Patents by Inventor Joshua E. Allen

Joshua E. Allen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-BENZYL-4-(2-METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO [1,2-A]PYRIDO[3,4-E]PYRIMIDIN-5(1H)-ONE, ANALOGS THEREOF, AND SALTS THEREOF AND METHODS FOR THEIR USE IN THERAPY
    Publication number: 20180072729
    Abstract: This disclosure relates to methods of treatment using compound (1) or analogs thereof, and pharmaceutically acceptable salts thereof. Also disclosed are compounds of formula (10): as defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the same. Methods of treatment, such as for cancer, are provided that comprise administering the compounds and their salts to a subject in need of such treatment.
    Type: Application
    Filed: November 20, 2017
    Publication date: March 15, 2018
    Applicant: ONCOCEUTICS, INC.
    Inventors: Joshua E. ALLEN, Martin STOGNIEW, Richard S. POTTORF, Bhaskara Rao NALLAGANCHU, Gary OLSON, Yanjun SUN
  • 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-A]pyrido[3,4-E]pyrimidin-5(1H)-one, analogs thereof, and salts thereof and methods for their use in therapy
    Patent number: 9845324
    Abstract: This disclosure relates to methods of treatment using compound (1) or analogs thereof, and pharmaceutically acceptable salts thereof. Also disclosed are compounds of formula (10): as defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the same. Methods of treatment, such as for cancer, are provided that comprise administering the compounds and their salts to a subject in need of such treatment.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: December 19, 2017
    Assignee: Oncoceutics, Inc.
    Inventors: Joshua E. Allen, Martin Stogniew, Richard S. Pottorf, Bhaskara Rao Nallaganchu, Gary Olson, Yanjun Sun
  • 7-BENZYL-4-(METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO[1,2-A]PYRIDO[3,4-E]PYRIMIDIN-5 (1H)-ONE, SALTS THEREOF AND METHODS OF USING THE SAME IN COMBINATION THERAPY
    Publication number: 20170319587
    Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.
    Type: Application
    Filed: June 19, 2017
    Publication date: November 9, 2017
    Applicant: Oncoceutics, Inc.
    Inventors: Martin STOGNIEW, Joshua E. ALLEN
  • SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY AND TUMOR CELLS AS AN ANTICANCER THERAPY
    Publication number: 20170224690
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Application
    Filed: April 23, 2017
    Publication date: August 10, 2017
    Applicant: The Penn State Research Foundation
    Inventors: Joshua E. ALLEN, Gen Sheng WU, Wafik S. EL-DEIRY
  • 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy
    Patent number: 9688679
    Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): (structurally represented) or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: June 27, 2017
    Assignee: Oncoceutics, Inc.
    Inventors: Martin Stogniew, Joshua E. Allen
  • Small molecule TRAIL gene induction by normal and tumor cells as an anticancer therapy
    Patent number: 9629842
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: April 25, 2017
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu
  • 7-BENZYL-4-(2-METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO [1,2-A]PYRIDO[3,4-E]PYRIMIDIN-5(1H)-ONE, ANALOGS THEREOF, AND SALTS THEREOF AND METHODS FOR THEIR USE IN THERAPY
    Publication number: 20170096431
    Abstract: This disclosure relates to methods of treatment using compound (1) or analogs thereof, and pharmaceutically acceptable salts thereof. Also disclosed are compounds of formula (10): as defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the same. Methods of treatment, such as for cancer, are provided that comprise administering the compounds and their salts to a subject in need of such treatment.
    Type: Application
    Filed: February 22, 2016
    Publication date: April 6, 2017
    Applicants: ONCOCEUTICS INC., PROVID PHARMACEUTICALS INC.
    Inventors: Joshua E. Allen, Martin Stogniew, Richard S. Pottorf, Bhaskara Rao Nallaganchu, Gary Olson, Yanjun Sun
  • SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY
    Publication number: 20170000790
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Application
    Filed: September 19, 2016
    Publication date: January 5, 2017
    Applicant: The Penn State Research Foundation
    Inventors: Wafik S. EL-DEIRY, Joshua E. ALLEN, Gen Sheng WU
  • Small molecule TRAIL gene induction by normal and tumor cells as an anticancer therapy
    Patent number: 9452165
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: September 27, 2016
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu
  • 7-BENZYL-4-(METHYLBENZYL)-2,4,6,7,8,9-HEXAHYDROIMIDAZO[1,2-A]PYRIDO[3,4-E]PYRIMIDIN-5 (1H)-ONE, SALTS THEREOF AND METHODS OF USING THE SAME IN COMBINATION THERAPY
    Publication number: 20160264574
    Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): (structurally represented) or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.
    Type: Application
    Filed: September 12, 2014
    Publication date: September 15, 2016
    Applicants: ONCOCEUTICS, INC., PROV PHARMACEUTICALS INC.
    Inventors: Martin STOGNIEW, Joshua E ALLEN, Richard S. POTTORF, Bhaskara Rao NALLAGANCHU, Gary OLSON
  • 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
    Patent number: 9376437
    Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.
    Type: Grant
    Filed: July 25, 2014
    Date of Patent: June 28, 2016
    Assignee: Oncoceutics, Inc
    Inventors: Martin Stogniew, Joshua E. Allen, Richard S. Pottorf, Bhaskara Rao Nallaganchu, Gary Olson
  • 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-A]pyrido[4,3-D]pyrimidin-5(3H)-one, salts thereof and methods of using the same in combination therapy
    Patent number: 9265765
    Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: February 23, 2016
    Assignee: Oncoceutics, Inc.
    Inventors: Martin Stogniew, Joshua E. Allen, Richard S. Pottorf, Bhaskara Rao Nallaganchu, Gary Olson
  • METHODS AND COMPOSITIONS RELATING TO TREATMENT OF CANCER
    Publication number: 20150328310
    Abstract: Compositions and methods for treating cancer in a subject in need thereof are provided according to aspects of the present disclosure which include both cetuximab and ISC-4, as a combination formulation or as separate formulations. Methods of treating cancer in a subject in need thereof are provided according to aspects of the present disclosure wherein the subject has cancer characterized by wild-type KRAS wherein the methods include administering a combination of cetuximab and ISC-4 as a combination formulation or separately, and wherein administration of the combination of cetuximab and ISC-4 provides a synergistic anti-cancer effect, treating the cancer.
    Type: Application
    Filed: December 20, 2013
    Publication date: November 19, 2015
    Inventors: Joshua E. Allen, Wafik S. El-Deiry, Arun K. Sharma, Shantu G. Amin
  • SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY
    Publication number: 20150265619
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Application
    Filed: June 8, 2015
    Publication date: September 24, 2015
    Applicant: The Penn State Research Foundation
    Inventors: Wafik S. EL-DEIRY, Joshua E. Allen, Gen Sheng Wu
  • SMALL MOLECULE TRAIL GENE INDUCTION BY NORMAL AND TUMOR CELLS AS AN ANTICANCER THERAPY
    Publication number: 20150202206
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Application
    Filed: July 22, 2014
    Publication date: July 23, 2015
    Applicant: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng WU
  • Small molecule trail gene induction by normal and tumor cells as an anticancer therapy
    Patent number: 9072744
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: July 7, 2015
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu
  • Small molecule trail gene induction by normal and tumor cells as an anticancer therapy
    Patent number: 9061032
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: June 23, 2015
    Assignee: The Penn State Research Foundation
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu
  • 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, Salts Thereof and Methods of Using the Same in Combination Therapy
    Publication number: 20140335048
    Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.
    Type: Application
    Filed: July 25, 2014
    Publication date: November 13, 2014
    Applicant: ONCOCEUTICS, INC.
    Inventors: Martin STOGNIEW, Joshua E. ALLEN
  • 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3H)-one, Salts thereof And Methods of Using The Same in Combination Therapy
    Publication number: 20140271540
    Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: ONCOCEUTICS, INC.
    Inventors: Martin STOGNIEW, Joshua E. ALLEN
  • Small molecule trail gene induction by normal and tumor cells as an anticancer therapy
    Patent number: RE46290
    Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: January 31, 2017
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Wafik S. El-Deiry, Joshua E. Allen, Gen Sheng Wu