Patents by Inventor Joshua Trueheart

Joshua Trueheart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10385308
    Abstract: The present invention relates to the use of a thermophilic nuclease for degrading nucleic acids in vivo and/or in situ, wherein the thermophilic nuclease is heterologous to the host cell and is produced by the host rather than being added exogenously. The present invention further relates to a genetically modified cell which was produced according to the above method. The present invention is particularly beneficial in inactivating the biological activity of recombinant DNA in biomass or biomass-derived products.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 20, 2019
    Assignee: DSM IP Assets B.V.
    Inventors: Joshua Trueheart, Jessica McGrath
  • Publication number: 20190010508
    Abstract: The present invention is directed to a process for switching the mating type of a Yarrowia fungus strain into an opposite mating type, and to the use thereof to sexually cross two individual strains resulting in new strains.
    Type: Application
    Filed: January 6, 2017
    Publication date: January 10, 2019
    Inventors: Adam G. LAWRENCE, Peter Louis HOUSTON, Jessica Leigh MCGRATH, Joshua TRUEHEART
  • Patent number: 9909130
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: March 6, 2018
    Assignee: DSM IP Assets B.V.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart
  • Publication number: 20160186128
    Abstract: The present invention relates to the use of a thermophilic nuclease for degrading nucleic acids in vivo and/or in situ, wherein the thermophilic nuclease is heterologous to the host cell and is produced by the host rather than being added exogenously. The present invention further relates to a genetically modified cell which was produced according to the above method. The present invention is particularly beneficial in inactivating the biological activity of recombinant DNA in biomass or biomass-derived products.
    Type: Application
    Filed: March 13, 2014
    Publication date: June 30, 2016
    Applicant: DSM IP Assets B.V.
    Inventors: Joshua TRUEHEART, Jessica Leigh
  • Patent number: 9297031
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express retinolic compounds.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: March 29, 2016
    Assignee: DSM IP Assets B.V.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
  • Publication number: 20150104543
    Abstract: Improved systems for the biological production of organic acids are described.
    Type: Application
    Filed: September 25, 2014
    Publication date: April 16, 2015
    Inventors: Aaron Adriaan WINKLER, Abraham Frederik DE HULSTER, Johannes Pieter VAN DIJKEN, Jacobus Thomas PRONK, Joshua TRUEHEART, Kevin T. MADDEN, Carlos Gancedo RODRIGUEZ, Carmen-Lisset Flores MAURIZ, Antonius Jeroen Adriaan VAN MARIS, Jacob C. HARRISON
  • Publication number: 20150031868
    Abstract: The present invention relates to a recombinant microorganism comprising one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity, whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol. The recombinant microorganism may also be capable of expressing one or more UDP-glucosyltransferases such that the microorganism is capable of producing one or more steviol glycosides.
    Type: Application
    Filed: January 23, 2013
    Publication date: January 29, 2015
    Inventors: Martin Lehmann, Joshua Trueheart, Priscilla Zwart Jens, Liang Wu, Viktor Marius Boer, Cornelis Maria Jacobus Sagt, Manoj Kumar, Bernard Meijrink, Marco Alexander Van Den Berg
  • Publication number: 20140315279
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express quinone derived compounds.
    Type: Application
    Filed: December 12, 2013
    Publication date: October 23, 2014
    Applicant: DSM IP ASSETS b.v.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart
  • Publication number: 20140234928
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express retinolic compounds.
    Type: Application
    Filed: February 18, 2014
    Publication date: August 21, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
  • Patent number: 8691555
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: April 8, 2014
    Assignee: DSM IP Assests B.V.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
  • Patent number: 8633009
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express quinone derived compounds.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: January 21, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart
  • Publication number: 20130189722
    Abstract: The present disclosure provides technologies for identifying, characterizing and/or sorting pellet-forming microorganisms such as bacteria and/or fungi (e.g., yeast) in liquid culture, and particularly under fermentation conditions. In some embodiments, the pellet-forming microorganisms produce one or more commercial products. For example, in some embodiments the pellet-forming microorganisms produce one or more organic acids, carotenoid compounds, essential fatty acids, industrial enzymes, active pharmaceuticals, extracellular carbohydrates, and insecticidal compounds, etc. In many embodiments, the organisms are sorted while in their pellet form.
    Type: Application
    Filed: September 5, 2008
    Publication date: July 25, 2013
    Inventors: Joshua Trueheart, Jefferson Clay Lievense, Sara Iverson
  • Publication number: 20130045504
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids
    Type: Application
    Filed: August 15, 2012
    Publication date: February 21, 2013
    Applicant: DSM IP ASSETS B.V.
    Inventors: Richard Bailey, Kevin T. Madden, Joshua Trueheart
  • Patent number: 8367395
    Abstract: The present invention provides methods for production of one or more sterol compounds. Further provided are methods and systems for producing engineered oleaginous yeast or fungi that are capable of production of one or more sterol compounds, and compositions which utilize the produced sterol compound(s).
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: February 5, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: Richard B. Bailey, Joshua Trueheart, Kevin T. Madden
  • Patent number: 8288149
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: October 16, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart
  • Publication number: 20120149886
    Abstract: The present disclosure provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Application
    Filed: April 10, 2009
    Publication date: June 14, 2012
    Applicant: MICROBIA, INC.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
  • Publication number: 20110045559
    Abstract: The present disclosure relates to modified yeast, wherein the yeast has reduced pyruvate decarboxylase polypeptide (PDC) activity and methods of using such yeast to produce malic and/or succinic acid.
    Type: Application
    Filed: May 19, 2008
    Publication date: February 24, 2011
    Inventors: Aaron Adriaan Winkler, Abraham Frederik De Hulster, Johannes Pieter Van Dijken, Jacobus Thomas Pronk, Joshua Trueheart, Kevin T. Madden, Jacob C. Harrison, Carlos Gancedo Rodriguez, Carmen-Lisset Flores Mauriz
  • Publication number: 20110039327
    Abstract: Improved systems for the biological production of organic acids are described.
    Type: Application
    Filed: May 19, 2008
    Publication date: February 17, 2011
    Inventors: Aaron Adriaan Winkler, Abraham Frederik De Hulster, Johannes Pieter Van Dijken, Jacobus Thomas Pronk, Joshua Trueheart, Kevin T. Madden, Carlos Gancedo Rodriguez, Carmen-Lisset Flores Mauriz, Antonius Jeroen Adriaan Van Maris, Jacob C. Harrison
  • Publication number: 20110039299
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Application
    Filed: September 28, 2007
    Publication date: February 17, 2011
    Applicant: MICROBIA PRECISION ENGINEERING
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
  • Publication number: 20110021843
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids
    Type: Application
    Filed: October 13, 2010
    Publication date: January 27, 2011
    Applicant: MICROBIA, INC.
    Inventors: Richard Bailey, Kevin T. Madden, Joshua Trueheart