Abstract: The present disclosure provides compositions and methods for using fixed biological samples in partition-based assays. In at least one embodiment, the disclosure provides a composition comprising a fixed biological sample and an un-fixing agent contained in a partition, such as a discrete droplet. In some embodiments, the disclosure provides un-fixing agent compounds capable of catalytically cleaving crosslinks in fixed biological samples, particularly crosslinked nucleic acids, such as RNA.

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: A method of estimating a continuous blood pressure waveform or a continuous blood pressure in a subject including: measuring an arterial blood pressure waveform or an arterial blood pressure with a sensor supported by a supporting structure comprising a polymeric substrate and connected to a processor and a transmitter, wherein the supporting structure is configured to press the sensor against a skin surface of a subject, wherein the sensor is configured to detect a biological metric of the subject, and wherein the processor is configured to quantify one or more signal(s) corresponding to the biological metric and the transmitter is configured to transmit the one or more signals to an external user system, and transforming the arterial blood pressure waveform or the arterial blood pressure to the continuous blood pressure waveform or the continuous blood pressure using a transfer function.

Abstract: Soft capacitive pressure sensors for continuous wearable health monitoring applications are described herein. Wrinkled gold thin films on elastomeric substrates are used as robust parallel plate electrodes to create a robust integration with the polymer, allowing repeated normal force to deform the thin film without failure. By incorporating micro-ridged structures that support the counter electrodes to create air cavities within the elastomeric dielectric layer, pressure sensitivity is further increased. The pressure sensors are configured to measure human physiological signals such as pressure exerted from a radial pulse on a skin's surface. The radial pulse pressure detected by the sensor can be correlated to an arterial blood pressure. Calibration of said pressure sensors using a neural network allows for determination of absolute blood pressure.

Abstract: Blood pressure measurement through the use of a sensor array system capable of tracking displacement, motion, environmental impact, and other electrical signals, and recalibration based on said tracking. The sensor array system may comprise a plurality of sensors, and each sensor may be capable of measuring one or more parameters. The system may further comprise an electronic board communicatively coupled to the sensor array. The electronic board may be capable of transmitting a plurality of parameter measurements from the sensor array to a computing device capable of detecting changes to the sensor array based on the plurality of parameter measurements. The changes to the sensor array may be detected by measuring an increased parameter reading from at least a first sensor and a decreased parameter reading from at least a second sensor compared to a baseline measurement.

Abstract: Disclosed is a liquefied hydrogen filling apparatus configured such that connection between liquefied hydrogen injection lines is performed stepwise, whereby there is no concern of leakage of liquefied hydrogen the moment the liquefied hydrogen injection lines are connected to each other, and therefore it is possible to guarantee safety and to prevent loss of fuel. In addition, the state of connection between the liquefied hydrogen injection lines is securely maintained, whereby there is no concern of separation due to internal pressure at the time of filling or other external force, and therefore it is possible to perform safe filling.

Abstract: Disclosed is a gas discharge apparatus for liquefied hydrogen storage tanks, the gas discharge apparatus including a receptacle mounted to a liquefied hydrogen storage tank, the receptacle having a stationary valve configured to be opened by external force mounted therein, a multistage opening and closing device coupled to the receptacle such that the position of the multistage opening and closing device is adjustable, the multistage opening and closing device being configured to be opened by reaction force transmitted from the receptacle when moved relative to the receptacle, the multistage opening and closing device having a sliding valve configured to push open the stationary valve in the state in which the multistage opening and closing device is open, and a manipulation unit configured to move the multistage opening and closing device relative to the receptacle such that the sliding valve and the stationary valve are sequentially opened.

Abstract: A mobile medical device for monitoring a respiratory condition in a subject, the medical device including: a sensor configured to be adhered to the skin of a patient, the sensor configured to yield a resistance signal that is modulated by movements of a chest of a patient during respiration; a sensor attachment module configured to receive the signal from the sensor and to output data to a mobile electronic device an indication of an adverse respiratory event. Also disclosed is a server for integrating data collected from a plurality of the mobile medical devices and a crowd-sourced respiration advisory system including a plurality of the mobile medical devices and a server for integrating data collected by the mobile medical devices.

Abstract: Aspects of the subject technology relate to electronic devices having speakers with vented resonators. A vented resonator may have a resonator chamber and a channel that fluidly couples a front volume of the speaker with the resonator chamber. A vent such as a barometric vent may be disposed in a wall of the resonator chamber that separates the resonator chamber from the back volume of the speaker. The barometric vent may thus allow airflow from the front volume to the back volume via the resonator chamber, and prevent fluid flow from the front volume to the back volume via the resonator chamber.

Abstract: A vascular compression device is described. The device includes a first compression loop having a first pneumatic bulb configured to inflate and deflate, a second compression loop having a second pneumatic bulb configured to inflate and deflate, and a pneumatic pump system connected via tubing to the first and second pneumatic bulbs. A method for enhancing blood supply to vital organs is also described.

Abstract: A wearable sensor apparatus is disclosed that includes a flexible substrate adapted to be coupled with a skin surface of an expectant mother. A conductor is disposed on the flexible substrate. The conductor can include micron-scale invaginations. The conductor can be capable of repeatable variation in resistance when subject to a strain. Also disclosed is a system for monitoring the health of a fetus in utero that includes a wearable sensor apparatus. The wearable sensor apparatus is configured to output a signal responsive to an electrical input. The system includes a computing system with one or more hardware processors. The computing system is programmed to implement a signal processing module configured to access the output signal from the wearable strain gauge and generate an output indicative of health of the baby in utero.

Abstract: Disclosed is a liquefied hydrogen filling apparatus configured such that connection between liquefied hydrogen injection lines is performed stepwise, whereby there is no concern of leakage of liquefied hydrogen the moment the liquefied hydrogen injection lines are connected to each other, and therefore it is possible to guarantee safety and to prevent loss of fuel. In addition, the state of connection between the liquefied hydrogen injection lines is securely maintained, whereby there is no concern of separation due to internal pressure at the time of filling or other external force, and therefore it is possible to perform safe filling.

Abstract: Disclosed is a gas discharge apparatus for liquefied hydrogen storage tanks, the gas discharge apparatus including a receptacle mounted to a liquefied hydrogen storage tank, the receptacle having a stationary valve configured to be opened by external force mounted therein, a multistage opening and closing device coupled to the receptacle such that the position of the multistage opening and closing device is adjustable, the multistage opening and closing device being configured to be opened by reaction force transmitted from the receptacle when moved relative to the receptacle, the multistage opening and closing device having a sliding valve configured to push open the stationary valve in the state in which the multistage opening and closing device is open, and a manipulation unit configured to move the multistage opening and closing device relative to the receptacle such that the sliding valve and the stationary valve are sequentially opened.

Abstract: A method of estimating a continuous blood pressure waveform or a continuous blood pressure in a subject including: measuring an arterial blood pressure waveform or an arterial blood pressure with a sensor supported by a supporting structure comprising a polymeric substrate and connected to a processor and a transmitter, wherein the supporting structure is configured to press the sensor against a skin surface of a subject, wherein the sensor is configured to detect a biological metric of the subject, and wherein the processor is configured to quantify one or more signal(s) corresponding to the biological metric and the transmitter is configured to transmit the one or more signals to an external user system, and transforming the arterial blood pressure waveform or the arterial blood pressure to the continuous blood pressure waveform or the continuous blood pressure using a transfer function.

Abstract: An apparatus comprising a wearable device comprising a supporting structure, a sensor and an electronics module, wherein the supporting structure is configured to press the sensor against a skin surface of a subject, wherein the sensor is configured to detect a biological metric of the subject, and wherein the electronics module is configured to quantify and/or transmit one or more signal(s) corresponding to the biological metric. Some aspects relate to a method of monitoring a biological metric in a subject comprising: adorning a subject with the wearable device; and detecting the biological metric over a period of time in the subject with the wearable device. Other aspects relate to a method of treating a disease in a subject comprising: monitoring a biological metric in the subject over a period of time, and treating the subject with a therapeutic protocol, and monitoring the biological metric in the subject to assess treatment efficacy.

Abstract: A method of making a sensor apparatus including placing a mask over a polymeric sheet, wherein the mask is configured to block regions of the polymeric sheet, depositing a conductive structure on the polymeric sheet at regions exposed through the mask, shrinking the polymeric sheet with conductive structure patterned on its surface by heating, and transferring the conductive structure to a flexible substrate.

Abstract: Soft capacitive pressure sensors for continuous wearable health monitoring applications are described herein. Wrinkled gold thin films on elastomeric substrates are used as robust parallel plate electrodes to create a robust integration with the polymer, allowing repeated normal force to deform the thin film without failure. By incorporating micro-ridged structures that support the counter electrodes to create air cavities within the elastomeric dielectric layer, pressure sensitivity is further increased. The pressure sensors are configured to measure human physiological signals such as pressure exerted from a radial pulse on a skin's surface. The radial pulse pressure detected by the sensor can be correlated to an arterial blood pressure. Calibration of said pressure sensors using a neural network allows for determination of absolute blood pressure.

Abstract: A method of making a sensor apparatus including placing a mask over a polymeric sheet, wherein the mask is configured to block regions of the polymeric sheet, depositing a conductive structure on the polymeric sheet at regions exposed through the mask, shrinking the polymeric sheet with conductive structure patterned on its surface by heating, and transferring the conductive structure to a flexible substrate.

Abstract: An apparatus for providing an autonomous fire extinguishing system including a tank filled with an extinguishing agent with a targeting system with independently mounted targeting servos and targeting gimbal to position an emitter and an infra-red camera. A microcontroller provides control signals to the targeting servos and an actuation valve. One or more heat sensors, smoke detectors, humidity sensors, and/or carbon monoxide detectors are electrically connected to the microcontroller; and the microcontroller continuously reads in the sensor data till appropriate conditions indicating a potential fire are detected; these appropriate can be based on temperature, rate of temperate increase, smoke levels, humidity, and/or carbon monoxide levels. Once the appropriate conditions are detecting, the microcontroller commands the targeting gimbal to position the infra-red camera to a number of calculated positions, taking infra-red pictures covering the environment requiring protection.

Abstract: A sensor apparatus including a flexible substrate and a wrinkled conductor disposed on the flexible substrate. In some embodiments, the conductor includes micro-scale invaginations. Also disclosed are methods of making a sensor apparatus, including: placing a mask over a polymeric sheet, wherein the mask is configured to block regions of the polymeric sheet, depositing a conductive structure on the polymeric sheet at regions exposed through the mask, shrinking the polymeric sheet with conductive structure patterned on its surface by heating, and transferring the conductive structure to a flexible substrate. Also disclosed are methods of sensing a health condition of a user or patient. The methods include coupling a sensor apparatus to a surface of a user or patient overlying structures to be monitored. The sensor apparatus may include a crumpled conductor capable of detecting strain.