Abstract: Provided herein are epigenetic-modifying DNA-targeting systems, such as CRISPR-Cas/guide RNA (gRNA) systems, for the transcriptional repression of Hepatitis B viral (HBV) genes to promote a cellular phenotype that leads to the reduction of HBV infection. In some embodiments, the epigenetic-modifying DNA-targeting systems bind to or target a target site of at least one gene or regulatory element thereof in a Hepatitis B viral DNA sequence in cell. In some aspects, the provided systems relate to the transcriptional repression of one or more Hepatitis B viral gene and/or regulatory element thereof. In some aspects, also provided herein are methods and uses related to the provided compositions, for example in repressing Hepatitis B viral replication and expression in connection with Hepatitis B infections.

Abstract: Provided herein are epigenetic-modifying DNA-targeting systems, such as CRISPR-Cas/guide RNA (gRNA) systems, for the transcriptional repression of Hepatitis B viral (HBV) genes to promote a cellular phenotype that leads to the reduction of HBV infection. In some embodiments, the epigenetic-modifying DNA-targeting systems bind to or target a target site of at least one gene or regulatory element thereof in a Hepatitis B viral DNA sequence in cell. In some aspects, the provided systems relate to the transcriptional repression of one or more Hepatitis B viral gene and/or regulatory element thereof. In some aspects, also provided herein are methods and uses related to the provided compositions, for example in repressing Hepatitis B viral replication and expression in connection with Hepatitis B infections.

Abstract: Described herein are injectable compositions composed of one or more polycationic polyelectrolytes and anionic counterions, one or more one polyanionic polyelectrolytes and cationic counterions, and a transient contrast agent. The injectable compositions have an ion concentration that is sufficient to prevent association of the polycationic polyelectrolytes and the polyanionic poly-electrolytes in water. Upon introduction of the composition into a subject, a solid is produced in situ. The transient contrast agent diffuses out of the solid over hours or days providing temporary contrast and does not remain in the subject unlike permanent contrast agents. This feature provides sufficient time for the clinician to perform medical procedures prior to the diffusion of the contrast agent out of the solid. The viscosity of the injectable compositions can be varied depending upon the application of the injectable composition.

Abstract: A trailer hitch system for equalizing trailer loads and reducing trailer sway. The trailer hitch system may include spring bars that may be attached to a hitch head using a trunnion style connection. The spring bars may be attached to the trailer using rigid brackets that reduce swinging of the spring bars. The rigid brackets having a plurality of contact points may include an upward extending portion for attaching to the trailer tongue, and a lateral extending portion for receiving the spring bars thereupon. The rigid brackets may include a spacing member and an attachment member.

Abstract: A method for operating a light detection and ranging (LIDAR) device is provided. The method includes driving, by an LLC resonant power converter, a wireless power signal at a primary winding of a transformer disposed on a first platform. The method includes transmitting the wireless power signal across a gap separating the first platform and a second platform. The second platform is configured to rotate relative to the first platform. The method includes receiving the wireless power signal at a secondary winding of the transformer. The secondary winding is disposed on the second platform. The method includes operating, by the LLC resonant power converter at a unity gain operating point and in an open loop mode without feedback control, a device mounted on the second platform based on the secondary winding receiving the wireless power signal.

Abstract: A data access manager is provided on a computing device to manage access to secure files stored in memory. The data access manager intercepts function calls from applications to the memory management unit and determines whether an application is allowed to access secure data stored in the memory of the computing device. When an initial request to map the data is received, the data access manager maps both secure data and clear data, obtaining pointers to both secure and clear data. When an application has permission to access the requested data, the data access manager returns the pointer to the clear data. When an application does not have permission to access the requested data, the data access manager returns the pointer to the secure data.

Abstract: A method of isomerizing ?9-tetrahydrocannabinol (“?9-THC”) to ?10-tetrahydrocannabinol (“?10-THC”). The method includes the steps of: extracting ?9-THC from cannabis biomass, which optionally contains one or more of the components found in fire retardant such as PHOS-CHEK®; dewaxing of crude extracts by winterization; pH-adjusting extracts by washing the extracts in heptane solution with aqueous solutions of: citric acid, sodium bicarbonate, and brine; isomerizing ?9-THC to ?10-THC by exposure to suitable conditions and in the presence of a catalyst based on the components of fire retardant; vacuum distillation of ?10-THC at a predetermined temperature range and vacuum level; collecting the distillate and redistilling it up to three times to acquire distillate containing less than 60% ?10-THC; and purification of the MO-THC to a purity of 99% or greater by crystallization from n-pentane solution.

Abstract: A data access manager is provided on a computing device to manage access to secure files stored in memory. The data access manager intercepts function calls from applications to the memory management unit and determines whether an application is allowed to access secure data stored in the memory of the computing device. When an initial request to map the data is received, the data access manager maps both secure data and clear data, obtaining pointers to both secure and clear data. When an application has permission to access the requested data, the data access manager returns the pointer to the clear data. When an application does not have permission to access the requested data, the data access manager returns the pointer to the secure data.

Abstract: Soft tissue supports, soft tissue implants, and methods of making and using soft tissue supports are disclosed. One soft tissue support includes a unitary piece of processed porous tissue material having an anterior portion and a posterior portion. The anterior and posterior portions define a cavity therebetween. The cavity is sized to receive a breast implant therein. The cavity has at least one opening sized to receive the breast implant therethrough. One soft tissue implant includes the soft tissue support and a breast implant positioned within the cavity of the soft tissue support. The implant may further include a soft tissue graft configured to support the processed porous tissue material and the breast implant. A method of using a soft tissue support includes inserting a breast implant into the soft tissue support, and implanting the soft tissue support containing the breast implant in the cavity.

Abstract: Aspects of the present disclosure relate to systems and methods for merging versions and activities associated with a file into a history feed and displaying the history feed on a user interface of a client computing device. In one aspect, a file is identified and activities associated with the file are also identified. It may be determined whether the file has at least one activity. When it is determined that the file has at least one activity, at least one actionable history element for the at least one activity is generated. Additionally, the generated history elements are merged to generate a history feed. The history feed is displayed on a user interface. The history feed may be displayed with an application that has opened the file.

Abstract: Soft tissue grafts, packaged soft tissue grafts, and methods of making and using soft tissue grafts are disclosed. One soft tissue graft includes processed tissue material having first and second opposed surfaces. The first and second opposed surfaces are bounded by first and second edges. The first edge has a concave shape that curves toward the second edge. The second edge has a convex shape that curves away from the first edge. The first surface comprises a plurality of apertures. At least one of the apertures is formed from a multi-directional separation in the first surface. One method of making a soft tissue graft includes positioning a cutting die on a surface of tissue material, pressing the cutting die into the tissue material to cut the tissue material, and processing the cut tissue material to create processed tissue material.

Abstract: Soft tissue grafts, packaged soft tissue grafts, and methods of making and using soft tissue grafts are disclosed. One soft tissue graft includes processed tissue material having first and second opposed surfaces. The first and second opposed surfaces are bounded by first and second edges. The first edge has a concave shape that curves toward the second edge. The second edge has a convex shape that curves away from the first edge. The first surface comprises a plurality of apertures. At least one of the apertures is formed from a multi-directional separation in the first surface. One method of making a soft tissue graft includes positioning a cutting die on a surface of tissue material, pressing the cutting die into the tissue material to cut the tissue material, and processing the cut tissue material to create processed tissue material.

Abstract: A method includes applying, by a switching circuit, pulses of an input voltage to an input of an inductor. The method includes charging, in accordance with an off state of a switch, a charge storage device through the inductor using the pulses of the input voltage such that the circuit node develops a charge voltage that is greater than the input voltage. The method includes discharging, in accordance with an on state of the switch, the charge storage device such that a first portion of the charge voltage is applied to a light emitter and a second portion of the charge voltage is applied to parasitic inductance. The method includes controlling, by a controller, a timing of the pulses of the input voltage applied by the switching circuit based on a parasitic inductance from a previous charging cycle of the charge storage device, so as to control the charge voltage.

Abstract: The present invention relates to devices for detecting esophageal state changes. More specifically, the present invention relates to a lightweight, portable, user-operable device capable of detecting gastroesophageal reflux events. The sonography array can also be used to track the frequency of gastroesophageal reflux events, and can either store or deliver the data either to a practitioner's server or to a user's electronic device.

Abstract: An access manager that detects a derivative work and automatically transfers digital access rights associated with an original work to the derivative work executes on a computing device. The access manager detects data to be written to a storage device and generates a new file signature for the data. The access manager compares the new file signature to existing file signatures, where the file signatures include piecewise signatures. When at least one of the piecewise signatures from the new file signature matches one of the piecewise signatures in the existing file signatures, the access manager determines that the new data to be written to the storage device is a derivative work generated from the existing file. The access rights associated with the existing file signature are copied to the new file such that the file access rights associated with the original work are passed on to the derivative work.

Abstract: The present invention relates to devices for detecting esophageal state changes. More specifically, the present invention relates to a lightweight, portable, user-operable device capable of detecting gastroesophageal reflux events. The sonography array can also be used to track the frequency of gastroesophageal reflux events, and can either store or deliver the data either to a practitioner's server or to a user's electronic device.

Abstract: Vulnerable code allows outside actors to interfere with the normal operation of current systems. To help defend against these outside actors, it is desirable to identify vulnerabilities in existing systems, including systems where the original source code is not available for study. Described herein are methods for identifying functional attributes that change the intended operation of a compiled binary extracted from a target system.

Abstract: An access manager that detects a derivative work and automatically transfers digital access rights associated with an original work to the derivative work executes on a computing device. The access manager detects data to be written to a storage device and generates a new file signature for the data. The access manager compares the new file signature to existing file signatures, where the file signatures include piecewise signatures. When at least one of the piecewise signatures from the new file signature matches one of the piecewise signatures in the existing file signatures, the access manager determines that the new data to be written to the storage device is a derivative work generated from the existing file. The access rights associated with the existing file signature are copied to the new file such that the file access rights associated with the original work are passed on to the derivative work.

Abstract: Vulnerable code allows outside actors to interfere with the normal operation of current systems. To help defend against these outside actors, it is desirable to identify vulnerabilities in existing systems, including systems where the original source code is not available for study. Described herein are methods for identifying functional attributes that change the intended operation of a compiled binary extracted from a target system.

Abstract: Aspects of the present disclosure relate to systems and methods for merging versions and activities associated with a file into a history feed and displaying the history feed on a user interface of a client computing device. In one aspect, a file is identified and activities associated with the file are also identified. It may be determined whether the file has at least one activity. When it is determined that the file has at least one activity, at least one actionable history element for the at least one activity is generated. Additionally, the generated history elements are merged to generate a history feed. The history feed is displayed on a user interface. The history feed may be displayed with an application that has opened the file.