Abstract: Described herein are methods of treating, preventing, or reducing dendritic spine density loss in a subject, the method comprising administering a compound selected from: metformin, pentosan polysulfate, amlexanox, leflunomide, prasterone, glutathione disulfide, pazopanib, bosutinib, dabrafenib, baricitinib, or a pharmaceutically acceptable salt, prodrug, or derivative thereof; or any combination thereof; or compositions described herein.

Abstract: A medical device system may include an occlusive implant including a central hub and a plurality of elongate members configured to shift between extended and radially expanded configurations. The central hub includes a plurality of conduits extending from a proximal end to a radially outward facing surface. The plurality of elongate members is configured to extend through the conduits in the radially expanded configuration. An implant remodeling tool may include an elongate sheath having at least one lumen, a plunger guide, and a plurality of plunger shafts extending from the at least one lumen through the plunger guide. The plunger guide is configured to direct the plunger shafts radially outward as the plunger shafts are advanced distally. The plunger shafts are configured to engage a medical implant and urge at least a portion of the implant radially outward.

Abstract: Methods and systems are described for generating assessment maps. A method includes receiving a first vector map comprising a first set of vectors each indicating a distortion of a particular location on a substrate and generating a second vector map indicating a change in direction of a magnitude of the distortion of the particular location on the substrate. The method further includes generating a third vector map comprising vectors reflecting reduced noise in distortions across the plurality of locations on the substrate and generating a fourth vector map projecting a direction component of each vector component in the third set of vectors to a radial direction. The method further includes generating a fifth vector map by grouping the vectors of the fourth set of vectors and determining a magnitude associated with each group of vectors.

Abstract: A method for matching a vehicle with a user including receiving a user ride request for a vehicle from a plurality of available vehicles from a user, receiving a threshold vehicle risk score preference for the user, receiving a user risk score for the user, receiving a threshold user risk score preference for the plurality of available vehicles, identifying a subset of the plurality of available vehicles having a vehicle risk score at or below the threshold vehicle risk score preference of the user and a threshold user risk score preference at or above the user risk score of the user, and presenting the user with ride options for selecting one of the subset of the plurality of available vehicles of the subset of available vehicles for the user ride request.

Abstract: Features relating to a vaporizer body are provided. The vaporizer body may include an outer shell that includes an inner region defined by an outer shell sidewall. A support structure is configured to fit within the inner region of the outer shell. The support structure includes a storage region defined by a top support structure, a bottom support structure, a bottom cap, and a gasket. An integrated board assembly is configured to fit within the storage region of the support structure. The integrated board assembly may include a printed circuit board assembly formed of multiple layers that form a rigid structure and that include an inner, flexible layer. A first antenna is integrated at a proximal end of the flexible layer, and a second antenna is integrated at a distal end of the flexible layer.

Abstract: Techniques are described for maintaining contextual data to support content-related actions. In an example, a system stories second content at a source. The source is associated with first content. The system sends, to a device, an object that indicates the first content. From the device at a first time, the system receives first data indicating a first request for the second content and including source information that indicates the source. From the device at a second time, the system receives second data indicating a second request for the second content, the second data including the source information, the first data and the second data received at a frequency indicated by the object. The system determines that the requests are associated with the first content based on the source information included in the received data, and stores third data indicating a presentation of the first content by the device.

Abstract: The present application provides tricyclic triazolo compounds that modulate the activity of diacylglycerol kinase (DGK), which are useful in the treatment of various diseases, including cancer.

Abstract: Systems and methods are provided for clustering videos. The system accesses a plurality of content items, the plurality of content items comprising a first set of RGB video frames and a second set of optical flow frames corresponding to the first set of RGB video frames. The system processes the first set of RGB video frames by a first machine learning model to generate a first optimal assignment for the first set of RGB video frames, the first optimal assignment representing initial clustering of the first set of RGB video frames. The system generates an updated first optimal assignment for the first set of RGB video frames based on the first optimal assignment for the first set of RGB video frames and a second optimal assignment of the second set of optical flow frames, the second optimal assignment representing initial clustering of the second set of optical flow frames.

Abstract: An implantable medical device such as but not limited to a left atrial appendage closure (LAAC) device includes an expandable frame that is movable between a collapsed configuration for delivery and an expanded configuration for deployment. The expandable frame may include a plurality of frame members that are biased into the expanded configuration. The expandable frame may include a biasing member. The LAAC device includes a membrane or covering that spans across an end of the expandable frame.

Abstract: Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.

Abstract: Composite anode materials and methods of making same, the anode materials including capsules including graphene, reduced graphene oxide, graphene oxide, or a combination thereof, and particles of an active material disposed inside of the capsules. The particles may each include a core and a buffer layer surrounding the core. The core may include crystalline silicon, and the buffer layer may include a silicon oxide, a lithium silicate, carbon, or a combination thereof.

Abstract: One example method involves obtaining a plurality of images using a camera located at a given position relative to a light detection and ranging device (LIDAR). A first image of the plurality may be indicative of a view, via one or more optical elements of the LIDAR, of a receiver of the LIDAR. The method also involves determining simulated detector positions for intercepting reflections of simulated light beams associated with a plurality of light sources in a transmitter of the LIDAR. The method also involves determining one or more alignment offsets between the transmitter and the receiver based on at least the simulated detector positions and the plurality of images.

Abstract: A recharging system for recharging batteries or providing power to an implantable device includes an electric coil adapted to be coupled to the implantable device, the electric coil defining a coil interior and a coil exterior. A magnetic component is coupled to the electric coil and adapted to at least partially surround the implantable device. A mechanical actuator is attached to the magnetic component, the mechanical actuator converting compression motion into motion of the magnetic component relative to the electric coil.

Abstract: Methods and systems are described for dynamically managing resources when submitting bids for advertising content opportunities. The system may determine whether a bid request is likely to be accepted or rejected, or whether an impression event associated with an impression from a bid associated with the bid request is delayed by a time duration. The system may determine, based on information associated with a bid request, a plurality of features associated with the bid request. Each feature of the plurality of features may be associated with one or more distributions indicating a percentage likelihood that the that the impression from the bid associated with the bid request is delayed by the time duration, or whether a bid is likely to be rejected or accepted. The selected features may be based on the impact the features have on indicating whether a bid is likely to be accepted or rejected or result in a delayed impression.

Abstract: One example method involves obtaining a plurality of images using a camera located at a given position relative to a light detection and ranging device (LIDAR). A first image of the plurality may be indicative of a view, via one or more optical elements of the LIDAR, of a receiver of the LIDAR. The method also involves determining simulated detector positions for intercepting reflections of simulated light beams associated with a plurality of light sources in a transmitter of the LIDAR. The method also involves determining one or more alignment offsets between the transmitter and the receiver based on at least the simulated detector positions and the plurality of images.

Abstract: A recharging system for recharging batteries or providing power to an implantable device includes an electric coil adapted to be coupled to the implantable device, the electric coil defining a coil interior and a coil exterior. A magnetic component is coupled to the electric coil and adapted to at least partially surround the implantable device. A mechanical actuator is attached to the magnetic component, the mechanical actuator converting compression motion into motion of the magnetic component relative to the electric coil.

Abstract: One example method involves obtaining a plurality of images using a camera located at a given position relative to a light detection and ranging device (LIDAR). A first image of the plurality may be indicative of a view, via one or more optical elements of the LIDAR, of a receiver of the LIDAR. The method also involves determining simulated detector positions for intercepting reflections of simulated light beams associated with a plurality of light sources in a transmitter of the LIDAR. The method also involves determining one or more alignment offsets between the transmitter and the receiver based on at least the simulated detector positions and the plurality of images.

Abstract: One example method involves obtaining a plurality of images using a camera located at a given position relative to a light detection and ranging device (LIDAR). A first image of the plurality may be indicative of a view, via one or more optical elements of the LIDAR, of a receiver of the LIDAR. The method also involves determining simulated detector positions for intercepting reflections of simulated light beams associated with a plurality of light sources in a transmitter of the LIDAR. The method also involves determining one or more alignment offsets between the transmitter and the receiver based on at least the simulated detector positions and the plurality of images.