Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.

Abstract: An electric machine includes windings, a terminal block, and terminal connectors. The windings have lead ends and neutral ends. The terminal block has a plurality of bus bars, a neutral bar, and an insulating material. Each bus bar is connected to one or more of the lead ends. The neutral bar is connected to one or more of the neutral ends. The insulating material encapsulates the plurality of bus bars and the neutral bar, defines a plurality of orifices, and defines a plurality of slots. Each lead end extends through one of the orifices from the outer boundary to one of the bus bars. Each neutral end extends through one of the orifices from the outer boundary to neutral bar. Each terminal connector extends through one of the slots from the outer boundary to one of the bus bars.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network system used to control an agent interacting with an environment to perform a specified task. One of the methods includes causing the agent to perform a task episode in which the agent attempts to perform the specified task; for each of one or more particular time steps in the sequence: generating a modified reward for the particular time step from (i) the actual reward at the time step and (ii) value predictions at one or more time steps that are more than a threshold number of time steps after the particular time step in the sequence; and training, through reinforcement learning, the neural network system using at least the modified rewards for the particular time steps.

Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.

Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for controlling agents. In particular, an interactive agent can be controlled based on multi-modal inputs that include both an observation image and a natural language text sequence.

Abstract: A computerized platform provides centralized access for users to for on-line (electronic) services, such as social media, travel, education, and online banking including payments, via public Application Programming Interfaces (APIs).

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network system used to control an agent interacting with an environment to perform a specified task. One of the methods includes causing the agent to perform a task episode in which the agent attempts to perform the specified task; for each of one or more particular time steps in the sequence: generating a modified reward for the particular time step from (i) the actual reward at the time step and (ii) value predictions at one or more time steps that are more than a threshold number of time steps after the particular time step in the sequence; and training, through reinforcement learning, the neural network system using at least the modified rewards for the particular time steps.

Abstract: A computerized platform provides centralized access for users to for on-line (electronic) services, such as social media, travel, education, and online banking including payments, via public Application Programming Interfaces (APIs).

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network system used to control an agent interacting with an environment to perform a specified task. One of the methods includes causing the agent to perform a task episode in which the agent attempts to perform the specified task; for each of one or more particular time steps in the sequence: generating a modified reward for the particular time step from (i) the actual reward at the time step and (ii) value predictions at one or more time steps that are more than a threshold number of time steps after the particular time step in the sequence; and training, through reinforcement learning, the neural network system using at least the modified rewards for the particular time steps.

Abstract: Body-mountable devices are provided to detect the presence or status of a tumor in a body by detecting probes associated with circulating cells of the tumor that travel to subsurface vasculature of the body. The probe enters a tumor and associates with cells of the tumor before the cells metastasize. A wearable body-mountable device can be worn for a protracted period of time to detect the probe associated with circulating tumor cells in the vasculature at low concentrations and/or at low rates. A body-mounted device could detect the presence of such released, tumor-cell-associated probes to determine a presence or status of a tumor in the body.

Abstract: A method for profiling extracellular vesicles (EV) is provided.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training a neural network system used to control an agent interacting with an environment to perform a specified task. One of the methods includes causing the agent to perform a task episode in which the agent attempts to perform the specified task; for each of one or more particular time steps in the sequence: generating a modified reward for the particular time step from (i) the actual reward at the time step and (ii) value predictions at one or more time steps that are more than a threshold number of time steps after the particular time step in the sequence; and training, through reinforcement learning, the neural network system using at least the modified rewards for the particular time steps.

Abstract: Body-mountable devices are provided to detect the presence or status of an analyte in subsurface vasculature of a body by detecting fluorescent reporters that are bound to instances of the analyte in the subsurface vasculature. Such devices further operate to exert an attractive magnetic force on magnetic nanoparticle-containing probes that are configured to bind to the analyte, thus concentrating the analyte proximate the devices by magnetically exerting attractive forces on such probes that are bound to instances of the analyte. The analyte can be an extracellular vesicle that is characteristic of a cancer, and a body-mountable device as described herein could be used to detect such extracellular vesicles in a portion of subsurface vasculature such that a presence or status of a tumor could be determined based on an amount, presence, or other detected property of the extracellular vesicle.

Abstract: Body-mountable devices are provided to detect the presence or status of a tumor in a body by detecting one or more properties of a probe located in subsurface vasculature of the body. A wearable body-mountable device can be worn for a protracted period of time to detect a probe in the vasculature at low concentrations and/or at low rates. A body-mountable device can detect properties of the probe that are indicative of whether the probe has interacted with a tumor of the body and determine the presence or status of a tumor in the body based on such detected properties. Additionally or alternatively, the probe could be introduced into the body as a probe aggregate and released from if the probe aggregate is absorbed by a tumor. The presence of released probes could be detected to determine a presence or status of a tumor in the body.

Abstract: Various embodiments provide systems and methods that implement domain-specific obfuscating of data when processing the data through machine learning (ML), which can secure and preserve privacy of information contained within the data. For instance, various embodiments provide domain-specific techniques for obscuring, and possibly compressing, data. Additionally, various embodiments provide for remote inference using domain-specific techniques for obscuring, and possibly compressing, data for transport.

Abstract: A system is provided which includes nanoparticle conjugates configured to bind with a tumor cell, the nanoparticle conjugate comprising a nanoparticle, at least one targeting entity bound to the nanoparticle, and at least one shielding entity that shields at the at least one targeting entity, the nanoparticle, or both; a body-mountable device mounted on an external surface of a living body and configured to detect a tumor cell binding response signal transmitted through the external surface, wherein the tumor cell binding response signal is related to binding of the nanoparticle conjugates with one or more tumor cells; and a processor configured to non-invasively detect the one or more tumor cells based on the tumor cell response signal. Nanoparticle conjugates and methods for use for treating or imaging tumor cells are also provided.

Abstract: A system is provided which includes nanoparticle conjugates configured to bind with a tumor cell, the nanoparticle conjugate comprising a nanoparticle, at least one targeting entity bound to the nanoparticle, and at least one shielding entity that shields at the at least one targeting entity, the nanoparticle, or both; a body-mountable device mounted on an external surface of a living body and configured to detect a tumor cell binding response signal transmitted through the external surface, wherein the tumor cell binding response signal is related to binding of the nanoparticle conjugates with one or more tumor cells; and a processor configured to non-invasively detect the one or more tumor cells based on the tumor cell response signal. Nanoparticle conjugates and methods for use for treating or imaging tumor cells are also provided.