Abstract: A system is provided which includes nanoparticle conjugates configured to bind with a tumor cell, the nanoparticle conjugate comprising a nanoparticle, at least one targeting entity bound to the nanoparticle, and at least one shielding entity that shields at the at least one targeting entity, the nanoparticle, or both; a body-mountable device mounted on an external surface of a living body and configured to detect a tumor cell binding response signal transmitted through the external surface, wherein the tumor cell binding response signal is related to binding of the nanoparticle conjugates with one or more tumor cells; and a processor configured to non-invasively detect the one or more tumor cells based on the tumor cell response signal. Nanoparticle conjugates and methods for use for treating or imaging tumor cells are also provided.

Abstract: A device and system for detecting an antigen present in a sample is provided. The system includes a cartridge and a reader device. The cartridge includes a solid support having an addressable array of at least one type of antibody that is specific for a target antigen and forms a complex in the presence of the target antigen, a substrate having a mounting surface for the solid support, Protein M for competitively displacing the target antigen from the complex, and a housing for protecting the substrate. The reader device is configured to detect the antigen in a liquid sample via interaction with the cartridge.

Abstract: The disclosed embodiments relate to the design of a system that facilitates review of electronic healthcare records to identify potential Health Insurance Portability and Accountability Act (HIPAA) violations. During operation, the system obtains health-care-related data from electronic healthcare records for a population of patients from multiple data sources. The system then analyzes the obtained health-care-related data to generate cases-of-interest based on surveillance criteria associated with potential HIPAA violations, wherein each case-of-interest is related to a specific patient and a specific user who has accessed health-care-related data for the specific patient. Next, the system presents the cases-of-interest to an analyst through a user interface, and allows the analyst to indicate through the user interface whether each case-of-interest requires further investigation.

Abstract: The disclosed embodiments relate to the design of a system that manages access rights for an EMR system. During operation, the system receives a request to provision access rights for a user of the EMR system. In response to the request, the system performs a mapping operation that checks the request against attributes of the user to determine the user's access rights in the EMR system. If the request generates an exception, the system presents the request to an analyst to handle the exception. If the request does not generate an exception, the system automatically approves the request.

Abstract: A wearable device mounted on a living body can detect an analyte response signal transmitted from tissue in the living body. The tissue contains at particles conjugated to at least one complex of (i) an antibody labeled with a fluorophore, the labeled antibody having a target analyte binding site; and (ii) protein M labeled with a quencher that is complimentary to the fluorophore of the labeled antibody, wherein the labeled protein M competes with the target analytes for the target analyte binding site on the labeled antibody; wherein the fluorophore and quencher are spectrally matched such that there is a detectable change in the fluorescent signal. The analyte response signal is related to interaction of the target analytes with the complexes. A processor can determine a presence or absence of the analytes based on the analyte response signal.

Abstract: Body-mountable devices are provided to detect the presence or status of an analyte in subsurface vasculature of a body by detecting fluorescent reporters that are bound to instances of the analyte in the subsurface vasculature. Such devices further operate to exert an attractive magnetic force on magnetic nanoparticle-containing probes that are configured to bind to the analyte, thus concentrating the analyte proximate the devices by magnetically exerting attractive forces on such probes that are bound to instances of the analyte. The analyte can be an extracellular vesicle that is characteristic of a cancer, and a body-mountable device as described herein could be used to detect such extracellular vesicles in a portion of subsurface vasculature such that a presence or status of a tumor could be determined based on an amount, presence, or other detected property of the extracellular vesicle.

Abstract: A system is provided which includes nanoparticle conjugates configured to bind with a tumor cell, the nanoparticle conjugate comprising a nanoparticle, at least one targeting entity bound to the nanoparticle, and at least one shielding entity that shields at the at least one targeting entity, the nanoparticle, or both; a body-mountable device mounted on an external surface of a living body and configured to detect a tumor cell binding response signal transmitted through the external surface, wherein the tumor cell binding response signal is related to binding of the nanoparticle conjugates with one or more tumor cells; and a processor configured to non-invasively detect the one or more tumor cells based on the tumor cell response signal. Nanoparticle conjugates and methods for use for treating or imaging tumor cells are also provided.

Abstract: A spatially resolved spectral device comprising a dispersive array to receive an incident light comprising a principal ray. The dispersive array comprising a plurality of dichroic layers, each of the plurality of dichroic layers disposed in a path of a direction of the principal ray. Each of the plurality of dichroic layers configured to at least one of reflect or transmit a different wavelength range of the incident light. The device further comprising a detection array operatively coupled with the dispersive array. The detection array comprising a photosensitive component including a plurality of detection pixels, each of the plurality of detection pixels having a light-receiving surface disposed parallel to the direction of the principal ray to detect a respective one of the different wavelength ranges of incident light reflected from a corresponding one of the plurality of dichroic layers.

Abstract: An electronic device case includes an upper shell having an upper edge, a lower edge, a left edge, a right edge and a center region surrounded by the edges. A lower shell is pivotally coupled with the upper shell and formed to include a frame configured to surround and hold an electronic device input peripheral. A number of grips are adjustably engaged with a guide track of the upper shell to support and stabilize any of a variety of electronic devices of different sizes. A number of actuation rods having first ends comprising knobs and second ends coupled with the grips cause translation of the grips along the guide track when slid along the upper, left and right edges of the upper shell.

Abstract: A support system for one or more display items is configured with side walls extending in a longitudinal direction from a base towards a top such that an interior is defined between the base, top and side walls. A plurality of receptacles are configured in the base and a plurality of holes are configured in a floor parallel to and spaced apart from the base. Within the interior, a plurality of transparent platforms of a plurality of different sizes are configured at a plurality of different distances from the base. One or more transparent pillars are configured to extend between the receptacles, through the holes and into a supporting relationship with each of the one or more platforms.

Abstract: A spatially resolved spectral device comprising a dispersive array to receive an incident light comprising a principal ray. The dispersive array comprising a plurality of dichroic layers, each of the plurality of dichroic layers disposed in a path of a direction of the principal ray. Each of the plurality of dichroic layers configured to at least one of reflect or transmit a different wavelength range of the incident light. The device further comprising a detection array operatively coupled with the dispersive array. The detection array comprising a photosensitive component including a plurality of detection pixels, each of the plurality of detection pixels having a light-receiving surface disposed parallel to the direction of the principal ray to detect a respective one of the different wavelength ranges of incident light reflected from a corresponding one of the plurality of dichroic layers.

Abstract: Bone graft compositions comprising demineralized bone matrix, calcium phosphate, collagen and bioinductive cellular solution. Methods to repair and heal defective and missing bone using the bone graft compositions are also described.

Abstract: A ceramic scaffold comprising a ceramic substrate having a surface with a first microtexture on at least a portion of the surface and a first erodable coating having a smooth surface, said first coating covering at least a portion of the first microtexture. The microtexture may be formed of peaks, valleys, or a combination of peaks and valleys from about 1 micrometer to about 100 micrometers in each of height, length, and width. The peaks, valleys, or combination of peaks and valleys may be elongated and oriented in the same direction on the surface. The microtexture may also be asymmetrically arranged on the surface of the ceramic substrate.

Abstract: Compositions and methods for treating an annulus fibrosis defect comprising an angiogenic factor and a carrier. Methods include administering the composition to the annulus fibrosis defect, where the administering can include injecting the composition. The present compositions can stimulate angiogenesis and revascularization thereby facilitating repair of the defect.

Abstract: A biodegradable bone replacement material for the treatment of bone defects and delivery of antibiotic compounds, particularly for treating bone infections, comprising calcium sulfate hemihydrate, calcium sulfate dihydrate, an antibiotic mixture comprising a tetracycline compound and an ansamycin compound. Preferably, the ratio of calcium sulfate hemihydrate to calcium sulfate dihydrate is from 1:1 to about 3:1. Methods for treating, repairing or augmenting an osseous defect using the bone replacement material are also provided.

Abstract: Bone graft compositions comprising demineralized bone matrix, calcium phosphate, collagen and bioinductive cellular solution. Methods to repair and heal defective and missing bone using the bone graft compositions are also described.