steps of thoroughly hydrating cellulose fibers, mixing clay and mineral particulates with a liquid to produce an emulsion, adding the emulsion to the hydrated cellulose fibers, and thoroughly impregnating the cellulose fibers with components from the emulsion and producing an aggregate admix product. The aggregate admix product is combined with cement and a liquid to create a cementitious product that can be directly sprayed onto building structures.

Abstract: A preload collar for a vehicle spring is described. The preload collar is coupled to the shock absorber of a vehicle so that the lower end of the vehicle spring is pressing against the preload collar. The preload collar does not allow the lower end of the vehicle spring to extend toward the ground, or toward the lower end of the shock absorber, as much as it normally would. This pre-loading of the vehicle spring provides suspension lift to the vehicle.

Abstract: Aspects of the present disclosure involve systems, methods, devices, and the like for obtaining real-time estimates. In one embodiment, a novel customizable, transferable system architecture is presented that enables the characterization of a task, designated for time estimate, into steps or processes. The characterization may occur using the novel architecture which introduces an estimates service module that can provide an initial timing estimate by obtaining a composite time estimate of all steps. Timing of each of the steps can be predicted using a job scheduling enterprise designed to model the job or step. In another embodiment, delays are captured by time estimate monitors which can provide the alerts and delta time differences. Such alerts and time differences can be updated and presented to the user.

Abstract: A breakaway stethoscope includes a chest piece, a headset, a tube, and a coupler. The chest piece captures sounds generated inside a person's body when the chest piece is positioned adjacent the person's body. The headset directs the sounds captured by the chest piece toward a person's ear when the headset is positioned on an ear of the person. The tube connects the chest piece to the headset and conveys the sounds captured by the chest piece toward the headset. The tube has a length and includes a first portion connected to the chest piece and a second portion connected to the headset. The coupler releasably connects the tube's first portion to the tube's second portion and releases one of the tube's portions when the tube experiences a force that urges at least one of the tube's portions to move away from the coupler.

Abstract: Bimodal high-density polyethylene polymer compositions with increased high melt strength and good processability. The compositions comprise a base resin having a density of about 945 kg/m3 to about 955 kg/m3, and an ethylene polymer (A) having a density of at least about 968 kg/m3, in an amount ranging from 45% to 55% by weight and an ethylene polymer (B) having a density lower than the density of polymer (A). The composition has a complex viscosity at a shear rate of 0.01 rad/s ranging from about 200 to 450 kPa·s and a complex viscosity at a shear rate of 100 rad/s ranging from about 1900 to 2500 Pa·s. Articles made from these compositions, such as pipes and fittings achieve long-term oxidative resistance and have a low wall thickness variability while maintaining high production output.

Abstract: Computer systems and associated methods are disclosed to detect a future change point in time series data used as input to a machine learning model. A forecast for the time series data is generated. In some embodiments, a fitting model is generated from the time series data, and residuals of the fitting model are obtained for respective portions of the data both before and after a potential change point in the future. The change point is determined based on a ratio of residual metrics for the two portions. In some embodiments, data features are extracted from individual segments in the time series data, and the segments are clustered based on their data features. A change point is determined based on a dissimilarity in cluster assignments for segments before and after the point. In some embodiments, when a change point is predicted, an update of the machine learning model is triggered.

Abstract: The present disclosure is directed to processes for the selective separation of carbon dioxide (CO2) from multi-component feedstreams containing CO2. The processes use a potassium-form MER framework type zeolite having a stick-like morphology. The potassium is present in the zeolite as K+ in extra-framework locations, and the zeolite is essentially free of an extra-framework cation other than potassium.

Abstract: An application programming interface (API) platform accesses cloud-based software services in a cloud computing system. API requests used in the API platform include a tenant specific endpoint (TSE) that uses a unique tenant identifier and an API endpoint as a URL domain. The unique tenant identifier identifies a tenant associated with the API request and the API endpoint identifies one of the cloud-based software services. The combination of the unique tenant identifier and the API endpoint in the domain of the TSE maps to an IP address for a specific software service in a specific one of the data centers in the cloud computing system assigned to the tenant. This allows API requests to be routed directly to the tenant specific data centers without first being routed through a central routing service.

Abstract: Computer systems and associated methods are disclosed to detect a future change point in time series data used as input to a machine learning model. A forecast for the time series data is generated. In some embodiments, a fitting model is generated from the time series data, and residuals of the fitting model are obtained for respective portions of the data both before and after a potential change point in the future. The change point is determined based on a ratio of residual metrics for the two portions. In some embodiments, data features are extracted from individual segments in the time series data, and the segments are clustered based on their data features. A change point is determined based on a dissimilarity in cluster assignments for segments before and after the point. In some embodiments, when a change point is predicted, an update of the machine learning model is triggered.

Abstract: Aspects of the present disclosure involve systems, methods, devices, and the like for segmentation of the processor architecture platform. In one embodiment, a system and method are introduced which enable the use of a segmented platform in an extended network. The segmented platform is introduced for processing using standardized plugins enabling the use of processing and services available at the segmented network. In another embodiment, processing on the segmented platform can include the integration of microservices for the completion of the transaction.

Abstract: Aspects of the present disclosure involve systems, methods, devices, and the like for obtaining real-time estimates. In one embodiment, a novel customizable, transferable system architecture is presented that enables the characterization of a task, designated for time estimate, into steps or processes. The characterization may occur using the novel architecture which introduces an estimates service module that can provide an initial timing estimate by obtaining a composite time estimate of all steps. Timing of each of the steps can be predicted using a job scheduling enterprise designed to model the job or step. In another embodiment, delays are captured by time estimate monitors which can provide the alerts and delta time differences. Such alerts and time differences can be updated and presented to the user.

Abstract: A beverage dispenser for dispensing beverages and process may include a fluid container containing a fluid ingredient, a conduit fluidly connected to the fluid container, and an electrical conductivity sensor. The electrical conductivity sensor may be (i) fluidly connected to the conduit, and (ii) configured to sense an electrical conductivity of the fluid ingredient flowing through the conduit. The electrical conductivity sensor may further be configured to output (i) a first electrical signal in response to sensing an air bubble, and (ii) a second electrical signal in response to not sensing an air bubble.