Patents by Inventor Juan Santiago

Juan Santiago has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10416082
    Abstract: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: September 17, 2019
    Assignees: The Regents of the University of California, Board of Trustees of the Leland Stanford Junior University
    Inventors: Carl D. Meinhart, Brian Piorek, Seung Joon Lee, Martin Moskovits, Sanjoy Banerjee, Juan Santiago
  • Patent number: 10408827
    Abstract: A combination of surface plasmon field enhanced fluorescence spectroscopy (SPFS) and isotachophoresis (ITP) technologies for detecting biomolecules is disclosed. It uses ITP to preconcentrate the reactants and accelerate the reaction, and then delivers the reacted sample to an SPFS sensor for detection. A microfluidic device with a T-junction is provided, which has two reservoirs respectively containing a low-mobility trailing electrolyte buffer and a high-mobility leading electrolyte buffer, and a main fluid channel between the two reservoirs, where the SPFS sensor is located on a side channel joined to the main channel. A two-step technique is employed, including a step of sample loading and ITP extraction, and a step of delivery of concentrated sample to the detector chamber by pressure-driven flow. In another embodiment, the SPFS sensor is located on the main fluid channel between the two reservoirs. In a particular example, the technique is used in a DNAzyme assay.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: September 10, 2019
    Assignees: KONICA MINOLTA LABORATORY U.S.A., INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Noriaki Yamamoto, Juan Santiago, Denitsa Milanova
  • Patent number: 10075064
    Abstract: A circuit includes a reconfigurable rectifier, a voltage balancer, and a pair of converters. The reconfigurable rectifier includes an ac input port and three output ports. In a first configuration, the reconfigurable rectifier can deliver power at a first output port and, in a second configuration, to at least a second output port. The voltage balancer includes first and second ports coupled to second and third output ports of the reconfigurable rectifier and is configured to balance received voltage at the first and second ports. The first converter has an input coupled to the first port of the voltage balancer and an output at which a first converted voltage signal is provided. The second converter has an input coupled to the second port of the voltage balancer and an output at which a second converted voltage signal is provided.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: September 11, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: David J. Perreault, Khurram K. Afridi, Juan A. Santiago-Gonzalez, David M. Otten
  • Patent number: 9939435
    Abstract: A combination of surface plasmon field enhanced fluorescence spectroscopy (SPFS) and isotachophoresis (ITP) technologies for detecting biomolecules is disclosed. It uses ITP to preconcentrate the reactants and accelerate the reaction, and then delivers the reacted sample to an SPFS sensor for detection. A microfluidic device with a T-junction is provided, which has two reservoirs respectively containing a low-mobility trailing electrolyte buffer and a high-mobility leading electrolyte buffer, and a main fluid channel between the two reservoirs, where the SPFS sensor is located on a side channel joined to the main channel. A two-step technique is employed, including a step of sample loading and ITP extraction, and a step of delivery of concentrated sample to the detector chamber by pressure-driven flow. In another embodiment, the SPFS sensor is located on the main fluid channel between the two reservoirs. In a particular example, the technique is used in a DNAzyme assay.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: April 10, 2018
    Assignees: KONICA MINOLTA LABORATORY U.S.A., INC., THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Noriaki Yamamoto, Juan Santiago, Denitsa Milanova
  • Publication number: 20180095080
    Abstract: A combination of surface plasmon field enhanced fluorescence spectroscopy (SPFS) and isotachophoresis (ITP) technologies for detecting biomolecules is disclosed. It uses ITP to preconcentrate the reactants and accelerate the reaction, and then delivers the reacted sample to an SPFS sensor for detection. A microfluidic device with a T-junction is provided, which has two reservoirs respectively containing a low-mobility trailing electrolyte buffer and a high-mobility leading electrolyte buffer, and a main fluid channel between the two reservoirs, where the SPFS sensor is located on a side channel joined to the main channel. A two-step technique is employed, including a step of sample loading and ITP extraction, and a step of delivery of concentrated sample to the detector chamber by pressure-driven flow. In another embodiment, the SPFS sensor is located on the main fluid channel between the two reservoirs. In a particular example, the technique is used in a DNAzyme assay.
    Type: Application
    Filed: November 21, 2017
    Publication date: April 5, 2018
    Applicants: Konica Minolta Laboratory U.S.A., Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Noriaki Yamamoto, Juan Santiago, Denitsa Milanova
  • Publication number: 20180024067
    Abstract: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
    Type: Application
    Filed: July 31, 2017
    Publication date: January 25, 2018
    Inventors: Carl D. Meinhart, Brian Piorek, Seung Joon Lee, Martin Moskovits, Sanjoy Banerjee, Juan Santiago
  • Patent number: 9719930
    Abstract: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: August 1, 2017
    Assignees: The Regents of the University of California, Board of Trustees of the Leland Stanford Junior University
    Inventors: Carl D. Meinhart, Brian Piorek, Seung Joon Lee, Martin Moskovits, Sanjoy Banerjee, Juan Santiago
  • Publication number: 20160209407
    Abstract: A combination of surface plasmon field enhanced fluorescence spectroscopy (SPFS) and isotachophoresis (ITP) technologies for detecting biomolecules is disclosed. It uses ITP to preconcentrate the reactants and accelerate the reaction, and then delivers the reacted sample to an SPFS sensor for detection. A microfluidic device with a T-junction is provided, which has two reservoirs respectively containing a low-mobility trailing electrolyte buffer and a high-mobility leading electrolyte buffer, and a main fluid channel between the two reservoirs, where the SPFS sensor is located on a side channel joined to the main channel. A two-step technique is employed, including a step of sample loading and ITP extraction, and a step of delivery of concentrated sample to the detector chamber by pressure-driven flow. In another embodiment, the SPFS sensor is located on the main fluid channel between the two reservoirs. In a particular example, the technique is used in a DNAzyme assay.
    Type: Application
    Filed: March 16, 2016
    Publication date: July 21, 2016
    Applicants: KONICA MINOLTA LABORATORY U.S.A., INC., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Noriaki Yamamoto, Juan Santiago, Denitsa Milanova
  • Publication number: 20160033415
    Abstract: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
    Type: Application
    Filed: July 31, 2015
    Publication date: February 4, 2016
    Inventors: Carl D. Meinhart, Brian Piorek, Seung Joon Lee, Martin Moskovits, Sanjoy Banerjee, Juan Santiago
  • Publication number: 20160006365
    Abstract: A circuit includes a reconfigurable rectifier, a voltage balancer, and a pair of converters. The reconfigurable rectifier includes an ac input port and three output ports. In a first configuration, the reconfigurable rectifier can deliver power at a first output port and, in a second configuration, to at least a second output port. The voltage balancer includes first and second ports coupled to second and third output ports of the reconfigurable rectifier and is configured to balance received voltage at the first and second ports. The first converter has an input coupled to the first port of the voltage balancer and an output at which a first converted voltage signal is provided. The second converter has an input coupled to the second port of the voltage balancer and an output at which a second converted voltage signal is provided.
    Type: Application
    Filed: July 6, 2015
    Publication date: January 7, 2016
    Inventors: David J. Perreault, Khurram K. Afridi, Juan A. Santiago-Gonzalez, David M. Otten
  • Patent number: 9097676
    Abstract: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
    Type: Grant
    Filed: April 29, 2013
    Date of Patent: August 4, 2015
    Assignees: The Regents of the University of California, Board of Trustees of the Leland Stanford Junior University
    Inventors: Carl D. Meinhart, Brian Piorek, Seung Joon Lee, Martin Moskovits, Sanjoy Banerjee, Juan Santiago
  • Patent number: 8999129
    Abstract: The present invention provides a mechanism for separating or isolating charged particles under the influence of an electric field without metal electrodes being in direct contact with the sample solution. The metal electrodes normally in contact with the sample are replaced with high conductivity fluid electrodes situated parallel and adjacent to the sample. When the fluid electrodes transmit the electric field across the sample, particles within the sample migrate according to their electrophoretic mobility.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: April 7, 2015
    Assignees: Lawrence Livermore National Security, LLC, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Byoungsok Jung, Klint A. Rose, Maxim Shusteff, Alexandre Persat, Juan Santiago
  • Patent number: 8618694
    Abstract: System, method, and computer program product for dampening oscillations of the electrical power on a power grid. The system includes a wind park with multiple wind turbines. Each wind turbine includes a rotor, a generator operatively coupled with the rotor for generating electrical power, and an inverter coupling the generator with the power grid to output the electrical power to the power grid. A controller is configured to generate a first control signal to cause the inverter of the first wind turbine to modulate the electrical power output by the first wind turbine for dampening oscillations of one frequency in electrical power on the power grid and to generate a second control signal to cause the inverter of the second wind turbine to modulate the electrical power output by the second wind turbine for dampening oscillations of a different frequency in the electrical power on the power grid.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: December 31, 2013
    Assignee: Vestas Wind Systems A/S
    Inventors: Juan Santiago Santos, Brett D. Rollow, Jason Hoffman
  • Publication number: 20130121884
    Abstract: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
    Type: Application
    Filed: August 1, 2012
    Publication date: May 16, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Carl Meinhart, Brian Piorek, Seung Joon Lee, Martin Moskovits, Sanjoy Banerjee, Juan Santiago
  • Patent number: 8431409
    Abstract: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: April 30, 2013
    Assignees: The Regents of the University of California, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Carl D. Meinhart, Brian Piorek, Seung Joon Lee, Martin Moskovits, Sanjoy Banerjee, Juan Santiago
  • Publication number: 20120228141
    Abstract: The present invention provides a mechanism for separating or isolating charged particles under the influence of an electric field without metal electrodes being in direct contact with the sample solution. The metal electrodes normally in contact with the sample are replaced with high conductivity fluid electrodes situated parallel and adjacent to the sample. When the fluid electrodes transmit the electric field across the sample, particles within the sample migrate according to their electrophoretic mobility.
    Type: Application
    Filed: March 6, 2012
    Publication date: September 13, 2012
    Inventors: Byoungsok Jung, Klint A. Rose, Maxim Shusteff, Alexandre Persat, Juan Santiago
  • Patent number: 8247238
    Abstract: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: August 21, 2012
    Assignee: The Regents of the University of California
    Inventors: Carl D. Meinhart, Brian Piorek, Seung Joon Lee, Martin Moskovits, Sanjoy Banerjee, Juan Santiago
  • Publication number: 20120148451
    Abstract: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.
    Type: Application
    Filed: August 25, 2011
    Publication date: June 14, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Carl Meinhart, Brian Piorek, Seung Joon Lee, Martin Moskovits, Sanjoy Banerjee, Juan Santiago
  • Publication number: 20120004781
    Abstract: System, method, and computer program product for dampening oscillations of the electrical power on a power grid. The system includes a wind park with multiple wind turbines. Each wind turbine includes a rotor, a generator operatively coupled with the rotor for generating electrical power, and an inverter coupling the generator with the power grid to output the electrical power to the power grid. A controller is configured to generate a first control signal to cause the inverter of the first wind turbine to modulate the electrical power output by the first wind turbine for dampening oscillations of one frequency in electrical power on the power grid and to generate a second control signal to cause the inverter of the second wind turbine to modulate the electrical power output by the second wind turbine for dampening oscillations of a different frequency in the electrical power on the power grid.
    Type: Application
    Filed: June 30, 2010
    Publication date: January 5, 2012
    Applicant: VESTAS WIND SYSTEMS A/S
    Inventors: Juan Santiago Santos, Brett D. Rollow, Jason Hoffman
  • Patent number: 7799453
    Abstract: Water flooding at the cathode of a fuel cell is a common problem in fuel cells. By integrating an electroosmotic (EO) pump to remove product water from the cathode area, fuel cell power can be increased. Integration of EO pumps transforms the designs of air channel and air breathing cathodes, reducing air pumping power loads and increasing oxidant transport. Hydration of gas streams, management of liquid reactants, and oxidant delivery can also be accomplished with integrated electroosmotic pumps. Electroosmotic pumps have no moving parts, can be integrated as a layer of the fuel cell, and scale with centimeter to micron scale fuel cells.
    Type: Grant
    Filed: August 4, 2004
    Date of Patent: September 21, 2010
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Honda Motor Co., Ltd.
    Inventors: Juan Santiago, Jonathan Posner, Friedrich B. Prinz, Tibor Fabian, John Eaton, Suk-Won Cha, Cullen Buie, Daejoogn Kim, Hideaki Tsuru, Jun Sasahara, Tadahiro Kubota, Yuji Saito