Abstract: A speech signal dereverberation processing method includes extracting an amplitude spectrum feature and a phase spectrum feature of a current frame in an original speech signal, extracting subband amplitude spectrums from the amplitude spectrum feature corresponding to the current frame, determining, based on the subband amplitude spectrums and by using a first reverberation predictor, a reverberation strength indicator corresponding to the current frame, and determining, based on the subband amplitude spectrums and the reverberation strength indicator, and by using a second reverberation predictor, a clean speech subband spectrum corresponding to the current frame.

Abstract: The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to Factor VIII proteins containing modifications in the amino acid sequence of the Factor VIII protein, as well as nucleic acid constructs encoding the Factor VIII proteins and methods of using these compositions to treat a bleeding disorder.

Abstract: This invention relates to polynucleotides encoding mini-dystrophin proteins, viral vectors comprising the same, and methods of using the same for delivery of mini-dystrophin to a cell or a subject.

Abstract: The invention belongs to the field of polymers, and relates to biaxially oriented polypropylene dielectric film, a modified polypropylene material and use thereof. The preparation raw materials of the biaxially oriented polypropylene dielectric film comprise a modified polypropylene grafted with an alkenyl-containing functional monomer. The modified polypropylene grafted with an alkenyl-containing functional monomer comprises a structural unit derived from polypropylene as a matrix phase and a structural unit derived from an alkenyl-containing functional monomer as a dispersion phase. The ash content of the modified polypropylene grafted with an alkenyl-containing functional monomer is less than 50 ppm.

Abstract: Provided are an esterase mutant and the use thereof. The esterase mutant obtained by means of rational design and several rounds of evolution screening with enzymes on the basis of an amino acid sequence as shown in SEQ ID NO: 1 is changed in terms of protein structure and function compared with a wild-type esterase; in practical use, the catalytic activity and/or stereoselectivity of the esterase mutant is greatly improved; and when a system contains some organic cosolvents, the esterase mutant still has relatively stable catalytic activity and/or stereoselectivity. In addition, the improvement of the catalytic activity and/or stereoselectivity of the esterase mutant reduces the use amount of the enzyme to a certain extent and reduces the difficulty of post-treatment, and therefore the esterase mutant is suitable for industrial production.

Abstract: A luminescent probe and its preparation method and application are provided. The luminescent probe has a steric hindrance group R1 of aliphatic hydrocarbon structure such as adamantane or norborneol, a detection group R2 of nitrobenzyl and its derivative structure, an electron-withdrawing group R3 containing cyano group and an electron-donating group methoxy group. In the presence of HSA or BSA, the detection group is cut off to form a parent structure that exposes atomic oxygen anions and is activated under external light irradiation, the luminescent probe can be used in solution or cells, when detecting HSA or BSA, the luminescent probe has obvious chemiluminescence characteristics, which can sensitively distinguish HSA and BSA, quantitatively analyze HSA and BSA, and determine the mixing ratio of HSA and BSA at the same time, and the luminescent probe has been successfully used for cell fluorescence imaging.

Abstract: Embodiments of this application provide a multi-device collaboration method, an electronic device, and a related product. The method includes: A first electronic device switches from a first page to a second page, and establishes a first near field communication connection to a first near field device in response to a user's operation on the first page, where on the second page, a device identifier of the first electronic device comes into contact with a device identifier of the first near field device; and the first electronic device switches to a third page, maintains the first near field communication connection to the first near field device, and establishes the first near field communication connection to a second near field device in response to the user's operation on the second page.

Abstract: The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to optimized polynucleotide sequences encoding Factor IX proteins, vector comprising the same, and methods of using these compositions to treat a bleeding disorder.

Abstract: The present invention provides mutant adeno-associated virus serotype 5 (AAV5) that exhibit altered capsid properties, e. g., increased infectivity in human liver cells and/or minimal binding to human neutralizing antibodies. The present invention further provides libraries of mutant AAV5 comprising one or more mutations in a capsid gene. The present invention further provides methods of generating the mutant AAV5 and mutant AAV5 libraries, and compositions comprising the mutant AAV5. The present invention further provides recombinant AAV5 (rAAV5) virions that comprise a mutant capsid protein. The present invention further provides nucleic acids comprising nucleotide sequences that encode mutant capsid proteins.

Abstract: A polyethylene composition has a polyethylene matrix resin and a pore-forming agent. The content of the pore-forming agent is 30-110 parts by weight on the basis of 100 parts by weight of the polyethylene matrix resin. The pore-foaming agent contains maleic anhydride copolymer microspheres, a copolymer in the microsphere comprises a structural unit A from maleic anhydride, a structural unit B from a vinyl-containing comonomer M and an optional cross-linking structure unit from a cross-linking agent, and the average particle size of the maleic anhydride copolymer microspheres is 500-2000 nm. The polyethylene composition can be used for preparing a breathable film without using a coupling agent, a dispersing agent and/or a surfactant, and achieves uniform air permeability and a high water vapor transmission rate. The film can be used for breathable composite products such as sanitary products, medical products, and food packaging or building products.

Abstract: In certain embodiments, a method includes accessing, by a processing device, actual operating condition information for an operating condition parameter associated with actual operation of a vehicle. The actual operating condition information corresponds to sensor measurements associated with a vehicle component of the vehicle. The method includes analyzing, by the processing device and using an artificial intelligence model, the actual operating condition information to generate predicted load information for the vehicle component. The method includes determining, according to the predicted load information, an estimated fatigue life for the vehicle component that is individualized for the vehicle component.

Abstract: A refrigeration system and a refrigeration device are provided. The refrigeration system includes a circulation circuit. The circulation circuit includes a main flow path, and a first branch and a second branch that are connected to the main flow path and are connected in parallel. The main flow path is provided with a condenser and a compressor. The condenser has an output end in communication with an end of the first branch and an end of the second branch. The compressor has two suction holes in communication with another end of the first branch and another end of the second branch, respectively. The first branch and the second branch are provided with a first evaporator and a second evaporator, respectively.

Abstract: An ethylene-copolymerized olefin copolymer having a high comonomer dispersion index, a preparation method therefor, an application thereof, and a composition comprising an ethylene-?-olefin copolymer are disclosed. The ethylene-?-olefin copolymer contains 70-95 mol % a structural unit derived from ethylene and 5-30 mol % a structural unit derived from ?-olefin. The ?-olefin is an olefin having 5-10 carbon atoms. The dispersion index RMD of the ?-olefin structural unit in the molecular chain is greater than 102%. The ethylene-?-olefin copolymer has a high comonomer dispersion index.

Abstract: A catalyst composition includes the following components: a) a metallocene compound, b) a co-catalyst component, and c) a phenol, the co-catalyst component being a combination of an organoaluminum compound and an alkyl aluminoxane, or a combination of an organoaluminum compound and an organoboron compound. The catalyst composition is used for the copolymerization of ethylene and a cycloolefin or an alkenol, which can increase the molecular weight of the polymer as well as the content of cycloolefin or alkenol structural unit in the copolymer.

Abstract: The invention belongs to the field of insulating materials, in particular cable insulating materials, and particularly relates to a modified flexible polypropylene insulating material, and preparation method and use thereof. The modified flexible polypropylene insulating material comprises a propylene-based continuous phase, and a rubber phase and a grafted phase derived from an unsaturated bond-containing polymerizable monomer dispersed in the propylene-based continuous phase; wherein, the modified flexible polypropylene insulating material has a content of xylene solubles of 10-55 wt %, preferably 15-45 wt %, more preferably 18-40 wt %, and still more preferably 20-40 wt %, based on the total weight of the modified flexible polypropylene insulating material; the content of structural units derived from the unsaturated bond-containing polymerizable monomer and in a grafted state in the modified flexible polypropylene insulating material is 0.3-6 wt %, and preferably 0.

Abstract: The invention relates to synthetic liver-specific promoters and expression constructs for producing polypeptides and functional nucleic acids in the liver of a subject. The invention further relates to Factor VIII proteins containing modifications in the amino acid sequence of the Factor VIII protein, as well as nucleic acid constructs encoding the Factor VIII proteins and methods of using these compositions to treat a bleeding disorder.

Abstract: A composite polyvinyl alcohol (PVA) preservative film, a preparation method and an application thereof are provided. The film includes PVA of 9-12 parts, modified silicon dioxide nanoparticles of 2-5 parts, antimicrobial of 0.3-2 parts and deionized water of 100 parts. Fruits and vegetables sensitive to sunlight have lower requirements for illumination while preserving. With PVA as matrix and silicon dioxide (SiO2) nanoparticles as modified materials, composite PVA is obtained by controlling a particle size of SiO2 and modifying its surface. The composite PVA preservative film takes advantages of different refractive indexes between PVA and SiO2 and controlling the particle size of SiO2, thereby having a low luminous transmittance. The preservative film has an effect of light-proof on fruits and vegetables suitable for light-proof storage, and improves its gas transmission and water resistance because of adding SiO2, thereby facilitating packaging preservation of the fruits and vegetables.

Abstract: This application discloses a container management method, apparatus, and device. The method includes: obtaining a provisioning request that carries an identifier of a first user and an identifier of a first container image; querying and obtaining the identifier of the first container image in a container image information database of the first user; obtaining the container image based on the identifier of the first container image; and provisioning a container based on the container image.