Abstract: An obstructive sleep apnea treatment device is disclosed herein. In embodiments the device eliminates the need for large peripheral equipment such as an air pump and hoses commonly associated with current treatment devices. In embodiments, the device is comprised of a main mask body component, at least one expiratory or exhalation pressure valve, at least one inspiratory or inhalation valve. In other embodiments, the device is further comprised of a forehead cushion component, a facial seal component, and an attachment component. In embodiments, the main mask body component is a nasal covering mask configured with a positive end expiratory adjustable pressure valve to generate a resistance on a patient's exhalation thus pressuring the nasal airways without the need of an air pump or electrical power source. Positive pressurization of the airways reduces the occurrence of apneas.

Abstract: An automated system for brewing and dispensing a brewed beverage is provided including a beverage brewing apparatus configured to dispense the brewed beverage into a container. A user interface is disposed with said beverage brewing apparatus. The user interface includes at least one iced beverage user input directed to preparation of the brewed beverage when the brewed beverage is to be dispensed over ice. A controller is operably coupled to the user interface and the beverage brewing apparatus. The controller is programmable to compensate for dilution of the brewed beverage in the container.

Abstract: Disclosed herein are methods and systems for brewing coffee. In one example, a method of brewing coffee includes delivering a predetermined amount of water from a reservoir to a heater, heating the predetermined amount of water with the heater to form heated water, delivering the predetermined amount of the heated water from the heater to a brew basket containing ground coffee, and soaking the ground coffee with the predetermined amount of the heated water for a predetermined period of time to enable the heated water delivered to the brew basket to presoak the ground coffee contained in brew basket prior delivering a remaining amount of water from to the quantity of water to the brew basket to complete the brewing cycle.

Abstract: An automated beverage brewing apparatus is provided including a controller for identifying a volume of bloom water and a bloom time for preparing a brewed beverage. A user interface provides at least one input to the controller. The controller is configured to vary the volume of the bloom water based on a type of brewed beverage and a size of brewed beverage input via the user interface.

Abstract: A beverage system is provided including a housing having a water outlet. A water reservoir is mounted to the housing. The water reservoir is arranged in fluid communication with the water outlet via at least one fluid conduit. A flow meter is disposed within the at least one fluid conduit. The flow meter is configured to measure a volume of water supplied to the water outlet. A heating mechanism is configured to heat at least a portion of the water within the at least one fluid conduit. Water is selectively supplied to the water outlet without a pump.

Abstract: A method for supporting retinal, intestinal, and/or nervous system development in a neonate is provided. The method involves enterally administering arginine-glutamine dipeptide to a neonate.

Abstract: The subject invention provides for the administration of docosahexaenoic acid in preventing pathological proliferation of blood vessels. The compositions of the subject invention are particularly advantageous because they are stable, bioavailable, and can be formulated in an aqueous solution.

Abstract: The present invention is directed to a novel method for modulating the expression of one or more genes in a subject by administering an amount of DHA and ARA to the subject.

Abstract: The present invention is directed to a novel method for preventing or treating anemia in a subject. The method comprises administration of a therapeutically effective amount of DHA and ARA to the subject.

Abstract: The present invention is directed to a novel method for preventing or treating obesity in a subject. The method comprises administration of a therapeutically effective amount of DHA and ARA, alone or in combination with one another, to the subject.

Abstract: The present invention relates to a nutritional supplement for administration to children. The supplement comprises a protein component, a carbohydrate component, and a fat or lipid component which further comprises a source of DHA. The supplement has an ?-6:?3 fatty acid ratio of about 6:1 or less. The present invention also relates to a method of providing nutrition to a pediatric subject comprising administering to the subject a nutritional supplement comprising a protein component; a carbohydrate component; and a fat or lipid component, which further comprises a source of DHA, wherein the composition has an ?-6:?-3 fatty acid ratio of about 6:1 or less.

Abstract: The subject invention provides a method and compositions for preventing and/or treating abnormal vascular proliferation in a human infant where the method involves enterally administering arginine and glutamine to the infant in about equimolar amounts to provide a total amount of arginine and glutamine that is effective to prevent or treat the abnormal vascular proliferation. Arginyl-glutamine dipeptide was shown to be an advantageous form in which to provide the two amino acids.

Abstract: The present invention relates to a continuous method to prepare encapsulated cyclopropenes, a method to purify cyclopropene gas, and a method to prepare an ?-cyclodextrin/cyclopropene complex.

Abstract: A nutritionally complete infant formula containing sialic acid derived from one or a number of nutritionally appropriate sources is described.

Abstract: The subject invention provides dipeptides useful in preventing pathological proliferation of blood vessels. The dipeptides of the subject invention are particularly advantageous because they are stable, bioavailable, and can be formulated in an aqueous solution, and in particular, into infant formulations.

Abstract: The present invention relates to a continuous method to prepare encapsulated cyclopropenes, a method to purify cyclopropene gas, and a method to prepare an &agr;-cyclodextrin/cyclopropene complex.

Abstract: The present invention provides a solventless process for the catalytic hydrogenation of esters of 4,4,4-trihaloacetoacetic acid using a platinum catalyst in the presence of an acid or base co-catalyst to provide the analagous 3-hydroxybutyrate ester. Such 3-hydroxybutyrate esters are useful as solvents, cleaners or fine chemical intermediates.

Abstract: The present invention provides a process for preparing esters or thioesters of trifluoroacetic acid from trifluoroacetyl chloride and an alcohol or a thiol with the ester or thioester being present as the solvent. Esters and thioesters of trifluoroacetic acid are fine chemical intermediates which can be used in the manufacture of pharmaceuticals, agricultural chemicals, liquid crystals, dyes and industrial chemicals. Trifluoroacetate esters and thioesters can also be used as solvents in the manufacture of other fine chemicals, pharmaceuticals, agricultural chemicals, liquid crystals, industrial chemicals and dyes.

Abstract: A nucleophilic substitution reaction on optionally substituted dihalobenzenes is carried out in the presence of an optional catalyst followed by formation of and subsequent carboxylation of a Grignard reaction intermediate. In particular the present invention provides a process leading to optionally substituted hydroxybenzoic, alkanoyloxybenzoic, formyloxybenzoic and alkoxybenzoic acids from 1-substituted 2,6-dihalobenzenes. The invention also provides a process for the direct formation of an acyl chloride from a Grignard reagent by quenching with phosgene.

Abstract: Nucleophilic substitution reactions on halobenzenes or triflyl substituted benzenes are carried out in the presence of catalysts. In particular the present invention provides a process leading to optionally substituted hydroxybenzoic, alkanoyloxybenzoic, formyloxybenzoic and alkoxybenzoic acids and optionally substituted hydroxybenzonitriles and alkoxybenzonitriles from substituted 2,6-dihalobenzenes, 2-halo-6-triflylbenzene and 2,6-ditriflylbenzenes.