Abstract: The present invention relates to a thyroid hormone receptor ? selective agonist compound represented by formula I, a pharmaceutical composition and use thereof. The compound improves the selectivity to THR-? and the druggability of the compound while maintaining good THR-? agonistic activity, and shows a certain activity in in vivo pharmacological experiments.

Abstract: Among other things, one or more techniques and/or systems are provided for location-aware content detection. In particular, content may be grouped into topic clusters (e.g., images, articles, and/or websites may be grouped into a football cluster, an earthquake cluster, etc.). A topic of a cluster may be assigned a global ranking (e.g., based upon an importance of a topic on a global scale) and/or local rankings for local regions (e.g., based upon importance of a topic to various local regions). A local ranking may be based upon user interaction with content associated with the topic (e.g., many users from Japan may be reading about the earthquake). In this way, content may be provided to users based upon global rankings and/or local rankings (e.g., content from around the world about the earthquake may be presented to users in Japan and/or other areas that have expressed interest in the earthquake).

Abstract: Among other things, one or more techniques and/or systems are provided for location-aware content detection. In particular, content may be grouped into topic clusters (e.g., images, articles, and/or websites may be grouped into a football cluster, an earthquake cluster, etc.). A topic of a cluster may be assigned a global ranking (e.g., based upon an importance of a topic on a global scale) and/or local rankings for local regions (e.g., based upon importance of a topic to various local regions). A local ranking may be based upon user interaction with content associated with the topic (e.g., many users from Japan may be reading about the earthquake). In this way, content may be provided to users based upon global rankings and/or local rankings (e.g., content from around the world about the earthquake may be presented to users in Japan and/or other areas that have expressed interest in the earthquake).