Patents by Inventor Juergen Kleinschmidt

Juergen Kleinschmidt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10344057
    Abstract: The present invention relates to nucleic acids encoding the novel parvoviral protein “assembly activating protein” (AAP), the encoded polypeptides, methods of producing the polypeptides, antibodies specific for AAP, the use of the nucleic acids for the preparation of the polypeptides, the use of the nucleic acids or the polypeptides for the preparation of the parvoviral particle and methods of producing parvoviral particles essentially consisting of VP3 by providing in addition to the coding sequence of the parvoviral structural protein VP3 a sequence fragment Z/a nucleic acid encoding AAP in the cell and expressing VP3 and fragment Z under control of a rep-independent promoter. Furthermore, the present invention relates to parvoviral particles essentially consisting of VP3 and/oror obtainable by the above method as well as expression cassettes comprising (i) a heterologous promoter and (ii) VP3 coding sequence and/oror fragment Z.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: July 9, 2019
    Assignees: Deutsches Krebsforschungszentrum, Medigene AG
    Inventors: Florian Sonntag, Juergen Kleinschmidt, Markus Hoerer, Kerstin Pino Tossi
  • Publication number: 20170226160
    Abstract: The present invention relates to nucleic acids encoding the novel parvoviral protein “assembly activating protein” S(AAP), the encoded polypeptides, methods of producing the polypeptides, antibodies specific for AAP, the use of the nucleic acids for the preparation of the polypeptides, the use of the nucleic acids or the polypeptides for the preparation of the parvoviral particle and methods of producing parvoviral particles essentially consisting of VP3 by providing in addition to the coding sequence of the parvoviral structural protein VP3 a sequence fragment Z/a nucleic acid encoding AAP in the cell and expressing VP3 and fragment Z under control of a rep-independent promoter. Furthermore, the present invention relates to parvoviral particles essentially consisting of VP3 and/or obtainable by the above method as well as expression cassettes comprising (i) a heterologous promoter and (ii) VP3 coding sequence and/or fragment Z.
    Type: Application
    Filed: September 12, 2016
    Publication date: August 10, 2017
    Inventors: Florian SONNTAG, Juergen KLEINSCHMIDT, Markus HOERER, Kerstin LUX
  • Patent number: 9464119
    Abstract: The present invention relates to nucleic acids encoding the novel parvoviral protein “assembly activating protein” (AAP), the encoded polypeptides, methods of producing the polypeptides, antibodies specific for AAP, the use of the nucleic acids for the preparation of the polypeptides, the use of the nucleic acids or the polypeptides for the preparation of the parvoviral particle and methods of producing parvoviral particles essentially consisting of VP3. Furthermore, the invention relates to parvoviral particles essentially consisting of VP3 and/or obtainable by the above method as well as expression cassettes comprising (i) a heterologous promoter and (ii) VP3 coding sequence and/or fragment Z. The invention further relates to a medicament, particularly a vaccine, comprising the parvoviral particles or expression cassettes and their use.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: October 11, 2016
    Assignees: Deutsches Krebsforschungszentrum, Medigene AG
    Inventors: Florian Sonntag, Juergen Kleinschmidt, Markus Hoerer, Kerstin Lux
  • Patent number: 9170505
    Abstract: The invention is directed to an arrangement for generating EUV radiation particularly for source modules in exposure installations for EUV lithography for semiconductor chip fabrication. The object of the invention, to find a novel possibility for realizing an EUV source module which appreciably improves the ratio of resources to results in the transfer of radiation from the primary source location (plasma 3) to the secondary source location (output opening (6) of the source module (1)/intermediate focus plane (62)), is met according to the invention in that the plasma (3) is formed as a volume emitter for direct illumination of the output opening (6) without collector optics (5), and the transverse dimension (d) of the plasma (3) is greater than the diameter (D) of the output opening (6), wherein the extent to which the diameter is exceeded depends on the distance (L) between the plasma (3) and the output opening (6) and on the numerical aperture (NA) of the illumination system downstream.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: October 27, 2015
    Assignee: USHIO Denki Kabushiki Kaisha
    Inventors: Vladimir Korobochko, Juergen Kleinschmidt
  • Patent number: 9077318
    Abstract: The invention relates to a device for locking an adjusting means (5), in particular an electrical addressing device, mounted on a printed circuit board (1) which extends in an x and/or y direction. The device includes an essentially flat base plate (2) having a length (L), a width (B), and a thickness (D), to which a first detent spring (4) is attached for locking engagement with marking means (23, 23?) of the adjusting means (5). The first detent spring preferably has an oblong spring leg (7), wherein in the installed state the base plate (2) is mounted on the printed circuit board (1).
    Type: Grant
    Filed: April 26, 2013
    Date of Patent: July 7, 2015
    Assignee: Phoenix Contact GmbH & Co. KG
    Inventors: Markus Becker, Rainer Gockel, Daniel Klein, Frank Hakemeyer, Christian Starke, Jürgen Kleinschmidt
  • Patent number: 8975543
    Abstract: An electric terminal module includes a plurality of electric contact elements configured to connect to electric conductors and a housing including an opening in at least one side wall thereof. A printed circuit board is disposed in the housing. The printed circuit board includes a circuit arrangement having a plurality of electric components configured to perform a specific function and a mount. An adjusting device is operable to change at least one electric characteristic quantity of the circuit arrangement. The adjusting device is mounted directly onto the printed circuit board on the mount and is operable from outside the housing through the opening so as to swivel or turn.
    Type: Grant
    Filed: November 17, 2009
    Date of Patent: March 10, 2015
    Assignee: Phoenix Contact GmbH & Co. KG
    Inventors: Frank Hakemeyer, Christian Starke, Juergen Kleinschmidt
  • Patent number: 8610354
    Abstract: The invention is related to a gas discharge-based radiation source which emits short-wavelength radiation, wherein an emitter is ionized and compressed by pulse-shaped currents between two electrodes arranged in a vacuum chamber and is excited to form an emitting plasma. According to the invention, the plasma is preserved by means of a high-frequency sequence of pulse-shaped currents the pulse repetition period of which is adjusted so as to be shorter than a lifetime of the plasma so that the plasma is kept periodically alternating between a high-energy state of an emitting compressed plasma and a low-energy state of a relaxing plasma. For exciting the relaxing plasma to the compressed plasma, excitation energy is coupled into the relaxing plasma by making use of pulse-shaped currents with repetition frequencies between 50 kHz and 4 MHz and pulse widths equal to the pulse repetition period.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: December 17, 2013
    Assignee: XTREME technologies GmbH
    Inventors: Max Christian Schuermann, Lutz Dippmann, Juergen Kleinschmidt, Guido Schriever
  • Patent number: 8546775
    Abstract: The invention is directed to a method and an apparatus for stabilizing the source location during the generation of EUV radiation based on a discharge plasma. The object of finding a novel possibility for stabilizing the source location during the generation of EUV radiation which allows changes in position of the source location to be compensated in a simple manner during the operation of the radiation source is met according to the invention in that a first beam aligning unit (7), a second beam aligning unit (4), and a beam focusing unit (5) are arranged in the vaporization beam (3) and are connected to first to third measuring devices (8, 9, 10) and can be adjusted in order to acquire and compensate for direction deviations and divergence deviations of the vaporization beam (3) with respect to reference values.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: October 1, 2013
    Assignee: XTREME technologies GmbH
    Inventor: Juergen Kleinschmidt
  • Patent number: 8476418
    Abstract: The present invention is concerned with the provision of a polynucleotide encoding an AAV capsid polypeptide comprising an inserted peptide and a vector comprising said polynucleotide. Moreover, contemplated is a host cell comprising said polynucleotide or vector, a method for the manufacture of said capsid polypeptide as well as said polypeptide. Further included is an antibody specifically binding to said polypeptide and a medicament comprising said polynucleotide, vector, polypeptide, or antibody. Also contemplated are the use of said polynucleotide, vector, polypeptide, or antibody for the manufacture of a medicament for the treatment of vascular disease and a method for the identification of a compound binding to said polypeptide.
    Type: Grant
    Filed: May 28, 2010
    Date of Patent: July 2, 2013
    Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls-Universitat Heidelberg
    Inventors: Oliver Mueller, Hugo Katus, Karl Varadi, Jürgen Kleinschmidt
  • Patent number: 8426834
    Abstract: The invention relates to a method and an apparatus for generating EUV radiation from a gas discharge plasma. The object of the invention, to generate EUV radiation from a gas discharge plasma by with is optimized conversion efficiency of the EUV emission while locally limiting the electric discharge channel, is met in that a channel-generating beam of pulsed high-energy radiation is supplied in at least two partial beams which are focused in a pulse-synchronized manner into a superposition region along a spacing axis between the electrodes, and an electrically conductive discharge channel is generated along the superposition region due to an ionization at least of a buffer gas present in the discharge space, wherein the pulsed high-energy radiation of the channel-generating beam is triggered in such a way that the discharge channel is generated before a discharge current pulse has reached its maximum value.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: April 23, 2013
    Assignee: XTREME technologies GmbH
    Inventor: Juergen Kleinschmidt
  • Patent number: 8410422
    Abstract: The invention is related to the adjustment of characteristics of a beam bundle of high-energy radiation emitted from a plasma, particularly for applications in semiconductor lithography. For acquiring and adjusting characteristics of a beam bundle of high-energy radiation emitted from a plasma and focused by means of collector optics, an intensity distribution of the radiation is acquired over the cross section of a convergent beam bundle in a measuring plane perpendicular to the optical axis in front of an intermediate focus of the collector optics, and intensity values are recorded in defined sectors for a quantity of reception regions of a measuring device which are aligned with different radii concentric to the optical axis, and measured quantities and control variables are determined from a comparison of the intensity values of different sectors for aligning the collector optics.
    Type: Grant
    Filed: March 31, 2012
    Date of Patent: April 2, 2013
    Assignee: XTREME technologies GmbH
    Inventors: Denis Bolshukhin, Alexander Christian Keller, Max Christian Schuermann, Guido Schriever, Imtiaz Ahmad, Juergen Kleinschmidt
  • Publication number: 20120248327
    Abstract: The invention is related to the adjustment of characteristics of a beam bundle of high-energy radiation emitted from a plasma, particularly for applications in semiconductor lithography. For acquiring and adjusting characteristics of a beam bundle of high-energy radiation emitted from a plasma and focused by means of collector optics, an intensity distribution of the radiation is acquired over the cross section of a convergent beam bundle in a measuring plane perpendicular to the optical axis in front of an intermediate focus of the collector optics, and intensity values are recorded in defined sectors for a quantity of reception regions of a measuring device which are aligned with different radii concentric to the optical axis, and measured quantities and control variables are determined from a comparison of the intensity values of different sectors for aligning the collector optics.
    Type: Application
    Filed: March 31, 2012
    Publication date: October 4, 2012
    Applicant: XTREME technologies GmbH
    Inventors: Denis Bolshukhin, Alexander Christian Keller, Max Christian Schuermann, Guido Schriever, Imtiaz Ahmad, Juergen Kleinschmidt
  • Publication number: 20120202732
    Abstract: The present invention is concerned with the provision of a polynucleotide encoding an AAV capsid polypeptide comprising an inserted peptide and a vector comprising said polynucleotide. Moreover, contemplated is a host cell comprising said polynucleotide or vector, a method for the manufacture of said capsid polypeptide as well as said polypeptide. Further included is an antibody specifically binding to said polypeptide and a medicament comprising said polynucleotide, vector, polypeptide, or antibody. Also contemplated are the use of said polynucleotide, vector, polypeptide, or antibody for the manufacture of a medicament for the treatment of vascular disease and a method for the identification of a compound binding to said polypeptide.
    Type: Application
    Filed: May 28, 2010
    Publication date: August 9, 2012
    Inventors: Oliver Mueller, Hugo Katus, Karl Varadi, Jürgen Kleinschmidt
  • Publication number: 20120153829
    Abstract: The invention is related to a gas discharge-based radiation source which emits short-wavelength radiation, wherein an emitter is ionized and compressed by pulse-shaped currents between two electrodes arranged in a vacuum chamber and is excited to form an emitting plasma. According to the invention, the plasma is preserved by means of a high-frequency sequence of pulse-shaped currents the pulse repetition period of which is adjusted so as to be shorter than a lifetime of the plasma so that the plasma is kept periodically alternating between a high-energy state of an emitting compressed plasma and a low-energy state of a relaxing plasma. For exciting the relaxing plasma to the compressed plasma, excitation energy is coupled into the relaxing plasma by making use of pulse-shaped currents with repetition frequencies between 50 kHz and 4 MHz and pulse widths equal to the pulse repetition period.
    Type: Application
    Filed: December 5, 2011
    Publication date: June 21, 2012
    Applicant: XTREME TECHNOLOGIES GMBH
    Inventors: Max Christian SCHUERMANN, Lutz DIPPMANN, Juergen KLEINSCHMIDT, Guido SCHRIEVER
  • Publication number: 20120135022
    Abstract: The present invention relates to nucleic acids encoding the novel parvoviral protein “assembly activating protein” (AAP), the encoded polypeptides, methods of producing the polypeptides, antibodies specific for AAP, the use of the nucleic acids for the preparation of the polypeptides, the use of the nucleic acids or the polypeptides for the preparation of the parvoviral particle and methods of producing parvoviral particles essentially consisting of VP3 by providing in addition to the coding sequence of the parvoviral structural protein VP3 a sequence fragment Z/a nucleic acid encoding AAP in the cell and expressing VP3 and fragment Z under control of a rep-independent promoter. Furthermore, the present invention relates to parvoviral particles essentially consisting of VP3 and/or obtainable by the above method as well as expression cassettes comprising (i) a heterologous promoter and (ii) VP3 coding sequence and/or fragment Z.
    Type: Application
    Filed: March 4, 2010
    Publication date: May 31, 2012
    Applicants: MediGene AG, Deutsches Krebsforschungszentrum
    Inventors: Florian Sonntag, Juergen Kleinschmidt, Markus Hoerer, Kerstin Lux
  • Publication number: 20120112101
    Abstract: The invention is directed to a method and an apparatus for stabilizing the source location during the generation of EUV radiation based on a discharge plasma. The object of finding a novel possibility for stabilizing the source location during the generation of EUV radiation which allows changes in position of the source location to be compensated in a simple manner during the operation of the radiation source is met according to the invention in that a first beam aligning unit (7), a second beam aligning unit (4), and a beam focusing unit (5) are arranged in the vaporization beam (3) and are connected to first to third measuring devices (8, 9, 10) and can be adjusted in order to acquire and compensate for direction deviations and divergence deviations of the vaporization beam (3) with respect to reference values.
    Type: Application
    Filed: November 8, 2011
    Publication date: May 10, 2012
    Applicant: XTREME TECHNOLOGIES GMBH
    Inventor: Juergen Kleinschmidt
  • Publication number: 20120080619
    Abstract: The invention relates to a method and an apparatus for generating EUV radiation from a gas discharge plasma. The object of the invention, to generate EUV radiation from a gas discharge plasma by with is optimized conversion efficiency of the EUV emission while locally limiting the electric discharge channel, is met in that a channel-generating beam of pulsed high-energy radiation is supplied in at least two partial beams which are focused in a pulse-synchronized manner into a superposition region along a spacing axis between the electrodes, and an electrically conductive discharge channel is generated along the superposition region due to an ionization at least of a buffer gas present in the discharge space, wherein the pulsed high-energy radiation of the channel-generating beam is triggered in such a way that the discharge channel is generated before a discharge current pulse has reached its maximum value.
    Type: Application
    Filed: September 22, 2011
    Publication date: April 5, 2012
    Applicant: XTREME TECHNOLOGIES GMBH
    Inventor: Juergen Kleinschmidt
  • Publication number: 20110211355
    Abstract: An electric terminal module includes a plurality of electric contact elements configured to connect to electric conductors and a housing including an opening in at least one side wall thereof. A printed circuit board is disposed in the housing. The printed circuit board includes a circuit arrangement having a plurality of electric components configured to perform a specific function and a mount. An adjusting device is operable to change at least one electric characteristic quantity of the circuit arrangement. The adjusting device is mounted directly onto the printed circuit board on the mount and is operable from outside the housing through the opening so as to swivel or turn.
    Type: Application
    Filed: November 17, 2009
    Publication date: September 1, 2011
    Applicant: PHOENIX CONTACT GMBH & CO. KG
    Inventors: Frank Hakemeyer, Christian Starke, Juergen Kleinschmidt
  • Patent number: 7974321
    Abstract: The invention is directed to a method and an arrangement for stabilizing the average emitted radiation output of a pulsed radiation source. It is the object of the invention to find a novel possibility for stabilizing the average emitted radiation output of a pulsed radiation source which enables a reliable regulation even when there is no sufficiently reliable manipulated variable for influencing the emitted pulse energy (Ei). According to the invention, this object is met in that the individual pulse energy (Ei) of the current radiation pulse is measured, the deviation of the current individual pulse energy (Ei) from a previously determined target value (E0) is determined, and the pulse interval (?ti+1) preceding the triggering of the next radiation pulse is controlled depending on the magnitude of the deviation between the current individual pulse energy (Ei) and the target value (E0) of the pulse energy.
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: July 5, 2011
    Assignee: XTREME technologies GmbH
    Inventors: Jesko Brudermann, Juergen Kleinschmidt
  • Patent number: D626516
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: November 2, 2010
    Assignee: Phoenix Contact GmbH & Co. KG
    Inventors: Frank Hakemeyer, Christian Starke, Juergen Kleinschmidt