Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

Abstract: The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).

Abstract: The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).

Abstract: Compounds of formula: wherein the variable substituents are defined herein.

Abstract: An example method can include storing, on a CSM, a first content item and representations of second and third content items, the second content item having content/features enabled by a cloud service and designed for access through a native online application and the third content item having content/features supported by a local application and having additional features designed for access through a cloud service and native online application; when the first content item is invoked, presenting the content/features of the first content item; in response to a request to access the representation of the second or third content item, sending, to a cloud service, a request for the additional features of the third content item or the content/features of the second content item; and based on metadata received from a cloud service, providing the additional features/content of the third content item or the content/features of the second content item.

Abstract: The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).

Abstract: The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).

Abstract: The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (TLD), or chronic kidney disease (CKD).

Abstract: The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

Abstract: The present technology addresses a scenario when a user attempts to create a cloud content item using a file system interface on a client device. The present technology can immediately create a content item that is representative of a cloud content item once the user requests a cloud content item to be created. The content item that is representative of the cloud content item can be created even before the cloud content item itself is created. After the cloud content item is created, the present technology provides a mechanism to relate the content item that this representative of the cloud content item with the actual cloud content item.

Abstract: Provided is a compound of Formula (I): wherein the variable groups are defined herein.

Abstract: The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

Abstract: Systems and methods for integrating cloud-based and cloud-backed content items with a content management system are provided. In some examples, a method can include receiving a request to open a content item using a client application at a first client device; detecting that the content item is open at a second client device from a different client application that supports live collaboration; and directing the first client device to an instance of the different client application at the first client device.

Abstract: Systems and methods for integrating cloud-based and cloud-backed content items with a content management system (CSM) are provided. In some examples, a method can include storing a content item in a shared folder on a CSM, the content item representing a cloud-backed or cloud-based content item associated with a cloud content provider; receiving a request to access the content item in the shared folder; in response to the request, determining, based on permissions configured at the CSM, whether a user account has permissions allowing the user account to access the shared folder or the content item; based on a determination that the user account has permissions, granting the user account access to the content item and providing to the user account a content and features of the content item, the features being supported by the cloud content provider and provisioned at least partly through the cloud content provider.

Abstract: Provided is a compound of Formula (I): wherein the variable groups are defined herein.

Abstract: An example method can include storing, on a CSM, a first content item and representations of second and third content items, the second content item having content/features enabled by a cloud service and designed for access through a native online application and the third content item having content/features supported by a local application and having additional features designed for access through a cloud service and native online application; when the first content item is invoked, presenting the content/features of the first content item; in response to a request to access the representation of the second or third content item, sending, to a cloud service, a request for the additional features of the third content item or the content/features of the second content item; and based on metadata received from a cloud service, providing the additional features/content of the third content item or the content/features of the second content item.

Abstract: Systems and methods for creating content items are provided. In some examples, a method can include receiving a user selection of an interface element located in a persistent user interface of an operating system desktop of a client device, displaying, in response to the user selection of the interface element, a set of user options, the set of user options comprising a option to create a content item of a particular type, receiving a user selection of the option to create the content item, and initiating the creation of the content item.

Abstract: An example method can include storing, on a CSM, a first content item and representations of second and third content items, the second content item having content/features enabled by a cloud service and designed for access through a native online application and the third content item having content/features supported by a local application and having additional features designed for access through a cloud service and native online application; when the first content item is invoked, presenting the content/features of the first content item; in response to a request to access the representation of the second or third content item, sending, to a cloud service, a request for the additional features of the third content item or the content/features of the second content item; and based on metadata received from a cloud service, providing the additional features/content of the third content item or the content/features of the second content item.

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

Abstract: The present technology addresses a scenario when a user attempts to create a cloud content item using a file system interface on a client device. The present technology can immediately create a content item that is representative of a cloud content item once the user requests a cloud content item to be created. The content item that is representative of the cloud content item can be created even before the cloud content item itself is created. After the cloud content item is created, the present technology provides a mechanism to relate the content item that this representative of the cloud content item with the actual cloud content item.