Abstract: The invention provides a wearable device, such as a watch, that provides a way to calculate an appropriate camera shutter speed and aperture setting for a given ISO speed setting to obtain settings that, when entered into a camera, will result in an appropriate photographic exposure. The devices of the invention provide a simple, fast, convenient way to calculate appropriate settings for the components of the photographic exposure triangle.

Abstract: The present invention describes an integrated apparatus that enables identification of invasive tumor cells directly from a specimen. The methods using the apparatus can be used to prognose or predict the survivability of the cancer in a subject and the risk of recurrence of the cancer in the subject after treatment. The methods disclosed herein can be used to determine which chemotherapeutic or other therapies most strongly inhibit the tumor cells invasiveness as a form of personalized therapy.

Abstract: The present invention describes an integrated apparatus that enables identification of invasive tumor cells directly from a specimen. The methods using the apparatus can be used to prognose or predict the survivability of the cancer in a subject and the risk of recurrence of the cancer in the subject after treatment. The methods disclosed herein can be used to determine which chemotherapeutic or other therapies most strongly inhibit the tumor cells invasiveness as a form of personalized therapy.

Abstract: The effect of laser stimulation, e.g., R:GEN, of the RPE and its impact on MMPs and RAAS pathways are used to guide patient therapies. Certain biomarkers, namely MMPs, TIMPs, and components associated with RAAS, are effective indicators of healing response levels generated by the patients undergoing the therapy. An eye disease is diagnosed in a patient and a first biomarker sample is obtained from a biomatrix, e.g., patient's blood in containers with protease inhibitors. An initial subthreshold laser treatment is then performed on the eye. By monitoring the presence, amount, and relative levels of one or more of the above biomarkers as the patient heals, it is determined when the patient's body has sufficiently responded to the previous treatment, such that retreatment may be appropriate. The present disclosure demonstrates effective treatment of eye diseases, e.g., dry age-related macular degeneration, which utilize laser treatment alone or in combination with other treatments.

Abstract: The present invention provides compositions comprising Verteporfin and other anticancer compounds linked to a hydrophilic peptide through a degradable linker molecule to allow the anticancer compounds to penetrate tissues via in situ administration. The compounds of the present invention are useful for sensitizing tumor cells to radiotherapy, preventing recurrence of tumors after surgical resection and for treating remaining unremoved cancer cells at the site of the tumor.

Abstract: The present invention provides compositions comprising Verteporfin and other anticancer compounds linked to a hydrophilic peptide through a degradable linker molecule to allow the anticancer compounds to penetrate tissues via in situ administration. The compounds of the present invention are useful for sensitizing tumor cells to radiotherapy, preventing recurrence of tumors after surgical resection and for treating remaining unremoved cancer cells at the site of the tumor.

Abstract: An apparatus is provided for retaining a spare tire in a storage position on a motor vehicle. The apparatus includes a retainer assembly and a cooperating post. The retainer assembly includes a housing and a first actuator, a first retainer and a first biasing element carried by the housing. The post includes a retainer receiver wherein the first biasing element biases the first retainer into engagement with the retainer receiver. A related method of removing a spare tire from a storage position in a motor vehicle is also presented.

Abstract: The present invention describes an integrated apparatus that enables identification of invasive tumor cells directly from a specimen. The methods using the apparatus can be used to prognose or predict the survivability of the cancer in a subject and the risk of recurrence of the cancer in the subject after treatment. The methods disclosed herein can be used to determine which chemotherapeutic or other therapies most strongly inhibit the tumor cells invasiveness as a form of personalized therapy.

Abstract: A corrugated paperboard wraparound blank for forming a shipping case is provided, including five wall panels and four sets of end flaps connected via fold lines, at least two sets of stacking tabs, and at least two corresponding sets of receiving slots for receiving the stacking tabs. The wraparound blank is formed of a heavier material than a conventional blank, which would typically be difficult for automatic packaging equipment to form into a case, but the fold lines are creased with optional perforations or scoring. An optional modification aiding folding is presented for conventional case packers. The heavier fiberboard better supports and protects an inner product, such as cartons or paper bottles of liquids and reduces damage to the cap and neck. The heavier material in combination with the stacking tabs allows an increase in stacking height, thereby reducing transportation costs.

Abstract: An apparatus is provided for retaining a spare tire in a storage position on a motor vehicle. The apparatus includes a retainer assembly and a cooperating post. The retainer assembly includes a housing and a first actuator, a first retainer and a first biasing element carried by the housing. The post includes a retainer receiver wherein the first biasing element biases the first retainer into engagement with the retainer receiver. A related method of removing a spare tire from a storage position in a motor vehicle is also presented.

Abstract: An automotive part for manufacturing an automotive lighting device housing, the automotive part including a first wall and a second wall. The first height of the first wall is greater than the wall distance, the first wall being suitable for being bent over the second wall thus creating a wire retainer.

Abstract: The present invention provides compositions comprising Verteporfin and other anticancer compounds linked to a hydrophilic peptide through a degradable linker molecule to allow the anticancer compounds to penetrate tissues via in situ administration. The compounds of the present invention are useful for sensitizing tumor cells to radiotherapy, preventing recurrence of tumors after surgical resection and for treating remaining unremoved cancer cells at the site of the tumor.

Abstract: A corrugated paperboard wraparound blank for forming a shipping case is provided, including five wall panels and four sets of end flaps connected via fold lines, at least two sets of stacking tabs, and at least two corresponding sets of receiving slots for receiving the stacking tabs. The wraparound blank is formed of a heavier material than a conventional blank, which would typically be difficult for automatic packaging equipment to form into a case, but the fold lines are creased with optional perforations or scoring. An optional modification aiding folding is presented for conventional case packers. The heavier fiberboard better supports and protects an inner product, such as cartons or paper bottles of liquids and reduces damage to the cap and neck. The heavier material in combination with the stacking tabs allows an increase in stacking height, thereby reducing transportation costs.

Abstract: A corrugated paperboard wraparound blank for forming a shipping case is provided, including five wall panels and four sets of end flaps connected via fold lines, at least two sets of stacking tabs, and at least two corresponding sets of receiving slots for receiving the stacking tabs. The wraparound blank is formed of a heavier material than a conventional blank, which would typically be difficult for automatic packaging equipment to form into a case, but the fold lines are creased with optional perforations or scoring. An optional modification aiding folding is presented for conventional case packers. The heavier fiberboard better supports and protects an inner product, such as cartons or paper bottles of liquids and reduces damage to the cap and neck. The heavier material in combination with the stacking tabs allows an increase in stacking height, thereby reducing transportation costs.

Abstract: A brake rotor for attachment to a wheel of a vehicle may include outer and inner friction members, and a plurality of fin elements connecting the outer friction member to the inner friction member. Each fin element may include radially spaced first and second pillars that are connected by a single bridge portion to define an opening in the fin element. The opening may also be defined by an interior surface of one of the annular disks. The opening may be tapered along an entire length between a first pillar and a second pillar. A width of each fin element may taper toward a center of the brake rotor.

Abstract: An electrical wire connector includes a connector body having a first end engageable with one or more electrical wires and a second end removably engageable with a complementary end of a mating connector, the one or more electrical wires electrically bridgeable to one or more wires of the complementary connector when the connector body is engaged with the complementary connector. The electrical wire connector further includes a movable portion configured to selectively secure an engagement between the connector body and the complementary end of the mating connector, and a shield removably engaged to the connector body to cover a portion of the movable portion.

Abstract: A brake rotor for attachment to a wheel of a vehicle may include an inner friction member and an outer friction member. The brake rotor may further include a plurality of posts connecting the inner friction member to the outer friction member, each post inclining at an angle between the inner friction member and the outer friction member.

Abstract: An electrical wire connector includes a connector body having a first end engageable with one or more electrical wires and a second end removably engageable with a complementary end of a mating connector, the one or more electrical wires electrically bridgeable to one or more wires of the complementary connector when the connector body is engaged with the complementary connector. The electrical wire connector further includes a movable portion configured to selectively secure an engagement between the connector body and the complementary end of the mating connector, and a shield removably engaged to the connector body to cover a portion of the movable portion.

Abstract: A brake rotor for attachment to a wheel of a vehicle may include outer and inner friction members, and a plurality of fin elements connecting the outer friction member to the inner friction member. Each fin element may include radially spaced first and second pillars that are connected by a single bridge portion to define an opening in the fin element. The opening may also be defined by an interior surface of one of the annular disks. The opening may be tapered along an entire length between a first pillar and a second pillar. A width of each fin element may taper toward a center of the brake rotor.

Abstract: A brake rotor for attachment to a wheel of a vehicle may include an inner friction member and an outer friction member. The brake rotor may further include a plurality of posts connecting the inner friction member to the outer friction member, each post inclining at an angle between the inner friction member and the outer friction member.